Circulation: Heart Failure最新文献

{"title":"Alterations in Cardiac and Systemic Metabolism in Heart Failure.","authors":"Edoardo Bertero, Federico Capone, Ambra Costa, Christoph Maack, Pietro Ameri","doi":"10.1161/CIRCHEARTFAILURE.125.013766","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013766","url":null,"abstract":"<p><p>Altered cardiac and systemic metabolism is a hallmark of heart failure (HF). In the failing heart, cardiomyocytes develop alterations in substrate preference, mitochondrial oxidative metabolism, and the shuttling of high-energy phosphates from mitochondria to the cytosol that compromise energetic efficiency and contribute to disease progression. At the systemic level, neurohormonal activation plays a dominant role in HF with reduced ejection fraction, whereas HF with preserved ejection fraction is shaped by the clustering of multiple comorbidities, such as diabetes, obesity and hypertension, which disrupt the physiological crosstalk between the heart and metabolically active organs. This review provides a perspective on cardiac metabolism in HF. We delineate the specific alterations in substrate metabolism that characterize HF with reduced ejection fraction versus HF with preserved ejection fraction, examine the impact of interorgan communication on myocardial function, and highlight how the benefits of emerging HF therapies, including sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists, may be mediated, at least in part, through the restoration of metabolic homeostasis.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013766"},"PeriodicalIF":8.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HERZCHECK: Early Detection of Subclinical Heart Failure Using Mobile Cardiac Magnetic Resonance and Telemedicine in Rural and Underressourced Regions.","authors":"Sebastian Kelle, Maximilian Leo Müller, Rebecca Elisabeth Beyer, Gisela Thiede, Anna Clara Nolden, Henning Steen, Bjoern Andrew Remppis, Johannes Wieditz, Alex Tuit, Mina Cvetkovic, Patrick Doeblin, Undine Ella Witt, Florian André, Sein Schmidt, Alexander Huppertz, Dusan Simic, Dirk Müller, Arim Shukri, Katrin Christiane Reber, Ulf Landmesser, Norbert Frey, Burkert Pieske, Eike Nagel, Stephanie Stock, Volkmar Falk, Hannah Kentenich, Tim Friede","doi":"10.1161/CIRCHEARTFAILURE.125.013935","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013935","url":null,"abstract":"<p><strong>Background: </strong>There is a growing consensus that screening for subclinical preheart failure (HF) may reduce the burden of symptomatic HF by allowing for timely preventive interventions. However, validated screening algorithms are currently lacking. The aim of this study was to evaluate a fully mobile telemedically supervised cardiac magnetic resonance, as a simple standardized, and ubiquitously applicable screening algorithm for subclinical pre-HF in rural and underresourced regions.</p><p><strong>Methods: </strong>HERZCHECK was a cross-sectional cohort study conducted at 12 sites across rural and underresourced regions of Germany. Asymptomatic participants (40-69 years) with ≥1 cardiovascular risk factor-obesity, smoking, arterial hypertension, diabetes, hypercholesterolemia, or chronic kidney disease-were enrolled and underwent telemedically supervised contrast-free short cardiac magnetic resonance in mobile screening units. Subclinical pre-HF was diagnosed using a predefined cutoff of global longitudinal strain ≥-15%. A matched and entropy-balanced control cohort constructed from claims data was used to determine the time difference between detection of subclinical pre-HF in HERZCHECK and the first symptom-based diagnosis of HF within the standard of care.</p><p><strong>Results: </strong>Between June 2021 and April 2023, 4666 participants were enrolled in the study, of which 4509 participants were included in the final analysis. The prevalence of subclinical pre-HF in the studied at-risk population was 22.7% (95% CI, 21.5%-23.9%). Global longitudinal strain-based screening identified subclinical pre-HF 6.7 years before the average onset of symptomatic HF within the standard of care (n=8420).</p><p><strong>Conclusions: </strong>Subclinical pre-HF affects approximately one-fourth of the at-risk population in rural and underresourced regions. The HERZCHECK approach identifies patients suitable for targeted preventive interventions ≈7 years earlier than the standard of care.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT05122793.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013935"},"PeriodicalIF":8.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Ali et al Regarding Article \"Resolution of Systemic Inflammation in Patients With Recently Decompensated Heart Failure With Reduced Ejection Fraction With and Without Interleukin-1 Blockade by Anakinra\".","authors":"Zeeshan Ali, Muhammad Anwar, Wasiq Subhani","doi":"10.1161/CIRCHEARTFAILURE.126.014565","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.126.014565","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014565"},"PeriodicalIF":8.3,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Status Exceptions in the 2018 Heart Allocation Policy: Is It Time for Another Revision?","authors":"Natasha Aleksova","doi":"10.1161/CIRCHEARTFAILURE.126.014462","DOIUrl":"10.1161/CIRCHEARTFAILURE.126.014462","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014462"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Rate of Transplantation Before Review of Status Exception Requests Among Adult Heart Transplant Candidates.","authors":"Daniel J Ahn, Toshihiro Nakayama, Antony Attia, Molly White, Dalin Eap, Nikhil Narang, Kiran K Khush, William F Parker, Kazunari Sasaki","doi":"10.1161/CIRCHEARTFAILURE.125.013994","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013994","url":null,"abstract":"<p><strong>Background: </strong>In the US heart allocation system, when transplant centers submit applications for status exceptions to increase waitlist priority, patients obtain the requested status upgrades immediately while their applications are sent to the regional review boards (RRBs) and reviewed retrospectively. How often transplants occur during this period is unknown.</p><p><strong>Methods: </strong>Using the Scientific Registry of Transplant Recipients, we identified all adult heart transplant candidates listed between October 18, 2018, and May 31, 2025, with submitted applications for status exceptions. We assessed (1) the time elapsed between submission of exception applications and their receipt by the RRBs and (2) the rate of heart transplantation during this travel time, stratified by whether the applications were eventually approved or denied. Additionally, we estimated how many listed patients were skipped by candidates who received transplants with exceptions that were ultimately denied.</p><p><strong>Results: </strong>138 transplant centers submitted status exception requests on behalf of 11 508 adult candidates during the study period, of whom 913 (7.9%) received a denial at least once. The median time from obtaining status upgrades to application receipt by the RRBs was 3 days. Three thousand seven out of 11 508 (26.1%) patients received transplants before the RRBs even received their applications, with 174 (19.1%) among 913 with eventual denials and 2833 (26.7%) among 10 595 with approvals. The cumulative incidence of heart transplantation before application receipt for eventual denials was 19.1% (95% CI, 16.6%-21.7%), and that for approvals was 27.2% (95% CI, 26.4%-28.0%; <i>P</i><0.001) at 2 weeks. Candidates who received transplants despite being denied exceptions bypassed more than 11 thousand potential transplant recipients.</p><p><strong>Conclusions: </strong>More than 25% of patients with status exception requests receive heart transplants before their applications are even received by their RRBs, raising significant concerns about the fairness of retrospective review of exception requests for the allocation of donor hearts.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013994"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Avila et al to Letter Regarding Article, \"Impact of Pregnancy on Mortality in Dilated Cardiomyopathy: Immediate and 12-Month Postpartum Outcomes: Data from the InCor Pregnancy and Heart Disease Registry\".","authors":"Mônica Samuel Avila, Walkiria Samuel Avila","doi":"10.1161/CIRCHEARTFAILURE.126.014363","DOIUrl":"10.1161/CIRCHEARTFAILURE.126.014363","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014363"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time Served or Time Missed? Durable LVAD Allocation and the Myth of Stability.","authors":"Scott Silvestry","doi":"10.1161/CIRCHEARTFAILURE.126.014497","DOIUrl":"10.1161/CIRCHEARTFAILURE.126.014497","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014497"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Vandenbriele et al to Letter Regarding Article, \"Arterial Versus Mixed Venous Lactate Levels in 1526 Cardiac Intensive Care Patients\".","authors":"Christophe Vandenbriele, Eftychia Galiatsou, Alex Rosenberg","doi":"10.1161/CIRCHEARTFAILURE.126.014476","DOIUrl":"10.1161/CIRCHEARTFAILURE.126.014476","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014476"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Wang and Sheu Regarding Article, \"Impact of Pregnancy on Mortality in Dilated Cardiomyopathy: Immediate and 12-Month Postpartum Outcomes: Data From the InCor Pregnancy and Heart Disease Registry\".","authors":"Po-Hui Wang, Kai-Lun Sheu","doi":"10.1161/CIRCHEARTFAILURE.126.014203","DOIUrl":"10.1161/CIRCHEARTFAILURE.126.014203","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014203"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIGIT-HF: Results From the Win Ratio Analyses.","authors":"Xiaofei Liu, Nele Henrike Thomas, Dominik Berliner, Johannes Schwab, Andreas Rieth, Christina Strack, Sven Schallhorn, Samira Soltani, Lea Haebel, Welf Geller, Marija Zdravkovic, Martin Hülsmann, Heiko von der Leyen, Christian Veltmann, Stefan Störk, Michael Böhm, Johann Bauersachs, Armin Koch, Udo Bavendiek, Anika Großhennig","doi":"10.1161/CIRCHEARTFAILURE.126.014396","DOIUrl":"10.1161/CIRCHEARTFAILURE.126.014396","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e014396"},"PeriodicalIF":8.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13390985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}