Clinical and Experimental Hypertension最新文献_第9页

Proprotein convertase subtilisin/kexin type 9 is associated with atherosclerosis in patients with Behcet’s disease 蛋白转化酶枯草杆菌素/ keexin 9型与白塞氏病患者动脉粥样硬化相关

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-05-03 DOI: 10.1080/10641963.2022.2071921

R. Aydogan Baykara, Pinar Diydem Yilmaz, M. H. Göktepe, C. Kadıyoran, Mustafa Ogul, A. Kucuk, Medine Cumhur Cüre, Erkan Cüre

{"title":"Proprotein convertase subtilisin/kexin type 9 is associated with atherosclerosis in patients with Behcet’s disease","authors":"R. Aydogan Baykara, Pinar Diydem Yilmaz, M. H. Göktepe, C. Kadıyoran, Mustafa Ogul, A. Kucuk, Medine Cumhur Cüre, Erkan Cüre","doi":"10.1080/10641963.2022.2071921","DOIUrl":"https://doi.org/10.1080/10641963.2022.2071921","url":null,"abstract":"ABSTRACT Objectives The incidence of cardiovascular disease is increased in patients with Behcet’s disease (BD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) causes the acceleration of atherosclerosis. We aimed to investigate whether there is a relationship between PCSK9 with carotid artery intima-media thickness (cIMT), a marker of subclinical atherosclerosis, and BD disease activity. Methods Fifty-eight patients with BD and 58 age-, gender-, and body mass index (BMI)-matched healthy control subjects were included in the study. The disease activity of the patients was estimated. Individuals’ cIMT values were measured, and PCSK9 levels were studied. Results Patients with BD’ cIMT (0.51 ± 0.1 vs 0.41 ± 0.1 mm, p < .001) and PCSK9 (623.2 ± 101.7 ± 10.1 vs 528.3 ± 242.7 ng/ml, p = .007), values were significantly higher than the control group. In stepwise regression analysis, there was an independent relationship between cIMT with PCSK9 (β = 0.179, p < .050). There was no independent relationship between disease activities with PCSK9. Based on the ROC curve analysis, the PCSK9 optimal cutoff value for cIMT was 595.1 ng/ml, sensitivity 66.7%, specificity 64.7% (AUC = 0.672; 95% CI: 0.530–0.815, p = .040). Conclusion There is a strong independent association between subclinical atherosclerosis and PCSK9 in patients with BD. There may be no independent association between PCSK9 and disease activity.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"10 1","pages":"480 - 486"},"PeriodicalIF":12.3,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84314477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of RAAS blocker use on AKI in elderly hypertensive STEMI patients with propensity score weighed method 倾向评分加权法观察RAAS阻滞剂对老年高血压STEMI患者AKI的影响

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-05-03 DOI: 10.1080/10641963.2022.2071922

G. Zeren, İ. Avcı, M. Sungur, B. Şimşek, Aylin Sungur, F. Can, M. F. Yılmaz, Ufuk Gürkan, S. Kalkan, A. Karagöz, I. Tanboğa, C. Karabay

{"title":"Effects of RAAS blocker use on AKI in elderly hypertensive STEMI patients with propensity score weighed method","authors":"G. Zeren, İ. Avcı, M. Sungur, B. Şimşek, Aylin Sungur, F. Can, M. F. Yılmaz, Ufuk Gürkan, S. Kalkan, A. Karagöz, I. Tanboğa, C. Karabay","doi":"10.1080/10641963.2022.2071922","DOIUrl":"https://doi.org/10.1080/10641963.2022.2071922","url":null,"abstract":"ABSTRACT Studies reported conflicting results on the effect of renin-angiotensin-aldosterone system (RAAS) blocker use on acute kidney injury (AKI) in patients undergoing elective coronary angiography but association in elderly patients with ST-elevation myocardial infarction (STEMI) is not known. Also, there are limited data on the effect of inflammatory markers on AKI. We aimed to investigate the effects of RAAS blocker pretreatment and inflammatory markers on AKI in this population. A total of 471 patients were compared according to presence of RAAS blocker pretreatment at admission. Conventional and inverse probability weighed conditional logistic regression were used to determine independent predictors of AKI. Mean age of the study group was 75.4 ± 7.1 years and 29.1% of the patients were female. AKI was observed in 17.2% of the study population. Weighted conditional multivariable logistic regression analysis revealed that AKI was associated with baseline creatinine levels and C-reactive protein/albumin ratio (CAR) (OR 2.08, 95% CI = 1.13–3.82, p = .02 and OR 1.19, 95% CI = 1.01–1.41, p = .04, respectively). No significant association was found between RAAS blocker pretreatment and AKI. CAR and elevated baseline creatinine levels were independent predictors of AKI in this patient group.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"386 1","pages":"487 - 494"},"PeriodicalIF":12.3,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74278385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study 接受β受体阻滞剂或血管紧张素受体阻滞剂的高血压女性运动训练后心血管反应的不同:一项初步研究

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-23 DOI: 10.1080/10641963.2022.2065290

Igor M Mariano, A. Amaral, Victor Hugo V Carrijo, J. G. Costa, M. D. L. Rodrigues, T. Cunha, G. Puga

{"title":"Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study","authors":"Igor M Mariano, A. Amaral, Victor Hugo V Carrijo, J. G. Costa, M. D. L. Rodrigues, T. Cunha, G. Puga","doi":"10.1080/10641963.2022.2065290","DOIUrl":"https://doi.org/10.1080/10641963.2022.2065290","url":null,"abstract":"ABSTRACT Aim To verify the influence of β-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. Methods Postmenopausal women were allocated into: healthy control group (CON; n = 9); angiotensin receptor blockers users (ARB; n = 19); and β-adrenergic blockers users (BB; n = 19). Before and after 12 weeks of combined (aerobic and resistance) exercise training they were evaluated by: heart rate (HR) and its variability (HRV), blood pressure (BP) under stress (Cold pressor and Stroop color tests), and ambulatorial BP and its variability. Results In ambulatorial BP analysis only in ARB group awake systolic BP decreased (p = .011; ARB: From 122 ± 11 to 117 ± 9; BB: From 118 ± 7 to 114 ± 5; CON: From 121 ± 7 to 127 ± 11 mmHg). There were time effects in BP reactivity to stress, where BP reactivity after Stroop color and Cold pressor test decreased in all groups. In BP variability analysis, only BB group has significative decreased values in systolic SD24 (p = .007; ΔARB = −0.3 ± 2.0; ΔBB = −1.3 ± 2.0; ΔCON = 0.8 ± 1.7 mmHg) and SDdn (p = .006; ΔARB = −0.2 ± 1.6; ΔBB = −1.3 ± 2.0; ΔCON = 0.4 ± 2.1 mmHg). HRV analysis demonstrated that post-training, only in BB group LF/HF decreased (p = .001; ΔARB = 0.1 ± 0.8; ΔBB = −0.4 ± 1.5; ΔCON = 1.0 ± 1.7). Conclusion ARB present pronounced responses in awake ambulatorial systolic BP, while β-blockers users present greater responses in BP variability. Besides that, exercise can mitigate BP reactivity to stress with no differences between groups. Lastly, there were no major differences in HRV. Trial registry at “Clinicaltrials.gov” NCT03529838","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"131 1","pages":"442 - 450"},"PeriodicalIF":12.3,"publicationDate":"2022-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76375124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats 莪术提取物对肾血管性高血压大鼠的抗高血压作用

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-20 DOI: 10.1080/10641963.2022.2065286

Xoan Thi Le, Loan Thanh Thi Nguyen, Phuong Thi Tuyet Nguyen, Tai Van Nguyen, Hiep Van Nguyen, Hang Thi Nguyet Pham, Hong Nguyen Tran, Thang Dac Hoang, Dong Van Le, Kinzo Matsumoto

{"title":"Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats","authors":"Xoan Thi Le, Loan Thanh Thi Nguyen, Phuong Thi Tuyet Nguyen, Tai Van Nguyen, Hiep Van Nguyen, Hang Thi Nguyet Pham, Hong Nguyen Tran, Thang Dac Hoang, Dong Van Le, Kinzo Matsumoto","doi":"10.1080/10641963.2022.2065286","DOIUrl":"https://doi.org/10.1080/10641963.2022.2065286","url":null,"abstract":"ABSTRACT Objectives This study aims to investigate the anti-hypertensive effects of aqueous extract of Callisia fragrans and their underlying mechanism using a two-kidney one-clip (2K1C) model of reno-vascular hypertension in rats. Methods The reno-vascular hypertensive rats were treated with C. fragrans leaf extract (100 and 500 mg/kg; p.o.) and a reference drug, captopril (20 mg/kg; p.o.), for 4 weeks. The blood pressure and heart rate were recorded using a tail-cuff. The heart weight, left ventricular wall thickness, and serum creatinine and urea levels were measured. A spectrophotometric assay was used to analyze the angiotensin-converting enzyme (ACE) inhibition activity of the extract and the reference drug. The total volume and the concentration of sodium, potassium, and chloride in urine samples were evaluated. Results C. fragrans extract significantly reduced both systolic and diastolic blood pressures in the reno-vascular hypertensive rats. No significant difference in the heart rate was observed between each animal group. C. fragrans extract reduced the 2K1C-induced increase in the heart and body weight ratio and the left ventricular wall thickness. Moreover, the extract also attenuated the increase in serum urea induced by the 2K1C treatment. C. fragrans extract inhibited ACE activity in vitro with an IC50 of 20.97 ± 3.94 µg/ml. The urine output and urinary electrolyte excretion significantly increased in C. fragrans extract-treated rats. Conclusions These findings demonstrated that C. fragrans extract can mitigate hypertension and alleviate ventricular hypertrophy and renal dysfunction in reno-vascular hypertensive rats, at least in part via ACE activity inhibition and diuretic property.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"34 1","pages":"411 - 418"},"PeriodicalIF":12.3,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78055624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension 老年高血压患者急性高强度间歇运动与中等强度连续热水运动的血流动力学、心脏自主神经和血管反应对比

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-19 DOI: 10.1080/10641963.2022.2065288

I. Roque Marçal, Vanessa Teixeira Do Amaral, Bianca Fernandes, Raphael Martins de Abreu, Cristian Alvarez, Guilherme Veiga Guimarães, V. Cornelissen, Emmanuel Gomes Ciolac

{"title":"Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension","authors":"I. Roque Marçal, Vanessa Teixeira Do Amaral, Bianca Fernandes, Raphael Martins de Abreu, Cristian Alvarez, Guilherme Veiga Guimarães, V. Cornelissen, Emmanuel Gomes Ciolac","doi":"10.1080/10641963.2022.2065288","DOIUrl":"https://doi.org/10.1080/10641963.2022.2065288","url":null,"abstract":"ABSTRACT Objectives This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension. Methods Twenty (67 ± 7 y) older individuals with hypertension were randomly assigned to perform HIIE, MICE, or control (CON) sessions in the heated swimming pool (30–32°C). Blood pressure (BP), arterial stiffness, endothelial reactivity, and heart rate variability (HRV) were measured pre, post, and 45 min (recovery) after each intervention followed by 24-h ambulatory BP and HRV. Results One single aerobic exercise session was not effective to provoke post-exercise hypotension and vascular improvements. HIIE was superior to MICE and CON to increasing parasympathetic modulation at post and recovery. Exercise sessions showed to disturb the autonomic system at nighttime compared to CON. Conclusions These results may have important implications in water-based therapy and the elderly with hypertension","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"1 1","pages":"427 - 435"},"PeriodicalIF":12.3,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89418254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efficacy of using walnuts as statin adjuvants in hypertension management 核桃作为他汀类药物辅助治疗高血压的疗效观察

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-17 DOI: 10.1080/10641963.2022.2065287

P. Amadi, E. Agomuo, J. Amadi, A.I. Bob-Chile Agada, U. Njoku, Chinedu S Ogunwa, Prince C. Odika, J. O. Osuoha, A. Ogbolosingha, Chiamaka Adumekwe, I. N. Chigbu

{"title":"Efficacy of using walnuts as statin adjuvants in hypertension management","authors":"P. Amadi, E. Agomuo, J. Amadi, A.I. Bob-Chile Agada, U. Njoku, Chinedu S Ogunwa, Prince C. Odika, J. O. Osuoha, A. Ogbolosingha, Chiamaka Adumekwe, I. N. Chigbu","doi":"10.1080/10641963.2022.2065287","DOIUrl":"https://doi.org/10.1080/10641963.2022.2065287","url":null,"abstract":"ABSTRACT Background Due to the widespread unorthodox use of nuts to improve cardiovascular health, this clinical trial was carried out to evaluate the efficacy of walnut as an adjuvant statin in hypertensive subjects. Method A single-blind placebo-controlled randomized clinical trial that lasted for 3 months. Forty-five screened hypertensive subjects on treatment, aged 45–65 years, were randomized into intervention and placebo groups according to their blood pressure defined by the American Heart Association criteria. Fifteen (15) normotensive subjects were also recruited for this study. The participants in the intervention group included daily 7 g of boiled walnut taken as snacks. The study was not controlled for type of diet and frequency of meals in a day. Low-density lipoprotein cholesterol (LDLc) was the primary endpoint for this study. Results The mean LDLc levels of the intervention groups (84.6 mg/dl and 79.7 mg/dl, respectively) were significantly (p < .005) lower than the placebo (137.6 mg/dl). The high-density lipoprotein cholesterol (HDLc) levels of the intervention groups were significantly higher than the placebo. The mean total cholesterol levels of the intervention groups were significantly lower than the placebo group. The intervention groups recorded a significantly lower systolic and diastolic blood pressure compared to the placebo. The supplementation of walnut significantly decreased the apolipoprotein E (APOE), proprotein convertase subtilisin kexin 9 (PCSK9), and cholesteryl ester transfer protein (CETP) activities relative to the placebo. Conclusion The use of walnut as a statin adjuvant during hypertension treatment reduced LDLc levels within 42.1% and improved HDL levels by 33.6%, and the LDLc decrease related to reduced PCSK9 and APOE activities while the HDLc increase related to reduced CETP activities.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"45 1","pages":"419 - 426"},"PeriodicalIF":12.3,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90581815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Pressure and Blood Glucose Responses to Combined Exercise Sessions of Different Intensities in Individuals with Cardiovascular Risk Factors 有心血管危险因素个体不同强度联合运动对血压和血糖的反应

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-14 DOI: 10.1080/10641963.2022.2065289

Mabel Diesel, Isabel Heberle, G. Juchem, Guilherme Tadeu de Barcelos, Juliana Cavestré Coneglian, A. Gerage, R. S. Delevatti

{"title":"Blood Pressure and Blood Glucose Responses to Combined Exercise Sessions of Different Intensities in Individuals with Cardiovascular Risk Factors","authors":"Mabel Diesel, Isabel Heberle, G. Juchem, Guilherme Tadeu de Barcelos, Juliana Cavestré Coneglian, A. Gerage, R. S. Delevatti","doi":"10.1080/10641963.2022.2065289","DOIUrl":"https://doi.org/10.1080/10641963.2022.2065289","url":null,"abstract":"ABSTRACT Objective The purpose of the present study was to verify the acute effects of blood pressure and blood glucose after two sessions of combined exercise sessions performed at two levels of intensity in trained individuals with cardiovascular risk factors. Methods Eighteen individuals (66.22 ± 8.61 years) of both sexes (6 women/12 men) with cardiovascular risk factors performed two sessions of combined exercises at different levels of intensity: moderate (MOD) and high (HI). To control the intensity of the aerobic training, the Borg Rating of Perceived Exertion (RPE) Scale was used. For the strength training, the maximum number of repetitions was carried out within a predetermined duration of sets. Blood pressure and blood glucose measurements were collected before and 20 minutes after the sessions. The data were analyzed using Generalized Estimating Equations, α 5%. Results Reductions were observed in systolic blood pressure (MOD – Δ = −4.95 mmHg; HI – Δ = −3.31 mmHg) and blood glucose (MOD – Δ = −16.06 mg/dL; HI – Δ = −29.45 mg/dL) after the two sessions, with no difference between sessions. Diastolic blood pressure did not change (p < .05). Conclusion Combined exercises sessions of moderate or high intensity can promote an acute reduction in systolic blood pressure and glycemia in individuals with cardiovascular risk factors.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"18 1","pages":"436 - 441"},"PeriodicalIF":12.3,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84959219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inter-arm blood pressure difference is associated with contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. st段抬高型心肌梗死患者行原发性经皮冠状动脉介入治疗后，臂间血压差与造影剂肾病相关。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-03 Epub Date: 2022-01-21 DOI: 10.1080/10641963.2022.2029471

Zeki Simsek, Regayip Zehir, Sedat Kalkan, Doğancan Ceneli, Elnur Alizade, Emrah Bayam, Özkan Candan

{"title":"Inter-arm blood pressure difference is associated with contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention.","authors":"Zeki Simsek, Regayip Zehir, Sedat Kalkan, Doğancan Ceneli, Elnur Alizade, Emrah Bayam, Özkan Candan","doi":"10.1080/10641963.2022.2029471","DOIUrl":"https://doi.org/10.1080/10641963.2022.2029471","url":null,"abstract":"Objective: Contrast-induced nephropathy (CIN) is a serious complication in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (p-PCI). An interarm systolic blood pressure difference (IASBD) ≥10 mmHg has been identified as an independent risk factor for cardiovascular disease and mortality. The aim of this study was to evaluate the predictive value of the IASBD for the risk of CIN in patients with STEMI who underwent p-PCI.Method: We prospectively investigated 2120 consecutive patients who were hospitalized with a diagnosis of STEMI and underwent p-PCI. A relative increase in serum creatinine levels of ≥ 25% or an absolute increase of ≥ 0.5 mg/dL from baseline within 72 h of contrast exposure was defined as CIN. The IASBD was calculated on admission to the emergency department. The risk of CIN was evaluated.Results: The incidence of CIN was 6.6% (n = 139). The patients were divided into 2 groups based on the development of CIN. Age (p = .001), baseline creatinine levels (p < .001), DM (p < .001), HT (p < .001) and anemia (p = .001) were higher in patients with CIN. An IASBD ≥10 mmHg was noted in 13 (9.3%) patients in the CIN group and 83 (4.1%) (p = .001) in the non-CIN group (Table 1). According to the multivariate analysis, the IASBD was found to be a predictor of CIN development (OR: 2.36, 95% CI: 1.42-3.90, p: 0.001).Conclusion: The IASBD on admission can be a potential predictor of CIN development in patients with STEMI who underwent p-PCI.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"44 3","pages":"258-262"},"PeriodicalIF":12.3,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39707008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular protective effect of nano selenium in hypothyroid rats: protection against oxidative stress and cardiac fibrosis. 纳米硒对甲状腺功能减退大鼠的心血管保护作用:对氧化应激和心脏纤维化的保护作用。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-03 Epub Date: 2022-02-10 DOI: 10.1080/10641963.2022.2036994

Seyed Hamidreza Rastegar Moghaddam, Mahmoud Hosseini, Fereshteh Sabzi, Fatemeh Hojjati Fard, Narges Marefati, Farimah Beheshti, Majid Darroudi, Alireza Ebrahimzadeh Bideskan, Akbar Anaeigoudari

{"title":"Cardiovascular protective effect of nano selenium in hypothyroid rats: protection against oxidative stress and cardiac fibrosis.","authors":"Seyed Hamidreza Rastegar Moghaddam, Mahmoud Hosseini, Fereshteh Sabzi, Fatemeh Hojjati Fard, Narges Marefati, Farimah Beheshti, Majid Darroudi, Alireza Ebrahimzadeh Bideskan, Akbar Anaeigoudari","doi":"10.1080/10641963.2022.2036994","DOIUrl":"https://doi.org/10.1080/10641963.2022.2036994","url":null,"abstract":"Background: Nano selenium (Nano Sel) has many therapeutic properties including antioxidant, anticancer, and anti-inflammatory actions.Objective: Impacts of Nano Sel administration against cardiac fibrosis and heart and aorta tissue oxidative damage observed in hypothyroid rats were explored.Methods: The animals were randomly grouped and treated as: 1) Control; 2) Propylthiouracil (PTU) in which PTU was added to the drinking water (0.05%) to induce hypothyroidism; 3-5) PTU-Nano Sel 50, PTU-Nano Sel 100, and PTU-Nano Sel 150 groups, which received daily PTU plus 50,100 or 150 µg/kg of Nano Sel for 6 weeks intraperitoneally. The heart and aorta tissues were removed under deep anesthesia and then biochemical parameters including malondialdehyde (MDA), total thiol groups, catalase (CAT), and superoxide dismutase (SOD), as well as cardiac fibrosis were assessed.Results: Hypothyroidism induced by PTU was remarkably associated with myocardial hypertrophy and perivascular fibrosis in Masson's trichrome staining. Moreover, hypothyroidism increased MDA level, while it subtracted total thiol group content and activity of SOD and CAT. Treatment with Nano Sel recovered hypothyroidism-induced cardiac fibrosis in the histological assessment. Nano Sel also promoted CAT and SOD activity and thiol content, whereas alleviated MDA levels in the heart and aorta tissues.Conclusion: Results propose that administration of Nano Sel exerts a protective role in the cardio vascular system via preventing cardiac fibrosis and inhibiting oxidative stress.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"44 3","pages":"268-279"},"PeriodicalIF":12.3,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Serum irisin and adropin levels may be predictors for coronary artery ectasia. 血清鸢尾素和促肾上腺素水平可能是冠状动脉扩张的预测因子。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2022-04-03 Epub Date: 2022-01-07 DOI: 10.1080/10641963.2021.2018601

Bayram Ali Uysal, Mevlut Serdar Kuyumcu

{"title":"Serum irisin and adropin levels may be predictors for coronary artery ectasia.","authors":"Bayram Ali Uysal, Mevlut Serdar Kuyumcu","doi":"10.1080/10641963.2021.2018601","DOIUrl":"https://doi.org/10.1080/10641963.2021.2018601","url":null,"abstract":"Background: There is strong evidence that oxidative stress and inflammation may contribute to the coronary artery ectasia (CAE) pathophysiology. Recent studies have shown that serum irisin and adropin levels are associated with oxidative stress and inflammation. In the light of this information, we aimed to investigate the possible relationship between serum irisin, adropin levels and CAE.Patients & methods: A total of 50 consecutive patients with CAE and 50 consecutive patients with normal coronary anatomy (NCA) were enrolled into the study. Serum irisin, adropin and other clinical parameters were compared between groups.Results: Adropin (p < .001) and irisin (p < .001) levels were lower in the CAE group. Low adropin (p = .014) and irisin (p < .001) levels were detected as an independent risk factor for CAE in multiple regression analysis. Receiver operating characteristic curve analysis showed that serum adropin (p < .001) and irisin (p < .001) leves was significant predictor of CAE.Conclusions: The results of this study showed that serum irisin and adropin level was lower in the CAE group than in the NCA group. Irisin and adropin could play a role in the pathogenesis of CAE.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"44 3","pages":"223-227"},"PeriodicalIF":12.3,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39882443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1