Clinical and experimental hypertension. Part A, Theory and practice最新文献_第5页

Erythrocyte sodium-lithium countertransport in Chinese: its relationship to family history of hypertension. 中国人红细胞钠锂反转运及其与高血压家族史的关系。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036202

Y T Lau, D Wu, H C Liang, M C Chen

引用次数: 3

ACTH hypertension in the rat: role of sodium chloride. 大鼠ACTH高血压:氯化钠的作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036208

M Li, J A Whitworth

引用次数: 7

Protein kinase C and cell proliferation in spontaneously hypertensive rats. 蛋白激酶C与自发性高血压大鼠细胞增殖的关系。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036224

D L Zhu, T Herembert, P Marche

{"title":"Protein kinase C and cell proliferation in spontaneously hypertensive rats.","authors":"D L Zhu, T Herembert, P Marche","doi":"10.3109/10641969209036224","DOIUrl":"https://doi.org/10.3109/10641969209036224","url":null,"abstract":"Cultured aortic fibroblasts from spontaneously hypertensive rats (SHR) exhibit increased proliferation rate compared with cells from normotensive Wistar Kyoto (WKY) rats. The present study was designed to investigate whether this growth abnormality could be accounted for by alteration in protein kinase C (PKC). The enzyme activation by 12-O-tetradecanoyl phorbol 13-acetate (TPA) promoted 3H-thymidine incorporation which was higher in SHR-derived fibroblasts compared with WKY-derived cells. Likewise, 3H-phorbol 12,13-dibutyrate (PDBu) binding to intact cells was markedly increased in SHR-derived fibroblasts. These findings suggest a difference in PKC activity between the two cell types. In both cell types, serum-induced 3H-thymidine incorporation was enhanced by PKC down-regulation, which was obtained by prolonged treatment of cells with high dose of TPA, whereas it was inhibited in a dose-dependent manner by activation of the enzyme. The changes in serum-induced 3H-thymidine incorporation elicited either by activation or desensitization of PKC, did not differ between SHR and WKY fibroblasts. Our results indicate therefore i) that in the presence of serum PKC exerts an antiproliferative effect in rat aortic fibroblasts and ii) that the increase in PKC activity and in sensitivity to TPA exhibited by SHR-derived fibroblasts, is not involved in the increased proliferation rate displayed by SHR-derived fibroblasts in serum-containing medium.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 5","pages":"875-87"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12565815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Hormonal aspects of the relation of liver cirrhosis to essential hypertension. 激素方面肝硬化与原发性高血压的关系。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036225

F Veglio, G Pinna, R Melchio, F Rabbia, M Panarelli, D Schiavone, P Mulatero, L Chiandussi

引用次数: 8

Relaxation of non-contracted smooth muscle by atrial natriuretic peptide. 心房利钠肽对非收缩平滑肌的松弛作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209038197

M Peral de Bruno, A Coviello, M Meyer, W G Forssmann

{"title":"Relaxation of non-contracted smooth muscle by atrial natriuretic peptide.","authors":"M Peral de Bruno, A Coviello, M Meyer, W G Forssmann","doi":"10.3109/10641969209038197","DOIUrl":"https://doi.org/10.3109/10641969209038197","url":null,"abstract":"Atrial natriuretic peptide (alpha-hANP-99-126), 1 x 10(-8) to 5 x 10(-10) M was able to further relax the non-contracted aortic smooth muscle of rabbit after complete recovery from a previous challenge with human angiotensin II (AII), 1 x 10(-6) M. The relaxation was directly proportional to the response of the ring or strip to the previous challenge with AII. ANP does not have effect on basal tension in isolated strips or rings of the rabbit aorta not previously exposed to AII. Norepinephrine (NE), 10(-7) M was less potent in inducing reactivity of the vessel to ANP, ie, only a small relaxant effect on basal tension could be observed. A similar vasorelaxant effect of ANP on basal tension could be obtained in the absence of extracellular calcium: Ca(2+)-free Ringers' solution containing 2 mM ethylene-glycol-bis (beta-aminoethyl ether)N',N' tetraacetic acid (EGTA-Ringer). In contrast, sodium nitroprusside 10(-8) M does not affect basal tension. Present results demonstrate the role of the physiological state of the vessel in the reactivity to ANP.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 6","pages":"1125-39"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209038197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12596078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Factors associated with acute salt-sensitivity in borderline hypertensive patients. 边缘型高血压患者急性盐敏感性的相关因素。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036222

C Borghi, S Boschi, F V Costa, E Ambrosioni

{"title":"Factors associated with acute salt-sensitivity in borderline hypertensive patients.","authors":"C Borghi, S Boschi, F V Costa, E Ambrosioni","doi":"10.3109/10641969209036222","DOIUrl":"https://doi.org/10.3109/10641969209036222","url":null,"abstract":"The acute sensitivity to sodium loading has been investigated in 26 borderline hypertensive patients (BHT) undergoing acute i.v. NaCl infusion. Measurements included blood pressure (BP), forearm vascular resistance (FVR) and venous distensibility (VV30), plasma renin activity (PRA), plasma aldosterone, plasma atrial natriuretic factor (ANF), and plasma levels of endogenous Na+/K+ATPase inhibitor. Sodium loading was associated with a greater than 8% increase in mean BP in 12 patients defined as salt-sensitive (NaCl-SENS) in comparison to salt-insensitive (NaCl-INSENS) subset. NaCl-SENS patients in comparison to NaCl-INSENS exhibited 1) a greater baseline VV30 (2.1 vs 1.4 ml/100 ml; p less than .005), and a response to saline characterized by 2) increased FVR (21.4 vs -6.5%; p less than .005), 3) blunted PRA suppression (-42 vs -67%; p less than .05), 4) delayed ANF response and 5) release of a Na+/K+ATPase inhibitor. Post-loading cumulative urinary sodium excretion was reduced in NaCl-SENS borderline hypertensives compared to NaCl-INSENS (2.6 vs 3.8 mumol/min/Kg; p less than .05). We conclude that acute salt-sensitivity in BHT is characterized by a blunted hormonal response to sodium loading which could be responsible of the activation of hemodynamic as well as humoral mechanisms leading to progressive blood pressure increase.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 5","pages":"837-51"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12567293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of immobilization stress on renal sympathetic neurotransmission. 固定应激对肾交感神经传递的影响。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036199

D C Eikenburg

{"title":"Effects of immobilization stress on renal sympathetic neurotransmission.","authors":"D C Eikenburg","doi":"10.3109/10641969209036199","DOIUrl":"https://doi.org/10.3109/10641969209036199","url":null,"abstract":"The effects immobilization stress on renal sympathetic neurotransmission as well as on heart, spleen and adrenal catecholamine content were examined in the rat. A single 2.5 hr stress period produced significant increases in blood pressure, heart rate, plasma norepinephrine and plasma epinephrine concentrations. However, no changes in renal catecholamine content or in stimulus-induced (1 Hz, 120 pulses, supramax. V) overflow of catecholamines were observed when the isolated perfused rat kidney was studied immediately after the 2.5 hr stress period. In contrast, the single stress period produced a 3-4 fold increase in cardiac epinephrine content while no effects on spleen or adrenal catecholamine content were observed. When stress was applied for 7 daily 2.5 hr periods, the repetition of the stress failed to produce any changes in renal neurotransmitter content or stimulus-induced overflow from the isolated perfused rat kidney. The data suggest that the accumulation of epinephrine into peripheral sympathetic nerves as a result of stress-induced adrenal catecholamine release is not a phenomenon which can be generalized to all regions of the cardiovascular system.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 3","pages":"435-51"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12492441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Renal renin secretion rate and norepinephrine secretion rate in response to centrally administered angiotensin-II: role of the medial basal forebrain. 肾素分泌率和去甲肾上腺素分泌率对中央给药血管紧张素ii的反应:内侧基底前脑的作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036227

L B Weekley

{"title":"Renal renin secretion rate and norepinephrine secretion rate in response to centrally administered angiotensin-II: role of the medial basal forebrain.","authors":"L B Weekley","doi":"10.3109/10641969209036227","DOIUrl":"https://doi.org/10.3109/10641969209036227","url":null,"abstract":"The influence that centrally administered angiotensin-II (ANG-II) and saralasin (SAR) has on renal norepinephrine secretion rate (NESR) and renal renin secretion rate (RSR) were studied. Rats were given thermal lesions of the medial basal forebrain (MBF) or sham surgery. Twenty-four hours later the right kidney was vascularly isolated (but neurally intact) and perfused with an artificial plasma at either a constant pressure (100 mm Hg) or constant flow (600 microliters/min). Renal perfusate was collected before (pre-injection) and at 10 min intervals after central administration of peptides for determination of NESR and RSR. In both perfusion models, intracerebroventricular (ICV) ANG-II increased renal NESR. In MBF lesioned rats pre-injection renal NESR is reduced and the response to ICV ANG-II is blocked. In both perfusion models ICV ANG-II decreases renal RSR. Concomitant administration of SAR blocks the effect of ANG-II on both NESR and RSR. MBF lesioned rats had significantly elevated pre-injection levels of RSR and there is no change in RSR following ICV ANG-II. These experiments indicate that centrally administered ANG-II increases renal NESR concomitant with a decrease in renal RSR and that MBF lesions block those changes.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 5","pages":"923-45"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12565818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Effects of growth hormone and estrogen on rat angiotensinogen quantified by an enzyme linked immunosorbent assay. 用酶联免疫吸附法测定生长激素和雌激素对大鼠血管紧张素原的影响。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036206

R Karlsson, T Stigbrand, J Oscarsson, S Edén, J Bouhnik, M Celio, B von Schoultz

引用次数: 3

Role of gonadal hormones in hypertension in the Dahl salt-sensitive rat. 性激素在达尔盐敏感大鼠高血压中的作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036195

N E Rowland, M J Fregly

引用次数: 106