L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2025-12-01 Epub Date: 2025-07-12 DOI:10.1080/10641963.2025.2515924

Gary S Bird, Yu-Ping Lin, Charles J Tucker, Geoffrey Mueller, Min Shi, Sandosh Padmanabhan, Anant B Parekh

引用次数: 0

Abstract

Amlodipine has been used as a front-line anti-hypertensive therapy for decades by virtue of blocking voltage-operated calcium channels with high affinity and specificity. Recently, the safety of amlodipine has been questioned, as it was reported to activate Ca²⁺ release-activated Ca²⁺ (CRAC) channels and increase the risk of heart failure. Here we show, using a variety of approaches, that amlodipine does not activate CRAC channels at therapeutic concentrations. Combined with our previous meta-analysis, our study should reassure physicians that amlodipine should continue to be prescribed for treating hypertension.

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治疗浓度的l型钙通道阻滞剂与CRAC通道和心力衰竭无关。

氨氯地平作为一线抗高血压药物已有几十年的历史，因为它具有高亲和力和特异性阻断电压操作钙通道的作用。最近，氨氯地平的安全性受到质疑，因为有报道称它会激活Ca2+释放激活的Ca2+ (CRAC)通道并增加心力衰竭的风险。在这里，我们使用多种方法表明，氨氯地平在治疗浓度下不会激活CRAC通道。结合我们之前的荟萃分析，我们的研究应该让医生放心，氨氯地平应该继续作为治疗高血压的处方。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.