中华泌尿外科杂志最新文献

{"title":"Evaluation and prediction of therapeutic response to neoadjuvant androgen deprivation therapy for prostate cancer by diffusion weighted imaging","authors":"Y. Mi, Jing Wu, Q. Shen, Wei Yu","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.008","url":null,"abstract":"Objective \u0000To evaluate the effect of neoadjuvant androgen deprivation therapy (ADT)for prostate cancer on diffusion weighted imaging base on the pathological results after radical prostatectomy. \u0000 \u0000 \u0000Methods \u0000Medical records of 33 patients diagnosed with prostate cancer and treated with neoadjuvant androgen deprivation therapy and radical prostatectomy between January 2016 and September 2019 at Peking University First Hospital were retrospectively reviewed. Average age of patients was 67.7 (49-81) years old. All of the patients underwent prostate MRI examination before and after neoadjuvant ADT. \u0000 \u0000 \u0000Results \u0000Mean prostate volume after neoadjuvant ADT is 28.5 (6.25-113.76) cm3, which decreased significantly by therapy (Z=-4.458, P<0.05). Apparent diffusion coefficient (ADC) values increased significantly in tumor (1.070±0.325) vs. (0.828±0.291)×10-3mm2/s (P<0.001) and decreased in benign prostatic tissue (P<0.05). Relative changes in ADC differed significantly between low-median level ISUP group and high level ISUP group (0.315±0.173) vs. (0.164±0.224)×10-3mm2/s (P<0.05), as well as obvious reaction group and focal reaction group(0.278±0.21) vs. (0.094±0.119)×10-3mm2/s (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000There were significant, quantitative measurable changes of ADC value in prostate cancer after neoadjuvant ADT. DWI can be used to assess the efficacy of neoadjuvant ADT for prostate cancer as well as predicting pathological features. \u0000 \u0000 \u0000Key words: \u0000Prostatic neoplasms; Prostate cancer; Neoadjuvant androgen deprivation therapy; Diffusion weighted imaging (DWI); Apparent diffusion coefficient (ADC)","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"120-125"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45655443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of large cell undifferentiated carcinoma of the urinary bladder","authors":"Huafeng Zhang, Jia Zhao, L. Xia, Shang-Wen Yang, Xuezhong Chen","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.013","url":null,"abstract":"The clinical pathological data of a patient large cell undifferentiated bladder carcinoma was retrospectively analyzed and understand. The clinical and imaging findings of large cell undifferentiated bladder carcinoma was nonspecific. Diagnosis depended on the pathological and immuno-histochemical staining. The tumor is aggressive with high risk of recurrence.It is mainly treated with radical resection. \u0000 \u0000Key words: \u0000Urinary bladder; Undifferentiated carcinoma; Large cell carcinoma","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"149-150"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43258490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases report of treatment of renal parapelvic cysts with incision and drainage by flexible ureteroscope combined with the All-Seeing needle","authors":"Ting Huang, Li Fang, Yue Cheng","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.014","url":null,"abstract":"Flexible ureteroscopic incision and drainage is an innovative surgical option for renal parapelvic cysts these years. Finding the thinnest part of the renal parapelvic cyst is the key point of the surgery. This paper reports two patients with renal parapelvic cysts treated with flexible ureteroscopic incision and drainage combined with All-Seeing needle. The operations were successful and had good outcomes with the two-year follow-up. \u0000 \u0000Key words: \u0000Kidney disease, cystic; Peripelvic cyst; Flexible ureterscope; All-Seeing needle","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"150-151"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42688327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feasibility and efficacy of total laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder","authors":"Liyuan Wu, Fei-ya Yang, L. Mou, Qinxin Zhao, Hongjiang Song, Xuesong Li, Qian Zhang, B. Shi, N. Xing","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.003","url":null,"abstract":"Objective \u0000To explore the feasibility and clinical effect of laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder. \u0000 \u0000 \u0000Methods \u0000Forty-one patients who underwent laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder from July 2013 to August 2019. There were 31 cases performed in Beijing Chaoyang hospital and 10 cases in National Cancer Center. Mean age was 59(range 44-78) years, mean BMI was 25.3(range 20.1-34.7)kg/m2 , and mean CCI was 3 (range 2-6). No urethral stricture or urinary incontinence was found by preoperative examination. No distant metastasis was identified by bone scans, chest X-ray and sonography. Cystoscopy or TURBT was performed on all patients and biopsy was taken to confirm the diagnosis. Preoperative pathology showed 30 cases (73.2%) of MIBC, 9 cases of NMIBC (22.0%) and 2 cases (4.9%) of in-situ cancer. Laparoscopic radical cystectomy and lymphadenectomy were performed under general anesthesia. Urinary diversion was completed in the peritoneal cavity, by intercepting the terminal ileum about 60 cm, and taking the proximal ileum 10 cm as input loop on the right side with proximal to distal way, and the middle 40 cm ileum was detubated. After u-shaped suture, the ileum was folded back and stitched into a sphere building a novel orthotopic neobladder with bilateral isoperistaltic afferent limbs. The prognosis of perioperative data and postoperative satisfaction regarding continence were analyzed, continence was defined as 0-1 pad/day. The 41 patients were divided into two groups to compare the difference in term of operation time and blood loss between the first 21 patients and the last 20 patients. \u0000 \u0000 \u0000Results \u0000Mean total operative time was 324.9 mins (range 210-480) mins, and mean estimated blood loss was 177.6(range 50-700) ml. There were significant statistical differences in term of total operation time, construction time and blood loss between the first 21 patients and the next 20 patients (P<0.05). Postoperative pathological results were urothelial carcinoma in 40 cases (2 in situ carcinoma) and small cell carcinoma in 1 case. Mean number of dissected lymph nodes was 19 (range 11-58), with 7 cases(17.1%)of positive lymph nodes, and 3 cases(7.3%)had positive surgical margin. At a mean follow up of 17.6(range 2-64) months, 36 patients (87.8%) survived, including 2 patients (4.9%) with metastasis and 1 patient (2.4%) with recurrence, and 5 cases (12.2%)died. All patients were able to urinate without catheterization. Thirty-seven patients (90.2%) were satisfied with voiding control during the daytime (0-1 urinal pad), and 29 patients (70.7%) were satisfied with voiding control at nighttime (0-1 urinal pad) by the follow-up 12 months after the operation. \u0000 \u0000 \u0000Conclusions \u0000Total laparoscopic radical cystectomy combined with Xing's orthotopic ileum neobladder is a simple method with fewer postoperative complications and a satisfactory continence rate. \u0000 \u0000 \u0000Key words: \u0000Urin","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"90-94"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44069055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in detection and clinical application of circulating tumor cells in renal cell carcinoma","authors":"Xin Du, B. Hong, Qiang Zhao, Yongpeng Ji, Yong Yang, Ning Zhang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.016","url":null,"abstract":"Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma. \u0000 \u0000Key words: \u0000Carcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"153-156"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42289638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of albumin-to-alkaline phosphatase ratio before radical cystectomy in patients with bladder cancer","authors":"Ming Zhao, Daqian Liu, X. Teng, Xiulong Zhong, Yonghua Wang, Haitao Niu, Xin-sheng Wang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.005","url":null,"abstract":"Objective \u0000To investigate the relationship between preoperative albumin-to-alkaline phosphatase ratio and overall survival (OS) after radical cystectomy of bladder cancer. \u0000 \u0000 \u0000Methods \u0000The clinical date of patients with bladder cancer who underwent radical cystectomy and urinary diversion and confirmed by pathology from Jan 2007 to Dec 2015 were analyzed retrospectively, with 140 cases undergoing laparoscopic surgery and 26 cases undergoing open surgery. There were 148 males and 18 females, aged was 33-85 years, with an average age of (65.1±9.4) years. There were 55 cases of cutaneous ureterostomy, 96 cases of Brick diversion with ileum, and 15 cases of ileal neobladder. The AAPR range 0.03-1.67, with an average 0.62±0.23, and body mass index (BMI) was 16.79-32.65 kg/m2, with an average of (24.00±3.32) kg/m2. There were 33 cases with hydronephrosis and 133 no hydronephrosis, 31 cases with hypertension and 135 cases no hypertension, and 14 cases with diabetes and 152 cases no diabetes. Four cases were classified as grade 0, 65 cases as grade 1, 86 cases as grade 2, and 11 cases as grade 3. Based on the preoperative AAPR(0.62±0.23), they were divided into three groups, with 55 cases in the low AAPR (0.42±0.09)group, 55 cases in the middle AAPR(0.58±0.05)group, and 56 cases in the high AAPR(0.86±0.21)group. Cox proportional hazards regression methodology were used to evaluate the relationship between preoperative AAPR and overall survival. Survival analysis was conducted using the Kaplan-Meier method and compared with the log-rank test. \u0000 \u0000 \u0000Results \u0000166 patients were followed up for 1-144 months, with a median of 63 months, and 71 cases died and 95 survived. The median serum AAPR level in all cases was 0.59(range 0.03-1.67). Results of univariate Cox regression model revealed that AAPR(HR=0.09, 95%CI 0.022-0.391, P=0.001), high AAPR (HR=0.40, 95%CI 0.216-0.742, P=0.003), age (HR=2.42, 95%CI 1.294-4.531, P=0.006), tumor size (HR=2.11, 95%CI 1.112-4.014, P=0.023), pT3 stage (HR=8.93, 95%CI 3.173-25.114, P<0.001), pT4 stage(HR=10.39, 95%CI 3.110-34.707, P<0.001), pN1 stage(HR=2.80, 95%CI 1.422-5.531, P=0.003), pN3 stage(HR=17.06, 95%CI 2.192-132.863, P=0.007), pathological grade (HR=0.30, 95%CI 0.113-0.817, P=0.019), hydronephrosis (HR=2.36, 95%CI 1.406-3.939, P=0.001), adjuvant chemotherapy (HR=2.66, 95%CI 1.674-4.247, P<0.001)were associated with OS. Compared with patients in the lowest of AAPR, the risk for death in the highest AAPR group decreased about 59%(HR=0.406, 95%CI 0.200-0.822, P=0.012)after adjustment for age, BMI, tumor size, number of tumor, T category, N category, pathological grade, hydronephrosis, ASA level, adjuvant chemotherapy in multiple Cox regression models. Each unit increase in the AAPR was associated with about 80% decreased risk of death (HR=0.199, 95%CI 0.051-0.779, P=0.020)after adjusting for the confounding variables. After adjusting for age, BMI, tumor size, number of tumor, T category, N category, pathological grade, ","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"102-108"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44231496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating the development of Chinese urology in clinical research by taking the advantages and making cooperation","authors":"Jian Huang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.001","url":null,"abstract":"The clinical research is an important cornerstone of medical innovation and development. In the past decade, there have been some breakthrough achievements in the field of urological clinical research internationally. However, there is still a large gap between Chinese urological clinical research and the international level. Urologists across China should improve the clinical research to a new level of awareness, starting with the idea of patients’expectation being our concern, and making clinical research our priority. The multi-center clinical research should be the priority, involving the real-world study, prospective randomized controlled trails, translational medicine, and artificial intelligence, etc. The standardized method must be adopted and the integrity of scientific research should be concerned in the process of clinical research. The clinical research results should not only be published in the international journals, but more importantly be published in the domestic journals. The proposal of \"publishing the studies on the land of our motherland\" should be vigorously advocated. \u0000 \u0000Key words: \u0000Clinical research; Multicenter; Real-world study; Prospective randomized contro-lled trails; Translational medicine; Artificial intelligence; Research integrity","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"81-84"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47900397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of duplex kidney and ureter abnormality accompanied with lower giant hydronephrosis","authors":"Tao Yang, Hong Xie, Xiaoyong Hu, Jianwen Huang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.012","url":null,"abstract":"Duplex kidney and ureter abnormality are one of the most common malformation in urinary system, with most of patients present no apparent symptom, and only a few patients being complicated by ureter obstruction and serious hydronephrosis, which is difficult to differentiate with renal cyst. Therefore a case with duplex kidney and ureter abnormality was reported to provide information for clinical practice. \u0000 \u0000Key words: \u0000Ureteral disease; Duplex kidney and ureter abnormality; Hydronephrosis","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"147-148"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42431562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of spermatic neuroblastoma","authors":"Jian-xiang Xie, Jia-xi Li, C. Du","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.015","url":null,"abstract":"The purpose of this study is to study the clinical characteristics of spermatic cord tumor. The clinical data of a case of varicocele in our hospital were analyzed retrospectively. In this case, the patients with varicocele had a good recovery after operation. Varicocele is a rare case. The best mode of treatment is surgical resection and follow-up after operation. \u0000 \u0000Key words: \u0000Spermatic cord; Spermatic schwannoma; Benign mass","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"152-152"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48864171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application and outcomes of C. R.P.C. four-step radical prostatectomy under extraperitoneal laparoscopy","authors":"Jun Xiao, Gan Yu, Huixia Zhou, Henglong Hu, Xueyou Ma, Yanan Wang, Chunguang Yang, Zhiquan Hu, Shaogang Wang, Z. Ye, Zhihua Wang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.006","url":null,"abstract":"Objective \u0000To summarize the preliminary experience of extraperitoneal laparoscopic radical prostatectomy (C.R.P.C. four-step) for localized prostate cancer and the outcomes based on early follow-up. \u0000 \u0000 \u0000Methods \u0000A total of 102 prostate cancer patients were screened by prostate specific antigen (PSA) and diagnosed by prostate magnetic resonance imaging and prostatic puncture biopsy with cT1c-cT3b, with average age of (67±5) years old, average preoperative total PSA value of (45.32±18.33) ng/ml, and average prostate volume was (42±12)cm3. All these patients underwent extraperitoneal laparoscopic radical prostatectomy by the four-step technique, abbreviating as C. R.P.C.[C: control DVC (dorsal deep venous complex). R: recognize three anatomical layers (prostate and bladder junction, seminal vesicle, and Denonvilliers’fascia surface). P: preserve urethral sphincter and bladder neck. C: continuous anastomosis between urethra and bladder neck (4 key needles at 3, 5, 7 and 9 o’clock)]. The operative time, estimated blood loss, length of hospital stay and postoperative complications were recorded, and the postoperative PSA was followed up. \u0000 \u0000 \u0000Results \u0000All the 102 cases were successfully treated by laparoscopic radical prostatectomy. The operative time was from 55 to 156 min (mean 92 min), and the estimated blood loss was from 55 to 185 ml (mean 105 ml). There was no case converted of open surgery, only one case received blood transfusion for postoperative hemorrhage (0.98%), and positive surgical margin was found in 15 case (14.70%) by pathological examination. Postoperative urinary extravasation within one week occurred in 2 (1.96%) cases, and resolved after tensioning the catheter and prolonging the indwelling time. During the follow-up period of 12 to 45 months, 2 cases were incontinent (grade Ⅰ-Ⅱ), and the other cases(98.04%) had no incontinence or dysuria . However, 11 cases(10.78%) developed to biochemical recurrence within 6 months after the operation. \u0000 \u0000 \u0000Conclusions \u0000The C. R.P.C. four-step technique of lparoscopic radical prostatectomy is easily to be grasped and performed by the greenhand urologists, and was efficient and safe. \u0000 \u0000 \u0000Key words: \u0000Prostatic neoplasms; Radical prostatectomy; Extraperitoneal laparoscopy; Prostate cancer; Four-step method; Curative effect","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":"41 1","pages":"109-113"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45407050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}