Clinical science and molecular medicine最新文献_第5页

The respiratory response to inhaled carbon dioxide in man after 3 hours exposure to 3% carbon dioxide. 人体吸入3%二氧化碳3小时后的呼吸反应。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550309

K Prowse, C Duvivier, R Peslin, P Sadoul

{"title":"The respiratory response to inhaled carbon dioxide in man after 3 hours exposure to 3% carbon dioxide.","authors":"K Prowse, C Duvivier, R Peslin, P Sadoul","doi":"10.1042/cs0550309","DOIUrl":"https://doi.org/10.1042/cs0550309","url":null,"abstract":"1. The respiratory response to inhaled 3% and 6% CO2 was measured in 10 normal subjects after a 3 h acclimatization period to 3% CO2 in an environmental chamber. Control studies were carried out after a 3 h period of breathing air in the chamber. 2. At the end of the acclimatization period studies were carried out during 20 min periods breathing 3% CO2, 6% CO2 and air. 3. At 2-min intervals during the studies measurements were made of tidal volume (Vt), breathing frequency (fR), minute ventilation (Ve), viscous pulmonary rate of work (Wp) and total viscous rate of work across the lungs and apparatus (Wt). Blood gas tensions were measured at the end of this period. 4. After acclimatization to 3% CO2 there was a significant shift in the response curves Ve/Pa,CO2 and Wt/Pa,CO2 such that subjects showed higher Pa,CO2 values for given values of Ve or Wt. There was no significant change in the slope of the response curves. 5. No correlation was found between the slope of the response curve after the control period breathing air and the degree of shift of the response curve. 6. There was no difference in respiratory pattern or in pulmonary resistance. 7. Similar results were found in two subjects studied after 24 h acclimatization to 3% CO2 but one subject also showed a significant change in the slope of the Ve/Pa,CO2 curve.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 3","pages":"309-16"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11899750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasopressin effects on plasma renin activity in male and female rats. 抗利尿激素对雌雄大鼠血浆肾素活性的影响。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550301

I W Henderson, R J Balment, J A Oliver

引用次数: 15

Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance. 自发性高血压大鼠主动脉肾素的部分特征及其与血浆肾素、血压和钠平衡的关系。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550261

J D Barrett, P Eggena, M P Sambhi

{"title":"Partial characterization of aortic renin in the spontaneously hypertensive rat and its interrelationship with plasma renin, blood pressure and sodium balance.","authors":"J D Barrett, P Eggena, M P Sambhi","doi":"10.1042/cs0550261","DOIUrl":"https://doi.org/10.1042/cs0550261","url":null,"abstract":"1. A renin-like enzyme in aortic tissue of the spontaneously hypertensive rat was found to be a freely dissociable enzyme (saline homogenization) with an affinity for the renin inhibitor pepstatin. At neutral pH values, the enzyme was active in homologous plasma to produce angiotensin I, and therefore distinct from pseudorenin and cathepsin D. The arterial enzyme and semi-purified renal renin could not be distinguished on the basis of Km values by using homologous renin substrate 2. An inverse relationship between the aortic renin content of the spontaneously hypertensive rat and the progressive increase of systolic blood pressure was observed with age. In contrast to this strain of rat, aortic renin of the normotensive WKY strain did not decline with age. 3. Plasma renin concentration and the aortic renin content of the spontaneously hypertensive rat showed divergent changes in response to a blood pressure fall associated with acute diuretic therapy, chronic administration of hydrallazine and in some animals in response to chronic administration of propranolol. 4. A low sodium diet elevated both plasma and aortic renin and retarded the progressive increase of blood pressure in the spontaneously hypertensive rat. A high sodium diet accelerated the progress of hypertension with no effect on aortic or plasma renin. 5. Antihypertensive therapy (1--6 weeks), resulting in a lowering of conscious systolic blood pressure of the spontaneously hypertensive rat, consistently led to a decrease in aortic renin content.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 3","pages":"261-70"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11899745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow. 自由活动、无麻醉、永久胆道引流大鼠胆汁分泌和胆汁成分:食物摄入对胆汁流动的影响

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550253

R J Vonk, A B van Doorn, J H Strubbe

{"title":"Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow.","authors":"R J Vonk, A B van Doorn, J H Strubbe","doi":"10.1042/cs0550253","DOIUrl":"https://doi.org/10.1042/cs0550253","url":null,"abstract":"1. In freely moving, unanesthetized rats bile flow was measured continuously over the whole day--night cycle. Bile composition was analysed and the influence of food intake on bile flow was investigated. 2. In both sexes a distinct circadian variation of bile production was observed. The mean night-time production was 50% higher than the day-time value for female rats and 38% for male rats. In the morning when the light was switched on, a sharp decrease in secretion rate was prominent and bile flow gradually increased in the afternoon. 3. The pattern of food intake was positively correlated with the pattern of food bile secretion. During fasting only the general level of bile flow decreased, but the circadian variation persisted. Refeeding again increased the mean level of bile flow. 4. The chenodeoxycholate/cholate ratio in these rats with permanent bile fistulae was higher than in rats with \"acute\" bile fistulae and changed during the day--night cycle. The ratio decreased from 1.01 at 05.00 hours to a minimum of 0.41 at 15.00 hours. 5. During the day--night cycle the sodium, potassium, calcium and cholesterol concentrations were relatively constant. The total bile salt concentration was only slightly changed, so that both the bile salt-dependent fraction and the bile salt-independent fraction were subject to about the same circadian variations.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 3","pages":"253-9"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11899744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Abnormalities of renal transport of sodium o-[131I]iodohippurate (Hippuran) in essential hypertension. 原发性高血压患者o-[131I]碘马嘌呤钠(hipuran)肾转运异常

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550241

J Reeve, J C Crawley, A D Goldberg, C Kennard, D Kenny, I K Smith

引用次数: 6

Analytical subcellular fractionation of jejunal biopsy specimens: enzyme activities, organelle pathology and response to gluten withdrawal in patients with coeliac disease. 空肠活检标本的分析亚细胞分离:酶活性，细胞器病理和乳糜泻患者对谷蛋白戒断的反应。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550285

T J Peters, P E Jones, G Wells

引用次数: 35

The distribution of cardiac output in the anaesthetized spontaneously hypertensive rat. 麻醉自发性高血压大鼠心输出量分布。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550317

C R Hilley, M S Yates

引用次数: 15

A comparison of methods for measurement of rectal potential difference in man: effects of rectal infusion of amiloride. 男性直肠电位差测量方法的比较:直肠输注阿米洛利的效果。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550231

F Mohamed, P McSorley, D J Warren

引用次数: 8

Problems in the analysis of dynamic tracer studies. 动态示踪剂研究分析中的问题。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550225

J Reeve, N Veall, R Wootton

引用次数: 10

Renal vasoconstriction in glycerol-induced acute renal failure. Studies in the isolated perfused rat kidney. 甘油致急性肾衰竭的肾血管收缩。大鼠离体灌注肾的研究。

Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550249

K G Hofbauer, K Bauereiss, A Konrads, F Gross

{"title":"Renal vasoconstriction in glycerol-induced acute renal failure. Studies in the isolated perfused rat kidney.","authors":"K G Hofbauer, K Bauereiss, A Konrads, F Gross","doi":"10.1042/cs0550249","DOIUrl":"https://doi.org/10.1042/cs0550249","url":null,"abstract":"1. Acute renal failure was produced in rats by the intramuscular injection of glycerol (6.1 mol/l 10 ml/kg). Either 2 or 4--6 h later the right kidney was isolated and perfused for 1 h with an electrolyte solution containing a gelatin preparation (Haemaccel, 35 g/l) at pressures between 90 and 100 mm Hg in a single-pass system. 2. In kidneys taken from rats with acute renal failure renal vascular resistance was markedly increased immediately after the start of the perfusion as compared with control kidneys taken from untreated rats. During the following 30 min of perfusion the resistance progressively decreased and, at 1 h of perfusion, was similar to that in control kidneys or only moderately elevated. 3. Despite the reduction of renal vascular resistance glomerular filtration rate was still markedly increased immediately after the start of the perfusion as compared with control kidneys taken from untreated rats. During the following 30 min of perfusion the resistance progressively decreased and, at 1 h of perfusion, was similar to that in control kidneys or only moderately elevated. 3. Despite the reduction of renal vascular resistance glomerular filtration rate was still markedly impaired after 1 h of perfusion and fractional reabsorption of sodium and water as well as the secretion of p-aminohippurate were diminished. Renal venous renin concentration and renin release were lower in kidneys taken from rats with acute renal failure than in the control experiments. 4. These results suggest that the increase in renal vascular resistance and the stimulation of renin release after injection of glycerol in vivo are the consequence of extra- rather than intra-renal mechanisms.","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 3","pages":"249-52"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11899743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4