Progress in detection and clinical application of circulating tumor cells in renal cell carcinoma

Q4 Medicine

中华泌尿外科杂志 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1000-6702.2020.02.016

Xin Du, B. Hong, Qiang Zhao, Yongpeng Ji, Yong Yang, Ning Zhang

引用次数: 0

Abstract

Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma. Key words: Carcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker

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循环肿瘤细胞在肾癌中的检测及临床应用进展

肾细胞癌是泌尿生殖系统肿瘤中常见的恶性肿瘤之一。20%-30%的患者有远处转移。然而，目前用于诊断、复发监测和预后评估的生物标志物仍不确定。循环肿瘤细胞(CTCs)是从原发肿瘤或转移瘤中分离出来的肿瘤细胞，侵入并出现在外周血管中。因此，CTCs被认为是肿瘤转移过程中的关键步骤。然而，目前对肾癌ctc的研究存在检测方法不统一、临床应用受限等问题。本文就肾细胞癌CTCs的检测及临床应用进展作一综述。关键词:癌;肾细胞;循环肿瘤细胞(ctc);生物标志物

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华泌尿外科杂志 Medicine-Nephrology

CiteScore

0.10

自引率

0.00%

发文量

14180

期刊介绍： Chinese Journal of Urology (monthly) was founded in 1980. It is a publicly issued academic journal supervised by the China Association for Science and Technology and sponsored by the Chinese Medical Association. It mainly publishes original research papers, reviews and comments in this field. This journal mainly reports on the latest scientific research results and clinical diagnosis and treatment experience in the professional field of urology at home and abroad, as well as basic theoretical research results closely related to clinical practice. The journal has columns such as treatises, abstracts of treatises, experimental studies, case reports, experience exchanges, reviews, reviews, lectures, etc. Chinese Journal of Urology has been included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Chinese Science Citation Database Source Journal (including extended version), and also included in American Chemical Abstracts (CA). The journal has been rated as a quality journal by the Association for Science and Technology and as an excellent journal by the Chinese Medical Association.