Clinical and experimental obstetrics & gynecology最新文献

{"title":"Antagonistic Relationship of Interferon-Inducible Protein 10 and Lipoxin A4 in HTR-8-SVneo Cells: A Pilot Study","authors":"Jianfang null Wang, Chunxiao Fang, Limei null Quan, Yi null Zhou","doi":"10.31083/ceog45439","DOIUrl":"https://doi.org/10.31083/ceog45439","url":null,"abstract":"Background: Proper invasion and growth of trophoblast cells are crucial for the prevention of preeclampsia. This pilot study, conducted with a small sample size, focused on the regulatory effects of interferon-inducible protein 10 (IP-10) and lipoxin A4 (LXA4) on HTR-8-SVneo trophoblast cells. Methods: A total of 5 patients with preeclampsia and 5 normotensive pregnant women were enrolled in this study. Serum and placental levels of IP-10, LXA4, and the LXA4 receptor (ALX) were measured. Both IP-10 and ALX were silenced in HTR-8-SVneo cells. The effects on HTR-8-SVneo cell behaviors were assessed using wound healing assay, transwell assay, colony formation assay, Cell Counting Kit-8 (CCK8) assay, flow cytometry, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL) staining. Inflammatory and oxidative stress markers were measured using biochemical assay. Apoptosis-related proteins were measured via western blotting. Results: High levels of IP-10 and low levels of LXA4, accompanied by decreased ALX expression, were observed in patients with preeclampsia. IP-10 knockdown significantly stimulated the invasion, migration and proliferation of HTR-8-SVneo cells while inhibiting apoptosis, whereas ALX silencing exerted the opposite effects. Silencing of IP-10 or ALX also produced opposing effects on the regulation of oxidative stress and inflammation in HTR-8-SVneo cells. Conclusions: Although this pilot study has a small sample size (n = 5 per group) and inherent limitations, it provides noteworthy preliminary evidence of an antagonistic relationship between IP-10 and LXA4 in HTR-8-SVneo cells.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"52 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://storage.imrpress.com/IMR/2004069863669207000/application/2709-0094-52-12-45439.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yam Polysaccharide Ameliorates High-Fat and Fructose Diet-Induced Gestational Diabetes Mellitus in Mice via Gut Microbiota Remodeling","authors":"Simin null Zhao, Zekun null Deng, Bingfeng null Xing, Xueying null Hu, Wenkai null Xu, Min null Hong, Pingping null Jiang","doi":"10.31083/ceog45098","DOIUrl":"https://doi.org/10.31083/ceog45098","url":null,"abstract":"Background: Yam Polysaccharide (YP) is a major bioactive component extracted from the common yam rhizome and has been shown to have an antidiabetic effect. Previous research has demonstrated the association between gut microbiota (GM) and gestational diabetes mellitus (GDM); however, whether GM is essential for mediating the antidiabetic effects of YP in GDM remains unclear. Method: A high-fat and fructose diet (HFD) was administered to mice before and after pregnancy to induce GDM. An oral glucose tolerance test (OGTT) was performed, and the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated to evaluate glucose metabolism. The GM composition was analyzed using 16S rRNA sequencing. Results: During pregnancy, mice fed an HFD exhibited significant weight gain accompanied by impaired glucose tolerance. These metabolic disturbances were alleviated by YP treatment. Furthermore, consuming an HFD induced marked alterations in GM diversity compared to the control group, characterized by increased abundance of Alloprevotella and decreased abundance of the Lachnospiraceae NK4A136 group. Importantly, YP administration reversed these HFD-induced microbial changes. Conclusions: These findings suggest that modulation of the GM is one mechanism underlying the antidiabetic effects of YP in GDM.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"52 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://storage.imrpress.com/IMR/2002989923569864700/application/2709-0094-52-12-45098.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol Alleviates Polycystic Ovary Syndrome Symptoms by Reducing Inflammation, Oxidative Stress, and Ferroptosis Features in a Mouse Model: A Prospective Study","authors":"Jiao Cai, Fengqi Wan, Jumei Yang, Yalan Wang, Jiao Wang","doi":"10.31083/ceog41496","DOIUrl":"https://doi.org/10.31083/ceog41496","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is related to persistent low-grade inflammation and oxidative stress (OS). Resveratrol (RSV) exhibits potent anti-inflammatory and antioxidant effects, suggesting therapeutic potential for PCOS. However, its precise mechanisms of action, particularly concerning ferroptosis remain unclear. This study aimed to investigate whether RSV ameliorates PCOS by modulating inflammation, OS and ferroptosis features, thereby offering novel insights into its therapeutic role. Methods: PCOS was induced in mice through once-daily subcutaneous dosing of dehydroepiandrosterone (DHEA: 0.6 mg/kg), alongside a 21-day continuous high-fat diet regimen. Following successful model induction, the mice were assigned to the PCOS group or the RSV group. RSV was orally gavaged at doses of 20 and 40 mg/kg/day for 30 days. The body weight, ovarian weight and estrous cycle were monitored. Serum is used for the detection of hormones [follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T) and inflammatory markers [interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)]. Then the ovarian tissue samples were utilized for the assessment of OS indicators [malondialdehyde (MDA), glutathione (GSH)], glutathione peroxidase 4 (GPX4), and transcriptomic profiling. Results: RSV was shown to reduce body weight and ovarian weight. RSV also ameliorated symptoms of PCOS by decreasing chronic inflammation, OS and ferroptosis features in the ovaries. All the detected inflammatory factors in the PCOS group were significantly higher than those in the control group (IL-1β, p < 0.0001; IL-6, p < 0.001; TNF-α, p < 0.01) and were significantly decreased with the supplementation of RSV. Ovarian tissue MDA levels were markedly elevated in PCOS mice compared to controls (p < 0.0001), with RSV treatment significantly attenuating this increase. While GSH levels were significantly depleted in PCOS ovaries compared to controls (p < 0.0001), with RSV treatment effectively restoring concentrations. Western blot analysis revealed that GPX4 expression in ovaries was significantly diminished in the PCOS group compared with the control group (p < 0.01), but this reduction was effectively reversed by RSV treatment. Conclusions: RSV demonstrated therapeutic efficacy in PCOS mice by normalizing hormonal profiles and mitigating chronic inflammatory responses and oxidative damage. Furthermore, our investigation also revealed that RSV ameliorates PCOS pathology by modulating GPX4 pathways, which is consistent with ferroptosis features.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"52 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://storage.imrpress.com/IMR/1996759515652001800/application/2709-0094-52-11-41496.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidate Biomarkers for Intrauterine Adhesions Identified by Label-Free Quantitative Proteomics","authors":"Feiyan Li, Congxin Zhu, Jingxuan Ye, Yiwen Ren, Yong Li","doi":"10.31083/ceog27913","DOIUrl":"https://doi.org/10.31083/ceog27913","url":null,"abstract":"Background: The molecular mechanisms of intrauterine adhesions (IUA) are not yet fully understood, and there is a lack of specific diagnostic markers and effective molecularly targeted treatments in clinical practice. This study employed proteomic techniques to analyze differentially expressed proteins (DEPs) and associated signaling pathways in pathological tissues, aiming to identify potential diagnostic markers and therapeutic targets. Methods: This study collected 15 endometrial tissue samples from 10 patients treated at Changzhou Maternity and Child Health Care Hospital from March 2022 to September 2022. The tissue samples were divided into 3 groups: the adhesion group (Adhes group), the peri-adhesion endometrial group (Endome group), and the control group (Control group). Pairwise comparisons of the three groups were performed. Label-free quantitative (LFQ) proteomics was used to identify DEPs, and bioinformatics analyses, such as the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and protein domain analysis, were employed to identify the functions and pathways of DEPs. Parallel reaction monitoring (PRM) was used for the quantitative analysis of selected target proteins. Results: 1328, 290, and 1335 DEPs were found in the Adhes vs Control, Endome vs Control, and Adhes vs Endome groups, respectively. Bioinformatics analysis showed that these proteins are primarily involved in key processes such as muscle contraction, cytoskeletal dynamics balance, extracellular matrix (ECM) remodeling, and immune regulation. PRM validation identified out 14 target proteins, among which ADIPOQ, TGFB1, MYLK, and CAMK2G were closely associated with ECM remodeling and cytoskeletal regulation, while lactoferrin (LTF) was involved in immune regulation. Conclusions: This study identified a series of key proteins associated with IUA and found that they may participate in the disease process through mechanisms such as ECM remodeling, actin cytoskeleton regulation, and immune regulation. The identified target proteins (such as ADIPOQ, TGFB1, MYLK, and CAMK2G) provide potential biomarkers and intervention targets for the diagnosis and treatment of IUA.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"52 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.imrpress.com/journal/CEOG/52/3/10.31083/CEOG27913/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial","authors":"Haiyan Shan, Mingyuan Xu, Jie Ni, Ling Zhou, Meng Xue, Jun Xue, Xiaohuan Yuan, Luyang Tao, Mingyang Zhang, Hong Zhang","doi":"10.31083/ceog26554","DOIUrl":"https://doi.org/10.31083/ceog26554","url":null,"abstract":"Background: Severe endometrial injury constitutes a significant risk to female fertility, often leading to the development of intrauterine adhesions. Pyroptosis, a form of programmed cell death associated with inflammation, is initiated by the cleavage of gasdermin family proteins by caspase, which has been implicated in endometrial injury. In recent years, hydrogen sulfide (H2S), a gaseous signaling molecule, exerts significant regulatory effects on pyroptosis in diverse pathological processes. The aim of this study is to elucidate the role of H2S in facilitating functional recovery of the endometrium following injury in a murine model. Methods: A prospective laboratory based randomized control trial was performed to evaluate the protective role of H2S in endometrial injury. Ethanol-induced endometrial injury mouse models were established and H2S donor sodium hydrosulfide (NaHS) was randomly administered to the injured mice. Western blot analysis was conducted to assess changes in the expression of endogenous H2S metabolism and pyroptosis-related markers and histological analysis (Hematoxylin & Eosin and Masson staining) was employed to examine alterations in endometrial morphology. Finally, a fertility test was performed to evaluate the restoration of the uterine function. Results: Following endometrial injury, the expression of key endogenous H2S enzymes-cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST)-is significantly reduced, while the levels of pyroptosis-related proteins are elevated (p < 0.05). However, treatment with H2S resulted in an increase in the expression of endogenous H2S enzymes and a decrease in pyroptosis-associated proteins compared to the Model group (p < 0.05). Moreover, endometrial morphology and embryo count showed the most pronounced improvement in the H2S treatment group (p < 0.05). Conclusions: This study confirms the therapeutic efficacy of H2S in facilitating the recovery of injured endometrium and revealed its potential therapeutic mechanism, offering a promising therapeutic avenue for patients with severe endometrial injury.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.imrpress.com/journal/CEOG/52/1/10.31083/CEOG26554/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Value Evaluation of SKA3 in Endometrial Cancer and Its Promotion of Proliferation and Migration of Endometrial Cancer Cells","authors":"Xiaoxing Ding, Yue Zhang, Jiayun Qin, Yu Zhang, Jinwei Zhang","doi":"10.31083/j.ceog5110222","DOIUrl":"https://doi.org/10.31083/j.ceog5110222","url":null,"abstract":"Background: Endometrial cancer is one of the common cancers in gynecology, which seriously endangers women’s reproductive health. Therefore, it is urgent to search for new diagnostic and prognostic monitoring markers for endometrial cancer. This study aimed to explore the clinical significance and biological role of spindle and kinetochore-associated complex subunit 3 (SKA3) in endometrial cancer. Methods: Weighted gene co-expression network analysis (WGCNA) and identification of differentially expressed genes (DEGs) were conducted to identify the key gene in endometrial cancer. The clinical significance of SKA3 within endometrial cancer was assessed through receiver operating characteristic (ROC) and Kaplan-Meier (KM) curves. Spearman correlation analysis, the STRING database, Cytoscape software, and the molecular complex detection (MCODE) algorithm were employed to investigate genes associated with SKA3. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were carried out for elucidating the functional role and pathways involving SKA3. The cBioPortal online platform was utilized to explore mutations in SKA3. The biological effects of SKA3 were further investigated through Cell Counting Kit-8 (CCK8) and cell scratch experiments. Results: SKA3 emerges as a pivotal gene in endometrial cancer, exhibiting a statistically significant high expression level. Its area under the curve (AUC) for diagnosing endometrial cancer stands at 0.943. Patients displaying elevated SKA3 expression demonstrated a notably poorer prognosis. In the context of endometrial cancer, 9 genes directly interact with SKA3. The functional pathway of SKA3 in endometrial cancer likely involves the mitotic pathway. The alterations observed in SKA3 in endometrial cancer primarily manifest as “mutations”. Specifically, SKA3 exhibits 26 mutation sites in endometrial cancer, distributed across 7 distinct regions and involving 4 mutation types. Furthermore, SKA3 is implicated in promoting the proliferation and migration of HEC-1A cells. Conclusion: SKA3, a key gene in endometrial cancer, holds significant diagnostic and prognostic value and may influence the progression in endometrial cancer.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"51 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://storage.imrpress.com/IMR/CEOG25379/application/2709-0094-51-10-222.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPARC is a Novel Prognostic Biomarker for Ovarian Cancer and Associated with Immune Signatures and Drug Response","authors":"Xiaorong Guo, Huilin Tai, Xiaoqing Li, Peng Liu, Jin Liu, Shan Yu","doi":"10.31083/j.ceog5103061","DOIUrl":"https://doi.org/10.31083/j.ceog5103061","url":null,"abstract":"Background: The calcium-binding matricellular glycoprotein (SPARC, secreted protein, acidic and rich in cysteine) belongs to the extracellular-matrix-protein family, and its functions mainly focus on tissue injury, remodeling, and tumorigenesis. The role of SPARC in ovarian cancer remains controversial at present. Methods: We searched SPARC using The Cancer Genome Atlas/Genotype-Tissue Expression (TCGA/GTEx) and other databases to analyze the relationship between its expression level and survival, immunity signatures, and chemical drug response, in ovarian cancer. Additionally, we overexpressed SPARC with plasmids in ovarian cancer SKOV3 and ID8 cell lines, then measured the effects of SPARC on the proliferation, migration, invasiveness, clonality, and stemness of ovarian cancer cells by Cell Counting Kit-8 (CCK8), Transwell, wound healing assay, adhesion assay, plate cloning assay, and soft agar spheroid formation in vitro. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed the potential signaling pathway for SPARC. Results: The higher expression of SPARC in ovarian cancer is related to more advanced tumor stage, poorer clinical survival, and worse chemical drug response, whereas it is positively correlated with immune signatures. For ovarian cancer phenotypes, higher SPARC expression level promotes cell proliferation, migration, colony formation, and spheroid formation. The GO and KEGG enrichment highlighted the potential molecular mechanisms for SPARC with PI3K-AKT and MAPK signaling regulation. Conclusions: SPARC promotes ovarian cancer progression through proliferation, migration, invasiveness, clonality, and stemness. A high level of expression of SPARC in ovarian cancer patients can be used as a marker of poor prognosis and poor drug response.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"51 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.imrpress.com/journal/CEOG/51/3/10.31083/j.ceog5103061/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor","authors":"Huseyin Kiyak, Nazli Korkmaz, Sema Suzen Caypinar, Zuat Acar, Alev Atis Aydin, Batuhan Ustun, Zubeyde Aytufan, Ali Gedikbasi","doi":"10.31083/j.ceog5011225","DOIUrl":"https://doi.org/10.31083/j.ceog5011225","url":null,"abstract":"Background: The purpose of the study, to determine whether exposure to nifedipine before delivery is associated with an increased risk of postpartum blood loss in patients with preterm labor. Methods: This was a retrospective study screening a total of 486 patients who were admitted due to preterm labor from 2012 to 2019. Patients who were given nifedipine for tocolysis before delivery were considered as the study group (n: 240), and the patients who gave birth without getting tocolysis were considered as the control group (n: 246). The dose of nifedipine used during the last 24 hours, 72 hours and 1 week before delivery, the total dose of nifedipine given and the duration from the last dose to the delivery were recorded separately. Hemoglobin and hematocrit and platelet values measured before and 6 hours after delivery were recorded and postpartum bleeding amount was calculated. Results: No significant difference is observed in terms of mean difference between pre/postpartum hemoglobin and hematocrit levels between control group and nifedipine group (p > 0.05). But when subgroups that are created according to the time of use of nifedipine before delivery, a positive correlation was observed between difference in hemoglobin and hematocrit levels between prepartum and postpartum and nifedipine dosage for the last 24 hours (r = 0.176, p = 0.006), (r = 0.139, p = 0.030), but not for 72 hours or one week. Conclusions: The use of nifedipine in patients with preterm labor for tocolysis may be associated with increase in postpartum blood loss in the last 24 hours before delivery.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"34 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135167492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Deaths in Kayseri: Causes and Risk Factors","authors":"Mebrure Beyza Gökçek, Hümeyra Aslaner, Seçkin Özsaydı","doi":"10.31083/j.ceog5011226","DOIUrl":"https://doi.org/10.31083/j.ceog5011226","url":null,"abstract":"Background: About a quarter of a million women die from pregnancy-related conditions every year. This study aimed to contribute to the literature by assessing causes and demographic data of maternal deaths in our region. Methods: Our study is retrospective and descriptive. The study sample comprised 36 mothers who died in Kayseri between 2015 and 2019. The assessment was performed on the Provincial Directorate of Health data-“Maternal Death Record Forms”. Patients’ demographic and clinical characteristics and the factors associated with mortality were analyzed. Results: A total of 33 maternal deaths that occurred between 2015 and 2019 were assessed in our study. The mean age of mothers included in the study was 33.3 ± 6.3. Median gestational week was 24.5 (min: 3–max: 39) weeks of pregnancy. The majority of preventable deaths were from indirect causes. Cesarean history was higher in previous pregnancies in preventable maternal deaths (p = 0.006). First-phase and third-phase delay models were higher in preventable maternal deaths (p = 0.008, p = 0.007). Conclusions: The rates of preventable maternal mortality are considerably high. The first-phase delay model has an important place in preventable maternal deaths.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"16 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135167488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Add-Back and Combined Regulation in GnRH-a Treatment of Endometriosis","authors":"Huimin Tang, Qiucheng Jia, Zhiyong Dong, Yao Chen, Wulin Shan, Yihan Wu, Miao Miao, Tingwei Xing, Weiwei Wei, Bin Tang, Hong Zheng, Ruxia Shi, Bairong Xia, Jiming Chen","doi":"10.31083/j.ceog5010224","DOIUrl":"https://doi.org/10.31083/j.ceog5010224","url":null,"abstract":"Objective: The purpose of this review is to summarize drug selection for peri-menopausal symptoms caused by gonadotropin releasing-hormone agonist (GnRH-a) in the treatment of endometriosis. Mechanism: GnRH-a treatment often leads to low estrogen levels, resulting in peri-menopausal symptoms and osteoporosis. Add-back therapy relieves clinical symptoms by supplementing low-dose estrogen. The idea of “combined regulation” is to improve symptoms by adding plant preparations or proprietary Chinese medicines. Studies have shown that they may play a role by regulating serotonin activity. Findings in Brief: For patients treated with GnRH-a for less than 3 months, the combined-regulation regimen can be considered, whereas for patients who have had more than 3 courses of GnRH-a, add-back therapy with sex hormones must be used because the patients will have begun to have obvious bone-mass loss and even bone pain; this bone-mass loss is often irreversible. Conclusions: In the early treatment of endometriosis with GnRH-a, non-hormone combined-regulation therapy is a relatively safe and feasible choice, but hormone add-back therapy should be selected for patients who have had more than 3 courses of GnRH-a.","PeriodicalId":10312,"journal":{"name":"Clinical and experimental obstetrics & gynecology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135413781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}