Clinical Gastroenterology and Hepatology最新文献

{"title":"Long-term effectiveness of dupilumab in eosinophilic esophagitis: Results from the DUPEOETALY Study","authors":"Salvatore Oliva, Enrico Felici, Giusy Russo, Sara Curto, Domenico Gargano, Gaia Pellegatta, Francesca Giugliano, Fabiola Fornaroli, Silvia Iuliano, Alessandra Vultaggio, Elisa Marabotto, Elisabetta Favero, Edoardo Vespa, Barbara Parma, Maurizio G. Fuoti, Sara Renzo, Lorenzo Norsa, Matteo Ghisa, Daria Maniero, Giovanni Sarnelli, Marcella Pesce, Antonio Pizzol, Caterina Strisciuglio, Luca Bosa, Sara Lega, Nicola de Bortoli, Pierfrancesco Visaggi, Irene Spinelli, Renato Tambucci, Maurizio Mennini, Antonio Di Sabatino, Rossella Casella, Eustachio Nettis, Alessandra Spagnoli, Edoardo V. Savarino, DUPEOETALY Study Group, Andrea Pedrazzoli, Angelo Vacca, Antonio Marseglia, Beatrice Marinoni, Carlo Maria Rossi, Demurtas Mauro, Eleonora Carlini, Patrizia Zentilin, Emanuele Dilaghi, Erasmo Miele, Fernanda Cristofori, Flavio Labriola, Giovanni De Carlo, Irene Bergna, Leonardo Frazzoni, Luca Lo Sardo, Sonia Solito, Mancini Riccardo, Maria Beatrice Bilò, Mario Torrazza, Matteo Antonino, Matteo Maule, Naire Sansotta, Palma Carlucci, Paola Iovino, Salvatore Rizzi, Silvia Gallo Cassarino, Silvia Noviello, Graziano Troina","doi":"10.1016/j.cgh.2026.04.004","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.04.004","url":null,"abstract":"Dupilumab, a monoclonal antibody targeting the IL-4 receptor alpha, is increasingly used for eosinophilic esophagitis (EoE) treatment. The DUPEOETALY study evaluates its long-term effectiveness in an Italian cohort over 72 weeks.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"101 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor - response","authors":"Karlo Hünerbein MD","doi":"10.1016/j.cgh.2026.02.020","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.02.020","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"133 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Onboarding to Excellence: Creating Gastroenterology Advanced Practice Provider Fellowship Programs That Benefit Practices, Patient Access, and Specialty Growth","authors":"Catherine Brady, Katherine Dickerman","doi":"10.1016/j.cgh.2026.03.021","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.03.021","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"54 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Use of Noninvasive Testing for Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease","authors":"Maria Mironova, Rohit Loomba","doi":"10.1016/j.cgh.2026.03.014","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.03.014","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"9 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Trial of Rifaximin vs Low FODMAP Diet for Symptom Outcomes and Microbiome Changes in Irritable Bowel Syndrome","authors":"Allen Lee, Krishna Rao, Prashant Singh, Jared Fehlman, Jun Gao, Will Takakura, Amanda Lynett, Emily Haller, Sarah Ball, Alicia Marand, Amy Liu, Eric Shah, Stacy Menees, Raani Punglia, Borko Nojkov, Shanti Eswaran, Jason Baker, William D. Chey, Chung Owyang, Vincent Young, William L. Hasler","doi":"10.1016/j.cgh.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.04.014","url":null,"abstract":"The low FODMAP diet (LFD) and rifaximin are effective in <50% individuals with irritable bowel syndrome (IBS), highlighting the need to identify predictors of treatment response. We therefore conducted a randomized controlled trial comparing LFD and rifaximin to identify microbial predictors of response.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"22 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal inflammation impacts gestational weight gain in women with inflammatory bowel disease and growth in offspring","authors":"Taegyu Kim, Isabella Nguyen, Nicholas Thomas, Mellissa Picker, Jose C. Clemente, Manasi Agrawal, the MECONIUM Study Group, Kaitlyn Weinstein, Adam Cantor, Rosemary Chen, Anketse Debebe, Jianzhong Hu, Alexa Patricia Rendon, Leonid Tarassishin, Jose C. Clemente, Joana Torres, Jean-Frederic Colombel, Inga Peter","doi":"10.1016/j.cgh.2026.04.013","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.04.013","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"133 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic liver disease, clinical subtypes and adverse perinatal outcomes: the prospective Fatty Liver in Pregnancy Study","authors":"Tatyana Kushner, Rachel Meislin, Cecilia Katzenstein, Marcia Lange, Nina Rodriguez, Sonam Rosberger, Jeannette Rios, Lauren Alpert, Pamela Argiriadi, Tess Worthington, Carin Carroll, Joanne Stone, Emma Rosenbluth, Shaelyn Ohara, Himel Mallick, Phyllis August, Rhoda Sperling, Norah Terrault, Keith Sigel","doi":"10.1016/j.cgh.2026.04.011","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.04.011","url":null,"abstract":"Retrospective global data suggested a possible association of hepatic steatosis with adverse pregnancy outcomes. We sought to prospectively determine the prevalence of steatotic liver disease (SLD) using updated nomenclature and the independent influence of clinically relevant subtypes including metabolic dysfunction associated steatotic liver disease (MASLD) and lean SLD on pregnancy outcomes.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"43 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UNSEDATED TRANSNASAL ESOPHAGOGASTRODUODENOSCOPY FOR EVALUATION OF CELIAC DISEASE","authors":"Julia Sessions MD, Nathalie Nguyen MD, Kristen Liu MD, Michael Joseph MD MPH, Edwin Liu MD, Jacob A. Mark MD, the TEND-CeD working group, Michael Joseph MD MPH, Edwin Liu MD, Kristen Liu MD, Dr. Yamin Ma MD PhD, Jacob A. Mark MD, Nathalie Nguyen MD, Julia Sessions MD, Marisa Stahl MD MSCS","doi":"10.1016/j.cgh.2026.04.012","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.04.012","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"116 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germline Variants in Chronic Pancreatitis-associated Genes and Risk of Pancreatic Ductal Adenocarcinoma","authors":"Samuel O. Antwi Ph.D., Kari G. Rabe M.S., Erin E. Carlson B.A., Hugues Sicotte Ph.D., William R. Bamlet M.S., Krystal C. Mills M.B.B.S., Tom Konikoff M.D., MAYO-RGC Project Generation, James R. Cerhan M.D. Ph.D., Fergus J. Couch Ph.D, Nicholas B. Larson Ph.D., Eric W. Klee Ph.D., Zachary S. Fredericksen, Mine Cicek Ph.D, Janet E. Olson Ph.D, Lisa K. Colborn M.B.A., Andrew J. Danielsen, Jonathan J. Harrington, Regeneron Genetics Center, Aris Baras, Gonçalo Abecasis, Adolfo Ferrando, Giovanni Coppola, Andrew Deubler, Aris Economides, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Katherine Siminovitch, Jason Portnoy, Marcus B. Jones, Lyndon Mitnaul, Alison Fenney, Jonathan Marchini, Manuel Allen Revez Ferreira, Maya Ghoussaini, Mona Nafde, William Salerno. John D Overton, Christina Beechert, Erin Fuller, Laura M. Cremona, Eugene Kalyuskin, Hang Du, Caitlin Forsythe, Zhenhua Gu, Kristy Guevara, Michael Lattari, Alexander Lopez, Kia Manoochehri, Prathyusha Challa, Manasi Pradhan, Raymond Reynoso, Ricardo Schiavo, Maria Sotiropoulos Padilla, Chenggu Wang, Sarah E. Wolf, Hang Du, Kristy Guevara. Jeffrey G Reid, Mona Nafde, Manan Goyal, George Mitra, Sanjay Sreeram, Rouel Lanche, Vrushali Mahajan, Sai Lakshmi Vasireddy, Gisu Eom, Krishna Pawan Punuru, Sujit Gokhale, Benjamin Sultan, Pooja Mule, Eliot Austin, Xiaodong Bai, Lance Zhang, Sean O'Keeffe, Razvan Panea, Evan Edelstein, Ayesha Rasool, William Salerno, Evan K. Maxwell, Boris Boutkov, Alexander Gorovits, Ju Guan, Lukas Habegger, Alicia Hawes, Olga Krasheninina, Samantha Zarate, Adam J. Mansfield, Lukas Habegger, Gonçalo Abecasis, Manuel Allen Revez Ferreira, Joshua Backman, Kathy Burch, Adrian Campos, Liron Ganel, Sheila Gaynor, Benjamin Geraghty, Arkopravo Ghosh, Salvador Romero Martinez, Christopher Gillies, Lauren Gurski, Joseph Herman, Eric Jorgenson, Tyler Joseph, Michael Kessler, Jack Kosmicki, Adam Locke, Priyanka Nakka, Jonathan Marchini, Karl Landheer, Olivier Delaneau, Maya Ghoussaini, Anthony Marcketta, Joelle Mbatchou, Arden Moscati, Aditeya Pandey, Anita Pandit, Jonathan Ross, Carlo Sidore, Eli Stahl, Timothy Thornton, Sailaja Vedantam, Rujin Wang, Kuan-Han Wu, Bin Ye, Blair Zhang, Andrey Ziyatdinov, Yuxin Zou, Jingning Zhang, Kyoko Watanabe, Mira Tang, Frank Wendt, Suganthi Balasubramanian, Suying Bao, Kathie Sun, Chuanyi Zhang. Marcus B Jones, Esteban Chen, Michelle G. LeBlanc, Jason Mighty, Jennifer Rico-Varela, Nirupama Nishtala, Nadia Rana, Jaimee Hernandez. Alison Fenney, Randi Schwartz, Jody Hankins, Anna Han, Samuel Hart. Ann Perez-Beals, Gina Solari, Johannie Rivera-Picart, Michelle Pagan, Sunilbe Siceron, Robert R. McWilliams M.D., Ann L. Oberg Ph.D., Shounak Majumder M.D.","doi":"10.1016/j.cgh.2026.03.043","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.03.043","url":null,"abstract":"Hereditary chronic pancreatitis (CP) is associated with elevated risk of pancreatic ductal adenocarcinoma (PDAC), but the specific contributing genes and their associated risk magnitudes remain incompletely defined. We aimed to investigate whether pathogenic germline variants (PGVs) in all 11 known CP-associated genes (<ce:italic>CASR, CEL, CFTR, CLDN2, CPA1, CPB1, CTRC, PNLIP, PRSS1, SPINK1, TRPV6</ce:italic>) predispose to PDAC and to quantify their risk estimates.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"54 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147744152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Morphology: Influence of Stent Caliber and Indication on the Efficacy of Lumen-Apposing Metal Stents with Coaxial Pigtails","authors":"Koji Takahashi MD","doi":"10.1016/j.cgh.2026.03.044","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.03.044","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"22 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}