Clinical Gastroenterology and Hepatology最新文献

{"title":"Successful Treatment of Post-Operative Bronchoesophageal Fistula with Cardiac Septal Occluder","authors":"Amani Beshara, Olivier Taton, Arnaud Lemmers","doi":"10.1016/j.cgh.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.08.011","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"52 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated vs Step-Up Endoscopic Treatment for Pancreatic Walled-Off Necrosis: A Randomized Controlled Trial (ACCELERATE)","authors":"Olsen GA MD, Schmidt PN MD PhD, Hadi A MD, Prahm AP MD, Werge MP MD PhD, Roug S MD, Schefte DF MD, Lauritsen ML MD, Hansen EF MD PhD, Novovic S MD PhD, Karstensen JG MD PhD","doi":"10.1016/j.cgh.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.08.007","url":null,"abstract":"Endoscopic step-up treatment with ultrasound-guided drainage and necrosectomy has become the gold standard treatment of pancreatic walled-off necrosis (WON); however, the length of stay (LOS) in hospital of patients with large WON remains substantial. We hypothesized that an accelerated treatment protocol could reduce LOS and major complications in patients with large WON.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"15 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence for Quantifying Endoscopic Mucosal Ulceration in Crohn’s Disease","authors":"Lingrui Cai MS, Emily Wittrup MS, Cristian Minoccheri PhD, Tadd Hiatt MD, Michael Rice MD, Shrinivas Bishu MD, Aleksandar Stojmirovic PhD, Louis R. Ghanem MD PhD, Kayvan Najarian PhD, Ryan W. Stidham MD MS","doi":"10.1016/j.cgh.2025.05.026","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.026","url":null,"abstract":"Endoscopic scoring of Crohn’s disease (CD) is challenging as mucosal disease is patchy with highly variable morphology, size, and severity. Computer vision may help quantify disease activity with similar performance as standard instruments like the Simple Endoscopic Score for Crohn's Disease (SES-CD).","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"8 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world comparison of the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis: the TORUS study","authors":"Anthony BUISSON, Mélanie SERRERO, Romain ALTWEGG, Thomas GUILMOTEAU, Guillaume BOUGUEN, Maria NACHURY, Aurélien AMIOT, Lucine VUITTON, Xavier TRETON, Ludovic CAILLO, Bruno PEREIRA, Mathurin FUMERY","doi":"10.1016/j.cgh.2025.07.044","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.07.044","url":null,"abstract":"We compared the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis (UC) previously exposed to at least one anti-TNF agent.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"38 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Anne-Sophie R Stroes, Marc A Benninga, Bart G P Koot","doi":"10.1016/j.cgh.2025.08.006","DOIUrl":"10.1016/j.cgh.2025.08.006","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Five Dietary Emulsifiers on Inflammation, Permeability, and the Gut Microbiome: A Placebo-controlled Randomized Trial.","authors":"Judith Wellens, Julie Vanderstappen, Sien Hoekx, Eva Vissers, Martijn Luppens, Lies Van Elst, Matthias Lenfant, Jeroen Raes, Muriel Derrien, Bram Verstockt, Marc Ferrante, Kristin Verbeke, Christophe Matthys, Séverine Vermeire, João Sabino","doi":"10.1016/j.cgh.2025.08.005","DOIUrl":"10.1016/j.cgh.2025.08.005","url":null,"abstract":"<p><strong>Background & aims: </strong>Dietary emulsifier consumption might promote intestinal inflammation, eventually leading to inflammatory bowel diseases. However, human data are scarce and involve a limited number of emulsifiers. We studied the effects of an emulsifier-free diet (EFD) and specific emulsifier supplementation.</p><p><strong>Methods: </strong>Sixty healthy participants followed an EFD for 2 weeks. Then, using a randomized placebo-controlled trial design, participants continued an EFD for 4 weeks with the addition of either carboxymethyl cellulose, polysorbate-80, carrageenan, soy lecithin, native rice starch, or no additives administered through brownies. Effects on cardiometabolic markers, gut microbiota, intestinal inflammation, and permeability were explored.</p><p><strong>Results: </strong>After 2 weeks of an EFD, cholesterol levels decreased (P = .00006). Under emulsifier supplementation, alpha diversity remained stable, yet microbial composition was affected by treatment and visit. Compared with placebo, concentrations of all short chain fatty acids were lower in those consuming carboxymethyl cellulose, which was mirrored by other emulsifiers, although not all reached significance. No differences in fecal calprotectin, C-reactive protein, serum lipopolysaccharide-binding protein, cholesterol levels, or other metabolic markers were observed between placebo and emulsifiers at the end of the intervention. Serum inflammatory and cardiometabolic proteins remained unchanged. In individuals consuming carrageenan, transcellular intestinal permeability increased (P = .04) compared with baseline.</p><p><strong>Conclusion: </strong>In this double-blind placebo-controlled exploratory trial, emulsifier supplementation lowered short chain fatty acid concentration compared with placebo. Emulsifier supplementation did not impact intestinal or systemic inflammation or metabolic endpoints. Cholesterol levels decreased after 2 weeks of an EFD. These results point towards potential intestinal benefits of limiting dietary emulsifiers in the diet, requiring further investigation.</p><p><strong>Clinicaltrials: </strong>gov, Number: NCT06552156.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine Proteomics in Cirrhosis and Acute Kidney Injury: Insights Into the Pathogenesis of Hepatorenal Syndrome.","authors":"Laura Napoleone, Mikel Azkargorta, Julia Sidorova, Adrià Juanola, Elisa Pose, Pere Ginès","doi":"10.1016/j.cgh.2025.08.003","DOIUrl":"10.1016/j.cgh.2025.08.003","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal Involvement in Eosinophilic Granulomatosis With Polyangiitis.","authors":"Tan Yujia, Cui Yun, Zhao Shuliang","doi":"10.1016/j.cgh.2025.08.004","DOIUrl":"10.1016/j.cgh.2025.08.004","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time Use of Computer-aided Diagnosis in the Optical Diagnosis of Gastric Neoplasia: A Multicenter Randomized Controlled Trial.","authors":"Kazutoshi Higuchi, Mitsuru Kaise, Ai Fujimoto, Teppei Akimoto, Takashi Ikeya, Masakatsu Fukuzawa, Chizu Yokoi, Toshiro Iizuka, Hiroto Noda, Naoki Ishizuka, Kumiko Kirita, Osamu Goto, Katsuhiko Iwakiri","doi":"10.1016/j.cgh.2025.07.043","DOIUrl":"10.1016/j.cgh.2025.07.043","url":null,"abstract":"<p><strong>Background & aims: </strong>The multicenter, randomized, control trial was conducted to evaluate whether computer-aided diagnosis (CADx) improves the optical diagnosis of gastric neoplasia in nonexpert endoscopists.</p><p><strong>Methods: </strong>Patients undergoing endoscopy prior to endoscopic resection (ER) of gastric neoplasia or for surveillance after ER were randomized to the CADx-assisted and non-CADx-assisted groups. Endoscopy was performed by a nonexpert endoscopist blinded to the patient information. The CADx system provides a confidence level for gastric neoplasia on a still white light image (WLI) captured during endoscopy and indicates neoplasia if the level is ≥ a 60% cutoff. The targets were lesions diagnosed as neoplasia and those diagnosed as non-neoplasia but requiring biopsy. Endoscopists performed WLI diagnoses to differentiate between neoplasia and non-neoplasia. The accuracy, sensitivity, and specificity in nonexperts have been evaluated using pathology as the gold standard.</p><p><strong>Results: </strong>A total of 312 patients with 265 gastric neoplasias and 164 non-neoplasias were enrolled. The accuracy, sensitivity, and specificity among nonexperts were 65.3% vs 59.9% (P = .24), 68.6% vs 63.9% (P = .42), and 60.8% vs 53.3% (P = .34) in the CADx-assisted and non-CADx-assisted groups, respectively. Flat or superficially depressed small neoplasias tended to be missed by the CADx.</p><p><strong>Conclusions: </strong>The present CADx assistance did not improve the nonexpert optical diagnosis of gastric neoplasia. Further improvements of the CADx with WLI are needed by changing the confidence level cutoff and additional training on easily missed neoplasias. Another option is CADx with magnifying narrow band imaging. (Japan Registry of Clinical Trials, number jRCTs032210171).</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Proactive Therapeutic Drug Monitoring With Model-informed Precision Dosing in Pediatric Crohn's Disease.","authors":"Arno R Bourgonje, Paola Mian","doi":"10.1016/j.cgh.2025.06.046","DOIUrl":"10.1016/j.cgh.2025.06.046","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}