Clinical Gastroenterology and Hepatology最新文献

{"title":"Navigating the Maze of Functional Dyspepsia: Emergence of a New Entity, Postprandial Epigastric Pain Syndrome.","authors":"Cedric Van de Bruaene, Florencia Carbone, Karen Van den Houte, Esther Colomier, Karlien Raymenants, Bert Broeders, Lukas M Balsiger, Mike P Jones, Tim Vanuytsel, Jan Tack","doi":"10.1016/j.cgh.2025.05.017","DOIUrl":"10.1016/j.cgh.2025.05.017","url":null,"abstract":"<p><strong>Background & aims: </strong>The Rome IV criteria subdivide functional dyspepsia (FD) into postprandial distress syndrome (PDS) with meal-related symptoms (early satiation and/or postprandial fullness) and epigastric pain syndrome (EPS) with meal-unrelated symptoms (epigastric pain and/or burning). We aimed to systematically assess the relationship of epigastric pain to meal ingestion in 4 independent FD databases.</p><p><strong>Methods: </strong>In total, 1337 patients with FD were included. Three cohorts (local, national, and international; total n = 971) completed a Rome IV symptom questionnaire, with additional questions on meal relationships. In 498 patients undergoing a standard gastric emptying breath test, we analyzed the evolution of symptoms during a 4-hour window. Patients were categorized as postprandial epigastric pain (pEPS), meal-unrelated epigastric pain (murEPS), and PDS symptoms with/without postprandial epigastric pain. Symptom profiles and demographics were compared between these categories.</p><p><strong>Results: </strong>Distribution for Rome IV PDS, EPS, and overlap was 896, 252, and 186. Postprandial epigastric pain without PDS symptoms (ie, pEPS) was present in approximately 40% of patients with EPS, whereas 60% had murEPS. Fifty percent of patients with PDS reported postprandial epigastric pain. Patient demographics were similar across categories. Overall, patients with PDS and postprandial epigastric pain had the most associated gastrointestinal symptoms, compared with pEPS, murEPS, or PDS without postprandial epigastric pain.</p><p><strong>Conclusion: </strong>In contrast to earlier characterization of EPS symptoms as purely meal-unrelated, we identified a relevant patient cohort with postprandial epigastric pain in the absence of PDS symptoms in 4 different cohorts. Further research is needed to determine the underlying pathophysiology and the response to different treatment approaches in these newly defined patient cohorts.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yield of Advanced Neoplasia at 2nd Post-Polypectomy Surveillance Colonoscopy: A Systematic Review and Meta-Analysis","authors":"Pooja Pandita, Yi Le, Mehul Trivedi, Karen Heskett, Joshua Demb, Siddharth Singh, Brian A. Sullivan, Lin Liu, Samir Gupta","doi":"10.1016/j.cgh.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.02.038","url":null,"abstract":"Individuals who have had polypectomy and at least one surveillance colonoscopy exam are routinely encountered, but evidence to inform risk for subsequent neoplasia and timing of surveillance is limited. Our aim was to conduct a systematic review and meta-analysis of serial surveillance yield.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"8 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable Trends in Incidence of Young-Onset Esophageal Adenocarcinoma: A Twenty-Year Analysis from the United States Cancer Statistics Database","authors":"Anila Vasireddy MBBS, Yazan Abboud MD, Prasad G. Iyer MD MS, Srinivas Gaddam MD, Amrit K. Kamboj MD","doi":"10.1016/j.cgh.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.014","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"6 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALT is an effective screening tool for advanced MASLD in children with obesity and overweight","authors":"Anne-Sophie R. Stroes, Laura Draijer, Malika Chegary, Felix Kreier, Erim van Os, Joery Goede, Venje Boonstra, Ilse Westerbeek, Saskia Bouma, Meeike Kusters, Roosje Roelants, Ulrich Beuers, Adriaan G. Holleboom, Marc A. Benninga, Bart G.P. Koot","doi":"10.1016/j.cgh.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.011","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in children with obesity and overweight. However, neither the optimal method nor risks and benefits of screening have been established. This study aims to evaluate the effectiveness of an Alanine Aminotransferase (ALT)-based screening algorithm for detecting those at risk of significant fibrosis.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"8 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perianal Disease in Pediatric-Onset Crohn’s Disease: Incidence, Disease Course, and Long-Term Outcomes","authors":"Annika Ström, Sabine Jansson, Mads Damsgaard Wewer, Johan Burisch, Mikkel Malham, Vibeke Wewer","doi":"10.1016/j.cgh.2025.05.015","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.015","url":null,"abstract":"Perianal Crohn's disease (CD) is characterized by fistulae and/or abscesses in the anal region and leads to significant morbidity. We aimed to estimate the incidence and describe the disease course of perianal disease in pediatric-onset CD.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"1 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease","authors":"F. de Voogd, K.J. Beek, M. Pruijt, K. van Rijn, J. van der Bilt, C. Buskens, W. Bemelman, A. Neefjes-Borst, A. Mookhoek, G. D’Haens, J. Stoker, K.B. Gecse","doi":"10.1016/j.cgh.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.013","url":null,"abstract":"Crohn’s disease (CD) strictures exhibit varying levels of inflammation and chronicity. We evaluate whether intestinal ultrasound (IUS) is accurate in characterizing stricture composition.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"87 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychomotor development in infants following maternal exposure to biologics: Results from the DUMBO registry","authors":"Laura Palomino, Marta Velasco Rodríguez-Belvís, María José Casanova, Eduardo Leo-Carnerero, Cristina Calviño Suarez, Montserrat Rivero, Marta Calvo, María Teresa Arroyo, Agnes Fernández-Clotet, Isabel Pérez-Martínez, Ángeles Masedo González, Vicent Hernández, Alexandra Ruiz-Cerulla, Pilar López Serrano, Pablo Vega, Iago Rodríguez-Lago, Raquel Vicente Lidón, Miguel Ángel De Jorge, Iván Guerra, Lara Arias García, Gema Molina Arriero, Daniel Hervías Cruz, David Busquets, Ana Gutiérrez Casbas, Manuel Van Domselaar, Gemma Valldosera Gomis, Juan María Vázquez Morón, Marta Piqueras Cano, Alfredo J. Lucendo, María Dolores Martín Arranz, Patricia Ramírez de la Piscina, María del Pilar Martínez Tirado, Virginia Robles Alonso, Sandra Marín Pedrosa, Raquel Camargo Camero, Edisa Armesto Gonzalez, Carlos Tardillo Marín, Esther Bernardos Martín, María Carmen Rodríguez Grau, José M. Huguet, Lucía Márquez-Mosquera, Pau Sendra Rumbeu, Luis Bujanda, Carlos Castaño-Milla, Empar Sáinz Arnau, Luis Hernández, Laura Ramos, M.M. Boscá-Watts, Noemí Manceñido Marcos, Miquel Sans, Victor Jair Morales, Diana Acosta, Ana Garre, Rosana Muñoz Codoceo, Alberto García-Salido, Javier P. Gisbert, María Chaparro, DUMBO study group of GETECCU","doi":"10.1016/j.cgh.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.012","url":null,"abstract":"The impact of biologic treatment for inflammatory bowel disease (IBD) during pregnancy and lactation on infant psychomotor development is barely studied. We investigated the effect of exposure to biologics <ce:italic>in utero</ce:italic> or during breastfeeding on the psychomotor development of offspring during their first year","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"224 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Strategies for the Management of Severe Alcohol-associated Hepatitis: A Systematic Review and Meta-analysis","authors":"Alvi H. Islam, Claudia Alvizuri, Hailemichael Desalegn, Emily Stephenson, Francisco Idalsoaga, Luis Antonio Diaz, John K. MacDonald, Gene Y. Im, Ashwani K. Singal, Vipul Jairath, Mohammad Qasim Khan, Juan Pablo Arab","doi":"10.1016/j.cgh.2025.05.016","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.016","url":null,"abstract":"Alcohol-associated hepatitis (AH) is a severe form of alcohol-associated liver disease, with a short-term mortality of up to 50% within three months. The aim of this systematic review was to determine the optimal pharmacological treatment for severe AH that results in better survival outcomes.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"12 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of AFP Improves Sensitivity of Ultrasound for Early-Stage HCC Detection in Patients with Cirrhosis","authors":"Akash Patel, Darine Daher, Sruthi Yekkaluri, Michelle Ng, Nicole E. Rich, Amit G. Singal","doi":"10.1016/j.cgh.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.010","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"30 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus kinase (JAK) inhibitor-induced acne in inflammatory bowel disease – an international, multicenter, retrospective cohort study","authors":"Sailish Honap, Maria José Temido, Eathar Shakweh, Fakhirah Badrulhisham, Natalie Shields, Sonia Mehta, Jodie McBride, Mathieu Uzzan, Milan Lukáš, Mathurin Fumery, Akira Nogami, Taku Kobayashi, Stephane Nancey, Joana Camões Neves, João Martins Mendes, Birte-Antina Wegener, Emilie Bergereau, Rita Fernandes, Anish John Kuriakose Kuzhiyanjal, Sophie Vieujean, Ashley Spencer, Samantha Baillie, Maria Manuel Estevinho, Inês Simão, Catarina O’Neill, Madalina Gututui, Ellen Thompson, Amina Jama, Ningyu Chai, Polychronis Pavlidis, Ferdinando D'Amico, Jimmy Limdi, Fernando Magro, Shaji Sebastian, Jonathan Digby-Bell, Gareth C. Parkes, Shahida Din, Ailsa Hart, Laurent Peyrin-Biroulet, JAKne International Study Group","doi":"10.1016/j.cgh.2025.04.031","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.04.031","url":null,"abstract":"JAK inhibitor-associated acne is a common but poorly understood adverse event. This study aimed to investigate the epidemiology, clinical characteristics, and treatment outcomes of this condition in patients with inflammatory bowel disease (IBD).","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"42 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}