{"title":"Induction of lysinuria in the rat by two para-substituted guanidinophenylalanines.","authors":"C W Owens","doi":"10.1042/cs0540673","DOIUrl":null,"url":null,"abstract":"<p><p>1. p-Guanidino- and p-guanidinomethyl-phenylalanine increase the renal excretion of lysine especially and, to some extent, cystine in the phenylalanine-loaded rat. The methyl derivative is the more effective. 2. The lysinuria is dose-dependent, reversible, pronounced when the intravenous infusion of analogue exceeds 10 mumol min-1 kg-1 and does not appear to be secondary to changes in urine flow or sodium excretion. 3. A mechanism for induced basic amino-aciduria conditions is suggested.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"673-7"},"PeriodicalIF":0.0000,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540673","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical science and molecular medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1042/cs0540673","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
1. p-Guanidino- and p-guanidinomethyl-phenylalanine increase the renal excretion of lysine especially and, to some extent, cystine in the phenylalanine-loaded rat. The methyl derivative is the more effective. 2. The lysinuria is dose-dependent, reversible, pronounced when the intravenous infusion of analogue exceeds 10 mumol min-1 kg-1 and does not appear to be secondary to changes in urine flow or sodium excretion. 3. A mechanism for induced basic amino-aciduria conditions is suggested.
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