Clinical and experimental hypertension. Part A, Theory and practice最新文献_第4页

Efficacy and safety of felodipine, a new dihydropyridine calcium channel blocker, in elderly hypertensive patients. 新型二氢吡啶类钙通道阻滞剂非洛地平在老年高血压患者中的疗效和安全性。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209038187

V DeQuattro

引用次数: 1

Pathophysiology of cardiovascular structural changes in hypertension. 高血压患者心血管结构改变的病理生理学。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036179

S Jern

引用次数: 5

Alcohol and hypertension. 酒精和高血压

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036176

L J Beilin, I B Puddey

引用次数: 0

Molecular genetics of hypertension. 高血压的分子遗传学。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036168

R Kreutz, M Higuchi, D Ganten

引用次数: 25

Role of renin secretion and kidney function in hypertension and attendant heart attack and stroke. 肾素分泌和肾功能在高血压及其伴随的心脏病发作和中风中的作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036189

J H Laragh

{"title":"Role of renin secretion and kidney function in hypertension and attendant heart attack and stroke.","authors":"J H Laragh","doi":"10.3109/10641969209036189","DOIUrl":"https://doi.org/10.3109/10641969209036189","url":null,"abstract":"Control of blood pressure usually has not, by itself, affected the incidence of heart attack in hypertensive patients. This suggests a need for cause-specific therapy targeted against mechanisms that engage the risks of myocardial infarction. Study of the renin system, the ongoing, long-term servo-control over blood pressure and electrolyte homeostasis may provide answers. Inappropriately high renin production, generating the powerful vasoconstrictor, angiotensin II, may cause ischemic vascular damage in the heart, kidney and brain, predisposing to infarction. Many clinical situations associated with high plasma renin levels are accompanied by striking vascular damage, heart attack, or stroke. A recent prospective study of 1,717 hypertensive patients shows an unequivocally positive relationship between myocardial infarction and high-renin status regardless of other risk factors such as smoking, hypercholesteremia, or diabetes. The data also suggest the possibility that renin is a continuous variable, since the risk of heart attack was significantly weaker in medium-renin than in high and significantly greater than in low renin subjects. These observations are in keeping with concept that any renin secretion in the face of arterial hypertension is abnormal, since the truly normal kidney completely turns off its renin secretion. Thus the renin-sodium profile appears to be especially useful for evaluating the large fraction of patients who develop heart attacks in the absence of these other risk factors. Although, these findings suggest that a renin test should be performed routinely in hypertensive patients, the better to assess prognosis and design appropriate anti-renin therapy.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 1-2","pages":"285-305"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12709988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Changes in 24 hour blood pressure and in cardiac and vascular structure in normotensive subjects with parental hypertension. 父母高血压的正常血压受试者24小时血压及心脏和血管结构的变化。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036172

G Parati, A Ravogli, C Giannattasio, E Mutti, S Trazzi, A Villani, G Mancia

{"title":"Changes in 24 hour blood pressure and in cardiac and vascular structure in normotensive subjects with parental hypertension.","authors":"G Parati, A Ravogli, C Giannattasio, E Mutti, S Trazzi, A Villani, G Mancia","doi":"10.3109/10641969209036172","DOIUrl":"https://doi.org/10.3109/10641969209036172","url":null,"abstract":"Subjects with family history of hypertension represent a suitable model to investigate the mechanisms responsible for early cardiovascular structural and functional changes occurring in essential hypertension. In our study we have addressed the factors involved in determining the mild elevation in office blood pressure frequently observed in normotensive subjects with hypertensive parents. In 15 normotensive subjects with both parents hypertensive (FH++) and in 15 normotensive subjects with one parent hypertensive (FH(+)-) we found no evidence of a hyperreactivity to stress as compared to the responses of 15 normotensive subjects with no parental hypertension (FH--). On the contrary FH++ subjects were characterized by a significant although mild increase in their blood pressure values recorded either at rest and in ambulatory conditions over the 24 hours, including night sleep. FH++ and FH(+)- subjects also showed a greater left ventricular mass thickness and a greater minimal forearm vascular resistance than FH-- subjects. Thus, the elevation in blood pressure found in the pre-hypertensive stage in subjects with positive family history for hypertension does not reflect a hyperreactivity to the stress associated with physician's visit but indicates an early and persistent blood pressure elevation. This blood pressure elevation is accompanied by early cardiovascular structural changes which may indicate that these subjects are exposed to a higher risk even before developing overt hypertension.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 1-2","pages":"67-83"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12709994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Smoking as cardiovascular risk factor in low cholesterol population: the Hisayama Study. 吸烟是低胆固醇人群的心血管危险因素:Hisayama研究。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036174

M Fujishima, Y Kiyohara, K Ueda, Y Hasuo, I Kato, H Iwamoto

引用次数: 36

Studies with guanosine-5'-monophosphate (GMP): new method for measurement and effects on blood pressure. 鸟苷-5′-单磷酸(GMP):测量血压的新方法及其对血压的影响。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036212

F Ando, M Hayakawa, F Kuzuya

引用次数: 2

Plasma 19-hydroxy-androstenedione (19-OH-A) in essential hypertension. 原发性高血压患者血浆19-羟基雄烯二酮(19-OH-A)。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209038194

C Tosti-Croce, R Rinaldi, M Massaria, A Lomurno, T Felicioli, F Sciarra

{"title":"Plasma 19-hydroxy-androstenedione (19-OH-A) in essential hypertension.","authors":"C Tosti-Croce, R Rinaldi, M Massaria, A Lomurno, T Felicioli, F Sciarra","doi":"10.3109/10641969209038194","DOIUrl":"https://doi.org/10.3109/10641969209038194","url":null,"abstract":"19-hydroxy-androstenedione (19-OH-A), a C19 steroid, is an amplifier of the sodium retaining action of aldosterone under the control of ACTH and renin-angiotensin system. These findings suggest that 19-OH-A may be involved in the regulation of hydroelectrolyte balance and blood pressure. Aim of the present study was to examine the behaviour of 19-OH-A in normal volunteers (N) and in patients with Essential Hypertension (EH) in basal conditions and after dynamic tests such as postural changes, physical exercise and ACTH administration. The significant increase in 19-OH-A after ACTH confirms its adrenal origin. During bicycle exercise the significant increase in plasma catecholamines, renin-activity, aldosterone, blood pressure and heart rate at maximum effort was not associated with a parallel increase in 19-OH-A. No significant differences were found in plasma 19-OH-A levels between N and EH patients both in basal conditions and after dynamic tests. Therefore, our findings seem to exclude an important role of 19-OH-A in the pathogenesis of EH.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 6","pages":"1083-94"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209038194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12504651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin attenuates vasoconstriction by noradrenaline, serotonin and potassium chloride in rat mesenteric arterioles. 胰岛素减轻大鼠肠系膜小动脉中去甲肾上腺素、血清素和氯化钾的血管收缩。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036218

G K Wambach, D Liu

{"title":"Insulin attenuates vasoconstriction by noradrenaline, serotonin and potassium chloride in rat mesenteric arterioles.","authors":"G K Wambach, D Liu","doi":"10.3109/10641969209036218","DOIUrl":"https://doi.org/10.3109/10641969209036218","url":null,"abstract":"We investigated the effect of insulin on the vascular reactivity to noradrenaline, serotonin and potassium chloride in rat mesenteric resistance arterioles in vitro. Mesenteric artery segments were placed in a myograph system. Sensitivity to noradrenaline, serotonin and KCl was tested after an equilibration at 37 degrees C. Thereafter, arteries were incubated with buffer alone or with insulin (40, 100, 250 and 400 mU/ml) for one hour at 37 degrees C. Sensitivity to the three vasoconstrictors was retested. Incubation with noradrenaline, serotonin and KCl resulted in a dose dependent increase in wall force. Exposure with buffer did not change the shape of the dose-response-curve. The same was true for the lowest dose of insulin (40 mU/ml). However, incubation with insulin at concentrations of 100, 250 and 400 mU/ml led to a reduction in wall force by 37-77%. The reduction in the slope of the curve and the maximal response suggest a non-competitive inhibition. Supraphysiological doses of insulin attenuate the vasoconstriction by noradrenaline, serotonin and KCl in rat mesenteric arteries in vitro.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 4","pages":"733-40"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12795290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30