Clinical and experimental hypertension. Part A, Theory and practice最新文献_第10页

Alterations in vasopressin mechanisms in captopril-treated spontaneously hypertensive rats. 卡托普利治疗的自发性高血压大鼠抗利尿激素机制的改变。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109042108

K H Berecek, J M Wyss, B H Swords

{"title":"Alterations in vasopressin mechanisms in captopril-treated spontaneously hypertensive rats.","authors":"K H Berecek, J M Wyss, B H Swords","doi":"10.3109/10641969109042108","DOIUrl":"https://doi.org/10.3109/10641969109042108","url":null,"abstract":"The effects of lifetime captopril treatment on vasopressin (VP) were assessed in spontaneously hypertensive rats (SHR). Pregnant and nursing dams were treated with oral Captopril (100 mg/kg/day). After weaning, the pups were maintained on Captopril (50/kg/day) for 19-20 wks. Blood pressures of Captopril-treated SHR were in the normotensive range and significantly lower (p less than .001) than SHR control rats. Control and Captopril-treated SHR were perfused and brains were sectioned for immunohistochemical staining with a polyclonal antibody directed against vasopressin (VP). Compared to control SHR, Captopril-treated rats displayed decreased VP-like immunoreactivity in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. Captopril treatment also selectively decreased the number of brightly labeled cell bodies in the SON and PVN and reduced VP-like labeling in the axons of the neurons in these nuclei. Concurrent with a decrease in VP-like immunoreactivity, Captopril treatment reduced plasma VP levels (RIA) (p less than 0.01, Captopril, 5.6 +/- 0.5 pg/ml; control, 11.8 +/- 2.2 pg/ml). Scatchard analysis of 3H-VP binding indicated that Captopril treatment increased the number but not the affinity of VP receptors in the hypothalamus and brain stem of SHR. These results suggest that in SHR oral Captopril treatment attenuates the synthesis and release of VP, an effect that may contribute to the blood pressure lowering effect of converting enzyme inhibitors.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 5","pages":"1019-31"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109042108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12936792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Additive combination studies of captopril and ditekiren, a renin inhibitor, in nonhuman primates. 卡托普利和肾素抑制剂迪特克伦在非人灵长类动物中的加性联合研究。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109045061

D T Pals, G L DeGraaf, S J Couch, M N Brunden

{"title":"Additive combination studies of captopril and ditekiren, a renin inhibitor, in nonhuman primates.","authors":"D T Pals, G L DeGraaf, S J Couch, M N Brunden","doi":"10.3109/10641969109045061","DOIUrl":"https://doi.org/10.3109/10641969109045061","url":null,"abstract":"Additive combination studies of an angiotensin converting enzyme (ACE) inhibitor, captopril, and a renin inhibitor, ditekiren (U-71038), were carried out in conscious sodium-depleted and sodium replete cynomolgus monkeys. The agents elicited dose-additive hypotensive responses regardless of the order of drug administration in sodium-depleted monkeys. A dose-additive blood pressure response was also observed when the administration of captopril was preceded by ditekiren in conscious sodium replete monkeys. None of the animals in these groups exhibited significant alterations of heart rate. An apparent over-additive hypotensive response, accompanied by tachycardia, occurred in sodium replete monkeys when ditekiren was administered after captopril. It was proposed that the captopril-induced hyperreninemia may have allowed the blood pressure to become partially renin-dependent and therefore susceptible to the inhibitory action of ditekiren. The results of these studies suggested that both ditekiren and captopril elicited cardiovascular effects in conscious cynomolgus monkeys via a decreased formation of angiotensin II.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 3","pages":"425-36"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109045061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13053512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Adrenergic innervation of blood vessels in Dahl rats with salt hypertension. 盐性高血压大鼠血管的肾上腺素能神经支配。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109048797

J Kunes, G R Leontjeva, E Bysková, I Pohlová, V A Govyrin, J Zicha

{"title":"Adrenergic innervation of blood vessels in Dahl rats with salt hypertension.","authors":"J Kunes, G R Leontjeva, E Bysková, I Pohlová, V A Govyrin, J Zicha","doi":"10.3109/10641969109048797","DOIUrl":"https://doi.org/10.3109/10641969109048797","url":null,"abstract":"The adrenergic innervation of major arteries and veins was examined in Dahl salt-sensitive (DS) and salt-resistant (DR) rats using a histochemical fluorescent technique to detect the intraneuronal catecholamine content. Under the conditions of low salt intake the density of adrenergic plexus tended to be higher in DR than in DS rats. A decrease of catecholamine content with a subsequent reduction in the density of visible adrenergic plexus was observed in mesenteric and renal but not in femoral vascular beds of salt hypertensive DS rats. The adrenergic innervation was more altered in veins than in respective arteries. Pronounced alterations of vascular sympathetic innervation induced by high salt intake in DS rats contrasted with negligible changes occurring in DR animals. Observed changes of adrenergic innervation in particular vascular beds of salt hypertensive DS rats could reflect the enhanced catecholamine turnover and sympathetic hyperactivity which is important for the pathogenesis and/or maintenance of salt hypertension in Dahl salt-sensitive rats.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 8","pages":"1343-55"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109048797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12827457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Decreased cell membrane magnesium in some essential hypertension patients. 一些原发性高血压患者的细胞膜镁含量降低。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109082615

M T Mattingly, W A Brzezinski, I C Wells

{"title":"Decreased cell membrane magnesium in some essential hypertension patients.","authors":"M T Mattingly, W A Brzezinski, I C Wells","doi":"10.3109/10641969109082615","DOIUrl":"https://doi.org/10.3109/10641969109082615","url":null,"abstract":"The concentrations of total ([T-Mg]), ultrafilterable ([UF-Mg]), and protein-bound or nonfilterable ([NF-Mg]) magnesium were measured in the plasma and in the intracellular compartment of blood from 8 essential hypertensive patients and 9 normotensive subjects. In the former, [T-Mg] was unchanged in the plasma but decreased in whole blood due to decreases of both [UF-Mg] and [NF-MG]; [UF-Mg] was increased in plasma but decreased intracellularly while [NF-Mg] was decreased in plasma and unchanged intracellularly. These concentrations correlated significantly with the average blood pressures. Decreased Mg binding to the erythrocyte membrane was also observed in 13 additional essential hypertensive patients. This decreased binding may well be responsible for the decreased intracellular [UF-Mg] in the blood of such patients. The cause of the decreased Mg binding to the erythrocyte membrane is unknown, but the binding is returned to normal by incubating erythrocytes from essential hypertensive patients with blood plasma from normotensive subjects. Decreased Mg binding to cell membranes must also occur in frankly Mg-deficient patients, some of whom, as a consequence of the primary deficiency of this mineral, are hypertensive. Normal Mg binding to erythrocyte membranes was observed in two patients with hypertension indicating that hypertension per se does not cause decreased Mg binding to cell membranes. These observations suggest that decreased Mg binding to cell membranes may be an important contributing factor in some cases of essential hypertension.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 1","pages":"65-82"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109082615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13177906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Discriminant analysis of transmission of elevated blood pressure in first generation offspring of African green monkeys. 非洲绿猴第一代后代高血压传播的判别分析。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109082613

N Kraft-Schreyer, H Kushner, E T Angelakos

{"title":"Discriminant analysis of transmission of elevated blood pressure in first generation offspring of African green monkeys.","authors":"N Kraft-Schreyer, H Kushner, E T Angelakos","doi":"10.3109/10641969109082613","DOIUrl":"https://doi.org/10.3109/10641969109082613","url":null,"abstract":"A linear discriminant analysis was applied to blood pressure data of 162 first generation colony-born offspring of normotensive (C), hypertensive (H), or borderline hypertensive (B) African green monkeys who were being selectively bred in an attempt to establish a strain of spontaneously hypertensive monkeys. The offspring were classified according to their parents' blood pressures as CC, HH, or Mixed (e.g. HC). Blood pressures were measured by indirect methods from unanesthetized offspring aged 0.5-6 years of age. The discriminant score was used to classify each of the 533 blood pressure measurements of the CC, Mixed, and HH offspring into one of three predicted groups: normotensive, borderline hypertensive, or hypertensive. The group means of the three predicted groups compared without regard to offspring type were significantly different (p less than .001). In addition, the percentage of blood pressure measurements predicted to be normal or elevated differed among the three offspring groups (p less than .001). 82% of the blood pressure measurements from CC offspring were classified as normotensive, compared with 58% and 40% of the blood pressure measurements from the Mixed and HH groups, respectively. In contrast, 25% of the blood pressure measurements from the HH groups were classified as hypertensive, compared with 10% and 4% from the Mixed and CC groups, respectively. Blood pressures of the normotensive, borderline hypertensive, and hypertensive subgroups derived from the CC group were consistently and significantly lower (p less than .001) than their respective counterparts in the Mixed and HH groups. The results of the discriminant analysis indicate a trimodal distribution of blood pressures in the first generation offspring and a significant separation of blood pressures among the offspring after a single generation.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 1","pages":"35-52"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109082613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13178680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites. 延髓上部位对动脉压力和局部血流动力学的强直控制。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109042059

B F Cox, M J Brody

{"title":"Tonic control of arterial pressure and regional hemodynamics by supra-medullary sites.","authors":"B F Cox, M J Brody","doi":"10.3109/10641969109042059","DOIUrl":"https://doi.org/10.3109/10641969109042059","url":null,"abstract":"We examined the role of pontine sites in the tonic control of vasomotor tone under normal and reduced tidal volumes. Lidocaine was microinjected in pons at the level of the Kölliker-Fuse nucleus (KFN). Injections were made bilaterally 6, 7, 8, and 9 mm below dura, and 0.9 and 2.5 mm lateral to midline. Lidocaine in KFN produced a fall (-14 mmHg) in mean arterial pressure (MAP) at normal and reduced tidal volumes. These effects were mediated primarily by a reduction in hindquarter vascular resistance. Lidocaine into a ventromedial site (8.0 mm beneath dura, 0.9 mm lateral to midline) increased MAP by increasing renal, mesenteric, and hindquarter vascular resistance. After sino-aortic deafferentation (SAD), reduced tidal volume augmented the pressor and blunted the tachycardic responses to lidocaine injected into the ventromedial pons (9.0 mm beneath dura, 0.9 mm lateral to midline). SAD also enhanced the pressor response to lidocaine injected into ventromedial pons. This work demonstrates a role for supra-medullary sites in the tonic control of vasomotor tone.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 2","pages":"197-218"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109042059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13221515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hypotensive properties of the protein kinase inhibitor, staurosporine, in normotensive and spontaneously hypertensive rats. 蛋白激酶抑制剂staurosporine对正常血压和自发性高血压大鼠的降压作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109042060

R J Secrest, P Williams, R Bonjouklian, D Modlin, K Firman, J Turk, M L Cohen

{"title":"Hypotensive properties of the protein kinase inhibitor, staurosporine, in normotensive and spontaneously hypertensive rats.","authors":"R J Secrest, P Williams, R Bonjouklian, D Modlin, K Firman, J Turk, M L Cohen","doi":"10.3109/10641969109042060","DOIUrl":"https://doi.org/10.3109/10641969109042060","url":null,"abstract":"The protein kinase inhibitor, staurosporine, was examined for hemodynamic actions in conscious rats and for its effects on isolated vascular smooth muscle. In conscious normotensive rats, staurosporine, 0.1 to 1.0 mg/kg intravenous, produced a dose-related decrease in blood pressure. Doses of 0.1 and 0.5 mg/kg produced reflex tachycardia, while heart rate decreased following 1.0 mg/kg. Higher doses of staurosporine (5 and 10 mg/kg), although not significantly altering heart rate, caused a precipitous drop in blood pressure and all rats died within 48 hours of treatment. Spontaneously hypertensive rats were significantly more sensitive than normotensive rats to the blood pressure lowering effects of staurosporine. The depressor activity of staurosporine was also observed in cord-stimulated pithed rats indicating that hypotension is a peripherally- rather than centrally-mediated effect of staurosporine. In ring preparations of rat thoracic aorta, staurosporine (3 nM to 0.1 mM) produced a concentration-dependent inhibition of serotonin-induced contraction, consistent with its ability to lower blood pressure by an effect at a peripheral vascular site. These results provide the first documentation of the potent cardiovascular activity of staurosporine in the conscious rat and support the contention that protein kinases, in particular protein kinase C, may be important in the regulation of vascular tone.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 2","pages":"219-34"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109042060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13221516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effects of tryptophane on SHRSP offspring growth. 色氨酸对SHRSP子代生长的影响。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.1536/IHJ.30.599

H. Ito, H. Shiokawa, M. Torii, T. Suzuki

引用次数: 3

Renal dopamine and changes in dopamine receptor ligand binding during high sodium intake. 高钠摄入时肾多巴胺和多巴胺受体配体结合的变化。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109048799

A L Jadhav, A Ricci, F Amenta, M F Lokhandwala

引用次数: 7

Cardiac output and the blood pressure increase in deoxycorticosterone acetate-salt hypertension after nicotine infusion. 尼古丁输注后醋酸脱氧皮质酮盐高血压患者的心排血量和血压升高。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1991-01-01 DOI: 10.3109/10641969109082616

J C Passmore, A E Jimenez, W M Pierce

{"title":"Cardiac output and the blood pressure increase in deoxycorticosterone acetate-salt hypertension after nicotine infusion.","authors":"J C Passmore, A E Jimenez, W M Pierce","doi":"10.3109/10641969109082616","DOIUrl":"https://doi.org/10.3109/10641969109082616","url":null,"abstract":"We wished to determine if nicotine exaggerates the blood pressure increase in deoxycorticosterone (DOCA)-salt hypertension. Uninephrectomized, male Sprague-Dawley rats were implanted with DOCA pellets (75 mg) and placed on a 5.2% salt diet for sixteen days and then infused with nicotine (DOCA-Nicotine; 2.4 mg/kg/day) or vehicle (DOCA-Sham). Control animals were treated with vehicle (Control) or nicotine (Control-Nicotine). The DOCA-Nicotine group had significantly greater tail-cuff blood pressures than the DOCA-Sham group by one week of nicotine infusion. At 2.5 weeks of nicotine infusion the DOCA-Nicotine rats had significantly greater tail-cuff blood pressures, direct arterial blood pressures, and cardiac outputs compared to the DOCA-Sham animals. Renal blood flows were similar in the two groups. Control-Nicotine animals demonstrated no response to nicotine during 2.5 weeks of infusion. We conclude that in the DOCA-salt rat nicotine induces an exaggerated rise in blood pressure and that the mechanism involves an increase in cardiac output.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"13 1","pages":"83-102"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969109082616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13177907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2