Clinical Gastroenterology and Hepatology最新文献

{"title":"Determining Cirrhosis Status in Candidates for Resmetirom.","authors":"Mazen Noureddin, Mena Bansal, Mary E Rinella","doi":"10.1016/j.cgh.2025.04.022","DOIUrl":"10.1016/j.cgh.2025.04.022","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Index of Severity for Eosinophilic Esophagitis Helps Predict Treatment Response to Dupilumab.","authors":"Corey J Ketchem, Anwesh Dash, Gary W Falk, Evan S Dellon, Kristle L Lynch","doi":"10.1016/j.cgh.2025.04.016","DOIUrl":"10.1016/j.cgh.2025.04.016","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Donor Selection for FMT in UC: The Role of Chromobacteriaceae and Other Underrecognized Pro-inflammatory Taxa.","authors":"Hong Zhang, Jiaxin Li, Hu Zhang","doi":"10.1016/j.cgh.2025.04.019","DOIUrl":"10.1016/j.cgh.2025.04.019","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambulatory Acute Kidney Injury in Patients With Cirrhosis Is Common and Burdensome.","authors":"Kavish R Patidar, Ruben Hernaez, Yan Liu, George Cholankeril, Jennifer R Kramer, Thom Taylor, Prasun Jalal, Tzu-Hao Lee, Avegail G Flores, Giuseppe Cullaro, Andrew S Allegretti, Pere Gines, Fasiha Kanwal","doi":"10.1016/j.cgh.2025.03.015","DOIUrl":"10.1016/j.cgh.2025.03.015","url":null,"abstract":"<p><strong>Background & aims: </strong>Little is known about ambulatory acute kidney injury (A-AKI), which develops in an outpatient setting.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of patients diagnosed with cirrhosis between January 1, 2018, and December 31, 2019 from 130 hospitals in the Veterans Affairs healthcare system. Patients were classified as having incident A-AKI if they met the International Club of Ascites AKI criteria in an outpatient setting. We used multivariable regression models to identify factors associated with A-AKI development within 1 year of cirrhosis diagnosis. We also conducted a structured implicit review of patients' medical charts to determine the precipitants of A-AKI. We examined the rates of AKI-resolution, hemodialysis and death at 90 days.</p><p><strong>Results: </strong>Among 55,880 patients with cirrhosis [median age 66 years, 38% alcohol-related cirrhosis (alcohol-associated liver disease), median Model for End-Stage Liver Disease-Sodium 10, 34% ascites] followed for a median of 3.4 years, 6889 (12%) patients developed incident A-AKI. Patients with ascites (odds ratio [OR], 2.51), Model for End-Stage Liver Disease-Sodium >15 (OR, 1.58), hepatocellular carcinoma (OR, 1.45) or alcohol-associated liver disease (OR, 1.37) had higher odds of developing A-AKI. In total, 60% had AKI-resolution, 4.5% progressed to hemodialysis, and 12% died within 90 days of A-AKI onset. In a review of medical records of 250 randomly selected patients with A-AKI, key precipitants were hypovolemia due to diuretics and gastrointestinal losses, and nephrotoxin medication exposure. Overall, 42% of A-AKI events were unrecognized.</p><p><strong>Conclusions: </strong>A-AKI is common in cirrhosis, associated with high 90-day mortality, and significantly under-recognized. Targeted interventions for early diagnosis and treatment could improve outcomes in high-risk patients.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the Relationship Between Early Post Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy and Mortality: Are We Still Missing Something?","authors":"Dario Saltini, Silvia Nardelli, Filippo Schepis","doi":"10.1016/j.cgh.2025.04.020","DOIUrl":"10.1016/j.cgh.2025.04.020","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Pill Gastritis.","authors":"Grace Meulman, Joo-Shik Shin, Emily Nash","doi":"10.1016/j.cgh.2025.03.010","DOIUrl":"10.1016/j.cgh.2025.03.010","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verrucous Carcinoma of the Esophagus.","authors":"D Chamil Codipilly, Cadman L Leggett","doi":"10.1016/j.cgh.2025.03.013","DOIUrl":"10.1016/j.cgh.2025.03.013","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Takefumi Kimura, Nobuharu Tamaki, Masayuki Kurosaki","doi":"10.1016/j.cgh.2025.03.014","DOIUrl":"10.1016/j.cgh.2025.03.014","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Mortality After Cholecystectomy in a Nationwide Cohort of Swedish Individuals Between 1969 and 2016.","authors":"Louise Emilsson, Amit D Joshi, Jonas F Ludvigsson","doi":"10.1016/j.cgh.2025.04.015","DOIUrl":"10.1016/j.cgh.2025.04.015","url":null,"abstract":"<p><strong>Background and aims: </strong>Few studies have reported overall and subgroup long-term survival after cholecystectomy.</p><p><strong>Methods: </strong>Linking gallbladder histopathology reports from all of Sweden's 28 pathology departments to the Swedish Patient Register, we identified 159,946 adults 20-79 years of age with incident cholecystectomy between 1969 and 2016. Each patient was age- and sex- matched to 5 general population reference individuals (N = 764,681). Cox regression hazard ratios were conditioned on matching factors and additionally adjusted for type 2 diabetes, obesity, ischemic heart disease, chronic obstructive pulmonary disease, alcohol-related diseases, and education.</p><p><strong>Results: </strong>During a median follow-up of 12 years, we identified 38,401 deaths (18.5 deaths per 1000 person-years [PY]) among cholecystectomy participants and 181,197 deaths in reference individuals (18.4 per 1000 PY). This corresponded to an adjusted hazard ratio (aHR) of 0.91 (95% confidence interval [CI], 0.90-0.92) for overall mortality, and low cardiovascular mortality (aHR, 0.85; 95% CI, 0.83-0.86), which highly heterogeneous by age. Cholecystectomy was associated with higher mortality in individuals 20-39 years of age, with absolute mortality rates of 2.1 (95% CI, 1.9-2.2) in cholecystectomy participants vs 1.4 (95% CI, 1.3-1.4) per 1000 PY in reference individuals. Alcohol-related disease (12.2%) and smoking-related disorders (7.4%) were common among the 1015 patients diagnosed at 20-39 years of age who died during follow-up. Individuals >50 years of age undergoing cholecystectomy had a lower relative risk of overall and cardiovascular mortality. Cholecystectomy was not associated with cancer mortality (aHR, 1.01; 95% CI, 0.99-1.03).</p><p><strong>Conclusions: </strong>In a nationwide, Swedish cohort, we observed that cholecystectomy at younger age was associated with higher long-term mortality, potentially influenced by higher alcohol use and smoking. The inverse association among individuals >50 years of age may reflect better underlying health of individuals selected for cholecystectomy.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Gastroenterological Association Policy Priorities for Our 2025 Legislative Agenda.","authors":"Omeed Alipour, Sheila D Rustgi, Kathleen Teixeira, Leslie Narramore, Shazia Mehmood Siddique","doi":"10.1016/j.cgh.2025.04.021","DOIUrl":"10.1016/j.cgh.2025.04.021","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}