Effects of time-restricted eating on blood pressure in children: A cluster randomized controlled trial.

IF 6.8 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2026-12-31 Epub Date: 2026-02-24 DOI:10.1080/10641963.2026.2635384

Xiaofei Wu, Jingkun Miao, Zhilian Peng, Xizhou An, Qin Liu, Lanling Chen, Xiaohua Liang

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引用次数: 0

Abstract

Background: This study aimed to evaluate the safety and efficacy of a time-restricted eating (TRE) intervention to reduce blood pressure (BP) in children and adolescents.

Methods: We conducted a 12-month, three-arm cluster-randomized controlled trial in two schools, with classes as the unit of randomization (91 classes). Children and adolescents with elevated BP were allocated to TREa (12-hour eating window with the last meal before 8:00 PM), TREb (12-hour eating window without a fixed last mealtime), or control (no time restriction). A total of 192 participants were enrolled and analyzed under an intention-to-treat framework (64 per group). Follow-up completion (retention) rates were 65.1% (125/192) at 6 months and 59.4% (114/192) at 12 months, corresponding to loss-to-follow-up rates of 34.9% (67/192) and 40.6% (78/192), respectively. Analyses used mixed-effects models accounting for clustering, with multiple imputations as a sensitivity analysis for missing data.

Results: After 12 months of intervention, both the TREa and TREb groups showed significant reductions in BP, with TREa demonstrating the most significant changes. Systolic blood pressure (SBP) decreased significantly in the TREa (-7.03 mmHg, 95%CI, -10.77 to -3.29 mmHg; P < 0.001) and TREb groups (-5.29 mmHg, 95%CI, -9.44 to -1.14 mmHg; P = 0.013). Diastolic blood pressure (DBP) changes in the TREa group were -4.09 mmHg (-6.80 to -1.38 mmHg; P < 0.001), with significantly different compared to the control group (P = 0.006).

Conclusions: A 12-hour eating window, particularly with the last meal completed before 8 PM, may be associated with lower BP over 12 months in children and adolescents with elevated BP; interpretation should consider the cluster design and attrition.

Trial registration: ChiCTR2400090073 (retrospectively registered on 23 September 2024).

查看原文本刊更多论文

限时饮食对儿童血压的影响：一项随机对照试验。

背景：本研究旨在评估限时饮食（TRE）干预降低儿童和青少年血压（BP）的安全性和有效性。方法：在两所学校进行为期12个月的三组随机对照试验，以班级为随机化单位（91个班级）。血压升高的儿童和青少年被分配到TREa（12小时进食窗口，最后一餐在晚上8点之前），TREb（12小时进食窗口，没有固定的最后一餐时间）或对照组（没有时间限制）。在意向治疗框架下，共招募了192名参与者（每组64名）进行分析。6个月随访完成率为65.1%(125/192)，12个月随访完成率为59.4%(114/192)，失访率分别为34.9%（67/192）和40.6%（78/192）。分析使用混合效应模型，考虑聚类，多重输入作为缺失数据的敏感性分析。结果：干预12个月后，TREa组和TREb组血压均显著降低，其中TREa组变化最为显著。TREa组收缩压（SBP）显著降低（-7.03 mmHg, 95%CI, -10.77 ~ -3.29 mmHg; P = 0.013）。TREa组舒张压（DBP）变化为-4.09 mmHg （-6.80 ~ -1.38 mmHg; P = 0.006）。结论：在血压升高的儿童和青少年中，12小时进食窗口期，特别是最后一餐在晚上8点之前完成，可能与血压升高的儿童和青少年在12个月内降低血压有关；解释应考虑聚类设计和损耗。试验注册：ChiCTR2400090073（回顾性注册于2024年9月23日）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.