红细胞分布宽度(RDW)是反复植入失败的负面预测因子吗?

IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY
Özlem Kayacık Günday, Oya Aldemir, Runa Özelçi, Serdar Dilbaz, Emre Başer, Özlem Moraloğlu Tekin
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引用次数: 0

摘要

背景:体外受精/胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)后的重复植入失败(RIF)对一些不孕症患者来说是一个毁灭性的现实。我们的目的是评估全血细胞计数(CBC)参数对反复IVF植入失败患者治疗结果的潜在作用。方法:本回顾性临床研究共纳入173例患者,其中64例首次IVF- et周期的RIF患者和3个及以上IVF周期的RIF患者,以及109例首次IVF- et周期怀孕的对照组患者。结果:RIF患者的不孕持续时间、2级胚胎数量和红细胞分布宽度(RDW)显著高于RIF患者(p <0.001, p <0.001, p = 0.02)。2原核数(PN)与受精率(FR)呈极显著正相关(r: 0.6;p & lt;0.001)。为了了解CBC参数对FR的影响,以RDW数、2级胚胎数和2个PN数建立的模型被证明是显著的(ANOVA, p <0.001)。结论:RIF患者的RDW较高,不孕症持续时间较长,2级胚胎数量较多。RDW升高可能对FR有负面影响。2pn的数量增加FR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is Red Blood Cell Distribution Width (RDW) a Negative Predictor of Repeated Implantation Failure?
Background: Repeated implantation failure (RIF) after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) can be a devastating reality for some patients with infertility. Our objective was to evaluate the potential role of the complete blood count (CBC) parameters, on treatment outcome in patients with repeated IVF implantation failure. Methods: This retrospective clinical study, involving a total of 173 patients, consisted of 64 patients with RIF who underwent a fresh IVF-ET cycle, underwent 3 or more IVF cycles, and 109 patients in the control group who became pregnant in the first IVF-ET cycle. Results: Duration of infertility, number of grade 2 embryos and red cell distribution width (RDW) were significantly higher in RIF patients (p < 0.001, p < 0.001, p = 0.02). The number of 2 pronucleus (PN) showed a significant positive correlation with the fertilization rate (FR) (r: 0.6; p < 0.001). To understand the effects of CBC parameters on FR, the model established with the number of RDW, number of grade 2 embryos and the number of 2 PN proved to be significant (ANOVA, p < 0.001). Conclusions: RIF patients have higher RDW, longer duration of infertility, and higher number of grade 2 embryos. Elevated RDW may negatively impact FR. The number of 2 PN increased FR.
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
241
审稿时长
1 months
期刊介绍: CEOG is an international, peer-reviewed, open access journal. CEOG covers all aspects of Obstetrics and Gynecology, including obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine. All submissions of cutting-edge advances of medical research in the area of women''s health worldwide are encouraged.
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