Clinical science and molecular medicine最新文献_第9页

Parallel changes between lipoprotein lipase activating capacity and lipid concentrations in the serum of rats and ferrets during development and dietary manipulation. 大鼠和雪貂血清中脂蛋白脂肪酶激活能力和脂质浓度在发育和饮食调节过程中的平行变化。

Clinical science and molecular medicine Pub Date : 1978-07-01 DOI: 10.1042/cs0550121

A Cryer, H M Jones

引用次数: 7

Urinary kallikrein excretion and plasma renin activity in patients with essential hypertension and primary aldosteronism. 原发性高血压和醛固酮增多症患者尿钾激肽分泌和血浆肾素活性。

Clinical science and molecular medicine Pub Date : 1978-07-01 DOI: 10.1042/cs0550051

A Lechi, G Covi, C Lechi, A Corgnati, E Arosio, M Zatti, L A Scuro

{"title":"Urinary kallikrein excretion and plasma renin activity in patients with essential hypertension and primary aldosteronism.","authors":"A Lechi, G Covi, C Lechi, A Corgnati, E Arosio, M Zatti, L A Scuro","doi":"10.1042/cs0550051","DOIUrl":"https://doi.org/10.1042/cs0550051","url":null,"abstract":"1. The 24 h urinary excretion of kallikrein has been studied in 40 normotensive control subjects and in 74 age-matched patients with essential hypertension under similar conditions. By use of the renin-sodium index, hypertensive patients were divided into two subgroup: low-renin hypertension and normal-renin hypertension patients. Urinary kallikrein determinations were also obtained from six hypertensive patients with primary aldosteronism. 2. Urinary kallikrein was significantly lower both in patients with normal-renin and low-renin essential hypertension. Urinary kallikrein excretion was very high in the patients with primary aldosteronism. 3. In nine hypertensive patients beta-adreno-receptor-blocking therapy caused a significant decrease of plasma renin activity, but had no significant effect on urinary kallikrein excretion. 4. The results support the concept that low urinary kallikrein is likely to be a marker of essential hypertension. Under certain conditions its excretion is positively related to mineralocorticoid hormone concentrations but it is not primarily related to the renin-angiotensin system.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 1","pages":"51-5"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11869334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

Determinants of high blood pressure in salt-deprived renal hypertensive rats: role of changes in plasma volume, extracellular fluid volume and plasma angiotensin II. 盐剥夺性肾性高血压大鼠高血压的决定因素:血浆容量、细胞外液容量和血浆血管紧张素II变化的作用

Clinical science and molecular medicine Pub Date : 1978-07-01 DOI: 10.1042/cs0550081

A J Mourant

{"title":"Determinants of high blood pressure in salt-deprived renal hypertensive rats: role of changes in plasma volume, extracellular fluid volume and plasma angiotensin II.","authors":"A J Mourant","doi":"10.1042/cs0550081","DOIUrl":"https://doi.org/10.1042/cs0550081","url":null,"abstract":"1. Rats with indwelling aortic and right atrial cannulae were maintained on a sodium-free diet before and after renal arterial constriction combined with contralateral nephrectomy. Control animals underwent the same protocol except that non-constricting clips were used. 2. Plasma volumes in the salt-deprived animals were lower than previously determined values in animals with free access to sodium. After clipping plasma volume increased in the hypertensive animals. Extracellular fluid volume was increased equally in both normotensive and hypertensive animals on the second postoperative day only. 3. Before clipping and contralateral nephrectomy plasma angiotensin II values were higher than normal. After the operation angiotensin II concentrations fell to normal over a period of 14 days without significant differences between experimental and control groups. 4. It is concluded that high blood pressure after clipping may be in part maintained by increases in plasma volume. However, the results strongly suggest that other renal mechanisms are likely to be of major pathogenic importance.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 1","pages":"81-7"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11870020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Induction of lysinuria in the rat by two para-substituted guanidinophenylalanines. 两种对取代胍苯丙氨酸对大鼠赖氨酸尿的诱导作用。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540673

C W Owens

引用次数: 0

Role of endotoxin in glycerol-induced renal failure in the rat. 内毒素在甘油致大鼠肾衰中的作用。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540615

J P Nolan, R C Venuto, G S Goldmann

引用次数: 12

Effects of airway anaesthesia on the ability to detect added inspiratory resistive loads. 气道麻醉对检测吸入阻力负荷能力的影响。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540621

B A Chaudhary, N K Burki

{"title":"Effects of airway anaesthesia on the ability to detect added inspiratory resistive loads.","authors":"B A Chaudhary, N K Burki","doi":"10.1042/cs0540621","DOIUrl":"https://doi.org/10.1042/cs0540621","url":null,"abstract":"1. The effects of airway anaesthesia on the ability to detect added inspiratory resistive loads were studied in normal subjects. A 4% solution of lignocaine hydrochloride was used for anaesthesia of the airways. 2. After anaesthesia of the mouth and upper airways to the level of the vocal cords there was a significant deterioration in the detection ability expressed in terms of the absolute added resistance (deltaR), with a concomitant increase in pulmonary resistance (Rint.). However, there was no significant change in the detection ability expressed in terms of the ratio of deltaR to the sum of Rint. and the minimal resistance of the apparatus (deltaR/Ro). 3. After combined anaesthesia of the upper and lower airways there was no significant change in pulmonary resistance or in the detection ability expressed either as deltaR or as deltaR/Ro. 4. We conclude that, in normal subjects, the main site of detection of added inspiratory resistive loads does not lie in the upper or lower airways. Our results and those of previous studies suggest that the diaphragm is the most likely site of detection of added resistive loads.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"621-6"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Purine biosynthesis de novo by lymphocytes in gout. 痛风患者淋巴细胞重新合成嘌呤。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540595

P Kamoun, J Chanard, M Brami, J L Funck-Brentano

引用次数: 2

Effect of arterial pressure and inheritance on the sodium excretory capacity of normal young men. 动脉压和遗传对正常青年男性钠排泄能力的影响。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540639

R C Wiggins, I Basar, J D Slater

引用次数: 41

The metabolism and clinical relevance of the keto acid analogues of essential amino acids. 必需氨基酸的酮酸类似物的代谢和临床意义。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540589

P Richards

引用次数: 14

Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle. 人四头肌持续最大自主收缩的中枢和外周疲劳。

Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540609

B Bigland-Ritchie, D A Jones, G P Hosking, R H Edwards

{"title":"Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle.","authors":"B Bigland-Ritchie, D A Jones, G P Hosking, R H Edwards","doi":"10.1042/cs0540609","DOIUrl":"https://doi.org/10.1042/cs0540609","url":null,"abstract":"1. The fatigue of force that occurs during the first 60 s of a maximum voluntary contraction of the human quadriceps has been examined by comparing the voluntary force with that obtained by brief tetanic stimulation at 50 Hz in nine healthy subjects. In three subjects the voluntary force declined in parallel with the tetanic force whereas in the remainder it fell more rapidly, suggesting that central fatigue was present. 2. For those subjects who showed little or no central fatigue, surface electromyograph (EMG) activity remained approximately constant while the force declined by about 60%. In the others, EMG activity and force declined in parallel but when an extra effort was made the subjects could briefly increase their force and this was accompanied by a proportionately greater increase in EMG activity (generally up to the original value). 3. It is concluded that in sustained maximum voluntary contractions of the quadriceps (a) central fatigue may account for an appreciable proportion of the force loss, (b) surface EMG recordings provide no evidence that neuromuscular junction failure is the limiting factor determining the loss of force in this muscle.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"609-14"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 433