Clinical Gastroenterology and Hepatology最新文献_第4页

Hepatitis D virus infection markedly increases the risk of hepatocellular carcinoma in patients with viral B cirrhosis. D 型肝炎病毒感染会显著增加病毒性 B 型肝硬化患者罹患肝细胞癌的风险。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-24 DOI: 10.1016/j.cgh.2024.08.046

Dominique Roulot, Richard Layese, Ségolène Brichler, Nathalie Ganne, Tarik Asselah, Fabien Zoulim, Emmanuel Gordien, Pierre Nahon, Françoise Roudot-Thoraval

{"title":"Hepatitis D virus infection markedly increases the risk of hepatocellular carcinoma in patients with viral B cirrhosis.","authors":"Dominique Roulot, Richard Layese, Ségolène Brichler, Nathalie Ganne, Tarik Asselah, Fabien Zoulim, Emmanuel Gordien, Pierre Nahon, Françoise Roudot-Thoraval","doi":"10.1016/j.cgh.2024.08.046","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.08.046","url":null,"abstract":"Background and aims: The specific causative role of HDV infection in the development of hepatocellular carcinoma (HCC) remains debated and was not specifically demonstrated in cirrhotic patients. Here we compared HCC incidence in HBV-HDV co-infected and HBV mono-infected cirrhotic patients.Methods: A total of 142 HBV-HDV and 271 HBV-infected cirrhotic patients from the French ANRSCO12 CirVir and DeltaVir cohorts, with histologically proven cirrhosis and no history of decompensation, were included in the study.Results: HBV-HDV patients were younger than HBV patients (37.2 vs. 53.8 years), they were more often immigrants from sub-Saharan Africa, and displayed less co-morbidities and more altered liver tests. After adjustment for age, cumulative incidences of HCC in co-infected and mono-infected patients at 1, 3 and 5 years were 5.2%, 11.8% and 20.2% vs. 1.1%, 2.5% and 4.4%, respectively (P< .001). In multivariate analysis, HDV infection was an independent factor associated with the development of HCC (HR 2.94, 95% CI 1.19-7.25; P= .019). Other independent factors were age (HR 1.08, 1.05-1.11; P< .001), overweight (HR 0.45, 0.22-0.93; P= .031), smoking (HR 2.26, 1.23-4.16; P= .009), increased GGT (HR 2.73, 1.24-6.00; P= .013), total bilirubin >17 μmol/L (HR 2.68, 1.33-5.42; P= .006) and platelet count <150.000/mm3 (HR 3.11, 1.51-6.41; P= .002). HDV co-infection was not an independent factor of liver decompensation, transplantation or death.Conclusion: The incidence of HCC appears significantly higher in HBV-HDV than in HBV-infected cirrhotic patients. HDV infection emerges as an independent risk factor for HCC, indicating that in cirrhotic patients, HDV plays a causative role for HCC independently of HBV.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outpatient intensive nutrition therapy improves survival and frailty in males with Alcohol related ACLF - Randomised controlled trial. 门诊强化营养疗法可改善酒精相关前交叉韧带纤维化男性患者的存活率和虚弱程度--随机对照试验。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-24 DOI: 10.1016/j.cgh.2024.09.021

Patal Giri, Sunil Taneja, Nancy Sahni, Harish Bhujade, B K Padhi, Tanka Karki, Pratibha Garg, Sahaj Rathi, Arka De, Nipun Verma, Madhumita Premkumar, Ajay Duseja

{"title":"Outpatient intensive nutrition therapy improves survival and frailty in males with Alcohol related ACLF - Randomised controlled trial.","authors":"Patal Giri, Sunil Taneja, Nancy Sahni, Harish Bhujade, B K Padhi, Tanka Karki, Pratibha Garg, Sahaj Rathi, Arka De, Nipun Verma, Madhumita Premkumar, Ajay Duseja","doi":"10.1016/j.cgh.2024.09.021","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.09.021","url":null,"abstract":"Background and aims: Improvement in the nutritional status of Acute on Chronic Liver Failure(ACLF) patients may lead to reduction in morbidity and mortality. This study assessed the impact of dietician supported outpatient intensive nutrition therapy(OINT) on survival and frailty in patients with alcohol related ACLF METHODS: 70 patients with alcohol related ACLF(Asia Pacific Association for the Study of the Liver, APASL-criteria) and frailty were randomized 1:1 to receive standard medical therapy(SMT) plus OINT(intervention) versus SMT(control) alone. The primary outcome was an improvement in survival at 3 months. Secondary outcome measures included improvement in frailty, prognostic scores and hospitalization.Results: There was a significant improvement in overall survival in the OINT group as compared to SMT after 3 months of follow up, 91.4% (Standard error (SE): 4.7%) vs. 57.1% (SE: 8.4%), P<.00). On cox regression model, inclusion in the intervention arm, baseline Skeletal Muscle Index(SMI), and Asia Pacific Association for the Study of the Liver ACLF Research Consortium(AARC score) were independent predictors of survival (P<.05). The Liver frailty index(LFI) score also significantly improved in the OINT as compared to SMT, Δ-0.93 -(0.71-1.13) vs. Δ -0.33 -(0.44-0.72)(P<.00). The disease severity including MELD, MELD-Na, and AARC score showed a significant improvement in the OINT group as compared to the SMT group(P<.05). The patients in OINT group had lesser number of hospitalizations 6(17%) versus 16(45.7%)(P=.01) as compared to SMT group.Conclusion: Outpatient intensive nutrition therapy significantly improves survival, frailty and disease severity with a reduction in number of hospitalizations and supports the key role of nutrition in treatment of alcohol related ACLF patients.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Chronic liver disease in Cholangiocarcinoma: a Meta-Analysis. 胆管癌中慢性肝病的发病率：一项 Meta 分析。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-24 DOI: 10.1016/j.cgh.2024.09.028

Ethan Kai Jun Tham, Ryan Yanzhe Lim, Benjamin Koh, Darren Jun Hao Tan, Cheng Han Ng, Michelle Law, Elina Cho, Nicole Shu Ying Tang, Claire Shiying Tan, Benedix Kuan Loo Sim, En Ying Tan, Wen Hui Lim, Mei Chin Lim, Toru Nakamura, Pojsakorn Danpanichkul, Sakkarin Chirapongsathorn, Karn Wijarnpreecha, Hirokazu Takahashi, Asahiro Morishita, Ming-Hua Zheng, Alfred Kow, Mark Muthiah, Jia Hao Law, Daniel Q Huang

{"title":"Prevalence of Chronic liver disease in Cholangiocarcinoma: a Meta-Analysis.","authors":"Ethan Kai Jun Tham, Ryan Yanzhe Lim, Benjamin Koh, Darren Jun Hao Tan, Cheng Han Ng, Michelle Law, Elina Cho, Nicole Shu Ying Tang, Claire Shiying Tan, Benedix Kuan Loo Sim, En Ying Tan, Wen Hui Lim, Mei Chin Lim, Toru Nakamura, Pojsakorn Danpanichkul, Sakkarin Chirapongsathorn, Karn Wijarnpreecha, Hirokazu Takahashi, Asahiro Morishita, Ming-Hua Zheng, Alfred Kow, Mark Muthiah, Jia Hao Law, Daniel Q Huang","doi":"10.1016/j.cgh.2024.09.028","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.09.028","url":null,"abstract":"Introduction: Chronic liver disease is a known risk factor for cholangiocarcinoma (CCA), but the proportion of people with CCA who have concurrent chronic liver disease is unclear. We aimed to evaluate the prevalence of chronic liver diseases in people with cholangiocarcinoma.Methods: In this single-arm meta-analysis, we searched MEDLINE and EMBASE from inception to 10 August 2024 for articles in English containing data for cholangiocarcinoma with and without chronic liver diseases. Data were pooled to obtain the prevalence of different chronic liver diseases, with further stratification by geographical location and tumor location.Results: In total, 118068 individuals diagnosed with cholangiocarcinoma were included, of whom 16771 had chronic liver diseases. A pooled analysis of 109 studies determined that the prevalence of chronic liver disease was 25.23% (95% CI: 20.82% - 30.23%; I2=99.0%), and 10.21% (7.75% - 13.35%; I2=98.6%) of CCA patients had cirrhosis. Chronic liver diseases were associated more with intrahepatic CCAs, compared to extrahepatic CCAs (RR: 2.46, CI: 2.37 - 2.55, p < 0.0001). This was observed across all etiologies of liver disease, except for primary sclerosing cholangitis which was associated with extrahepatic CCAs (RR: 0.49; CI: 0.43 - 0.57, p < 0.0001).Conclusion: Around one in four people with cholangiocarcinoma have chronic liver diseases, and one in ten have cirrhosis.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxalate esophagitis. 草酸盐食管炎

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-24 DOI: 10.1016/j.cgh.2024.09.030

Rita Slim, Hussein Nassereddine

引用次数: 0

Introduction to Thirteenth Issue CGH The Future of Inflammatory Bowel Disease Care. 第十三期 CGH 引言炎症性肠病护理的未来。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-23 DOI: 10.1016/j.cgh.2024.10.004

Edward V Loftus, Joana Torres, Jason K Hou, Charles Kahi, Siddharth Singh

引用次数: 0

Reply to Letter to Editor re: Kamboj, A.K., D.A. Patel, and R. Yadlapati, Long-Term Proton Pump Inhibitor Use: Review of Indications and Special Considerations. Clin Gastroenterol Hepatol, 2024. 22(7): p. 1373-1376. 回复致编辑的信，内容为：Kamboj, A.K., D.A. Patel, and R. Yadlapati, Long-Term Proton Pump Inhibitor Use：适应症和特殊考虑因素综述》。临床胃肠病学肝病学》，2024 年。22(7): p. 1373-1376.

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-23 DOI: 10.1016/j.cgh.2024.09.017

Amrit K Kamboj, Dhyanesh A Patel, Rena Yadlapati

引用次数: 0

Exam 1: Definitions, Etiologies, and Outcomes of Acute on Chronic Liver Failure: A Systematic Review and Meta-Analysis 考试 1：急性和慢性肝衰竭的定义、病因和结果：系统回顾和元分析

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-23 DOI: 10.1016/j.cgh.2024.08.025

引用次数: 0

Natural history of clinically-suspected isolated perianal fistulizing Crohn's disease. 临床疑似孤立性肛周瘘管化克罗恩病的自然病史。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-23 DOI: 10.1016/j.cgh.2024.09.016

Lodoe Sangmo, Baseer Quraishi, Palak Rajauria, Elisabeth Giselbrecht, Jean-Frederic Colombel, Ryan Ungaro, Serre-Yu Wong

引用次数: 0

Letter Response to: Hernandez-Rocha C et al, Clin Gastroenterol Hepatol 2024. 信件回复：Hernandez-Rocha C 等人，Clin Gastroenterol Hepatol 2024。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-23 DOI: 10.1016/j.cgh.2024.09.026

Emily K Wright, Michael A Kamm

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Kidney Failure, Inflammatory Bowel Disease and Colectomy. 肾衰竭、炎症性肠病和结肠切除术。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2024-10-23 DOI: 10.1016/j.cgh.2024.09.013

Chen-Pi Li, Shuo-Yan Gau, Hui-Chin Chang

引用次数: 0