Clinical Gastroenterology and Hepatology最新文献

{"title":"External validation of the GOLDEN model for predicting HBsAg loss in non-cirrhotic chronic hepatitis B patients with interferon-alpha based therapy.","authors":"Xingmei Liao, Qing Xie, Xiaoguang Dou, Junqi Niu, Hong Ma, Yali Liu, Shumei Lin, Huiying Rao, Song Yang, Jianping Xie, Mingxiang Zhang, Qiang Li, Yanyan Yu, Qin Ning, Wu Li, Chengzhong Li, Liaoyun Zhang, Zhengang Zhang, Tao Han, Jian Sun, Jinlin Hou, Rong Fan","doi":"10.1016/j.cgh.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.005","url":null,"abstract":"<p><strong>Background and aims: </strong>The GOLDEN model is designed to predict hepatitis B surface antigen (HBsAg) loss based on chronic hepatitis B (CHB) patients receiving nucleos(t)ide analogues therapy. We aimed to validate GOLDEN model's effectiveness in predicting HBsAg loss or decline in interferon-alpha (IFN-α) treated CHB patients.</p><p><strong>Methods: </strong>IFN-α-treated patients were enrolled from EXCEL study, a randomized controlled trial included HBeAg-positive, non-cirrhotic, treatment-naïve CHB patients, as well as Search-B cohort, a prospective real-world observational cohort of CHB. Utilizing multiple quantitative HBsAg (qHBsAg) measurements, GOLDEN model was employed to calculate patient's probability of achieving HBsAg loss or decline.</p><p><strong>Results: </strong>Among 200 patients in EXCEL study and 1041 patients from Search-B cohort, the corresponding cumulative incidence of qHBsAg<100 IU/mL or HBsAg loss was 20.0% and 6.7%, after the median follow-up of 18.0 (IQR,18.0-30.0) and 66.7 (IQR,48.8-84.7) months, respectively. The GOLDEN model achieved an area under the curve of 0.820 (95% CI:0.737-0.902) for predicting qHBsAg<100 IU/mL in EXCEL study and 0.964 (95% CI:0.953-0.974) for predicting HBsAg loss in Search-B cohort, maintaining robust performance across subgroups. The favorable group showed higher cumulative incidences of qHBsAg<100 IU/mL (42.5% vs. 4.6%, p<0.001) or HBsAg loss (37.2% vs. 0%, p<0.001) than the unfavorable group, along with significantly lower qHBsAg levels and faster qHBsAg decline rates. Moreover, the favorable group defined by GOLDEN model and qHBsAg levels at enrolment were confirmed as independent predictors for HBsAg loss or decline.</p><p><strong>Conclusion: </strong>GOLDEN model is a robust tool for predicting HBsAg loss or decline in IFN-α-treated CHB patients, offering valuable support for clinicians in developing personalized, effective management strategies for CHB patients.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elsewhere in the AGA Journals","authors":"","doi":"10.1016/S1542-3565(25)00431-8","DOIUrl":"10.1016/S1542-3565(25)00431-8","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"23 8","pages":"Pages A15-A16"},"PeriodicalIF":11.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns are associated with variations in the global prevalence and severity of Rome IV Irritable Bowel Syndrome.","authors":"Hussain Jaafari, Lesley A Houghton, Robert M West, Farag Shuweihdi, Heidi Staudacher, Silviya Nikolova, Alexander C Ford, Peter J Whorwell, Shrikant I Bangdiwala, Olafur S Palsson, Ami D Sperber, Dipesh H Vasant","doi":"10.1016/j.cgh.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.06.004","url":null,"abstract":"<p><strong>Background and aims: </strong>The relationship between regional dietary patterns and the global prevalence and severity of irritable bowel syndrome (IBS) is unclear. We aimed to determine whether dietary patterns are associated with variation in the global prevalence and severity of IBS.</p><p><strong>Methods: </strong>54,127 participants from 26 countries completed online questionnaires including Rome IV IBS criteria and the frequency of intake of 10 foods or food groups (fruit, vegetables/legumes, milk, rice, bread, pasta, meat, fish, tofu, eggs). A latent class analysis was conducted to identify distinct dietary patterns (clusters), adjusted for country, religion, and age. Multivariable logistic regression analysis was then performed to explore the association between these clusters and IBS prevalence and severity.</p><p><strong>Results: </strong>Four clusters with marked differences in dietary intake frequency of the 10 foods and IBS prevalence (P<.001) were identified. Dietary clusters A (5.6% (95% CI: 5.2%-6.0%)) and B (4.5% (95% CI: 4.2%-4.8%)), with the highest IBS prevalence, also had the highest IBS symptom severity scores (P<.001), and were predominantly represented by Egypt, Brazil, and Colombia in cluster A, and Argentina, Germany, Poland, and the USA in cluster B. By contrast, the lower IBS prevalence clusters, cluster C (3.4% (95% CI: 3.1%-3.7%)) represented predominantly by Europe, and cluster D (2.6% (95% CI:2.3%-2.9%)) strongly represented by Asian countries, had lower IBS symptom severity.</p><p><strong>Conclusion: </strong>Dietary patterns adjusted by age, country, and religion are associated with the global prevalence and severity of IBS. Further studies are required to investigate population-specific dietary preferences and acceptability of dietary interventions for IBS.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NAVIGATING THE MAZE OF FUNCTIONAL DYSPEPSIA: EMERGENCE OF A NEW ENTITY, POSTPRANDIAL EPIGASTRIC PAIN SYNDROME.","authors":"C Van de Bruaene, F Carbone, K Van den Houte, E Colomier, K Raymenants, B Broeders, L M Balsiger, M P Jones, T Vanuytsel, J Tack","doi":"10.1016/j.cgh.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.017","url":null,"abstract":"<p><strong>Background and aims: </strong>The Rome IV criteria subdivide functional dyspepsia (FD) into postprandial distress syndrome (PDS) with meal-related symptoms (early satiation and/or postprandial fullness) and epigastric pain syndrome (EPS) with meal-unrelated symptoms (epigastric pain and/or burning). We aimed to systematically assess the relationship of epigastric pain to meal ingestion in four independent FD databases.</p><p><strong>Methods: </strong>In total, 1337 FD patients were included. Three cohorts (local, national and international, total n=971) completed a Rome IV symptom questionnaire, with additional questions on meal relationship. In 498 patients undergoing a standard gastric emptying breath test, we analyzed the evolution of symptoms during a 4-hour window. Patients were categorized as postprandial epigastric pain (pEPS), meal-unrelated epigastric pain (murEPS), and PDS symptoms with/without postprandial epigastric pain. Symptom profiles and demographics were compared between these categories.</p><p><strong>Results: </strong>Distribution for Rome IV PDS/EPS/overlap was 896/252/186. Postprandial epigastric pain without PDS symptoms, i.e. pEPS, was present in approximately 40% of EPS patients, while 60% had murEPS. 50% of PDS patients reported postprandial epigastric pain. Patient demographics were similar across categories. Overall, PDS patients with postprandial epigastric pain had most associated gastrointestinal symptoms, compared to pEPS, murEPS, or PDS without postprandial epigastric pain.</p><p><strong>Conclusion: </strong>In contrast to earlier characterization of EPS symptoms as purely meal-unrelated, we identified a relevant patient cohort with postprandial epigastric pain in the absence of PDS symptoms in 4 different cohorts. Further research is needed to determine the underlying pathophysiology, and the response to different treatment approaches in these newly defined patient cohorts.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yield of Advanced Neoplasia at 2nd Post-Polypectomy Surveillance Colonoscopy: A Systematic Review and Meta-Analysis","authors":"Pooja Pandita, Yi Le, Mehul Trivedi, Karen Heskett, Joshua Demb, Siddharth Singh, Brian A. Sullivan, Lin Liu, Samir Gupta","doi":"10.1016/j.cgh.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.02.038","url":null,"abstract":"Individuals who have had polypectomy and at least one surveillance colonoscopy exam are routinely encountered, but evidence to inform risk for subsequent neoplasia and timing of surveillance is limited. Our aim was to conduct a systematic review and meta-analysis of serial surveillance yield.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"8 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable Trends in Incidence of Young-Onset Esophageal Adenocarcinoma: A Twenty-Year Analysis from the United States Cancer Statistics Database","authors":"Anila Vasireddy MBBS, Yazan Abboud MD, Prasad G. Iyer MD MS, Srinivas Gaddam MD, Amrit K. Kamboj MD","doi":"10.1016/j.cgh.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.014","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"6 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALT is an effective screening tool for advanced MASLD in children with obesity and overweight","authors":"Anne-Sophie R. Stroes, Laura Draijer, Malika Chegary, Felix Kreier, Erim van Os, Joery Goede, Venje Boonstra, Ilse Westerbeek, Saskia Bouma, Meeike Kusters, Roosje Roelants, Ulrich Beuers, Adriaan G. Holleboom, Marc A. Benninga, Bart G.P. Koot","doi":"10.1016/j.cgh.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.011","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in children with obesity and overweight. However, neither the optimal method nor risks and benefits of screening have been established. This study aims to evaluate the effectiveness of an Alanine Aminotransferase (ALT)-based screening algorithm for detecting those at risk of significant fibrosis.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"8 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perianal Disease in Pediatric-Onset Crohn’s Disease: Incidence, Disease Course, and Long-Term Outcomes","authors":"Annika Ström, Sabine Jansson, Mads Damsgaard Wewer, Johan Burisch, Mikkel Malham, Vibeke Wewer","doi":"10.1016/j.cgh.2025.05.015","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.015","url":null,"abstract":"Perianal Crohn's disease (CD) is characterized by fistulae and/or abscesses in the anal region and leads to significant morbidity. We aimed to estimate the incidence and describe the disease course of perianal disease in pediatric-onset CD.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"1 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease","authors":"F. de Voogd, K.J. Beek, M. Pruijt, K. van Rijn, J. van der Bilt, C. Buskens, W. Bemelman, A. Neefjes-Borst, A. Mookhoek, G. D’Haens, J. Stoker, K.B. Gecse","doi":"10.1016/j.cgh.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.013","url":null,"abstract":"Crohn’s disease (CD) strictures exhibit varying levels of inflammation and chronicity. We evaluate whether intestinal ultrasound (IUS) is accurate in characterizing stricture composition.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"87 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychomotor development in infants following maternal exposure to biologics: Results from the DUMBO registry","authors":"Laura Palomino, Marta Velasco Rodríguez-Belvís, María José Casanova, Eduardo Leo-Carnerero, Cristina Calviño Suarez, Montserrat Rivero, Marta Calvo, María Teresa Arroyo, Agnes Fernández-Clotet, Isabel Pérez-Martínez, Ángeles Masedo González, Vicent Hernández, Alexandra Ruiz-Cerulla, Pilar López Serrano, Pablo Vega, Iago Rodríguez-Lago, Raquel Vicente Lidón, Miguel Ángel De Jorge, Iván Guerra, Lara Arias García, Gema Molina Arriero, Daniel Hervías Cruz, David Busquets, Ana Gutiérrez Casbas, Manuel Van Domselaar, Gemma Valldosera Gomis, Juan María Vázquez Morón, Marta Piqueras Cano, Alfredo J. Lucendo, María Dolores Martín Arranz, Patricia Ramírez de la Piscina, María del Pilar Martínez Tirado, Virginia Robles Alonso, Sandra Marín Pedrosa, Raquel Camargo Camero, Edisa Armesto Gonzalez, Carlos Tardillo Marín, Esther Bernardos Martín, María Carmen Rodríguez Grau, José M. Huguet, Lucía Márquez-Mosquera, Pau Sendra Rumbeu, Luis Bujanda, Carlos Castaño-Milla, Empar Sáinz Arnau, Luis Hernández, Laura Ramos, M.M. Boscá-Watts, Noemí Manceñido Marcos, Miquel Sans, Victor Jair Morales, Diana Acosta, Ana Garre, Rosana Muñoz Codoceo, Alberto García-Salido, Javier P. Gisbert, María Chaparro, DUMBO study group of GETECCU","doi":"10.1016/j.cgh.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.05.012","url":null,"abstract":"The impact of biologic treatment for inflammatory bowel disease (IBD) during pregnancy and lactation on infant psychomotor development is barely studied. We investigated the effect of exposure to biologics <ce:italic>in utero</ce:italic> or during breastfeeding on the psychomotor development of offspring during their first year","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"224 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}