大鼠ACTH高血压:氯化钠的作用。

M Li, J A Whitworth
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引用次数: 7

摘要

促肾上腺皮质激素(ACTH)在大鼠体内产生肾上腺依赖性的血压和盐(NaCl)食欲升高。本研究考察了大鼠自由摄入高盐对ACTH高血压的影响,以验证高盐摄入会放大血压升高的假设。假手术大鼠和ACTH治疗大鼠分别给予水或1%NaCl。皮下注射合成ACTH (0.5 mg/kg/天)10天导致1%NaCl (+240 +/- 6 ml/天)和水(+45 +/- 4 ml/天)的摄入量、尿量(1%NaCl + ACTH +182 +/- 4 ml/天、ACTH +水+36 +/- 2 ml/天)、肾上腺重量(ACTH +水176 +/- 18、ACTH + 1%NaCl + 367 +/- 129 mg/100 g体重)和最大收缩压(ACTH +水+18 +/- 5 mmHg)大幅增加;1%NaCl + ACTH +16 +/- 3 mmHg)。部分ACTH + 1%NaCl大鼠出现严重水肿。因此,在ACTH处理的Sprague Dawley大鼠中,NaCl的自由接触并没有增强高血压,但在一些动物中与水肿有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ACTH hypertension in the rat: role of sodium chloride.

Adrenocorticotrophin (ACTH) produces adrenally dependent increases in both blood pressure and salt (NaCl) appetite in the rat. The present study examines the effect of free access to a high intake of NaCl on ACTH hypertension in the rat to test the hypothesis that high NaCl intake would amplify the rise in blood pressure. Either water or 1%NaCl were offered to sham or ACTH treated Sprague-Dawley rats. Subcutaneous injections of synthetic ACTH (0.5 mg/kg/day) for 10 days caused large increases in the intake of both 1%NaCl (+240 +/- 6 ml/day) and water (+45 +/- 4 ml/day), urine volume (1%NaCl + ACTH +182 +/- 4 ml/day, ACTH + water +36 +/- 2 ml/day), adrenal weight (ACTH + water 176 +/- 18, ACTH + 1%NaCl 367 +/- 129 mg/100 g body weight) and maximum systolic blood pressure (SBP) (ACTH + water +18 +/- 5 mmHg; 1%NaCl + ACTH +16 +/- 3 mmHg). Some ACTH + 1%NaCl rats developed severe edema. Thus, free access to NaCl in ACTH treated Sprague Dawley rats did not potentiate the hypertension, but was associated with edema in some animals.

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