新诊断高血压患者红细胞分布宽度、全身免疫炎症指数与不良心血管预后的关系

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-06-01 DOI:10.1080/10641963.2022.2079668

F. Uzun, A. Güner, H. Pusuroğlu, A. Demir, S. Gündüz, İsmail Gürbak, S. Aslan, Gokhan Demirci, Ezgi Gültekin Güner, Enes Arslan, M. Erturk

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引用次数: 11

摘要

背景红细胞分布宽度(RDW)和全身免疫炎症指数(SII)作为几种心血管疾病发病率和死亡率的预测因子已被广泛研究。本前瞻性研究旨在探讨高血压患者长期主要心脏不良事件(mace)与单纯血液学参数的关系。方法纳入1202例新诊断的HT患者。其中女性662例(55.1%)，男性540例(44.9%)，平均年龄53.0±11.4岁。研究的主要终点是长期MACE，包括心源性死亡、中风和心肌梗死。这是第一个关注SII与HT患者主要不良心血管结局相关性的研究。结果89例(8.7%)患者在平均82.2±1.3个月的随访期间发生了至少一次MACE。MACEs患者的RDW(13.0±0.9比13.5±1.2%，p < 0.001)和SII[465.0(353.4-609.4)比584.4 (468.9-794.0)x103/µL, p < 0.001]显著升高。在RDW>13.1%的患者中，mace的患病率明显更高(10.4% vs. 5%;p < 0.001)， SII>465 x103/µL的患者(11.8 vs. 3.1%;P < 0.001)。多因素logistic回归分析显示SII和RDW是mace的独立预测因子。结论研究结果表明，RDW和SII是高血压患者长期心血管事件的独立预测因子。这些简单的血液学参数可作为新诊断HT患者MACE的预后指标。

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Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension

ABSTRACT Background Red cell distribution width (RDW) and the systemic immune-inflammation index (SII) have been extensively studied as predictors of morbidity and mortality in several cardiovascular diseases. This prospective study aimed to investigate the relationship between long term major adverse cardiac events (MACEs) and simple hematological parameters in hypertensive patients. Methods The study included a total of 1202 patients with newly diagnosed HT. Of the patients, 662 (55.1%) were female and 540 (44.9%) were male, with a mean age of 53.0 ± 11.4 years. The primary endpoint of the study was long term MACE, including cardiac death, stroke, and myocardial infarction. This is the first study focusing on the association of SII with major adverse cardiovascular outcomes in patients with HT. Results Eighty-nine patients (8.7%) developed at least one MACE during a mean follow-up period of 82.2 ± 1.3 months. RDW (13.0 ± 0.9 vs. 13.5 ± 1.2%, p < .001) and SII [465.0 (353.4–609.4) vs. 584.4 (468.9–794.0) x103/µL, p < .001] were significantly higher in patients with MACEs. The prevalence of MACEs was significantly higher in patients with RDW>13.1% (10.4 vs. 5%; p < .001) and in patients with SII>465 x103/µL (11.8 vs. 3.1%; p < .001). The multivariate logistic regression analysis showed SII and RDW were independent predictors of MACEs. Conclusion The results of the study demonstrated that the RDW and SII were independent predictors of long-term cardiovascular events in hypertensive patients. These simple hematological parameters may be used as prognosticators of MACE in patients with newly diagnosed HT.

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.