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Effect of administration of Sar1-Ala8-angiotensin II during the development and maintenance of renal hypertension in the rat. sar1 - ala8 -血管紧张素II在大鼠肾性高血压发生和维持中的作用。
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540633
M Fernandes, R Fiorentini, G Onesti, G Bellini, A B Gould, H Hessan, K E Kim, C Swartz
{"title":"Effect of administration of Sar1-Ala8-angiotensin II during the development and maintenance of renal hypertension in the rat.","authors":"M Fernandes,&nbsp;R Fiorentini,&nbsp;G Onesti,&nbsp;G Bellini,&nbsp;A B Gould,&nbsp;H Hessan,&nbsp;K E Kim,&nbsp;C Swartz","doi":"10.1042/cs0540633","DOIUrl":"https://doi.org/10.1042/cs0540633","url":null,"abstract":"<p><p>1. Sar1-Ala8-Angiotensin II (an angiotensin antagonist) was infused in rats during the development and maintenance of renal hypertension produced by aortic ligation between renal arteries. 2. In the early phase (5 and 12 days after ligation), infusion of the antagonist markedly decreased blood pressure although it did not reach normal pressures. Later (day 40) only a modest decrease in blood pressure was noted. 3. Removal of the small left kidney always decreased the blood pressure to normal pressures. 4. It is concluded that the renin-angiotensin system is the major pressor component in the initiation of this hypertension. Later, other factors of renal origin assume a pressor function.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"633-7"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Lysosomal enzymes in human urine: evidence for polymorphonuclear leucocyte proteinase involvement in the pathogenesis of human glomerulonephritis. 人尿溶酶体酶:多形核白细胞蛋白酶参与人肾小球肾炎发病的证据。
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540667
E Sanders, G A Coles, M Davies
{"title":"Lysosomal enzymes in human urine: evidence for polymorphonuclear leucocyte proteinase involvement in the pathogenesis of human glomerulonephritis.","authors":"E Sanders,&nbsp;G A Coles,&nbsp;M Davies","doi":"10.1042/cs0540667","DOIUrl":"https://doi.org/10.1042/cs0540667","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"667-72"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Effect of blood transfusion on the carbon monoxide transfer factor of the lung in man. 输血对人体肺部一氧化碳传递因子的影响。
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540627
E H Clark, R L Woods, J M Hughes
{"title":"Effect of blood transfusion on the carbon monoxide transfer factor of the lung in man.","authors":"E H Clark,&nbsp;R L Woods,&nbsp;J M Hughes","doi":"10.1042/cs0540627","DOIUrl":"https://doi.org/10.1042/cs0540627","url":null,"abstract":"<p><p>1. Ten studies were performed on nine patients with haematological disorders but with normal lungs, who required intermittent blood transfusions. The transfer factor for carbon monoxide and uptake of carbon monoxide per unit lung volume (KCO) were measured with the single breath technique before and at various intervals after transfusion. 2. The mean haemoglobin concentration increased from 7.7 to 11.1 g/dl. 3. The TLCO increased according to a formula based on the Roughton & Forster (1957) diffusion equations. TLCO (standardized) = TLCO (observed). (10.2 + Hb)/1.7 Hb, where haemoglobin (Hb) is expressed as g/dl. 4. The correlation between measured and predicted values was slightly better if changes in alveolar volume were taken into account, by using the KCO value.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"627-31"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 43
Renal function in chronic obstructive jaundice: a micropuncture study in rats. 慢性阻塞性黄疸大鼠肾功能的微穿刺研究。
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540649
M E Allison, N G Moss, M M Fraser, J W Dobbie, C J Ryan, A C Kennedy, L H Blumgart
{"title":"Renal function in chronic obstructive jaundice: a micropuncture study in rats.","authors":"M E Allison,&nbsp;N G Moss,&nbsp;M M Fraser,&nbsp;J W Dobbie,&nbsp;C J Ryan,&nbsp;A C Kennedy,&nbsp;L H Blumgart","doi":"10.1042/cs0540649","DOIUrl":"https://doi.org/10.1042/cs0540649","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"649-59"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540649","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Factors related to potassium transport in chronic stable renal disease in man. 慢性稳定型肾病患者钾转运相关因素研究
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540661
T Kahn, D M Kaji, G Nicolis, L R Krakoff, R M Stein
{"title":"Factors related to potassium transport in chronic stable renal disease in man.","authors":"T Kahn,&nbsp;D M Kaji,&nbsp;G Nicolis,&nbsp;L R Krakoff,&nbsp;R M Stein","doi":"10.1042/cs0540661","DOIUrl":"https://doi.org/10.1042/cs0540661","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"661-6"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Natriuretic effect of propranolol on dogs with chronic bile-duct ligation. 心得安对慢性胆管结扎犬的利钠作用。
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540603
J Winaver, C Chaimovitz, O S Better
{"title":"Natriuretic effect of propranolol on dogs with chronic bile-duct ligation.","authors":"J Winaver,&nbsp;C Chaimovitz,&nbsp;O S Better","doi":"10.1042/cs0540603","DOIUrl":"https://doi.org/10.1042/cs0540603","url":null,"abstract":"<p><p>1. Chronic ligation of the bile duct in dogs is associated with salt retention and a blunted natriuretic response to extracellular volume expansion. The mechanism of this phenomenon has not been clarified. 2. We have examined the influence of chronic beta-adrenergic blockade on sodium excretion in dogs with bile-duct ligation during extracellular hypotonic volume expansion. 3. Urinary excretion of sodium and fractional excretion of sodium rose significantly after 5 days of oral DL-propranolol administration to dogs with bile-duct ligation. 4. The antinatriuresis after bile-duct ligation was not followed by a significant alteration in the mean peripheral plasma renin activity as compared with control values. 5. It is suggested that propranolol can partially reverse the antinatriuresis of chronic bile-duct ligation, and that this is mediated by an extrarenal effect of the beta-adrenergic blockade.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"603-7"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The use of the human erythrocyte as a model for studying the action of diuretics on sodium and chloride transport. 以人红细胞为模型研究利尿剂对钠和氯化物运输的作用。
Clinical science and molecular medicine Pub Date : 1978-06-01 DOI: 10.1042/cs0540679
B A Brooks, A F Lant
{"title":"The use of the human erythrocyte as a model for studying the action of diuretics on sodium and chloride transport.","authors":"B A Brooks,&nbsp;A F Lant","doi":"10.1042/cs0540679","DOIUrl":"https://doi.org/10.1042/cs0540679","url":null,"abstract":"<p><p>1. The Na+ and Cl- transport systems of human erythrocytes have been compared for their sensitivities to diuretics known to act in the ascending limb of Henle's loop. In addition, chemical analogues of 'loop' compounds and also diuretics which act in other areas of the nephron have been examined. 2. The Na+ transport system lacks specificity with respect to inhibition by 'loop' diuretics and also a related chemical analogue studied at equivalent concentrations. 3. The Cl- transport system is inhibited, at low concentrations, by diuretics known to act in the ascending limb of Henle's loop. 4. Erythrocyte Cl- transport offers a useful model with which to study the biochemical action of diuretics.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 6","pages":"679-83"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11859536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Effect of zinc on leucocyte sodium transport in vitro. 锌对体外白细胞钠转运的影响。
Clinical science and molecular medicine Pub Date : 1978-05-01 DOI: 10.1042/cs0540585
J Patrick, J Michael, M N Golden, B E Golden, P J Hilton
{"title":"Effect of zinc on leucocyte sodium transport in vitro.","authors":"J Patrick,&nbsp;J Michael,&nbsp;M N Golden,&nbsp;B E Golden,&nbsp;P J Hilton","doi":"10.1042/cs0540585","DOIUrl":"https://doi.org/10.1042/cs0540585","url":null,"abstract":"<p><p>1. In a preparation of human leucocytes maintained in tissue culture fluid, increasing the extracellular zinc concentration leads to a significant increase in both ouabain-sensitive sodium efflux and in sodium influx. 2. Cell water and sodium content do not alter significantly with increasing extracellular zinc concentration. 3. A small increase in the ouabain-insensitive sodium efflux can be demonstrated when the external zinc concentration is raised from 0.75 mumol/l to 90 mumol/l.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 5","pages":"585-7"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11951091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats. 血清和萨拉拉萨素对急性肾功能衰竭大鼠肌血红蛋白尿的影响。
Clinical science and molecular medicine Pub Date : 1978-05-01 DOI: 10.1042/cs0540555
K Bauereiss, K G Hofbauer, A Konrads, F Gross
{"title":"Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats.","authors":"K Bauereiss,&nbsp;K G Hofbauer,&nbsp;A Konrads,&nbsp;F Gross","doi":"10.1042/cs0540555","DOIUrl":"https://doi.org/10.1042/cs0540555","url":null,"abstract":"<p><p>1. In rats deprived of food and water for 24 h acute renal failure was produced by the intramuscular injection of glycerol. Eight hours later plasma urea concentration had increased threefold despite a small rise in urine volume. Plasma concentrations of renin and renin substrate were elevated. 2. When saralasin, a competitive antagonist of angiotensin II, was infused for 8 h after glycerol injection, urine volume and plasma urea were similar to values in rats that had received an infusion of saline. 3. Administration of rat serum (4.5 ml h-1 kg-1) for 4 h suppressed plasma renin concentrations, but plasma urea increased to the same extent as in rats without serum. 4. When saralasin and serum were infused at the same time, urine volume, urine osmolality and solute excretion increased and the rise of plasma urea was diminished. 5. Saralasin has a protective effect against glycerol-induced acute renal failure only when volume is replaced concomitantly.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 5","pages":"555-60"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11950044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Control of enzymatically inactive renin in man under various pathological conditions: implications for the interpretation of renin measurements in peripheral and renal venous plasma. 不同病理条件下人体内酶失活肾素的控制:外周和肾静脉血浆中肾素测量的解释意义。
Clinical science and molecular medicine Pub Date : 1978-05-01 DOI: 10.1042/cs0540529
F H Derkx, G J Wenting, A J Man in 't Veld, R P Verhoeven, M A Schalekamp
{"title":"Control of enzymatically inactive renin in man under various pathological conditions: implications for the interpretation of renin measurements in peripheral and renal venous plasma.","authors":"F H Derkx,&nbsp;G J Wenting,&nbsp;A J Man in 't Veld,&nbsp;R P Verhoeven,&nbsp;M A Schalekamp","doi":"10.1042/cs0540529","DOIUrl":"https://doi.org/10.1042/cs0540529","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"54 5","pages":"529-38"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0540529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11258510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 95
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