Clinical and Experimental Hypertension最新文献

{"title":"FUNDC2 contributes to hypertensive vascular remodeling by regulating mitochondrial dynamics and ferroptosis in perivascular adipose tissue.","authors":"Yuanyuan Jin, Tingting Song, Tingting Jiang, Yongkang Wei, Yijie Bao, Zixuan Zhu, Ruizhe Zhou, Derun Wang, Yong Zhao, Huiying Li, Yu Fu","doi":"10.1080/10641963.2025.2610587","DOIUrl":"https://doi.org/10.1080/10641963.2025.2610587","url":null,"abstract":"<p><strong>Objective: </strong>Perivascular adipose tissue (PVAT) is closely related to the pathogenesis of vascular remodeling in hypertension. The objective of this study was to explore the specific molecular mechanisms underlying the role of PVAT in the onset and progression of hypertensive vascular remodeling.</p><p><strong>Methods: </strong>Thoracic aorta PVAT from male spontaneously hypertensive rats (SHRs) and male Wistar-Kyoto (WKY) rats was used for proteomic analysis, and the differential expression of the identified target proteins was verified by western blotting, immunohistochemistry and transmission electron microscopy (TEM). In vitro, FUN14 domain-containing 2 (FUNDC2) expression was knocked down in 3T3-L1 adipocytes to assess its effects on mitochondrial dynamics, ferroptosis, and adipokine secretion. Next, vascular smooth muscle cells (VSMCs) were cultured in the supernatant of the adipocytes to detect changes in their phenotypic switching and migration.</p><p><strong>Results: </strong>The proteomic results revealed that the expression of the outer mitochondrial membrane protein FUNDC2 was significantly upregulated in the PVAT of SHRs. Additionally, the expression of key proteins that regulate mitochondrial dynamics and ferroptosis was altered significantly in the PVAT of SHRs compared with the PVAT of WKY rats. Upon FUNDC2 knockdown in 3T3-L1 adipocytes, proteins related to mitochondrial dynamics, ferroptosis, and adipokines reversed the changes in their expression. Moreover, in VSMCs cultured with the supernatant of FUNDC2-knockdown adipocytes, the VSMC phenotype and migration changed.</p><p><strong>Conclusion: </strong>Our findings indicated that increased FUNDC2 expression might lead to PVAT dysfunction and abnormal adipokine secretion, potentially through its link to mitochondrial dynamics and ferroptosis in PVAT adipocytes, therefore leading to hypertensive vascular remodeling.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2610587"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANXA2, DBN1, ZNF385D, and IL6ST: Endothelial cell biomarkers linking atherosclerosis progression to immune microenvironment dysregulation.","authors":"Fenlong Xue, Ying Shi, Yuhui Zhang, Rangfei Zhu","doi":"10.1080/10641963.2026.2627352","DOIUrl":"https://doi.org/10.1080/10641963.2026.2627352","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis (AS) is a complex cardiovascular disorder driven by endothelial cell dysfunction and immune microenvironment dysregulation. We identified novel endothelial-related diagnostic biomarkers through multi-omics integration and machine learning approaches.</p><p><strong>Methods: </strong>Single‑cell atlas of AS was constructed from scRNA-seq data using the Seurat. Endothelial cell‑specific co‑expression modules and hub genes were identified via high-dimensional WGCNA (hdWGCNA), and key endothelial‑associated differentially expressed genes (DEGs) were obtained by integrating these modules with differential expression analysis. Diagnostic genes were screened using LASSO regression and SVM-RFE using glmnet and caret packages, respectively. Their correlations with immune cell infiltration were assessed by single-sample GSEA (ssGSEA) and the CIBERSORT algorithm. Finally, the binding capacity of the encoded proteins to potential therapeutic agents was evaluated through drug-target prediction using the Enrichr platform and the DSigDB database, followed by molecular docking simulations.</p><p><strong>Results: </strong>A total of 66 endothelial cell-associated DEGs were identified, from which four core feature genes (<i>ANXA2</i>, <i>DBN1</i>, <i>ZNF385D</i>, and <i>IL6ST</i>) were screened using machine learning approaches. Immune infiltration analysis revealed a global increase in immune cell infiltration (e.g., activated B cells, T cells, and macrophages) in atherosclerotic lesions, with the four genes showing significant correlations with specific immune subsets, while single-cell data further confirmed T cells, macrophages, and B cells as the predominant cellular components in the plaque microenvironment. Molecular docking results demonstrated strong binding capabilities of <i>ANXA2</i> with thalidomide and <i>IL6ST</i> with resveratrol, with binding energies of -6.7 kcal/mol and -7.4 kcal/mol, respectively.</p><p><strong>Conclusion: </strong>Our findings provided new insights for the targeted AS therapy.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2627352"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic determinants of hypertension: A meta-analysis of <i>AGTR1</i> and <i>CYP11B2</i> gene polymorphisms.","authors":"Sheena Mariam Thomas, Anu Shibi Anilkumar, Ramakrishnan Veerabathiran","doi":"10.1080/10641963.2026.2643329","DOIUrl":"https://doi.org/10.1080/10641963.2026.2643329","url":null,"abstract":"<p><strong>Background: </strong>Hypertension, or high blood pressure, is a long-lasting condition caused by sustained high blood pressure in the arteries. The increase and decrease of blood pressure is greatly affected by both dietary and physiological factors. Hence, hypertension may pose serious risks of developing multiple disorders, such as heart and vascular disorders and diabetes, since it is usually not detected for a long time, and thus, it can even speed up the development of some diseases.</p><p><strong>Objective: </strong>To examine how hypertension risk is related to the variants of the genes <i>AGTR1</i> (rs5186) and <i>CYP11B2</i> (rs1799998).</p><p><strong>Methods: </strong>The meta-analysis led us to search PubMed, Embase, ScienceDirect, NCBI, and Google Scholar for studies relevant to our objective. Case‒control analyses that identified a correlation between the mentioned SNPs and hypertension and provided sufficient data for OR (odds ratio) calculation were included. The rigor of the methodology was assessed using the Newcastle‒Ottawa Scale (NOS) and Hardy‒Weinberg equilibrium (HWE).</p><p><strong>Results: </strong>In total, 10 studies on AGTR1 (rs5186) and 12 on CYP11B2 (rs1799998) were considered. The polymorphism was examined for a correlation with hypertension risk under all genetic models (allelic, dominant, recessive, or overdominant), but no association was observed. Moreover, no significant findings were obtained from the analysis of publication bias and sensitivity testing.</p><p><strong>Conclusion: </strong>The <i>AGTR1 rs5186 and CYP11B2 rs1799998</i> polymorphisms did not show a statistically significant association with hypertension predisposition. A comprehensive study would be necessary to delineate the complex genetic landscape of hypertension.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2643329"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ApoB/ApoA-I ratio supersedes conventional lipids in predicting coronary artery disease and clinical phenotypes requiring revascularization.","authors":"Yuanyuan Jiang, Li He, Dongyu Hu, Kunmei Chen, Li Li, Jinxin Fu, Bingqing Zhou","doi":"10.1080/10641963.2025.2603463","DOIUrl":"https://doi.org/10.1080/10641963.2025.2603463","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) ratio as a biomarker for coronary heart disease (CHD) and its clinical phenotypes, beyond traditional lipid parameters.</p><p><strong>Methods: </strong>This single-center, case-control study analyzed 7,277 patients undergoing coronary angiography. Multivariable logistic regression assessed the independent association of the ApoB/ApoA-I ratio with CHD, acute myocardial infarction (AMI), multivessel disease (MVD), and percutaneous coronary intervention (PCI). Predictive performance was evaluated via ROC curve analysis, with prespecified subgroup analyses.</p><p><strong>Results: </strong>The ApoB/ApoA-I ratio was the strongest independent lipid predictor of CHD (adjusted OR 4.49, 95% CI 1.98-10.19). It significantly predicted severe clinical phenotypes: AMI (OR 1.94, 95% CI 1.44-2.62), MVD (OR 1.67, 95% CI 1.24-2.26), and PCI requirement (OR 1.95, 95% CI 1.43-2.66). The ratio showed significant discriminatory power for all endpoints (AUCs 0.569-0.608). Subgroup analyses revealed markedly stronger associations in males, older adults (≥60 years), and hypertensive patients, but substantially attenuated predictive value in diabetic patients.</p><p><strong>Conclusion: </strong>The ApoB/ApoA-I ratio is a superior biomarker for CHD risk stratification, particularly for identifying severe disease manifestations and guiding revascularization decisions in specific patient subgroups. Its integration into clinical practice could enable more precise cardiovascular risk management.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2603463"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of inflammatory and metabolic indices (HALP score, NLR, LMR, and TyG index) in healthy individuals, dipper, and non-dipper hypertensive phenotypes.","authors":"Huseyin Kandemir, Caglar Alp","doi":"10.1080/10641963.2026.2657358","DOIUrl":"https://doi.org/10.1080/10641963.2026.2657358","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the metabolic and inflammatory profiles of dipper and non-dipper hypertensive patients versus healthy controls, specifically evaluating the Triglyceride-glucose (TyG) index's association with nocturnal blood pressure patterns.</p><p><strong>Methods: </strong>This retrospective, cross-sectional study included 325 participants (110 normotensive controls, 106 dipper hypertensive, and 109 non-dipper hypertensive). Circadian blood pressure phenotypes were defined using 24-hour ABPM according to the 2024 ESC Hypertension Guidelines. Inflammatory indices (NLR, LMR, and HALP score) and the TyG index were calculated from fasting blood samples.</p><p><strong>Results: </strong>Hypertensive groups had higher BMI and waist circumference than controls (<i>p</i> < 0.001). HALP, NLR, and LMR did not differ between the cohorts (<i>p</i> > 0.05). The TyG index showed the greatest intergroup variation and was strongly associated with the non-dipper phenotype (OR = 3.6, <i>p</i> = 0.004). TyG was positively correlated with nocturnal SBP/DBP and negatively correlated with nocturnal SBP decline. It showed significant diagnostic performance for hypertension and non-dipper status (AUC 0.667-0.696, <i>p</i> < 0.001), but limited accuracy for classifying hypertensive subgroups (AUC = 0.573, <i>p</i> = 0.064).</p><p><strong>Conclusion: </strong>The TyG index serves as a significant independently associated with the non-dipper hypertension phenotype, reflecting predominant metabolic and cardio-renal stress rather than cellular inflammation. These findings suggest that clinical management should extend beyond blood pressure control to include early optimization of insulin resistance and atherogenic lipid imbalance. Ultimately, the TyG offers a practical and cost-effective clinical tool for multidimensional cardiometabolic and cardio-renal risk assessment.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2657358"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implications of aldosterone responsiveness to adrenocorticotropic hormone stimulation in two major subtypes of primary aldosteronism.","authors":"Daisuke Watanabe, Satoshi Morimoto, Noriko Morishima, Atsuhiro Ichihara","doi":"10.1080/10641963.2026.2637682","DOIUrl":"10.1080/10641963.2026.2637682","url":null,"abstract":"<p><strong>Objective: </strong>This study examined differences in aldosterone responsiveness to adrenocorticotropic hormone (ACTH) between the unilateral aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA) subtypes of primary aldosteronism (PA) and the impacts on vascular function and treatment outcomes.</p><p><strong>Methods: </strong>This retrospective study enrolled 97 patients with PA (63 with APA and 34 with IHA) who underwent adrenal venous sampling (AVS) with ACTH stimulation. During AVS, baseline and ACTH-stimulated plasma aldosterone concentration (PAC) and cortisol levels were also assessed. Vascular function was assessed by measuring flow-mediated dilation (FMD). APA tissues were analyzed for <i>KCNJ5</i> mutations.</p><p><strong>Results: </strong>Among 97 patients with PA, those with APA showed higher baseline and ACTH-stimulated plasma aldosterone concentration levels, which correlated inversely with FMD. In patients with IHA, the logarithmic difference between PAC measurements before and after ACTH stimulation correlated positively with the blood pressure-normalization effect after mineralocorticoid receptor antagonist (MRA) therapy, with a cutoff value of 2.140 for predicting treatment response.</p><p><strong>Conclusion: </strong>These findings suggest that ACTH-stimulated aldosterone may offer a useful marker for personalized management of PA, particularly in assessing vascular health and guiding MRA treatment.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2637682"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycyrrhetinic acid ameliorates chronic heart failure via the Nrf2 pathway.","authors":"Ruilei Zhang, Hou Zhang, Pengli Chen, Enwen Xu, Xueqi Li, Shiguang Li","doi":"10.1080/10641963.2025.2607404","DOIUrl":"https://doi.org/10.1080/10641963.2025.2607404","url":null,"abstract":"<p><strong>Objective: </strong>To explore the mechanism by which glycyrrhetinic acid (GA) alleviates chronic heart failure (CHF), focusing on NR3C1-mediated regulation of Nrf2 and oxidative stress.</p><p><strong>Methods: </strong>A CHF rat model was established via transverse aortic constriction and treated with GA or NR3C1 knockdown. Cardiac function, hypertrophy, fibrosis, and oxidative stress markers were evaluated. <i>In vitro</i>, H9c2 cells were treated with isoproterenol to mimic CHF and subjected to GA, Nrf2 inhibitor, or NR3C1 modulation. Gene/protein expression, ROS, GSH, MDA, and mitochondrial membrane potential were assessed. Regulatory interactions between NR3C1 and Nrf2 were examined using luciferase, ChIP-qPCR, and CHX assays.</p><p><strong>Results: </strong>GA alleviated myocardial hypertrophy and fibrosis in CHF rat models. GA also suppressed oxidative stress in CHF cell models. GA upregulated Nrf2 and its downstream target HO-1 at the protein level. NR3C1 was identified as a key upstream regulator of Nrf2, promoting its protein stability. NR3C1 knockdown decreased Nrf2 and HO-1 protein expression, disrupted mitochondrial membrane potential, and weakened the protective effects of GA against oxidative stress and cardiac dysfunction both <i>in vitro</i> and <i>in vivo</i>.</p><p><strong>Conclusion: </strong>GA alleviates CHF by enhancing NR3C1-mediated stabilization of Nrf2 and reducing oxidative stress.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2607404"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic index and advanced cardiovascular-kidney-metabolic syndrome in two population-based cohorts from the USA and China.","authors":"Huatao Zhou, Desong Yang, Wenxiang Wang, Chengming Fan","doi":"10.1080/10641963.2026.2652127","DOIUrl":"https://doi.org/10.1080/10641963.2026.2652127","url":null,"abstract":"<p><strong>Background: </strong>The cardiometabolic index (CMI) integrates central adiposity with atherogenic dyslipidaemia and may identify individuals at elevated cardiometabolic risk. However, evidence linking CMI to advanced cardiovascular-kidney-metabolic (CKM) syndrome across diverse populations remains limited.</p><p><strong>Methods: </strong>We conducted cross-sectional analyses on adults aged ≥ 45 years using data from NHANES (2001-2018) and CHARLS (2011/2015). CMI was calculated as (triglycerides/HDL-cholesterol) × (waist/height). The primary outcome was advanced CKM (stages 3-4). Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines and two-piecewise regression assessed non-linearity and thresholds.</p><p><strong>Results: </strong>The analytic sample included 10,198 participants from NHANES and 17,285 from CHARLS. Higher CMI was independently associated with advanced CKM (NHANES: OR 1.35, 95% CI 1.15-1.57; CHARLS: OR 1.86, 95% CI 1.70-2.04). In quartile analyses, the highest CMI quartile demonstrated the strongest associations compared to the lowest (NHANES: OR 1.72, 95% CI 1.30-2.26; CHARLS: OR 3.33, 95% CI 2.85-3.89). While the relationship was linear in NHANES, it was non-linear in CHARLS (<i>P</i> < 0.001), with a threshold effect at CMI = 0.509. Below this threshold, risk increased sharply (OR 3.879, 95% CI 2.137-7.040), whereas above it, the association was attenuated but remained significant (OR 1.528, 95% CI 1.360-1.717).</p><p><strong>Conclusions: </strong>CMI was associated with an increased risk of advanced CKM in two large, nationally representative cohorts. These findings support the potential utility of CMI in risk stratification. Future prospective studies are needed to confirm its predictive value and define clinically relevant thresholds.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2652127"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presenting non-insulin-based indices of insulin resistance relevant to pre-hypertension: A systematic review and meta-analysis.","authors":"Maryam Farahmand, Sima Nazarpour, Hanieh Malmir, Somayeh Hosseinpour-Niazi, Fahimeh Ramezani Tehrani","doi":"10.1080/10641963.2026.2625124","DOIUrl":"https://doi.org/10.1080/10641963.2026.2625124","url":null,"abstract":"<p><strong>Background: </strong>Using reliable, simple, and cost-effective tools to identify pre-hypertension (pre-HTN) early is crucial for reducing the risk of cardiovascular disease (CVD). This systematic review and meta-analysis aimed to assess the association between the risk of pre-HTN and non-insulin-based indices.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across electronic databases, including PubMed, Web of Science, and Scopus, until January 2025. Cross-sectional studies investigating the relationship between pre-HTN and IR indices were included. Two investigators independently performed study screening, data extraction, and quality assessment. A random-effects model was used to pool effect sizes, with odds ratios (ORs) as the primary measure of effect.</p><p><strong>Results: </strong>Overall, 15 studies met the inclusion criteria for this systematic review, and 14 were included in the meta-analysis. All were cross-sectional or employed a cross-sectional approach. The results of the random effects model showed that IR indices, including the fasting triglyceride and glucose index-to-body mass index (TyG-BMI), fasting triglyceride and glucose index-to-waist circumference (TyG-WC), triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C), metabolic score for insulin resistance (METS-IR), and fasting triglyceride and glucose index (TyG), increased the odds of pre-HTN significantly (<i>P</i> < 0.05). The diagnostic odds ratios (DORs) were 2.67 (95% CI: 2.39-2.97) for TyG and 3.45 (95% CI: 2.73-4.35) for TyG-BMI.</p><p><strong>Conclusions: </strong>This meta-analysis reveals that non-insulin-based IR indices are associated with a higher risk of pre-HTN. However, given the cross-sectional design of all included studies, a causal relationship cannot be inferred. As cost-effective and user-friendly tools, they could aid in the early detection and prevention of HTN, but further prospective and longitudinal research is needed to confirm these findings and establish causality.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2625124"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of blood pressure dipping status with Naples Prognostic Score and arterial stiffness in newly diagnosed hypertensive patients.","authors":"Muhammed Ulvi Yalcin, Kadri Murat Gurses, Abdullah Tuncez, Huseyin Tezcan, Yasin Özen, Halil Ozalp, Tugay Dedebali, Mustafa Abdullah Kebude, Muhammet Salih Ates, Bulent Behlul Altunkeser","doi":"10.1080/10641963.2026.2627333","DOIUrl":"https://doi.org/10.1080/10641963.2026.2627333","url":null,"abstract":"<p><strong>Background: </strong>Abnormal circadian blood pressure variation, particularly a non-dipper pattern, is associated with increased cardiovascular risk. Naples Prognostic Score (NPS) is a laboratory-based score that reflects the immune-inflammatory and nutritional status. Nevertheless, data regarding the relationship between NPS, circadian blood pressure patterns, and arterial stiffness in patients with newly diagnosed hypertension are limited. This study aimed to evaluate the relationship between blood pressure dipping status, the NPS, and arterial stiffness assessed by pulse wave velocity (PWV).</p><p><strong>Methods: </strong>This retrospective study included 297 newly diagnosed, untreated hypertensive patients who underwent 24-hour ambulatory blood pressure monitoring. Patients were classified as dipper (<i>n</i> = 145) or non-dipper (<i>n</i> = 152) according to nocturnal blood pressure decline. Laboratory parameters were recorded, NPS was calculated, and PWV was measured using a validated oscillometric device. Multivariate logistic regression analysis was performed to identify factors independently associated with non-dipper hypertension.</p><p><strong>Results: </strong>Non-dipper patients had significantly higher median NPS values compared with dippers [2 (0-4) vs. 1 (0-4), <i>p </i>< 0.001] and a higher prevalence of high NPS (score 3-4: 42.8% vs. 13.8%, <i>p </i>< 0.001). Median PWV was also significantly higher in the non-dipper group [7.70m/s (4.70-12.90) vs. 7.00m/s (4.40-11.20), <i>p</i> = 0.005]. After adjustment for clinically relevant covariates, both NPS (OR 1.71, 95% CI 1.19-2.47; <i>p</i> = 0.004) and PWV (OR 1.37, 95% CI 1.12-1.68; <i>p</i> = 0.002) were independently associated with non-dipper hypertension.</p><p><strong>Conclusion: </strong>In patients with newly diagnosed hypertension, a non-dipper blood pressure pattern is independently associated with higher systemic inflammatory burden and increased arterial stiffness. The NPS may serve as a simple and clinically applicable marker for early cardiovascular risk stratification in this population.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":"48 1","pages":"2627333"},"PeriodicalIF":3.5,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}