Clinical and experimental hypertension. Part A, Theory and practice最新文献_第6页

Sensitivity and reactivity to endothelin-1 in mesenteric beds and aortic rings of 4-week-old spontaneously hypertensive rats. 4周龄自发性高血压大鼠肠系膜床和主动脉环对内皮素-1的敏感性和反应性。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036200

L Criscione, H Thomann, T D Luu

{"title":"Sensitivity and reactivity to endothelin-1 in mesenteric beds and aortic rings of 4-week-old spontaneously hypertensive rats.","authors":"L Criscione, H Thomann, T D Luu","doi":"10.3109/10641969209036200","DOIUrl":"https://doi.org/10.3109/10641969209036200","url":null,"abstract":"The vasoconstrictor effects of endothelin-1 were studied in perfused mesenteric vascular beds (MVB) and aortic rings of 4-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar Kyoto rats (WKY). Mean blood pressure (124 +/- 4 vs. 97 +/- 3 mmHg) and initial perfusion pressure in the MVBs (25 +/- 2 vs. 19.7 +/- 1.2) were significantly higher in SHR. Reactivity to endothelin-1 was increased in MVBs of SHR, as indicated by the maximum perfusion pressure obtained (223 +/- 8 vs 155 +/- 7 mmHg, p less than 0.001), whereas there was no significant difference in sensitivity between the two strains (EC50 values: 50 +/- 12 and 80 +/- 15 pmol, respectively). By contrast, in aortic rings reactivity and sensitivity to endothelin-1 were similar in both strains, (EC50s: 1.8 +/- 0.12 and 1.4 +/- 0.1 nM). Reactivity to norepinephrine was increased in MVBs, but reduced in aortic rings of SHR. The unchanged sensitivity to endothelin-1 and the unspecifically increased reactivity in the MVBs of SHR to endothelin-1 and norepinephrine indicate rather a change in vascular structure and not a functional abnormality. These results suggest that hyperreactivity to endothelin-1 may not be a primary hypertensive mechanism in genetic hypertension.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 3","pages":"453-67"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12767590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Diuretic induced long term hemodynamic changes in hypertension. A retrospective study in a MRFIT clinical center. 利尿剂引起高血压的长期血流动力学改变。MRFIT临床中心的回顾性研究。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036194

P Kezdi, P C Kezdi, H J Khamis

{"title":"Diuretic induced long term hemodynamic changes in hypertension. A retrospective study in a MRFIT clinical center.","authors":"P Kezdi, P C Kezdi, H J Khamis","doi":"10.3109/10641969209036194","DOIUrl":"https://doi.org/10.3109/10641969209036194","url":null,"abstract":"Retrospective analysis of hemodynamic factors was performed on hypertensive participants of our Multiple Risk Factor Intervention Trial (MRFIT) center to determine whether these may have a role in the higher mortality in a subgroup of special intervention (SI) participants with minor baseline electrocardiographic abnormalities. Stroke volume was estimated by a formula [SV = K(LVETxPP)x(1 + LVET/DP) where the K factor was determined using a separate group of individuals undergoing cardiac catheterization. The Pearson correlation between the two methods (dye dilution and above formula) was 0.7744 with a 95% confidence interval of 0.57-0.89 for the true correlation. In 222 SI and 186 usual care (UC) participants with no differences in stroke volume index (SVI) and cardiac output index (CI) at baseline, SVI and CI were systematically lower during the entire period of treatment in SI receiving higher average doses of thiazide diuretics. There was a moderate increase of SVI and CI in SI participants toward baseline after hydrochlorothiazide was replaced by other antihypertensive medication in the fourth year of the trial. We conclude that the lower SVI and CI could have been a contributing factor in the higher mortality in the SI group with ECG abnormalities resulting in decreased coronary flow reserve under stress conditions in these participants with probably pre-existing asymptomatic coronary artery disease.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 3","pages":"347-65"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12767732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Insulin and blood pressure: possible role of hemodynamics. 胰岛素和血压:血流动力学的可能作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036188

E Ferrannini

引用次数: 26

Protecting arteries against hypertensive injury. 保护动脉免受高血压损伤。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036169

L Tobian

引用次数: 10

Electrophysiological responses of angiotensin peptides on the rat isolated nodose ganglion. 血管紧张素肽对大鼠离体结节神经节的电生理反应。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036210

R E Widdop, E Krstew, B Jarrott

{"title":"Electrophysiological responses of angiotensin peptides on the rat isolated nodose ganglion.","authors":"R E Widdop, E Krstew, B Jarrott","doi":"10.3109/10641969209036210","DOIUrl":"https://doi.org/10.3109/10641969209036210","url":null,"abstract":"Previous autoradiographic studies have identified angiotensin II (AII) binding sites over the nodose ganglion and along the vagal afferent neurons. In the present study, we examined whether these binding sites are functional receptors by measuring d.c. potential changes by extracellular recording techniques in the rat isolated nodose ganglion preparation in response to superfusion of angiotensin peptides. It was found that AII, as well as AI and AIII elicited concentration-dependent depolarisation of the nodose ganglion. However, the amino terminal angiotensin heptapeptide, A(1-7), failed to evoke any significant response. The AII receptor antagonist, saralasin had no intrinsic activity, but caused a concentration-dependent blockade of AII-induced depolarisation. This study provides evidence for direct neuronal effects of angiotensin peptides on rat vagal afferent neurons. Moreover, this preparation is a relatively convenient one in which to study functional neuronal AII receptor mechanisms on central or peripheral terminals of vagal sensory neurons.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 4","pages":"597-613"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12795287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Strategies and difficulties in dietary intervention in myocardial infarction patients. 心肌梗死患者饮食干预的策略与难点。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036183

L J Beilin

{"title":"Strategies and difficulties in dietary intervention in myocardial infarction patients.","authors":"L J Beilin","doi":"10.3109/10641969209036183","DOIUrl":"https://doi.org/10.3109/10641969209036183","url":null,"abstract":"Randomized controlled trials along with 'within group' studies of patients with symptomatic coronary artery disease suggest that dietary and other lifestyle changes can halt progression of coronary atherosclerosis, induce regression of pre-existing severe lesions, and reduce the severity or frequency of angina. Varying combinations have been tested, including restriction of dietary total, saturated and polyunsaturated fat using lean meat or vegetarian diets, fish oil supplements, smoking cessation, stress management, and exercise training. The relative importance of each of these remains unclear. In patients with recent myocardial infarction high fish diets appeared effective in reducing both ischaemic heart deaths and total death rates over two years, whereas modest changes in dietary saturated fats or fibre had no influence on outcome. These results suggest that a far more active dietary approach is needed for patients with symptomatic coronary disease. Further research is required into the possible complementary role of dietary measures and drug treatment for reversing the disease process and improving outcome, using new techniques for achieving behavioural change.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 1-2","pages":"213-21"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12486274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Erythrocyte sodium-lithium countertransport in Chinese: its relationship to family history of hypertension. 中国人红细胞钠锂反转运及其与高血压家族史的关系。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036202

Y T Lau, D Wu, H C Liang, M C Chen

引用次数: 3

ACTH hypertension in the rat: role of sodium chloride. 大鼠ACTH高血压:氯化钠的作用。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036208

M Li, J A Whitworth

引用次数: 7

Protein kinase C and cell proliferation in spontaneously hypertensive rats. 蛋白激酶C与自发性高血压大鼠细胞增殖的关系。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036224

D L Zhu, T Herembert, P Marche

{"title":"Protein kinase C and cell proliferation in spontaneously hypertensive rats.","authors":"D L Zhu, T Herembert, P Marche","doi":"10.3109/10641969209036224","DOIUrl":"https://doi.org/10.3109/10641969209036224","url":null,"abstract":"Cultured aortic fibroblasts from spontaneously hypertensive rats (SHR) exhibit increased proliferation rate compared with cells from normotensive Wistar Kyoto (WKY) rats. The present study was designed to investigate whether this growth abnormality could be accounted for by alteration in protein kinase C (PKC). The enzyme activation by 12-O-tetradecanoyl phorbol 13-acetate (TPA) promoted 3H-thymidine incorporation which was higher in SHR-derived fibroblasts compared with WKY-derived cells. Likewise, 3H-phorbol 12,13-dibutyrate (PDBu) binding to intact cells was markedly increased in SHR-derived fibroblasts. These findings suggest a difference in PKC activity between the two cell types. In both cell types, serum-induced 3H-thymidine incorporation was enhanced by PKC down-regulation, which was obtained by prolonged treatment of cells with high dose of TPA, whereas it was inhibited in a dose-dependent manner by activation of the enzyme. The changes in serum-induced 3H-thymidine incorporation elicited either by activation or desensitization of PKC, did not differ between SHR and WKY fibroblasts. Our results indicate therefore i) that in the presence of serum PKC exerts an antiproliferative effect in rat aortic fibroblasts and ii) that the increase in PKC activity and in sensitivity to TPA exhibited by SHR-derived fibroblasts, is not involved in the increased proliferation rate displayed by SHR-derived fibroblasts in serum-containing medium.","PeriodicalId":10339,"journal":{"name":"Clinical and experimental hypertension. Part A, Theory and practice","volume":"14 5","pages":"875-87"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641969209036224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12565815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Hormonal aspects of the relation of liver cirrhosis to essential hypertension. 激素方面肝硬化与原发性高血压的关系。

Clinical and experimental hypertension. Part A, Theory and practice Pub Date : 1992-01-01 DOI: 10.3109/10641969209036225

F Veglio, G Pinna, R Melchio, F Rabbia, M Panarelli, D Schiavone, P Mulatero, L Chiandussi

引用次数: 8