Clinical Gastroenterology and Hepatology最新文献

{"title":"Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease; a prospective multicenter study.","authors":"Kento Takenaka, Tadakazu Hisamatsu, Taku Kobayashi, Hironori Yamamoto, Naoki Ohmiya, Ryohei Hayashi, Katsuyoshi Matsuoka, Masayuki Saruta, Akira Andoh, Norimasa Fukata, Kenji Watanabe, Hiroyuki Imaeda, Fumihito Hirai, Takayuki Matsumoto, Akihiro Hirakawa, Tomonori Yano, Minoru Matsuura, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe","doi":"10.1016/j.cgh.2024.10.030","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.030","url":null,"abstract":"<p><strong>Background and aims: </strong>While biologic therapy has revolutionized the treatment of Crohn's disease (CD), surgery remains unavoidable in cases involving ileal complications. We aimed to evaluate the efficacy of biologics on proximal ileal lesions using balloon-assisted enteroscopy (BAE).</p><p><strong>Methods: </strong>This open-label multicenter prospective study was conducted at tertiary referral centers in Japan. We enrolled 253 patients with active ileal CD who were treated with biologics (infliximab/adalimumab/ustekinumab/vedolizumab). BAE was performed at week 0 and week 26, and endoscopic findings were centrally assessed. We evaluated the rate of endoscopic remission (defined as having a maximum mSES-CD <4) at week 26 and patient prognosis (CD-related hospitalization and surgery).</p><p><strong>Results: </strong>At baseline, 74 (29.2%) patients had proximal ileal ulcerations without terminal ileal ulcerations. The second BAE showed that endoscopic remission was achieved in 91 (36.0%) patients. Of the patients with complete ulcer healing of the terminal ileum, 28.6% (22/77) had residual ulcers in the proximal ileum. The rate of endoscopic remission in the proximal ileum (50.9%) was relatively lower compared to the colon (63.4%) and terminal ileum (56.7%), a trend consistently observed across all treatment agents. After a median follow-up of 134 weeks, residual ulcerations in the proximal ileum were associated with a poorer prognosis (P=0.0126 for hospitalization and P=0.0014 for surgery).</p><p><strong>Conclusions: </strong>A substantial proportion of patients with CD exhibited ulcerations in the proximal ileum which correlated with a poorer prognosis. These lesions proved challenging to heal, regardless of the type of biologic used.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic sleeve gastroplasty plus lifestyle intervention in patients with MASH: a multicentre, sham-controlled, randomized trial.","authors":"Javier Abad, Elba Llop, María Teresa Arias-Loste, Diego Burgos-Santamaría, José Luis Martínez Porras, Paula Iruzubieta, Javier Graus, Belén Ruiz-Antoran, María Rosario Sánchez Yuste, Manuel Romero-Gómez, Agustin Albillos, Javier Crespo, José Luis Calleja","doi":"10.1016/j.cgh.2024.10.027","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.027","url":null,"abstract":"<p><strong>Background and aims: </strong>Metabolic dysfunction-associated steatohepatitis(MASH) is commonly seen in biopsy proven steatotic liver disease(SLD). Life-style intervention reaching a weight loss higher than 10% promotes MASH resolution, but this goal is only achieved by a small number of patients. Endoscopic sleeve gastroplasty(ESG) has recently emerged as a safe and effective option to promote weight loss in obese population. We report the results of a multicenter, randomized, controlled and double-blind study to evaluate the effectiveness and safety of ESG in MASH patients METHODS: Forty patients were randomized 1:1 to ESG plus lifestyle modification vs. sham endoscopy (SE) plus lifestyle intervention. Inclusion criteria included biopsy proven MASH with NAS≥3 and fibrosis stage F0-F3. Eighteen patients from the ESG group and 19 from the ESI group completed follow-up during 72 weeks. Baseline to end of follow-up changes in body weight, liver tests, liver stiffness(VCTE) and liver histology were recorded RESULTS: Total Body weight loss(TBWL) was 9.47%(±9.38) in ESG group vs 3.91%(±5.43) in ESI group(p<0.05). Liver stiffness decreased 5.63(±7.17) KPa in ESG group vs 0.2(±5.38) KPa in ESI group(p<0.05). Steatosis was significantly reduced in ESG group(-0.94±0.87) vs ESI group(-0.26±0.99)[p= 0.033]. No differences on NAS(-1.89±2.11 vs -1.47±2.01) score neither fibrosis(-0.1±0.91 vs -0.84±1.21) was seen. In patients achieving weight loss>10% we found a significant improvement on NAS score(-4±0.94 vs. -0.81±1.62, p<0.01), but not in fibrosis stage(-0.3±1.06 vs -0.59±1.25). Only 2 patients of ESG group had adverse events that required admission that resolved conservatively in 72 hours CONCLUSION: ESG is an effective and safe method to promote weight reduction associated with significant improvement in patients with MASH and obesity.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Trend of MASH-associated Liver Cancer A Systematic Analysis from the Global Burden of Disease 2021.","authors":"Pojsakorn Danpanichkul, Kanokphong Suparan, Chuthatip Kaeosri, Pimtawan Jatupornpakdee, Abdelrahman M Attia, Thanathip Suenghataiphorn, Jerapas Thongpiya, Banthoon Sukphutanan, Daniel Q Huang, Mazen Noureddin, Amit G Singal, Karn Wijarnpreecha, Ju Dong Yang","doi":"10.1016/j.cgh.2024.10.026","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.026","url":null,"abstract":"<p><strong>Background & aims: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are the leading causes of liver disease and are emerging as the main risk factors for primary liver cancer (PLC). However, updated global data on MASH remain scarce.</p><p><strong>Methods: </strong>This study analyzed data from the Global Burden of Disease (GBD) study between 2000 and 2021 to assess the age-standardized incidence, mortality, and disability-adjusted life years (DALYs) from MASH-associated PLC, stratified by geographical region, sociodemographic index, age, and sex.</p><p><strong>Results: </strong>There were 42,290 incident cases, 40,920 deaths, and 995,470 DALYs from PLC globally. Global incidence (+98%), death (+93%), and DALYs (+76%) from MASH-associated PLC increased steeply over the study period. Among different etiologies, only MASH-associated PLC had increased mortality rates (APC: +0.46, 95% CI 0.33 to 0.59%). Africa and low sociodemographic index countries exhibited the highest age-standardized incidence, death, and DALYs from MASH-associated PLC. DALYs increased in females (annual percent change [APC]: 0.24%, 95% Confidence Interval [CI] 0.06 to 0.42%) while remaining stable in males. Americas experienced the highest percentage increase in age-standardized incidence rate (APC: 2.09%, 95% CI 2.02 to 2.16%), age-standardized death rate (APC: 1.96%, 95% CI 1.69 to 2.23%), and age-standardized DALYs (APC: 1.96%, 95% CI 1.63 to 2.30%) from MASH-associated PLC.</p><p><strong>Conclusions: </strong>Over the past two decades, the burden of MASH-associated PLC has risen, though there are sociodemographic and geographic disparities. This necessitates urgent strategies across the globe to mitigate the epidemic of MASH-associated PLC as well as its metabolic drivers.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Albumin and Its Trajectory Are Associated with Therapeutic Outcomes in Ulcerative Colitis.","authors":"Jieqi Zheng, Xi Zhang, Liqian Zhang, Li Li, Minhu Chen, Rirong Chen, Shenghong Zhang","doi":"10.1016/j.cgh.2024.10.036","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.036","url":null,"abstract":"<p><strong>Background and aims: </strong>The relationship between serum albumin levels and therapeutic outcomes in ulcerative colitis (UC) has been debated. Additionally, the dynamic changes in albumin levels remain understudied.</p><p><strong>Methods: </strong>We conducted a pooled analysis of five clinical trials involving 3,268 patients with UC. Short- and long-term therapeutic outcomes were assessed at the end of the induction and maintenance phases. Multivariate logistic regression and random effects models were used to pool the predictive effects of albumin levels. The dynamic trajectory of albumin was fitted using latent class growth mixed models.</p><p><strong>Results: </strong>Baseline and week-2 albumin were independent predictors of short-term outcomes, with pooled adjusted odds ratios (aORs) [95% confidence intervals (CIs)] of 1.07 [1.05-1.09] and 1.11 [1.08-1.15] per 1 g/L increase for clinical response, respectively. Higher post-induction albumin levels predicted better long-term outcomes, including clinical (aOR [95% CI]: 1.16 [1.12-1.21]), endoscopic (1.13 [1.10-1.16]) and histological remission (1.11 [1.03-1.18]). Furthermore, there are three classes of albumin trajectories: sustained medium-to-high, rapidly ascending and poor response. Compared to the sustained medium-to-high class, patients in the poor response class had a lower probability of long-term endoscopic remission (aOR 0.35 [95% CI: 0.23-0.50]; P<0.001), while no significant difference was observed between the rapidly ascending class and the sustained medium-to-high class.</p><p><strong>Conclusion: </strong>Higher albumin levels were associated with better therapeutic outcomes in patients with UC. However, patients with low but rapidly ascending albumin levels would achieve outcomes comparable to those with medium-to-high levels of albumin.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Budesonide Orodispersible Tablets for Eosinophilic Esophagitis up to 3 Years: an Open-Label Extension Study.","authors":"Luc Biedermann, Christoph Schlag, Alex Straumann, Alfredo J Lucendo, Stephan Miehlke, Michael Vieth, Cecilio Santander, Constanza Ciriza de Los Rios, Christoph Schmöcker, Ahmed Madisch, Petr Hruz, Jamal Hayat, Ulrike von Arnim, Albert Jan Bredenoord, Stefan Schubert, Mike Halstead, Sabrina Pfurr, Ralph Mueller, Alain M Schoepfer, Stephen Attwood","doi":"10.1016/j.cgh.2024.10.034","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.034","url":null,"abstract":"<p><strong>Background and aims: </strong>Budesonide orodispersible tablets (BOT) have been shown to be safe and effective in phase 3 double-blind trials of induction and 48-week maintenance therapy of eosinophilic esophagitis (EoE). We now analyzed the long-term efficacy and safety of BOT in a 96-week open-label extension (OLE) study.</p><p><strong>Methods: </strong>All EoE patients in the 48-week double-blind maintenance study were eligible to receive BOT treatment for up to 96 weeks. Dosage was 0.5 or 1.0 mg BOT, twice daily, at investigator's discretion. Clinical, histologic, endoscopic, quality of life, and safety measures were assessed.</p><p><strong>Results: </strong>A total of 186 patients participated in the OLE up to 96 weeks. At week 96, 81.9% of patients had clinical remission, defined as an EoE Symptom Activity Index (EEsAI) score of ≤ 20, versus 77.7% at OLE baseline. A further 80.1% of patients were in histologic remission, defined as peak eosinophils per high-power field of <5, at week 96 versus 91.8% at OLE baseline. Mean EoE endoscopic reference scores (EREFS) were 1 at all time points measured. Mean EoE Quality of Life (EoE-QoL-A) Scale scores improved from 3.3 at OLE baseline to 3.5 at week 96. No new safety concerns were observed across 96 weeks of treatment. Suspected symptomatic candidiasis occurred at similar rates to prior BOT studies, and was predominantly mild and resolved with treatment.</p><p><strong>Conclusions: </strong>Clinical and histological remission of EoE could be maintained with BOT in a large majority of patients for up to 96 weeks, and for up to 144 weeks in patients with uninterrupted BOT therapy across all trials. No additional safety concerns were identified with long-term BOT treatment. (ClinicalTrials.gov, Number: NCT02493335).</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercoagulation after Hospital Discharge in Acute Severe Ulcerative Colitis: A Prospective Study.","authors":"Benjamin J Griffiths, Michael J R Desborough, Marjolijn Duijvestein, Geert R A D'Haens, Yuhong Yuan, Robert V Bryant, Nicola Curry, Simon P L Travis, Vipul Jairath","doi":"10.1016/j.cgh.2024.10.031","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.031","url":null,"abstract":"<p><strong>Background & aims: </strong>Venous thromboembolism is a serious complication during and following hospitalization with acute severe ulcerative colitis (ASUC). We evaluated serial thrombotic profiles of patients with ASUC from the point of hospitalization up to 12 weeks post-discharge and compared these with control patients with quiescent UC.</p><p><strong>Methods: </strong>Twenty-seven patients with ASUC and 25 control patients with quiescent ulcerative colitis (UC) were recruited. Thrombin generation (endogenous thrombin potential), rotational thromboelastometry (EXTEM and FIBTEM maximum clot firmness), pro-coagulant factors, anti-coagulant factors and fibrinolytic markers were assessed for those with ASUC on admission (day 1), day 5, 4 weeks and at 8 to 12 weeks. These assessments were performed on a single occasion for control patients.</p><p><strong>Results: </strong>Endogenous thrombin potential and maximum clot firmness were significantly elevated in patients with ASUC compared to controls and remained significantly elevated for 4 weeks and for 8 to 12 weeks after admission (P< 0.05), respectively. Von Willebrand Factor (VWF) antigen, factor VIII, Clauss fibrinogen concentration and platelet count were significantly increased from presentation to 8 to 12 weeks and are likely to account for changes in the global haemostatic profile.</p><p><strong>Conclusions: </strong>Global measures of haemostasis demonstrated that patients with ASUC were pro-thrombotic compared to controls with quiescent colitis. This difference was maintained 8 to 12 weeks after the initial presentation, supporting clinical observations that patients with ASUC have an elevated risk of VTE after hospital discharge.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Lugol-Unstained Lesions: A New Predictor of Progression to Esophageal Squamous Cell Carcinoma?","authors":"Ali Soroush, Sanford M Dawsey","doi":"10.1016/j.cgh.2024.11.020","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.11.020","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE OPTIMAL DURATION OF pH-MONITORING: TESTING THE VALIDITY OF LYON 2.0 RECOMMENDATIONS FOR WIRELESS pH MEASUREMENT.","authors":"Radu I Rusu, Mark R Fox, Rami Sweis, Sebastian Zeki, Jason M Dunn, Angela Anggiansah, Jafar Jafari, Annastazia Learoyd, Terry Wong","doi":"10.1016/j.cgh.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.11.009","url":null,"abstract":"<p><strong>Background and aims: </strong>The Lyon 2.0 consensus recommends 96-hr wireless pH studies for GERD diagnosis; however, the optimal length of pH-measurement has not been established. Further it is uncertain if, and under what circumstances, shorter recording times are sufficient for a conclusive diagnosis.</p><p><strong>Methods: </strong>Data from 944 patients with 4-day recordings was reviewed. Patients were classified at 24, 48, and 72-hrs against the 96-hr reference standard. Acid exposure time (AET) <4% was conclusively negative and AET >6% conclusively positive for GERD. Esophagitis was an independent marker of disease. The effect of utilizing average day, worst-day, and dominant-pattern analysis (≥2 negative or positive days) was compared. Groups defined by AET thresholds from 1% to 7% at 24- and 48-hr were followed to assess when short recording periods were sufficient for conclusive diagnosis.</p><p><strong>Results: </strong>Diagnostic accuracy improved with study duration (p < 0.00001). The proportion of patients with inconclusive results (AET 4-6%) reduced from 113/944 at 24-hr to 40/113 at 96-hr (35% of subgroup; p = 0.02), with similar results for dominant pattern analysis. Diagnostic sensitivity for 24, 48 and 72-hr pH-monitoring for AET 6% threshold increased with study duration from 62.5% to 76.6% and 88.2%, respectively, when compared to the 96-hour reference standard.</p><p><strong>Conclusion: </strong>The results of this analysis validate the recommendation that prolonged reflux studies of at least 72-hr duration provide optimal AET measurements for GERD diagnosis. Prolonging studies can also resolve inconclusive results based on 24- and 48-hr studies.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Distribution of Colorectal Cancer Staging at Diagnosis: An Evidence Synthesis.","authors":"Lanwei Guo, Le Wang, Lin Cai, Yuelun Zhang, Xiaoshuang Feng, Chenxin Zhu, Wendong Gao, Rafael Cardoso, Haiyan Yang, Min Dai, Hermann Brenner, Hongda Chen","doi":"10.1016/j.cgh.2024.11.019","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.11.019","url":null,"abstract":"<p><strong>Background and aims: </strong>Stage at diagnosis is a key prognostic factor for colorectal cancer (CRC) survival. We aimed to assess the global distribution of CRC staging at diagnosis using population-based or hospital-based registry data.</p><p><strong>Methods: </strong>We systematically searched in MEDLINE and Embase from their inception until 6 December 2023. Grey literature was searched through published cancer reports. Studies from population-based or hospital-based cancer registries reporting the stage distribution of diagnosed CRC were included. We extracted stage-specific proportions among patients with CRC based on TNM, SEER, or Dukes staging systems. Subgroup analyses by sex, age, tumor site, calendar period, and status of population-based screening were performed. Correlations between the Human Development Index (HDI), Socio-Demographic Index (SDI), and the distant metastatic CRC proportion were also evaluated.</p><p><strong>Results: </strong>84 eligible studies/reports from 46 countries were analyzed, covering 3.8 million patients. Among 36 countries included in the main analysis, the most recent distant metastatic CRC proportions varied from 16.2% in Puerto Rico to 28.2% in Oman and Latvia, with a median (interquartile range) of 23.7% (21.8%-26.3%). Higher metastatic proportions were observed in younger patients, those with colon cancer, and those without screening implementation, with no apparent difference between males and females. Over time, some countries/regions, such as Southern Portugal (36.5% in 2000 to 22.2% in 2016), showed declining proportions of metastatic CRC, while others remained stable (e.g., Austria, Belgium) or increased (e.g., United States, Slovenia, Spain). Higher HDI and SDI were correlated with lower proportions of distant metastatic CRC (HDI: ρ=-0.48; SDI: ρ=-0.26).</p><p><strong>Conclusion: </strong>Global disparities in CRC staging exist, indicating a need for targeted interventions to enhance early detection and management, especially in high-metastasis areas.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIGH RISK OF DIGESTIVE CANCERS IN PATIENTS WITH CELIAC DISEASE: A NATIONWIDE CASE CONTROL COHORT STUDY.","authors":"Anne-Sophie Jannot, Yannick Girardeau, Stanislas Chaussade, Romain Coriat, Nadine Cerf-Bensussan, Georgia Malamut","doi":"10.1016/j.cgh.2024.10.028","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.028","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}