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Causality assessment is necessary in epidemiological studies on idiosyncratic DILI 在异质性DILI的流行病学研究中，有必要进行因果关系评估
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-27 DOI: 10.1016/j.cgh.2025.06.012
Helgi Kristinn Björnsson, Einar Stefan Björnsson
{"title":"Causality assessment is necessary in epidemiological studies on idiosyncratic DILI","authors":"Helgi Kristinn Björnsson, Einar Stefan Björnsson","doi":"10.1016/j.cgh.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.012","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"26 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable technologies in inflammatory bowel disease: A scoping review 可穿戴技术在炎症性肠病中的应用：范围综述
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-27 DOI: 10.1016/j.cgh.2025.06.013
Parna Pathak, Arup Choudhury, Adarsh Marikanty, Anuraag Jena, Shaji Sebastian, Vishal Sharma
{"title":"Wearable technologies in inflammatory bowel disease: A scoping review","authors":"Parna Pathak, Arup Choudhury, Adarsh Marikanty, Anuraag Jena, Shaji Sebastian, Vishal Sharma","doi":"10.1016/j.cgh.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.013","url":null,"abstract":"Use of wearable technologies is increasing and may offer potential benefits in collecting actionable health data. We performed a scoping review on the use of wearable technologies in patients with inflammatory bowel disease (IBD).","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"16 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter Response to: Ioannou S, Beecham A, Gomez L, et al. Ancestral Diversity in Pharmacogenomics Affects Treatment for Hispanic/Latine Populations With Inflammatory Bowel Disease. Clin Gastroenterol Hepatol August 2024:S1542-3565(24)00766-3. 回复：Ioannou S， Beecham A, Gomez L，等。药物基因组学的祖先多样性影响西班牙裔/拉丁裔人群炎症性肠病的治疗clinical Gastroenterol Hepatol August 2024:S1542-3565(24)00766-3。
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-27 DOI: 10.1016/j.cgh.2025.06.008
Bernabé I. Bustos, Juan Francisco Miquel, Cristian Hernández-Rocha
{"title":"Letter Response to: Ioannou S, Beecham A, Gomez L, et al. Ancestral Diversity in Pharmacogenomics Affects Treatment for Hispanic/Latine Populations With Inflammatory Bowel Disease. Clin Gastroenterol Hepatol August 2024:S1542-3565(24)00766-3.","authors":"Bernabé I. Bustos, Juan Francisco Miquel, Cristian Hernández-Rocha","doi":"10.1016/j.cgh.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.008","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"22 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal cutoffs of fatty liver index and hepatic steatosis index in diagnosing pediatric MASLD 脂肪肝指数和肝脂肪变性指数诊断小儿MASLD的最佳临界值
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-27 DOI: 10.1016/j.cgh.2025.06.011
Kyungchul Song MD PhD, Yu-Jin Kwon MD PhD, Eunju Lee MS, Hye Sun Lee PhD, Young Hoon Youn MD PhD, Su Jung Baik MD PhD, Hyun Joo Shin MD PhD, Hyun Wook Chae MD PhD
{"title":"Optimal cutoffs of fatty liver index and hepatic steatosis index in diagnosing pediatric MASLD","authors":"Kyungchul Song MD PhD, Yu-Jin Kwon MD PhD, Eunju Lee MS, Hye Sun Lee PhD, Young Hoon Youn MD PhD, Su Jung Baik MD PhD, Hyun Joo Shin MD PhD, Hyun Wook Chae MD PhD","doi":"10.1016/j.cgh.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.011","url":null,"abstract":"Despite the high global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), effective non-invasive diagnostic tools in pediatric populations remain limited. We aimed to validate the predictive performance of the fatty liver index (FLI) and hepatic steatosis index (HSI) in diagnosing MASLD in the young population and propose optimal cutoff points for the diagnosis of MASLD and severe MASLD.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"18 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of compensated Advanced Chronic Liver Disease (cACLD) in the United States: Insights from NHANES 2017-2020 代偿性晚期慢性肝病（cACLD）在美国的流行病学：来自NHANES 2017-2020的见解
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-26 DOI: 10.1016/j.cgh.2025.06.010
Ritik M. Goyal MD, Apoorva Doshi MD, Sameer Rao MD, Komal Arora MD, Supriya Maheshwari MD, Paul Gaglio MD
{"title":"Epidemiology of compensated Advanced Chronic Liver Disease (cACLD) in the United States: Insights from NHANES 2017-2020","authors":"Ritik M. Goyal MD, Apoorva Doshi MD, Sameer Rao MD, Komal Arora MD, Supriya Maheshwari MD, Paul Gaglio MD","doi":"10.1016/j.cgh.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.010","url":null,"abstract":"Compensated Advanced Chronic Liver Disease (cACLD) encompasses advanced fibrosis and cirrhosis in asymptomatic patients at risk of developing clinically significant portal hypertension (CSPH). Patients having cACLD are at high risk of decompensation and liver-related mortality, hence require further evaluation. Due to limited epidemiological data on cACLD, we aimed to assess its prevalence in the US.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"246 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable Devices Identify Altered Sleep Characteristics and Sleep Trajectories in Active Inflammatory Bowel Disease 可穿戴设备识别活动性炎症性肠病患者改变的睡眠特征和睡眠轨迹
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-26 DOI: 10.1016/j.cgh.2025.06.003
Robert P. Hirten MD, Matteo Danieletto PhD, Jessica K. Whang MS, Kyle Landell BA, Drew Helmus MPH, Hyder Said MD, Ipek Ensari PhD, Neomi Shah MD, Emilia Bagiella PhD, Mariana G. Figueiro PhD, Bruce E. Sands MD, Mayte Suarez-Farinas PhD
{"title":"Wearable Devices Identify Altered Sleep Characteristics and Sleep Trajectories in Active Inflammatory Bowel Disease","authors":"Robert P. Hirten MD, Matteo Danieletto PhD, Jessica K. Whang MS, Kyle Landell BA, Drew Helmus MPH, Hyder Said MD, Ipek Ensari PhD, Neomi Shah MD, Emilia Bagiella PhD, Mariana G. Figueiro PhD, Bruce E. Sands MD, Mayte Suarez-Farinas PhD","doi":"10.1016/j.cgh.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.003","url":null,"abstract":"Poor sleep is associated with flares of inflammatory bowel disease (IBD). Studies often rely on subjective assessments of sleep and disease activity. Our aim is to use wearable devices to objectively assess the impact of inflammation and symptoms on sleep architecture in IBD.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"27 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib in Mother with Inflammatory Bowel Disease: Placental Transfer and Breast milk Excretion Upadacitinib在炎性肠病母亲中的应用：胎盘转移和母乳排泄
IF 12.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-24 DOI: 10.1016/j.cgh.2025.06.007
Dana Duricova, Elena Sonnenberg, Patrick Augustijns, Katarina Mitrova, Philip O. Anderson, the Upadacitinib Pregnancy-Lactation Study Group, Barbora Pipek, Raf Mols, Kristyna Zdychyncova, Kristyna Kubickova, Milan Lukas, Mette Mejlby Hansen, Lise Svenningsen, Jeremiah Momper, Mette Julsgaard
{"title":"Upadacitinib in Mother with Inflammatory Bowel Disease: Placental Transfer and Breast milk Excretion","authors":"Dana Duricova, Elena Sonnenberg, Patrick Augustijns, Katarina Mitrova, Philip O. Anderson, the Upadacitinib Pregnancy-Lactation Study Group, Barbora Pipek, Raf Mols, Kristyna Zdychyncova, Kristyna Kubickova, Milan Lukas, Mette Mejlby Hansen, Lise Svenningsen, Jeremiah Momper, Mette Julsgaard","doi":"10.1016/j.cgh.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.007","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"26 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blue Notes 蓝色笔记
IF 11.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-23 DOI: 10.1016/j.cgh.2025.04.004
Charles J. Kahi MD, MS, AGAF
{"title":"Blue Notes","authors":"Charles J. Kahi MD, MS, AGAF","doi":"10.1016/j.cgh.2025.04.004","DOIUrl":"10.1016/j.cgh.2025.04.004","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"23 8","pages":"Pages 1275-1276"},"PeriodicalIF":11.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness of novel noninvasive screening tests for colorectal neoplasia. 新型无创结直肠肿瘤筛查试验的成本效益。
IF 11.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-23 DOI: 10.1016/j.cgh.2025.06.006
Aasma Shaukat, Theodore R Levin, Peter S Liang, Jennifer M Weiss, Caitlin Smare, Emily Boller, Meena Venkatachalam, Erica K Barnell
{"title":"Cost-effectiveness of novel noninvasive screening tests for colorectal neoplasia.","authors":"Aasma Shaukat, Theodore R Levin, Peter S Liang, Jennifer M Weiss, Caitlin Smare, Emily Boller, Meena Venkatachalam, Erica K Barnell","doi":"10.1016/j.cgh.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.006","url":null,"abstract":"<p><strong>Background and aims: </strong>This study assessed the economic and health impact of colorectal cancer (CRC) screening programs for average-risk individuals aged 45 and older.</p><p><strong>Methods: </strong>A 10-year Markov model simulated disease progression, comparing multitarget stool RNA test (mt-sRNA, ColoSense®), two mt-sDNA tests (Cologuard® and Cologuard Plus®), a blood-based test (cfDNA, Shield), and a fecal immunochemical test (FIT). Clinical inputs leveraged age-weighted sensitivity and specificity from independent studies. Outcomes were compared to a colonoscopy-based program and no screening. Model calibration and validation used previously reported CISNET models.</p><p><strong>Results: </strong>Among molecular tests, mt-sRNA detected the most advanced adenomas, referred the most individuals to surveillance, and prevented the highest number of CRC cases and deaths. At real-world adherence of 60%, mt-sRNA reduced CRC cases and deaths by 1% and 14% compared to FIT; 21% and 19% compared to mt-sDNA; 28% and 23% compared to mt-sDNA+; and 80% and 86% compared to cfDNA. For all adherence levels, FIT ($25/test) was the most cost effective strategy. For triennial molecular tests ($508/test), mt-sRNA was the most cost effective strategy. Relative to the mt-sRNA program, the cost to prevent a CRC case was 30% (mt-sDNA), 45% (mt-sDNA+), and 642% (cfDNA) more expensive. Relative to the mt-sRNA program, the cost to prevent a CRC death was 30% (mt-sDNA), 41% (mt-sDNA+), and 1,040% (cfDNA) more expensive.</p><p><strong>Conclusions: </strong>FIT was the most cost-effective strategy for preventing CRC cases and deaths. At real-world adherence of 60%, mt-sRNA demonstrated the greatest clinical benefit and was more cost-effective than other molecular strategies.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exam 1: Risk of Hepatocellular Carcinoma in Subcentimeter Liver Nodules Identified on Surveillance Ultrasound: A Systematic Review 检查1：监测超声发现的亚厘米肝结节的肝细胞癌风险：系统综述
IF 11.6 1区 医学
Clinical Gastroenterology and Hepatology Pub Date : 2025-06-23 DOI: 10.1016/j.cgh.2025.04.007
{"title":"Exam 1: Risk of Hepatocellular Carcinoma in Subcentimeter Liver Nodules Identified on Surveillance Ultrasound: A Systematic Review","authors":"","doi":"10.1016/j.cgh.2025.04.007","DOIUrl":"10.1016/j.cgh.2025.04.007","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"23 8","pages":"Pages e5-e6"},"PeriodicalIF":11.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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