Clinical and Experimental Hypertension最新文献_第3页

Chronic exercise improves renal AT₁ and ETB receptor functions via modulating GRK4 expression in obese Zucker rats. 慢性运动通过调节 GRK4 的表达改善肥胖扎克大鼠肾脏 AT1 和 ETB 受体的功能。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-03-12 DOI: 10.1080/10641963.2024.2323532

Jingjing Lu, Zhengsheng Li, Yinan Yang, Fangning Wei

{"title":"Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats.","authors":"Jingjing Lu, Zhengsheng Li, Yinan Yang, Fangning Wei","doi":"10.1080/10641963.2024.2323532","DOIUrl":"10.1080/10641963.2024.2323532","url":null,"abstract":"Background: Physical activity has profound benefits on health, especially in patients with cardiovascular and metabolic disease. Exercise training can reduce oxidative stress, improve renal function, and thus lower blood pressure. However, the effect of exercise training on angiotensin II type 1 receptors (AT1R) and endothelin subtype B receptors (ETBR)-mediated diuresis and natriuresis in obese Zucker rats is unclear.Methods: Lean and obese Zucker rats were exercised or placed on a nonmoving treadmill for 8 weeks. Blood pressure was measured by tail-cuff plethysmography, and functions of AT1R and ETBR in the kidney were measured by natriuresis, respectively.Results: Our data showed that exercise training improved glucose and lipid metabolism, renal function and sodium excretion in obese Zucker rats, accompanied by decreased oxidative stress and GRK4 expression in obese Zucker rats. Moreover, exercise training reduced the Candesartan-induced an increase in diuresis and natriuresis and increased ETBR agonists (BQ3020)-mediated diuresis and natriuresis in obese Zucker rats, which were associated with decreased renal AT1R expression and ETBR phosphorylation levels.Conclusions: The results demonstrate that exercise training lowers blood pressure via improving renal AT1R and ETBR function through modulating GRK4 expression in Obese Zucker Rats and provides potentially effective targets for obesity-related hypertension.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"46 1","pages":"2323532"},"PeriodicalIF":12.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis. CBS基因第8外显子区T833C、G919A和844ins68多态性与冠心病的关系：一项荟萃分析。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-03-15 DOI: 10.1080/10641963.2024.2328147

Zijiang Zhu, Yuhan Geng, Long Ma, Keying Yao, Ruitong Chang, Yongming Ma, Jialong Li

{"title":"Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis.","authors":"Zijiang Zhu, Yuhan Geng, Long Ma, Keying Yao, Ruitong Chang, Yongming Ma, Jialong Li","doi":"10.1080/10641963.2024.2328147","DOIUrl":"10.1080/10641963.2024.2328147","url":null,"abstract":"Background: Several studies indicate that the cystathionine β-synthase (CBS) gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region may be correlated with coronary artery disease (CAD) susceptibility, but the results have been inconsistent and inconclusive. Thus, a meta-analysis was conducted to provide a comprehensive estimate of these associations.Methods: On the basis of searches in the PubMed, EMBASE, Cochrane Library, Wanfang, VIP, and CNKI databases, we selected 14 case - control studies including 2123 cases and 2368 controls for this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated accordingly using a fixed-effect or random-effect model.Results: The results indicated an increased risk between the CBS T833C gene polymorphisms and susceptibility to CAD under the dominant model (CC+CT vs. TT: OR = 1.92, 95% CI: 1.11 ~ 3.32), recessive model (CC vs. CT+TT: OR = 1.88, 95% CI: 1.17 ~ 3.03), and homozygous model (CC vs. TT: OR = 2.46, 95% CI: 1.04 ~ 5.83). In these three genetic models, no significant association was identified for CBS G919A (AA+AG vs. GG: OR = 1.48, 95% CI: 0.45 ~ 4.82),(AA vs. AG+GG: OR = 1.58, 95% CI: 0.93 ~ 2.70),(AA vs. GG: OR = 1.66, 95% CI: 0.40 ~ 6.92) or CBS 844ins68 (II+ID vs. DD: OR = 1.04, 95% CI: 0.80 ~ 1.35),(II vs. ID+DD: OR = 1.09, 95% CI: 0.51 ~ 2.36),(II vs. DD: OR = 1.10, 95% CI: 0.51 ~ 2.39).Conclusions: This meta-analysis suggests that the CBS T833C gene polymorphism is significantly associated with the risk of CAD and it shows a stronger association in Asian populations. Individuals with the C allele of the CBS gene T833C polymorphism might be particularly susceptible to CAD.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"46 1","pages":"2328147"},"PeriodicalIF":12.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China. 血浆致动脉粥样硬化指数与新发高血压风险之间的正相关关系：一项在中国进行的全国性队列研究。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-01-24 DOI: 10.1080/10641963.2024.2303999

Yue Yuan, Jing Shi, Wei Sun, Xiangqing Kong

{"title":"The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China.","authors":"Yue Yuan, Jing Shi, Wei Sun, Xiangqing Kong","doi":"10.1080/10641963.2024.2303999","DOIUrl":"10.1080/10641963.2024.2303999","url":null,"abstract":"Background: The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.Methods: Prospective data were obtained from 3150 participants aged ≥ 18 years in the China Health and Nutrition Survey from 2009 to 2015. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol in molar concentration. Cox regression analysis was used to determine the association of AIP index with new-onset hypertension.Results: After the six-year follow-up, 1054 (33.4%) participants developed new-onset hypertension. The participants were divided into AIP quartile groups (Q1-Q4). Compared with those in Q1, subjects in Q3-4 had nearly 1.35 times the risk of new-onset hypertension after full adjustment [Q3: hazard ratio (HR): 1.35, 95% confidence interval (CI): 1.13-1.62; Q4: HR: 1.35, 95% CI: 1.13-1.64]. The risks of new-onset hypertension were nearly 1.30 times higher in subjects in Q2-4 than in subjects in Q1 (p < .01) after the full adjustment when we excluded subjects with diabetes and/or chronic kidney diseases. There was a significant difference [HR (CI): 1.27 (1.04-1.54) vs. 0.90 (0.69-1.18)] when subjects were divided into two groups according to body mass index (BMI) level (<24 vs. ≥24 kg/m2).Conclusions: The present study suggested that individuals with a higher AIP index are associated with new-onset hypertension, independent of kidney function and glucose levels. The association was stronger in subjects with normal BMI, which may provide early screening of metabolomics in hypertension prevention.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"46 1","pages":"2303999"},"PeriodicalIF":12.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis. 铁状况与先兆子痫-子痫之间的因果关系：孟德尔随机分析。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-03-12 DOI: 10.1080/10641963.2024.2321148

Xiaofeng Yang, Jiachun Wei, Lu Sun, Qimei Zhong, Xiaoxuan Zhai, Ya Chen, Shujuan Luo, Chunyan Tang, Lan Wang

{"title":"Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis.","authors":"Xiaofeng Yang, Jiachun Wei, Lu Sun, Qimei Zhong, Xiaoxuan Zhai, Ya Chen, Shujuan Luo, Chunyan Tang, Lan Wang","doi":"10.1080/10641963.2024.2321148","DOIUrl":"10.1080/10641963.2024.2321148","url":null,"abstract":"Background: Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preeclampsia/eclampsia, the causal relationship remains unclear. The aim of this study was to investigate the genetic causality between iron status and preeclampsia/eclampsia using large-scale genome-wide association study (GWAS) summary data and Mendelian randomization (MR) analysis.Methods: Summary data for the GWAS on preeclampsia/eclampsia and genetic markers related to iron status were obtained from the FinnGen Consortium and the IEU genetic databases. The \"TwoSampleMR\" software package in R was employed to test the genetic causality between these markers and preeclampsia/eclampsia. The inverse variance weighted (IVW) method was primarily used for MR analysis. Heterogeneity, horizontal pleiotropy, and potential outliers were evaluated for the MR analysis results.Results: The random-effects IVW results showed that ferritin (OR = 1.11, 95% CI: .89-1.38, p = .341), serum iron (OR = .90, 95% CI: .75-1.09, p = .275), TIBC (OR = .98, 95% CI: .89-1.07, p = .613), and TSAT (OR = .94, 95% CI: .83-1.07, p = .354) have no genetic causal relationship with preeclampsia/eclampsia. There was no evidence of heterogeneity, horizontal pleiotropy, or possible outliers in our MR analysis (p > .05).Conclusions: Our study did not detect a genetic causal relationship between iron status and preeclampsia/eclampsia. Nonetheless, this does not rule out a relationship between the two at other mechanistic levels.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"46 1","pages":"2321148"},"PeriodicalIF":12.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of Th17 cell differentiation by aerobic exercise improves vasodilatation in diabetic mice. 通过有氧运动抑制 Th17 细胞分化可改善糖尿病小鼠的血管舒张。

IF 1.5 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-07-04 DOI: 10.1080/10641963.2024.2373467

Xiao Liu, Yidan Su, Jie Liu, Dawei Liu, Changqing Yu

{"title":"Inhibition of Th17 cell differentiation by aerobic exercise improves vasodilatation in diabetic mice.","authors":"Xiao Liu, Yidan Su, Jie Liu, Dawei Liu, Changqing Yu","doi":"10.1080/10641963.2024.2373467","DOIUrl":"https://doi.org/10.1080/10641963.2024.2373467","url":null,"abstract":"Background: Aortic endothelial diastolic dysfunction is an early complication of diabetes and the abnormal differentiation of Th17 cells is involved in the development of diabetes. However, the exact role of exercise on regulating the Th17 cells differentiation and the underlying molecular mechanisms remain to be elucidated in diabetic mice.Methods: db/db and db/m+ mice were randomly divided into exercise and sedentary groups. Mice in exercise group were exercised daily, 6 days/week, for 6 weeks and mice in sedentary groups were placed on a nonmoving treadmill for 6 weeks. Vascular endothelial function was measured via wire myograph and the frequencies of Th17 from peripheral blood in mice were assessed via flow cytometry.Results: Our data showed that exercise improved insulin resistance and aortic endothelial diastolic function in db/db mice. In addition, the proportion of Th17 cells and IL-17A level in peripheral blood of db/db mice were significantly increased, and exercise could promote Th17 cell differentiation and reduce IL-17A level. More importantly, STAT3 or ROR-γt inhibitors could promote Th17 cell differentiation in db/db mice, while exercise significantly down-regulated p-STAT3/ROR-γt signaling in db/db mice, suggesting that exercise regulated Th17 differentiation through STAT3/ROR-γt signaling.Conclusions: This study demonstrated that exercise improved vascular endothelial function in diabetic mice via reducing Th17 cell differentiation through p-STAT3/ROR-γt pathway, suggesting exercise may be an important non-pharmacological intervention strategy for the treatment of diabetes-related vascular complications.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"46 1","pages":"2373467"},"PeriodicalIF":1.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of TGF-β/Smad pathway-related indices in patients with isolated iliac artery aneurysms complicated with iliac arteriovenous fistula and their relationship with prognosis. 孤立性髂动脉瘤并发髂动静脉瘘患者体内 TGF-β/Smad 通路相关指数的表达及其与预后的关系

IF 1.5 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-07-30 DOI: 10.1080/10641963.2024.2380291

ZiJia Zhu, Ye Yao, GuangHui Shen, HaiYang Wang

{"title":"Expression of TGF-β/Smad pathway-related indices in patients with isolated iliac artery aneurysms complicated with iliac arteriovenous fistula and their relationship with prognosis.","authors":"ZiJia Zhu, Ye Yao, GuangHui Shen, HaiYang Wang","doi":"10.1080/10641963.2024.2380291","DOIUrl":"https://doi.org/10.1080/10641963.2024.2380291","url":null,"abstract":"Objective: This study investigated the expression of TGF-β/Smad pathway-related indices in patients with isolated iliac artery aneurysms (IIAA) complicated with iliac arteriovenous fistula (IAVF) and their relationship with prognosis.Methods: From January 2016 to June 2022, 83 patients with IIAA complicated with IAVF (Study group) and 54 patients with IIAA not complicated with IAVF (control group) were studied. The related indices of TGF-β/Smad pathway were evaluated, and the effects of each index on the formation of IAVF were analyzed. The patients were divided into the survival group (64 cases) and death group (19 cases), and the prognostic value of indices in combination was analyzed.Results: TGF-β, p-Smad2, p-Smad3, p-JNK, and p-ERK in the study group were higher than those in the control group. Abnormal increase of pSmad3 expression was a risk factor for IAVF formation in patients with IIAA. TGF-β level in the death group was higher than that in the survival group, and p-Smad3 and p-JNK proteins were higher than those in the survival group. The AUC value of indices in the TGF-β/Smad pathway in combination was greater than that of each index alone. Abnormal increased expression of pSmad3 was a risk factor for prognosis of patients with IIAA complicated with IAVF.Conclusion: The abnormal increase of TGF-β/Smad pathway-related indices is related to poor prognosis of patients with IIAA complicated with IAVF, and the combined detection of all indices has a predictive value for patients' prognosis.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"46 1","pages":"2380291"},"PeriodicalIF":1.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between triglyceride-glucose index and new-onset hypertension in general population–a systemic review and meta-analysis of cohort studies 普通人群甘油三酯-葡萄糖指数与新发高血压之间的关系--队列研究的系统回顾和荟萃分析

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-04-14 DOI: 10.1080/10641963.2024.2341631

Changqiang Yang, Yue Song, Peijian Wang

引用次数: 0

Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis 大黄素通过使 ROS/PI3K/Akt/mTOR 轴失活改善小鼠心肌纤维化

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2024-03-20 DOI: 10.1080/10641963.2024.2326022

Wei Huang, Peiting Zhou, Xinyun Zou, Yunchuan Liu, Longfu Zhou, Yaolei Zhang

引用次数: 0

Visceral fat and its dynamic change are associated with renal damage: Evidence from two cohorts. 内脏脂肪及其动态变化与肾损伤有关：来自两个队列的证据。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2023-12-31 Epub Date: 2023-10-23 DOI: 10.1080/10641963.2023.2271187

Mengyue Lin, Shiwan Wu, Xiulian Deng, Yequn Chen, Xuerui Tan

{"title":"Visceral fat and its dynamic change are associated with renal damage: Evidence from two cohorts.","authors":"Mengyue Lin, Shiwan Wu, Xiulian Deng, Yequn Chen, Xuerui Tan","doi":"10.1080/10641963.2023.2271187","DOIUrl":"10.1080/10641963.2023.2271187","url":null,"abstract":"Background and aims: To evaluate the association of Chinese visceral adiposity index (CVAI) and its dynamic trends with risk of renal damage, and to compare its prediction performance with that of other obesity indices.Methods and results: A community-based population with 23 905 participants from Shantou city was included in the cross-sectional analysis. A total of 9,778 individuals from two separated cohort were included in the longitudinal portion. Five patterns of CVAI change were predefined (low-stable, decreasing, moderate, increasing, and persistent-high). Logistic and Cox regressions were used to evaluate the association between CVAI and renal damage. We explored potential mechanisms using the mediating effect method, and the prediction performance was determined by receiver operating characteristic curve analysis. Results from both cross-sectional and longitudinal data revealed a positive and linear association between CVAI and risk of renal damage. Pooled analysis of the two cohorts showed that per unit increase in Z score of CVAI induced 18% increased risk of renal damage (P = .008). Longitudinal trends of CVAI were also associated with renal damage, and the moderate, increasing, and persistent-high patterns showing a higher risk. Blood pressure and glucose had a mediating effect on renal damage induced by CVAI. Among several obesity indices, CVAI was the optimal for predicting renal damage.Conclusion: A higher level of immediate CVAI and longitudinal increasing and persistent-high patterns of CVAI were independently associated with increased risk of renal damage. Monitoring immediate level and long-term trend of CVAI may contribute to the prevention of renal damage.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"45 1","pages":"2271187"},"PeriodicalIF":12.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension. TyG指数是中老年高血压患者长期随访期间全因死亡率的预测指标。

IF 12.3 4区医学

Clinical and Experimental Hypertension Pub Date : 2023-12-31 Epub Date: 2023-10-30 DOI: 10.1080/10641963.2023.2272581

Jie Pang, Linyan Qian, Xiaoru Che, Ping Lv, Qiang Xu

{"title":"TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension.","authors":"Jie Pang, Linyan Qian, Xiaoru Che, Ping Lv, Qiang Xu","doi":"10.1080/10641963.2023.2272581","DOIUrl":"https://doi.org/10.1080/10641963.2023.2272581","url":null,"abstract":"Background: The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged and elderly with hypertension.Methods: A total of 3,614 participants with hypertension were enrolled from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The Cox proportional hazard ratios were used to evaluate the association between the TyG index and the risk of mortality.Results: Over a follow-up period of 7.87 years, 991 all-cause death and 189 cardiovascular deaths occurred. Compared with the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals were 1.28 (1.07-1.53; p = .006) in the fourth quartile for all-cause mortality and 0.63 (0.42-0.96; p = .031) in the second quartile for cardiovascular mortality. Dose-response analysis indicated an L-shaped relationship.Conclusions: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"45 1","pages":"2272581"},"PeriodicalIF":12.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0