Mark T Worthington, Jacqueline L Wolf, Seth D Crockett, Darrell S Pardi
{"title":"AGA Clinical Practice Update on Sclerosing Mesenteritis: Commentary.","authors":"Mark T Worthington, Jacqueline L Wolf, Seth D Crockett, Darrell S Pardi","doi":"10.1016/j.cgh.2024.12.025","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.12.025","url":null,"abstract":"<p><strong>Description: </strong>The purpose of this American Gastroenterological Association Institute Clinical Practice Update is to review the available evidence for diagnosing and treating, as well as examine opportunities for future research in, sclerosing mesenteritis.</p><p><strong>Methods: </strong>This Clinical Practice Update expert commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. This expert commentary incorporates important and recently published studies in this field, and it reflects the experiences of the authors who are gastroenterologists with expertise in this topic.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Henrik Karbannek, Marina Reljic, Andreas Stallmach, Alexander Zipprich, Cristina Ripoll
{"title":"Influence of low-dose acetylsalicylic acid on renal function in patients with liver cirrhosis and ascites.","authors":"Henrik Karbannek, Marina Reljic, Andreas Stallmach, Alexander Zipprich, Cristina Ripoll","doi":"10.1016/j.cgh.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.02.005","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Elsewhere in the AGA Journals","authors":"","doi":"10.1016/S1542-3565(25)00123-5","DOIUrl":"10.1016/S1542-3565(25)00123-5","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"23 5","pages":"Pages A19-A20"},"PeriodicalIF":11.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Kivelä, Claire Jansson-Knodell, Deborah Goldman, Kalle Kurppa, Alberto Rubio-Tapia
{"title":"Transition of Care in Celiac Disease: A Chance to Advance.","authors":"Laura Kivelä, Claire Jansson-Knodell, Deborah Goldman, Kalle Kurppa, Alberto Rubio-Tapia","doi":"10.1016/j.cgh.2025.01.006","DOIUrl":"10.1016/j.cgh.2025.01.006","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jérôme Boursier, Hugo Hervé, Marine Roux, Manal F Abdelmalek, Sven M Francque, Pierre Broqua, Jean-Louis Junien, Jean-Louis Abitbol, Philippe Huot-Marchand, Lucile Dzen, Michael P Cooreman, Sanjaykumar Patel
{"title":"Biomarkers of histological response in lanifibranor-treated patients with metabolic dysfunction-associated steatohepatitis.","authors":"Jérôme Boursier, Hugo Hervé, Marine Roux, Manal F Abdelmalek, Sven M Francque, Pierre Broqua, Jean-Louis Junien, Jean-Louis Abitbol, Philippe Huot-Marchand, Lucile Dzen, Michael P Cooreman, Sanjaykumar Patel","doi":"10.1016/j.cgh.2024.12.039","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.12.039","url":null,"abstract":"<p><strong>Background and aims: </strong>Lanifibranor, a pan-peroxisome proliferator-activated receptor agonist, has demonstrated therapeutic efficacy on MASH resolution and fibrosis improvement in the phase 2b NATIVE study. The histological endpoints MASH resolution and fibrosis improvement (E1), MASH resolution without worsening of fibrosis (E2) and fibrosis improvement without worsening of MASH (E3) were investigated with the aim to identify biological signatures of E1, E2, and E3 responders based on serum biomarkers in patients treated with lanifibranor.</p><p><strong>Methods: </strong>NATIVE evaluated lanifibranor 800 and 1200 mg daily versus placebo in patients with non-cirrhotic MASH treated over 24 weeks. Liver biopsy was obtained at baseline and the end of treatment (EOT). Patients receiving lanifibranor were pooled and those with liver biopsies were selected (N=142). A panel of 65 biomarkers were evaluated by assessing baseline and absolute as well as relative changes at EOT.</p><p><strong>Results: </strong>The biomarkers included in E1-score (baseline adiponectin and ferritin; delta of matrix metalloproteinase 9 and transferrin), E2-score (baseline cytokeratin 18 Fragment M65; delta of hyaluronic acid, fructosamine and ALT) and E3-score (baseline cytokeratin 18 Fragment M65 and gamma-GT; delta of AST, insulin, and urea) represented metabolic, apoptotic and fibrosis aspects of the disease. These signatures provided good accuracy for the non-invasive identification of histological response under lanifibranor with AUROC at 0.81±0.08 for E1-score, 0.80±0.08 for E2-score and 0.81±0.08 for E3-score.</p><p><strong>Conclusions: </strong>Results from this analysis show evidence that baseline values and changes in selected serum biomarkers can aid in predicting histological response in MASH under lanifibranor treatment. These findings support utilizing a similar approach in a larger sample size (NATiV3, NCT03008070).</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Superior Rectal Arteriovenous Fistula: A Rare Cause of Colon Ischemia.","authors":"Shinji Yamashita, Yoshiki Okita, Yuji Toiyama","doi":"10.1016/j.cgh.2025.01.022","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.01.022","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"VCTE and Liver Transplantation: Is There Still a Role for Liver Biopsy?","authors":"Lucy Meunier, Pauline Bozon-Rivière, Stéphanie Faure","doi":"10.1016/j.cgh.2024.12.037","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.12.037","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
