Chinese Journal of Physics最新文献

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Pattern dynamics in a predator–prey model with Smith growth function and prey refuge in predator poisoned environment 带有斯密增长函数的捕食者-猎物模型中的模式动力学以及捕食者中毒环境中的猎物避难所
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-19 DOI: 10.1016/j.cjph.2024.09.015
Debjit Pal , Dipak Kesh , Debasis Mukherjee
{"title":"Pattern dynamics in a predator–prey model with Smith growth function and prey refuge in predator poisoned environment","authors":"Debjit Pal ,&nbsp;Dipak Kesh ,&nbsp;Debasis Mukherjee","doi":"10.1016/j.cjph.2024.09.015","DOIUrl":"10.1016/j.cjph.2024.09.015","url":null,"abstract":"<div><div>In this article, we investigate temporal as well as spatiotemporal dynamics of a predator–prey system where prey grows according to Smith growth function and prey refuges in predator poisoned environment. Self as well as cross diffusion are taken into consideration to describe spatial moment of the species which make the system more realistic. This study aims to investigate the role of prey refuge, toxin-carrying carcass and the impact of cross-diffusion on the spatial distribution of species densities and associated patterns. The existence of equilibria and their stability conditions for non-spatial system are derived. We discuss the occurrence of Hopf bifurcation and detect the stability of limit cycle by computing first Lyapunov number. Temporal dynamics of the system is studied by varying the significant parameters. Study reveals that both prey refuge and fatality rate of predator due to toxin-carrying carcass, initially makes the system stable for low refuge and fatality rate but predator population goes to extinction as those effects increase. Turing instability conditions are listed and different instability regions so formed are discussed. In Turing region, pattern selection with the help of amplitude equation via weakly nonlinear analysis are performed which also numerically supported. Intensity of refuge and fatality rate due to toxin carrying carcass result paradox with real ecological world due to the presence of cross diffusion. Various kind of patterns such as mixture of stripe and spot, spot, irregular chaotic patterns emerge due to Hopf and Turing instability. Particularly, spatiotemporal chaos is a controversial topic because of its significant consequences for population dynamics. The results of this work are expected to contribute to a better understanding the level of prey refuge, use of toxin-carrying carcass considering movement in population and effect of cross-diffusion.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parameter-induced logical stochastic resonance in substrate potential with deformable sine-Gordon shape 具有可变形正弦-戈登形状的基底电势中的参数诱导逻辑随机共振
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-19 DOI: 10.1016/j.cjph.2024.09.025
Peihong Li , Zhiqiang Liao , Hitoshi Tabata
{"title":"Parameter-induced logical stochastic resonance in substrate potential with deformable sine-Gordon shape","authors":"Peihong Li ,&nbsp;Zhiqiang Liao ,&nbsp;Hitoshi Tabata","doi":"10.1016/j.cjph.2024.09.025","DOIUrl":"10.1016/j.cjph.2024.09.025","url":null,"abstract":"<div><div>Logical stochastic resonance (LSR) systems are physical nonlinear systems capable of robust Boolean logic operations under the influence of noise. While LSR systems suitable for electronic circuit implementation have been extensively studied, research on condensed matter LSR systems remains limited to constrained bistability with saturation characteristic. Considering the presence of periodic nonlinearities in many physical systems, a deformable sine-Gordon-shaped Remoissenet–Peyrard potential (RPP)-based LSR system is proposed for the first time in this work. Testing under both noise-free and noisy conditions proves the existence of parameter-induced LSR phenomena in the proposed system. Moreover, we find that a relatively wide potential well shape contributes to enhanced noise robustness in the RPP-based LSR system. Additionally, traditional polynomial nonlinearity-based LSR systems are compared with the proposed system. Regardless of whether the noise is Gaussian white noise or composite noise containing spiking pulses, the RPP-based LSR system exhibits superior robustness. The results demonstrate the exceptional advantages of the RPP-based LSR system and encourage further design of condensed matter LSR systems based on deformable periodic nonlinearities.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Node-to-node clustering asymptotic synchronized discrete stochastic neural networks in time and space with Bernoulli switching delay 具有伯努利开关延迟的节点到节点聚类渐近同步时空离散随机神经网络
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-18 DOI: 10.1016/j.cjph.2024.09.007
Tianwei Zhang , Yongyan Yang , Sufang Han
{"title":"Node-to-node clustering asymptotic synchronized discrete stochastic neural networks in time and space with Bernoulli switching delay","authors":"Tianwei Zhang ,&nbsp;Yongyan Yang ,&nbsp;Sufang Han","doi":"10.1016/j.cjph.2024.09.007","DOIUrl":"10.1016/j.cjph.2024.09.007","url":null,"abstract":"<div><div>The article proposes a new approach to synchronizing space–time discrete stochastic neural networks with random switching delays. This is achieved by employing a control in the boundary, which is based on node-to-node clustering and controlling theories. The design of the control in the boundary for synchronizing space–time discrete stochastic neural networks in the form of clusters is based on the establishment of several significant sequential inequalities and the creation of cluster information. Also, an executable computer algorithm has been developed to streamline the implementation of the findings presented in this paper. The current study represents a pioneering approach in considering spatial discrete factors, providing a solid foundation for future research and offering theoretical and practical guidance.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability and viability of charged anisotropic pulsar SAX J1748.9-2021 in extended symmetric teleparallel gravity 带电各向异性脉冲星 SAX J1748.9-2021 在扩展对称远平行引力中的稳定性和生存能力
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-17 DOI: 10.1016/j.cjph.2024.09.014
M. Sharif, Iqra Ibrar
{"title":"Stability and viability of charged anisotropic pulsar SAX J1748.9-2021 in extended symmetric teleparallel gravity","authors":"M. Sharif,&nbsp;Iqra Ibrar","doi":"10.1016/j.cjph.2024.09.014","DOIUrl":"10.1016/j.cjph.2024.09.014","url":null,"abstract":"<div><div>This manuscript aims to study the viability and stability of a pulsar SAX J1748.9-2021, containing a charged anisotropic matter configuration within the framework of <span><math><mrow><mi>f</mi><mrow><mo>(</mo><mi>Q</mi><mo>,</mo><mi>T</mi><mo>)</mo></mrow></mrow></math></span> theory (<span><math><mi>Q</mi></math></span> and <span><math><mi>T</mi></math></span> are the non-metricity scalar and energy–momentum tensor, respectively). We employ a non-singular solution and a specific model of this gravitational theory and use junction conditions to determine the unknown constants in the metric coefficients. We explore different geometric and physical properties using astrophysical observations from the pulsar SAX J1748.9-2021, which is found in X-ray binary systems within globular clusters. This framework establishes relationships between various physical quantities, including fluid parameters, anisotropy, mass–radius relation, redshift, the Zeldovich condition, energy conditions, causality conditions, adiabatic index, Tolman–Oppenheimer–Volkoff equation, equation of state parameter and compactness. Our findings affirm the feasibility and stability of the proposed charged pulsar within this theoretical framework.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High optical coupling between hybrid III-V and SOI platform with grating-assisted co-directional couplers 利用光栅辅助同向耦合器实现 III-V 和 SOI 混合平台之间的高光学耦合
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-16 DOI: 10.1016/j.cjph.2024.09.019
Ika Novitasari , San-Liang Lee
{"title":"High optical coupling between hybrid III-V and SOI platform with grating-assisted co-directional couplers","authors":"Ika Novitasari ,&nbsp;San-Liang Lee","doi":"10.1016/j.cjph.2024.09.019","DOIUrl":"10.1016/j.cjph.2024.09.019","url":null,"abstract":"<div><div>The technology for heterogeneously integrating active III-V material structures on silicon photonic platforms has gained considerable advancement in recent years. Most of the prior work utilizes the silicon-on-insulator (SOI) platform with a thicker waveguide than the popular 220 nm thick silicon layer to achieve high coupling between the III-V waveguide and SOI waveguide. The thicker SOI waveguide results in closer effective refractive indices between the two heterogeneous waveguide structures to achieve better resonance conditions. Here, we demonstrate excellent light coupling from an active III-V structure to an SOI waveguide with a standard 220 nm Si waveguide by incorporating the grating-assisted co-directional coupler (GACC) method. The GACC grating structure can be formed on either side of the III-V and Si wafers. With the GACC scheme, a thicker adhesive for bonding the two different materials can be used. The simulation verifies that over 94 % energy coupling efficiency can be obtained by using a 100 nm thick DVS-BCB as the bonding layer. High coupling performance can be maintained over a 40 nm wavelength range around 1550 nm. The high coupling efficiency can be achieved with good phase matching and mode matching between the super-modes of the hybrid structure.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency and voltage-modulation multistable wave plate based on liquid crystals doped with silica nanoparticles 基于掺杂二氧化硅纳米颗粒的液晶的频率和电压调制多稳态波板
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-15 DOI: 10.1016/j.cjph.2024.09.020
Hui-Chi Lin , Wei-Hao Chou , Yu-Sung Liu
{"title":"Frequency and voltage-modulation multistable wave plate based on liquid crystals doped with silica nanoparticles","authors":"Hui-Chi Lin ,&nbsp;Wei-Hao Chou ,&nbsp;Yu-Sung Liu","doi":"10.1016/j.cjph.2024.09.020","DOIUrl":"10.1016/j.cjph.2024.09.020","url":null,"abstract":"<div><div>In this study, we demonstrate an all-range multistable liquid crystal (LC) wave plate. Its multistability arises from the formation of silica nanoparticle networks within the LC cell on the substrates, which stabilize LC molecules and induce varying phase retardation. Modulating the phase retardation of the LC wave plate can be achieved through the application of a DC pulse or by adjusting the frequency of the pulse. This multistable characteristic not only conserves energy but also enhances its versatility across diverse domains.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-temperature magnetic refrigeration in Gd20Tb20Er20Al20M20 (M = Fe, Co) high-entropy metallic glasses Gd20Tb20Er20Al20M20 (M = Fe, Co) 高熵金属玻璃中的低温磁制冷
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-15 DOI: 10.1016/j.cjph.2024.09.021
Huaijin Ma , Lei Gao , Xiang Jin , Jing Zhao , Jianjun Zhao , Jiaohong Huang
{"title":"Low-temperature magnetic refrigeration in Gd20Tb20Er20Al20M20 (M = Fe, Co) high-entropy metallic glasses","authors":"Huaijin Ma ,&nbsp;Lei Gao ,&nbsp;Xiang Jin ,&nbsp;Jing Zhao ,&nbsp;Jianjun Zhao ,&nbsp;Jiaohong Huang","doi":"10.1016/j.cjph.2024.09.021","DOIUrl":"10.1016/j.cjph.2024.09.021","url":null,"abstract":"<div><div>This paper focuses on the magnetocaloric effect (MCE) of Gd<sub>20</sub>Tb<sub>20</sub>Er<sub>20</sub>Al<sub>20</sub>M<sub>20</sub> (M = Fe, Co) high-entropy metallic glasses (HE-MGs). XRD and TEM results indicate that both HE-MGs are amorphous. Magnetic studies show that both HE-MGs display spin-glass behavior, undergo a second-order phase transition from ferromagnetic to paramagnetic, and exhibit soft magnetic properties at the Curie temperature (<em>T</em><sub>C</sub>). Notable large and broad table-like magnetic entropy change characteristics of Gd<sub>20</sub>Tb<sub>20</sub>Er<sub>20</sub>Al<sub>20</sub>Fe<sub>20</sub> (Gd<sub>20</sub>Tb<sub>20</sub>Er<sub>20</sub>Al<sub>20</sub>Co<sub>20</sub>) appear near a <em>T</em><sub>C</sub> of 92 (51) K. Hence, under 7 T magnetic field, |-∆<em>S</em><sub>M</sub><sup>max</sup>|, ∆ <em>T</em><sub>FWHM</sub>, and <em>RCP</em> are 7.83 (10.10) J·kg<sup>-1</sup>·K<sup>-1</sup>, 120.07 (71.88) K, and 1008.26 (805.70) J·kg<sup>-1</sup>, respectively. Furthermore, the modulation of the magnetic and magnetocaloric properties of the samples after substitution of Fe for Co was revealed by the intricate 3d-3d and 3d-4f exchange interactions within the system. The magnetic phase transition critical behaviors in both HE-MGs were analyzed using the scaling law to clarify the deviation of amorphous materials from the mean-field theory. Thus, this study not only highlights the potential of this material for low-temperature magnetic refrigeration applications, but also expands our understanding of its physical properties.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonlinear Jeans instability analysis of gravitating astrofluids in Eddington-inspired Born-Infeld gravity framework 爱丁顿启发的玻恩-恩菲尔德引力框架下引力天体流体的非线性杰恩斯不稳定性分析
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-14 DOI: 10.1016/j.cjph.2024.09.018
Mritunjoy Das, Pralay Kumar Karmakar
{"title":"Nonlinear Jeans instability analysis of gravitating astrofluids in Eddington-inspired Born-Infeld gravity framework","authors":"Mritunjoy Das,&nbsp;Pralay Kumar Karmakar","doi":"10.1016/j.cjph.2024.09.018","DOIUrl":"10.1016/j.cjph.2024.09.018","url":null,"abstract":"<div><div>The nonlinear Jeans instability dynamics in viscoelastic astrofluids within the Eddington-inspired Born-Infeld (EiBI) gravitational framework excitable in star-forming interstellar cloud fluids is semi-analytically investigated. Application of multiple scaling techniques here results in a unique form of the Korteweg-de Vries (KdV) equation moderated with a peculiar set of distinctive fluid polyparametric coefficients. A numerical illustrative platform portrays the excitation of diversified compressive solitary-chain wave patterns. The evolutionary existence of such structural patterns is further confirmed geometrically with the help of illustrative phase-plane analyses. The various parametric stabilizers and destabilizers, alongside accelerating and decelerating factors on the clouds, are illustratively analysed. It is seen that the composite cloud stability is significantly influenced by the strength polarity of the gravitational EiBI-parameter <span><math><mrow><mo>(</mo><mi>χ</mi><mo>)</mo></mrow></math></span>. The dependency of the obtained solitary wave patterns on the EiBI-polarity is further confirmed in a numerical simulation platform illustratively. Our analysis also highlights that the influence of material density on the system stability is dependent on the EiBI-polarity. The nonlinear spatiotemporal evolution of the instability reveals a unique type of soliton fission phenomenon, indicative of inherently produced additional disturbances within the astrofluid. Our obtained results could be widely helpful in application to the EiBI-centric diverse astrocosmic phenomena, such as bounded structure formation and evolution in diverse complex astroenvirons.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robot-assisted pedestrian evacuation in fire scenarios based on deep reinforcement learning 基于深度强化学习的火灾场景下机器人辅助行人疏散
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-14 DOI: 10.1016/j.cjph.2024.09.008
Chuan-Yao Li , Fan Zhang , Liang Chen
{"title":"Robot-assisted pedestrian evacuation in fire scenarios based on deep reinforcement learning","authors":"Chuan-Yao Li ,&nbsp;Fan Zhang ,&nbsp;Liang Chen","doi":"10.1016/j.cjph.2024.09.008","DOIUrl":"10.1016/j.cjph.2024.09.008","url":null,"abstract":"<div><div>Indoor fires pose a significant challenge to the safe evacuation of pedestrians. In response to fire hazards, pedestrians instinctively seek alternative evacuation routes to avoid the hazard zone. However, the specific location and intensity of the fire hazard zone can influence pedestrians' decisions, leading to varying congestion levels in different areas. To address this challenge and enhance overall evacuation efficiency, this paper introduces an improved social force model to depict pedestrian movement in fire scenarios and proposes a methodology that leverages dynamic robot for pedestrian evacuation, employing Deep Reinforcement Learning (DRL) and Human-Robot Interaction (HRI). The results show that in the no-robot scenario, pedestrians will detour according to the varying locations of fire hazard zones and emergency levels, resulting in congestion at different positions. In the static robot scenario, robots placed in different locations exhibit varied effects on evacuation depending on the fire hazard zones' locations and intensities. In the DRL-control robot scenario, the robot controlled by DRL and HRL can always navigate to the appropriate position to promote evacuation, regardless of the fire's location and emergency levels or the robot's initial placement. Furthermore, our findings reveal that strategically positioned robots can enhance evacuation efficiency by alleviating crowding and increasing the distance between pedestrians and fire hazard zones in most cases, thereby improving pedestrian safety. This study offers practical guidance for managing pedestrian evacuation during fire incidents and establishes a theoretical foundation for refining evacuation strategies and safety measures at fire scenes.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-loading of herbal based curcumin and mitoxantrone anticancer drug on PEG and chitosan polymers for targeted cancer therapy: Computational molecular study 在 PEG 和壳聚糖聚合物上共负载姜黄素和米托蒽醌抗癌药物,用于癌症靶向治疗:计算分子研究
IF 4.6 2区 物理与天体物理
Chinese Journal of Physics Pub Date : 2024-09-13 DOI: 10.1016/j.cjph.2024.09.010
Yan Wang , Yudi Zhang , Jinghong Shi, Hui Zhou
{"title":"Co-loading of herbal based curcumin and mitoxantrone anticancer drug on PEG and chitosan polymers for targeted cancer therapy: Computational molecular study","authors":"Yan Wang ,&nbsp;Yudi Zhang ,&nbsp;Jinghong Shi,&nbsp;Hui Zhou","doi":"10.1016/j.cjph.2024.09.010","DOIUrl":"10.1016/j.cjph.2024.09.010","url":null,"abstract":"<div><div>In the current study, molecular dynamics (MD) computations were implemented to investigate and evaluate the loading of two drugs, namely mitoxantrone (MTX) and curcumin (CUR) onto polymeric carriers. The carrier considered in this study included polyethylene glycol (PEG) and Chitosan (CHI) as biological macromolecules. Lennard-Jones (LJ) and electrostatic potentials were computed to estimate the molecular interactions between polymer chains and drug molecules for the purpose of drug delivery design. To determine the adsorption site of drug molecules on polymer chains, the radial distribution function (RDF) was computed and analyzed. There was a strong LJ interaction between MTX and CUR and the PEG chains. Furthermore, CHI chains possess strong electrostatic interactions because they contain charged groups. 10C and 10P have been indicated as suitable carriers for MTX. Since 3PC and 5PC contain PEG and CHI, they are appropriate for loading both mitoxantrone and CUR drug molecules. Additionally, 5PC has stronger binding energy than 3PC for MTX and CUR. These results can be used for the design of polymer-based drug carriers.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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