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Biliary excretion of dibromosulphthalein in the freely moving unanaesthetized rat: circadian variation and effects of deprivation of food and pentobarbital anaesthesia. 自由运动未麻醉大鼠胆中二溴磺胺的排泄:昼夜变化和剥夺食物和戊巴比妥麻醉的影响。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550399
R J Vonk, E Scholtens, J H Strubbe
{"title":"Biliary excretion of dibromosulphthalein in the freely moving unanaesthetized rat: circadian variation and effects of deprivation of food and pentobarbital anaesthesia.","authors":"R J Vonk, E Scholtens, J H Strubbe","doi":"10.1042/cs0550399","DOIUrl":"https://doi.org/10.1042/cs0550399","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"399-406"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11912188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Adenine and adenosine metabolism in intact erythrocytes deficient in adenosine monophosphate-pyrophosphate phosphoribosyltransferase: a study of two families. 腺嘌呤和腺苷代谢在完整红细胞中缺乏腺苷单磷酸焦磷酸磷酸核糖转移酶:两个家族的研究。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550407
B M Dean, D Perrett, H A Simmonds, A Sahota, K J Van Acker
{"title":"Adenine and adenosine metabolism in intact erythrocytes deficient in adenosine monophosphate-pyrophosphate phosphoribosyltransferase: a study of two families.","authors":"B M Dean, D Perrett, H A Simmonds, A Sahota, K J Van Acker","doi":"10.1042/cs0550407","DOIUrl":"https://doi.org/10.1042/cs0550407","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"407-12"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11912189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Age-dependent difference of kidney response to temporary ischaemia in the rat. 大鼠肾脏对暂时性缺血反应的年龄依赖性差异。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550365
J Kunes, K Capek, J Stejskal, J Jelínek
{"title":"Age-dependent difference of kidney response to temporary ischaemia in the rat.","authors":"J Kunes, K Capek, J Stejskal, J Jelínek","doi":"10.1042/cs0550365","DOIUrl":"https://doi.org/10.1042/cs0550365","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"365-8"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11429658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Cardiovascular reflexes and autonomic neuropathy. 心血管反射和自主神经病变。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550321
D J Ewing
{"title":"Cardiovascular reflexes and autonomic neuropathy.","authors":"D J Ewing","doi":"10.1042/cs0550321","DOIUrl":"https://doi.org/10.1042/cs0550321","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"321-7"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11571297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 234
Effect of acute ethanol administration on liver oxidative capacity in rats. 急性乙醇给药对大鼠肝脏氧化能力的影响。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550341
L A Videla
{"title":"Effect of acute ethanol administration on liver oxidative capacity in rats.","authors":"L A Videla","doi":"10.1042/cs0550341","DOIUrl":"https://doi.org/10.1042/cs0550341","url":null,"abstract":"<p><p>1. The administration of a single oral dose of 2, 3, 4 or 5 g of ethanol/kg (43.5, 65.2, 87.0 or 108.7 mmol/kg respectively) to rats increases the rate of oxygen consumption by liver slices from animals killed 24--48 h later. 2. The increase in the rate of hepatic respiration can be blocked by incubation in a medium containing ouabain, an inhibitor of the sodium pump, or in a calcium-free medium. 3. The enhancement of oxygen uptake caused by a single dose of ethanol can be abolished by adrenalectomy or by prior administration of the alpha-adrenergic blocking agent phentolamine, and is markedly less in thyroidectomized animals. 4. It is suggested that the effect which is elicited by acute ethanol administration on respiration by liver slices is mediated by adrenaline and by throid hormones, both of which appear to exert a calorigenic effect by activation of the sodium pump. The results are discussed in relation to the changes in liver oxidative capacity induced by chronic alcohol ingestion.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"341-7"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11910205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Tracing the fate of oxygen consumed during phagocytosis by human neutrophils with 15O2. 用15O2追踪人类中性粒细胞吞噬过程中消耗的氧的命运。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550413
A W Segal, J Clark, A C Allison
{"title":"Tracing the fate of oxygen consumed during phagocytosis by human neutrophils with 15O2.","authors":"A W Segal,&nbsp;J Clark,&nbsp;A C Allison","doi":"10.1042/cs0550413","DOIUrl":"https://doi.org/10.1042/cs0550413","url":null,"abstract":"<p><p>1. The metabolism of oxygen by phagocytosing neutrophils was traced by using 15O2. 2. The isotope did not exchange with the incubation medium or cells to an appreciable extent and unmetabolized oxygen was readily eluted by gassing the cell suspension. 3. The polarographic measurements of oxygen consumption closely paralleled the recovery of metabolized 15O2. 4. Almost all the metabolized 15O2 was converted into water, both in the presence and absence of KCN, supporting the concept that the oxygen consumed by neutrophils is converted into H2O2. It is unlikely that an appreciable proportion of this oxygen is incorporated into the organic composition of the cell or of the ingested micro-organism.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"413-5"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11912190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effects of chronic renal insufficiency and metabolic acidosis on glutamine metabolism in man. 慢性肾功能不全和代谢性酸中毒对人谷氨酰胺代谢的影响。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550391
A Tizianello, G De Ferrari, G Garibotto, G Gurreri
{"title":"Effects of chronic renal insufficiency and metabolic acidosis on glutamine metabolism in man.","authors":"A Tizianello,&nbsp;G De Ferrari,&nbsp;G Garibotto,&nbsp;G Gurreri","doi":"10.1042/cs0550391","DOIUrl":"https://doi.org/10.1042/cs0550391","url":null,"abstract":"<p><p>1. Arterial concentration and arterial-venous differences of glutamine across the kidney, forearm, hepato-splanchnic bed and brain were measured in patients with chronic renal insufficiency and in patients with normally functioning kidneys before and during chronic ammonium chloride acidosis. 2. In chronic renal insufficiency and in chronic metabolic acidosis there is a rise in glutamine release from the muscles and a suppression of glutamine uptake by the hepato-splanchnic bed and the brain. 3. In chronic renal insufficiency arterial glutamine concentrations is significantly increased in comparison with subjects with normal renal function and either normal acid-base balance or chronic metabolic acidosis. 4. In patients with chronic renal insufficiency the kidney extracts negligible amounts of glutamine, which cannot account for the renal ammonia production measured in the same patients.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"391-7"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11912187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
Identification of a delivery-related influence on proximal tubular reabsorption during expansion with hyperoncotic albumin in the rat. 鉴定与分娩有关的影响近端小管重吸收扩张期间与大鼠高肿瘤白蛋白。
Clinical science and molecular medicine Pub Date : 1978-10-01 DOI: 10.1042/cs0550369
J F Donohoe, G S Lefavour, S Cortell, F J Gennari
{"title":"Identification of a delivery-related influence on proximal tubular reabsorption during expansion with hyperoncotic albumin in the rat.","authors":"J F Donohoe,&nbsp;G S Lefavour,&nbsp;S Cortell,&nbsp;F J Gennari","doi":"10.1042/cs0550369","DOIUrl":"https://doi.org/10.1042/cs0550369","url":null,"abstract":"","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 4","pages":"369-76"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11910207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of unconjugated and conjugated phenol and uraemia on the synthesis of adenosine 3' :5' -cyclic monophosphate in rat brain homogenates. 非偶联、偶联酚和尿毒症对大鼠脑匀浆中3′:5′-环磷酸腺苷合成的影响。
Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550271
G A Turner, E N Wardle
{"title":"Effect of unconjugated and conjugated phenol and uraemia on the synthesis of adenosine 3' :5' -cyclic monophosphate in rat brain homogenates.","authors":"G A Turner,&nbsp;E N Wardle","doi":"10.1042/cs0550271","DOIUrl":"https://doi.org/10.1042/cs0550271","url":null,"abstract":"<p><p>1. The effects of phenol and phenyl glucuronide on the responses of normal rat brain adenyl cyclase to noradrenaline and dopamine have been investigated. Neurotransmitter responses have also been examined in brains from uraemic and normal rats. 2. A depressive effect of phenol on the adenosine 3' :5' -cyclic monophosphate response of the neostriatum to dopamine was shown to be completely abolished if the toxin was present in the conjugated form; the response of the cortex to noradrenaline was stimulated by the presence of phenyl glucuronide, even though the unconjugated form had no effect. 3. The uraemic state in the rat also resulted in a depression of the neostriatum response to dopamine, yet an enhancement of the cortical response to noradrenaline. 4. The action of phenols of the brain is relevant to hepatic and uraemic coma.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 3","pages":"271-5"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11427067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Analytical subcellular fractionation of jejunal biopsy specimens: enzyme activities, organelle pathology and response to corticosteroids in patients with non-responsive coeliac disease. 空肠活检标本的分析亚细胞分离:酶活性、细胞器病理和对无反应性乳糜泻患者皮质类固醇的反应
Clinical science and molecular medicine Pub Date : 1978-09-01 DOI: 10.1042/cs0550293
T J Peters, P E Jones, W J Jenkins, G Wells
{"title":"Analytical subcellular fractionation of jejunal biopsy specimens: enzyme activities, organelle pathology and response to corticosteroids in patients with non-responsive coeliac disease.","authors":"T J Peters,&nbsp;P E Jones,&nbsp;W J Jenkins,&nbsp;G Wells","doi":"10.1042/cs0550293","DOIUrl":"https://doi.org/10.1042/cs0550293","url":null,"abstract":"<p><p>1. Jejunal biopsies from five patients with non-responsive coeliac disease have been subjected to analytical subcellular fractionation and enzymic microassay in order to compare the organelle pathology of this group with untreated but glutensensitive patients. 2. Compared with the gluten-sensitive group these non-responsive patients showed marked reduction of the endoplasmic reticulum enzymes, normal activities of lysosomal enzymes and slightly less severely reduced brush border activities. 3. It is suggested that the present biochemical studies in combination with previous clinical reports and measurements of DNA and protein synthesis by cultured mucosal biopsies delineate non-responsive coeliac disease as a distinct entity. 4. The patients were treated with oral prednisolone (20 mg daily) for between 5 and 9 weeks and the properties of the jejunal biopsies restudied. 5. Although morphologically there was only a partial restoration of the villus architecture the enzymic alterations and organelle abnormalities returned essentially to normal values.</p>","PeriodicalId":10356,"journal":{"name":"Clinical science and molecular medicine","volume":"55 3","pages":"293-300"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11899748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
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