Clinical and experimental obstetrics & gynecology最新文献

{"title":"Is Red Blood Cell Distribution Width (RDW) a Negative Predictor of Repeated Implantation Failure?","authors":"Özlem Kayacık Günday, Oya Aldemir, Runa Özelçi, Serdar Dilbaz, Emre Başer, Özlem Moraloğlu Tekin","doi":"10.31083/j.ceog5010214","DOIUrl":"https://doi.org/10.31083/j.ceog5010214","url":null,"abstract":"Background: Repeated implantation failure (RIF) after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) can be a devastating reality for some patients with infertility. Our objective was to evaluate the potential role of the complete blood count (CBC) parameters, on treatment outcome in patients with repeated IVF implantation failure. Methods: This retrospective clinical study, involving a total of 173 patients, consisted of 64 patients with RIF who underwent a fresh IVF-ET cycle, underwent 3 or more IVF cycles, and 109 patients in the control group who became pregnant in the first IVF-ET cycle. Results: Duration of infertility, number of grade 2 embryos and red cell distribution width (RDW) were significantly higher in RIF patients (p < 0.001, p < 0.001, p = 0.02). The number of 2 pronucleus (PN) showed a significant positive correlation with the fertilization rate (FR) (r: 0.6; p < 0.001). To understand the effects of CBC parameters on FR, the model established with the number of RDW, number of grade 2 embryos and the number of 2 PN proved to be significant (ANOVA, p < 0.001). Conclusions: RIF patients have higher RDW, longer duration of infertility, and higher number of grade 2 embryos. Elevated RDW may negatively impact FR. The number of 2 PN increased FR.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136039734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Tumour Progression of ID-8 Syngeneic Mouse Ovarian Cancer with Blood Biomarkers of CA-125, IL-6 and VEGF: A Prospective Laboratory-Based Study","authors":"Kenny Chitcholtan, Arron Dyer, Peter Sykes","doi":"10.31083/j.ceog5010212","DOIUrl":"https://doi.org/10.31083/j.ceog5010212","url":null,"abstract":"Background: A preclinical animal model is an imperative tool for uncovering and understanding the tumourigenic hallmarks of human ovarian cancer; the disease is often lethal because it is commonly diagnosed in the advanced stage, where widespread cancer nodules mainly reside within peritoneal regions. Mouse models as a xenograft tumour host or genetic manipulation ovarian cancer-derived mice are widely used for studying specific hypothesis rationale in ovarian cancer. However, limited information associated with disease progression is obtained from such studies; whether it is the best model to study advanced ovarian cancer phenotype or suitable preclinical biomarkers for detecting and monitoring ovarian cancer progression is under study. This study used an ID-8 syngeneic mouse ovarian cancer model with immunocompetence. We monitored cancer growth and development using combination modalities of cancer-specific cancer antigen-125 (CA-125), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) blood markers, which are well-known for their association with tumour progression in humans. Methods: Ten C57/BL6 female mice were intraperitoneally implanted with ID-8 Trp53 wild-type and monitored the progression of the tumour, until mice developed clinical ascites. Blood was taken at the time of intraperitoneal (IP) implantation (Day 0) and then collected weekly, and levels of biomarkers were analysed with enzyme-linked immunosorbent assay (ELISA). In addition, tumour tissue was collected and proceeded with histological staining. Results: We found that blood biomarkers CA-125, IL-6 and VEGF were not readily correlated with tumour progression. However, these biomarkers were markedly elevated in ascitic fluid at the advanced stage of the disease. Conclusions: We conclude that blood biomarkers in a syngeneic mouse model are, to some extent, not readily found in the blood as opposed to human ovarian cancer. Model anatomical and physiological differences between rodents and humans might explain this discrepancy.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"172 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Endometrial Cancer: Molecular Identikit and Tailored Therapeutic Approach","authors":"Ottavia D'Oria, Andrea Giannini, Aris Raad Besharat, Donatella Caserta","doi":"10.31083/j.ceog5010210","DOIUrl":"https://doi.org/10.31083/j.ceog5010210","url":null,"abstract":"IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to making positive contributions to academics, corporate libraries as well as to readers and authors. All the editors in IMR Press will provide the best service for researchers, allowing them to have a easy and smooth publication experience and helping maximize the impact and visibility of their research.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136014520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Noninvasive Cardiac Output Monitor (NICOTM) and Hemodynamic Monitor in Neonates","authors":"Fengying Li, Wenbin Dong","doi":"10.31083/j.ceog5010211","DOIUrl":"https://doi.org/10.31083/j.ceog5010211","url":null,"abstract":"Objective: Hemodynamic monitoring plays a crucial way in guiding the clinical decision-making process for the management of critically ill neonates. Noninvasive hemodynamic monitoring is characterized by continuous, convenient, and accurate assessment, presenting a viable option for implementation in neonatal intensive care units (NICU). This review article summarizes the research advancements made in noninvasive hemodynamic monitoring and electronic cardiometry (EC) applications in neonates, providing valuable reference resource for studies in the field of hemodynamic monitoring. Mechanism: The clinical significance of hemodynamic monitoring in neonates is first introduced and followed by a comprehensive description of both invasive and noninvasive techniques employed in hemodynamic monitoring. Furthermore, the research progress of EC in neonates is discussed, focusing particularly on its feasibility and accuracy. Finally, the application and influencing factors of EC in diverse diseases, encompassing neonatal conditions, are presented. Findings in Brief: Due to the risks associated with invasive cardiac output monitoring, noninvasive or minimally invasive alternative techniques are needed for hemodynamic monitoring. In recent years, noninvasive and minimally invasive techniques, such as ultrasound cardiac output monitor (USCOM) and impedance cardiography have been utilized. EC, as an impedance-based monitoring, facilitates noninvasive and real-time assessment of hemodynamic parameters. The integration of EC enables real-time and continuous monitoring of dynamic changes in cardiac and vascular functions in patients, thereby assisting in clinical evaluation and guiding the clinical decision-making. Conclusion: EC is a noninvasive, highly sensitive, and accurate monitoring technique that holds important guiding significance in clinical practice.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136014740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Uterocervical Angle and Prediction of Preterm Labor in Cases with an Inconclusive Cervical Length: A Prospective Cohort Pilot Study","authors":"İlgi Esen, İbrahim Kale, Ebru Alıcı Davutoğlu, Merve Dizdar, Rahime Nida Bayık","doi":"10.31083/j.ceog5010205","DOIUrl":"https://doi.org/10.31083/j.ceog5010205","url":null,"abstract":"Background: Cervical length measurement is still the most widely used method to predict preterm labor. Recent studies have reported that in addition to cervical length, uterocervical angle (UCA) may also be useful in predicting preterm labor. The main purpose of this study was to evaluate the use of the anterior UCA to predict preterm labor in symptomatic pregnant women with a cervical length of 20 to 30 mm. Methods: In this prospective cohort study, 48 patients with a cervical length of 20 to 30 mm who applied to the emergency department with any preterm labor symptoms, between September 2019 and February 2020, were included as the study group. Cervical length and anterior UCA were measured at the first admission. Of these 48 patients, 12 patients who gave birth before 37 weeks were called the ‘preterm labor group’, and 36 patients who gave birth at 37 weeks or later were named the ‘preterm threatened but delivered at term’ group. The control group consisted of 46 healthy pregnant women who were matched with the study group in terms of age, body mass index (BMI), and the gestational week at which anterior UCA was measured. The three groups were compared in terms of anterior UCA values. Results: The cervical lengths of the ‘preterm labor’ and ‘preterm threatened but delivery at term’ groups were similar and shorter than the control group (25.4 mm, 25.1 mm, and 35 mm, respectively, p < 0.001). Anterior UCA value in the ‘preterm labor’ group (116.1) was found to be significantly higher than both ‘preterm threatened but delivered at the term’ group (100.2) and the control group (98.6) (p = 0.001). Receiver operating curve (ROC) analysis was performed to determine a threshold value of anterior UCA that could predict preterm labor in symptomatic pregnant women with a cervical length of 20 to 30 mm. Area under curve (AUC) analysis of anterior UCA for estimation of preterm labor was 0.647 (p = 0.014, 95% confidence interval (CI) = 0.52–0.77). According to this analysis, the threshold value of anterior UCA was determined as 95.3, with 72% sensitivity, and 63% specificity. Conclusion: The anterior UCA can be used to better predict preterm labor in symptomatic pregnant women with a cervical length of 20 to 30 mm without cervical effacement and dilation.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine Rupture during Pregnancy: Can Laparoscopy be Performed Safely and Effectively?","authors":"Mustafa Gazi Uçar, Abdül Hamid Güler, Tolgay Tuyan İlhan, Feyza Nur Çintesun, Çetin Çelik, Mehmet Kulhan","doi":"10.31083/j.ceog5010202","DOIUrl":"https://doi.org/10.31083/j.ceog5010202","url":null,"abstract":"Background: The main purpose of this study was to investigate the feasibility and safety of performing a laparoscopic intervention for the conservative management of uterine rupture (UR) during pregnancy. This study also provides a brief overview on the challenges and understanding of the management of UR in pregnancy. Methods: Patients diagnosed with UR between 2011–2021 at Selçuk University, Faculty of Medicine were evaluated, retrospectively. The reproductive history, clinical characteristics, UR symptoms and signs, predisposing factors, operative findings, complications and outcomes were assessed. The choice of treatment was determined according to the patients’ age, fertility desire, the severity of disease, and hemodynamic status. A variety of options ranging from surgical rupture repair, to hysterectomy via minimally invasive surgery or laparotomy, were employed. Laparotomy was preferred in all patients with viable fetuses, and in those with hemodynamic instability. Results: A total of 23 cases of UR were operated over a 10-year period. Nine of them underwent laparoscopic surgery and the remaining 14 underwent laparotomy. The presenting signs and symptoms of UR, in order of decreasing frequency were: abdominal pain, vaginal bleeding, fetal distress/demise, non-reassuring fetal status, signs of hemodynamic changes, elevation of the fetal presenting parts and/or the absence of station changes with contractions, and the early detection of hemoperitoneum on ultrasound. The primary risk factors for UR were a history of uterine surgery, use of misoprostol during abortion and labor, obstructed labor, curettage, congenital uterine malformations and trauma. Total ruptures included 17 in the lower segment (Kerr incision) and 6 outside the lower segment. There were considerable differences in the incidence of Kerr incision site ruptures and UR in other sites. The major complication rates were higher in ruptures outside the lower segment (6/6, 100%) than lower segment ruptures (5/17, 29.4%). Hysterectomy rates in lower segment ruptures and other rupture sites were 5/17 (29.4%) and 4/6 (66.6%), respectively. Kerr incision site ruptures are easier to manage and with less catastrophic complications compared to cases of UR after trauma, and those of unscarred uteri or those with a history of uterine scars other than from a Kerr incision. Conclusions: This study provides evidence of the safety and feasibility of laparoscopic management of UR, and this may encourage surgeons to consider minimally invasive surgery in hemodynamically stable patients prior to more aggressive and radical treatments. With the appropriate skill set, laparoscopy may be considered the preferred route of intervention, even in potentially life-threatening conditions such as UR.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Identification of Relevant Factors for Breastfeeding Techniques in Postpartum Women Before Discharge in China: A Cross-Sectional Study","authors":"Sen Li, Dan Zhu, Guoli Liu","doi":"10.31083/j.ceog5010209","DOIUrl":"https://doi.org/10.31083/j.ceog5010209","url":null,"abstract":"Background: To assess breastfeeding techniques and identify the relevant factors among postpartum women in hospital. Methods: A cross-sectional study was conducted from March, 2022 to April, 2022 at a general hospital in China. A total of 331 postpartum women were investigated using a questionnaire survey that included the LATCH (latch, audible swallowing, type of nipple, comfort, and hold) scoring system, a general information and behavior questionnaire, a breastfeeding knowledge questionnaire, and the Chinese version of the maternal breastfeeding evaluation scale. Multiple regression analysis was used to identify independent factors for in-hospital breastfeeding techniques. Results: The average score for breastfeeding techniques before discharge was 7.88. In the bivariate analysis, the factors found to be significantly associated with scores for breastfeeding technique were parity, number of births, participation in online antenatal classes during pregnancy, mastery of the hand expression technique, nipple cracking and satisfaction with breastfeeding (each p < 0.05). The result displayed parity, participation in online antenatal classes, and satisfaction with breastfeeding were included in a multiple linear regression model (p < 0.05). Conclusions: Although breastfeeding techniques prior to discharge are improving, more improvements can be made. Clinical medical staff should therefore pay particular attention to primiparas, postpartum women who did not participate in online antenatal courses during pregnancy, and postpartum women with a low satisfaction for breastfeeding. Measures that promote breastfeeding techniques, publicize online antenatal training courses, provide breastfeeding guidance shortly after delivery, and provide timely evaluation and targeted guidance should help to improve breastfeeding techniques before discharge and increase the exclusive breastfeeding rate.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy Analysis of Cervical Cerclage in the Treatment of Cervical Insufficiencies","authors":"Qinghua Zhang, Yansong Liu, Changsheng Xu","doi":"10.31083/j.ceog5010207","DOIUrl":"https://doi.org/10.31083/j.ceog5010207","url":null,"abstract":"Background: This study aimed to assess the efficacy and safety of laparoscopic and transvaginal cervical cerclage treatments in patients with cervical insufficiency before and during pregnancy. Methods: A total of 70 patients diagnosed with cervical insufficiency and undergoing cervical cerclage at the Second Affiliated Hospital of Xinjiang Medical University between January 2020 and December 2022 were included. The patients were divided into three groups based on different surgical methods: transvaginal loop during pregnancy (Group 1, n = 30), transabdominal loop before pregnancy (Group 2, n = 20), and transabdominal loop during pregnancy (Group 3, n = 20). The groups were compared in terms of general clinical data, operation time, intraoperative bleeding, hospital stay, delivery gestational weeks, preterm delivery rate, prolonged gestational weeks, and neonatal births. Results: (1) There were no statistically significant differences in age, pregnancy, delivery, number of miscarriages, cervical length, and history of midterm pregnancy loss among the three groups (p > 0.05). (2) Prolonged gestational week, delivery gestational week, term delivery, and neonatal birth weight were higher in Groups 2 and 3 compared to Group 1, with statistically significant differences (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing Group 2 and Group 3. Premature rupture of membranes and preterm delivery were higher in Group 1 compared to Groups 2 and 3, with statistically significant differences (p < 0.05). There was no statistically significant difference when comparing Group 2 and Group 3 (p > 0.05). (3) The amount of surgical bleeding and surgical time showed statistically significant differences (p < 0.05) among the three groups. Group 1 had more surgical bleeding than Groups 2 and 3, with statistically significant differences (p < 0.05). When comparing Group 2 and Group 3, Group 3 had more surgical bleeding than Group 2, with a statistically significant difference (p < 0.05). Group 2 had a shorter surgical time than Group 1 and Group 3, with statistically significant differences (p < 0.05). When comparing Group 1 and Group 3, Group 3 had a longer surgical time than Group 1, with a statistically significant difference (p < 0.05). There was no statistically significant difference in hospital stay when comparing three groups (p > 0.05). Conclusions: Laparoscopic cervical cerclage is a safe and effective treatment option, yielding better pregnancy outcomes than transvaginal cervical cerclage, particularly for patients with previous failed transvaginal cerclage. Preconception laparoscopic cervical cerclage carries lower surgical risks and should be considered for clinical application.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135146352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of an Immune Cell Infiltration-Related Prognostic Model to Guide Immunotherapy in Endometrial Carcinoma","authors":"Haijun Zhu, Fangjia Luo, Wanhong He, Sufen Zhang, Jing Chen, Liyun Sun, Xiaohua Ni, Qihan Wu","doi":"10.31083/j.ceog5010204","DOIUrl":"https://doi.org/10.31083/j.ceog5010204","url":null,"abstract":"Background: Uterine corpus endometrial carcinoma (UCEC) is a prevalent gynaecologic malignancy. It has been demonstrated that the immune cell infiltration (ICI) pattern plays a critical role in the tumour progression of UCEC. Methods: To further investigate the immune microenvironment landscape of UCEC, we analysed the gene expression data of 539 UCEC patients from The Cancer Genome Atlas (TCGA) database using CIBERSORT and ESTIMATE for consensus clustering of immune cells. We used the limma package to compare differentially expressed genes (DEGs) among ICI patterns and constructed a prognostic model using Cox regression to calculate the risk score of UCEC patients. The immunophenoscore was downloaded to explore the immunotherapeutic effect between low- and high-risk score patients. Finally, the tumour mutation burden (TMB) was calculated using the somatic mutation data. Results: We identified two different immune infiltration patterns in 539 UCEC samples, the immune-desert and immune-inflamed phenotypes, which had distinct prognostic and biological features. We obtained 29 DEGs to construct the ICI-related prognostic model and established a four ICI-related gene-based prognostic model comprising LINC01871, CXCL13, IGKJ5, and LINC01281. The risk score was associated with distinct clinical outcomes, ICI, and immunotherapeutic effects. Patients with a low risk score had higher effective immune cells, which could be classified into the immune-inflamed phenotype. Additionally, patients with a low risk score had a significantly higher immunophenoscore, suggesting a better immunotherapeutic outcome. Finally, TMB was confirmed to be associated with prognosis, which was synergistic with the risk score. Conclusions: This study comprehensively analysed the ICI pattern in UCEC patients and established a four ICI-related gene-based prognostic model to predict prognosis and guide precise immunotherapy strategies.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Response to Fertility Decisions of Married and Parous Women with Unexpected Pregnancy: A Three Month Study at Tertiary Suzhou Hospital, China","authors":"Ying Zhang, Aiying Jin, Jiao Zhu, Jinhua Zhou, Jianzheng Cai, Yuqing Liu, Wenjie Sui","doi":"10.31083/j.ceog5010208","DOIUrl":"https://doi.org/10.31083/j.ceog5010208","url":null,"abstract":"Background: Unwanted pregnancies cause some type of stress in women, which negatively impacts their way of life. It is important to recognize this type of stress and consider potential interventions. We aimed to comprehend the factors influencing married and parous women’s fertility decisions facing pregnant unintentionally, to provide a reference point for health care, and policy development. Methods: 44 married and parous women with unintended pregnancies who visited a tertiary hospital in Suzhou from May 2021 to July 2021 were chosen using a combination of purposive and theoretical sampling techniques for semi-structured, open-ended interviews. The Lazarus stress-coping model was used to construct the central theme of the analysis, which was “stress-coping style for fertility decision-making among married and parous women with unwanted pregnancy”. The model is divided into three stages: identifying re-fertility stressors, assessing re-fertility coping skills, and making decisions. Results: It takes the combined efforts of society, healthcare, families, and couples to ensure that married and parous women feel secure about having another child. Social support, medical care, and family sharing are all significant factors in the decision to have a child with an unwanted pregnancy. Conclusions: To increase people’s internal motivation to have more children and to support balanced population development, we must first create a healthy and favorable environment for fertility in society.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}