Circulation: Heart Failure最新文献

{"title":"Hemodynamic Right Heart Catheterization Before Transcatheter Mitral and Tricuspid Therapies.","authors":"Cosmo Godino, Antonio Sisinni, Luca Raone, Francesco Maria Sparasci, Andrea Munafò, Alberto Margonato, Luca Testa, Maurizio Taramasso, Fabien Praz, Sami Alnasser, Neil Fam, Rodrigo Estevez-Loureiro, Francesco Saia, Francesco Bedogni, Azeem Latib, Claudia Baratto, Francesca Coppi, Marianna Adamo, Altin Palloshi, Gabriele Crimi, Scott Lim, Francesco Maisano, Ryan J Tedford, Sergio Caravita","doi":"10.1161/CIRCHEARTFAILURE.124.012489","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012489","url":null,"abstract":"<p><p>Recent findings emphasize the potential role of invasive hemodynamic assessment in guiding transcatheter mitral and tricuspid valve percutaneous interventions. Right heart catheterization-derived parameters offer insights into hemodynamic changes associated with valvular heart diseases, pulmonary hypertension phenotyping, and right ventricular to pulmonary artery coupling. This might improve prognostic stratification for candidates to transcatheter therapies. This review provides a clinical overview of available data regarding the utility of preoperative right heart catheterization-derived parameters in patients undergoing mitral and tricuspid percutaneous repair or replacement.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012489"},"PeriodicalIF":7.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Guide on the Use of Induction Immunosuppression in Heart Transplantation.","authors":"Andriana P Nikolova, Lavanya Bellumkonda, Anju Bhardwaj, Nadia Fida, Luise Holzhauser, Priya Umapathi, Teresa De Marco, Johanna Contreras","doi":"10.1161/CIRCHEARTFAILURE.124.012382","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012382","url":null,"abstract":"<p><p>Induction therapy is the use of potent immunosuppression in the perioperative period with the intent to diminish rejection rates in at-risk patients or as a renal-protective strategy. The potent immunomodulatory effects of these agents must be balanced against the recipient's risk of infectious or malignant complications, among others. There is a notable lack of clinically useful risk stratification models that integrate these competing risks and guide the clinician in the use of these therapies. This review integrates the existing evidence on the utility and safety of various induction regimens and highlights the gaps of knowledge in the field. In addition, we frame the discussion in view of the changing landscape of heart transplantation where many unknowns remain, such as the impact of induction immunosuppression on patients bridged with mechanical circulatory devices or receiving organs from hepatitis C-positive or donation after circulatory death donors, among others.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012382"},"PeriodicalIF":7.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Get With the Guidelines-Heart Failure: Twenty Years in Review, Lessons Learned, and the Road Ahead.","authors":"Amber B Tang, Sabra C Lewsey, Clyde W Yancy, Paul A Heidenreich, Stephen J Greene, Larry A Allen, Mariell Jessup, Michele Bolles, Christine Rutan, Natalie Navar, Kathie Thomas, Gregg C Fonarow","doi":"10.1161/CIRCHEARTFAILURE.125.012936","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.012936","url":null,"abstract":"<p><p>The Get With the Guidelines-Heart Failure program was developed in 2005 with the goal of bringing evidence-based guidelines in heart failure management into widespread clinical practice. The program includes workshops, webinars, tool kits, chart abstraction, performance benchmarking, and achievement awards to drive quality improvement at participating hospitals. Two decades after its inception, the program has grown to include over 600 participating institutions across the United States. Linking registry data to Centers for Medicare and Medicaid Services claims has also allowed for the evaluation of longitudinal outcomes. Get With the Guidelines-Heart Failure has helped improve the quality of care for patients and has contributed substantially to the understanding of clinical science and optimal management of heart failure. This narrative review provides an overview of the indelible impact of the Get With the Guidelines-Heart Failure program on quality heart failure care over the past 20 years and highlights future challenges and directions.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012936"},"PeriodicalIF":8.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiogenic Shock Teams: Past, Present, and Future Directions.","authors":"Vanessa Blumer, Thomas C Hanff, Ann Gage, Benedikt Schrage, Manreet K Kanwar","doi":"10.1161/CIRCHEARTFAILURE.124.011630","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.011630","url":null,"abstract":"<p><p>Cardiogenic shock (CS) remains a significant challenge in cardiovascular medicine, characterized by substantial morbidity and mortality. Historically, patient outcomes in CS have been varied, highly dependent on the timeliness of interventions and the expertise available at treating centers. Emerging evidence indicates that structured, team-based approaches significantly improve survival rates and diminish complications linked to CS. However, several challenges for implementing a team-based approach persist, including optimizing team composition and resource distribution. This article delves into the evolution, current implementations, and future directions of CS teams, emphasizing their crucial role in enhancing patient outcomes. We advocate for the adoption of standardized protocols to ensure uniformity of care across institutions, highlighting the critical need for prompt recognition and management strategies that integrate invasive hemodynamic monitoring and early mechanical circulatory support. Looking ahead, we propose the extension of CS team models into regional networks, broadening their impact through education, telemedicine and collaborative protocols. We also emphasize the importance of continuous research and data sharing via national registries to refine CS team strategies and substantiate their effects on patient outcomes. Ultimately, this review highlights the imperative for ongoing innovation and standardization in CS team operations to improve care delivery and enhance survival rates in CS scenarios.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011630"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroids in Fulminant Myocarditis Associated With Viral Infection.","authors":"Florent Huang, Enrico Ammirati, Maharajah Ponnaiah, Santiago Montero, Nadia Aïssaoui, Albert Ariza Solé, Martin Balik, Eduardo Barge-Caballero, Jeroen J H Bunge, Hergen Buscher, Clément Delmas, Dirk W Donker, Christoph Fisser, Guillaume Franchineau, Justin Fried, Francisco José Hernández-Pérez, Joshua Ihle, Jae-Seung Jung, Teresa Lόpez-Sobrino, Jamie McCanny, Armand Mekontso Dessap, Henrique Muglia, Shinichiro Ohshimo, Sunghoon Park, Romain Persichini, Beatriz Porral, Roberto Roncon-Albuquerque, Alessandro Sionis, Pauline Yeung Ng, Alain Combes, Matthieu Schmidt","doi":"10.1161/CIRCHEARTFAILURE.124.012399","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012399","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012399"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Trajectories of Left Heart Geometry, Mechanics, and Oxygen Demand After Bariatric Surgery.","authors":"Lisa M D Grymyr, Saied Nadirpour, Eva Gerdts, Bjørn G Nedrebø, Knut Matre, Dana Cramariuc","doi":"10.1161/CIRCHEARTFAILURE.124.012367","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012367","url":null,"abstract":"<p><strong>Background: </strong>The long-term impact of bariatric surgery on cardiac mechanics and energetics has been scarcely documented. We aimed to assess prospectively the 5-year trajectories of left heart geometry, mechanics, and myocardial oxygen (O₂) demand after bariatric surgery.</p><p><strong>Methods: </strong>In the Bariatric Surgery on the West Coast of Norway study, left ventricular (LV) and atrial remodeling was evaluated preoperatively, 6 months, and 1 and 5 years after Roux-en-Y gastric bypass in 102 patients. LV geometry was assessed by the LV mass/height^2.7 and the relative wall thickness, and mechanics by the global longitudinal strain and the midwall shortening. LV myocardial O₂ demand was estimated from the product LV mass×wall stress×heart rate. The left atrial reservoir function was measured by the emptying fraction.</p><p><strong>Results: </strong>After 63 (interquartile range, 62-66) months, LV mass index, global longitudinal strain, myocardial oxygen demand, and left atrial emptying fraction were improved (<i>P</i><0.001) while midwall shortening did not change significantly. Prevalence of normal LV geometry increased from 61% to 82%. In linear mixed-effects models with adjustment for clinical characteristics, improving global longitudinal strain and myocardial O₂ demand over time were associated with female sex and lower body mass index (<i>P</i><0.05). In logistic regression analysis, 5-year presence of abnormal LV geometry, low LV global longitudinal strain, or high myocardial O₂ demand was related to preoperative diabetes, hypertension, and higher body mass index, as well as higher 5-year systolic blood pressure (<i>P</i><0.05; Nagelkerke R²=0.40).</p><p><strong>Conclusions: </strong>Bariatric surgery results in favorable 5-year trajectories of LV geometry, myocardial O₂ demand, and left heart longitudinal mechanics. However, suboptimal postoperative body mass index and blood pressure control promote long-term LV structural disease.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT01533142.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012367"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Analysis of T1 Pseudonormalization in the Advanced Stage of Female Fabry Cardiomyopathy.","authors":"Hiroki Aida, Ryo Nishikawa, Toshiyuki Yano, Kei Nakata, Naoto Murakami, Atsuko Muranaka, Masato Furuhashi","doi":"10.1161/CIRCHEARTFAILURE.124.012234","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012234","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012234"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights From Living Myocardial Slices Into Chemotherapy-Induced Cardiotoxicity: A Novel Ex Vivo Tool to Guide Clinical Decision-Making.","authors":"Ilse R Kelters, Jort S A van der Geest, Peter-Paul M Zwetsloot, Maarten Jan Cramer, Manon G van der Meer, Niels P van der Kaaij, Jan Peter van Tintelen, Joost P G Sluijter, Vasco Sampaio-Pinto, Linda W van Laake","doi":"10.1161/CIRCHEARTFAILURE.124.011876","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.011876","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011876"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ca²⁺ Cycling Alteration in a Porcine Model of Right Ventricular Dysfunction.","authors":"Fabrice Antigny, Rui Luo, Romain Perrier, Bastien Masson, Guillaume Fadel, Grégoire Ruffenach, Anaïs Saint-Martin Willer, Ali Akamkam, Julien Grynblat, Xavier Jaïs, Jerôme Le Pavec, Simon Dang Van, Dorothée Brunet, Florence Lefebvre, Garance Gérard, Séverine Domenichini, Angèle Boët, Julien Guihaire, Ana-Maria Gomez, David Montani, Jean-Pierre Benitah, Marc Humbert, Olaf Mercier, Jessica Sabourin","doi":"10.1161/CIRCHEARTFAILURE.124.012293","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012293","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hypertension is a severe disease with high mortality rates due to right ventricular (RV) failure. The molecular and cellular processes involved in RV remodeling, including Ca²⁺ handling, remain elusive due to the lack of relevant animal models. In this study, we aim to understand better the pathophysiological mechanisms involved in RV failure.</p><p><strong>Methods: </strong>We used the chronic thromboembolic pulmonary hypertension (CTEPH) pig model, which leads to progressive RV hypertrophy and dysfunction. Cellular, molecular unbiased global transcriptional profiling and biochemical analyses were performed on RV cardiomyocytes from CTEPH and Sham-operated pigs.</p><p><strong>Results: </strong>CTEPH pigs replicated the hemodynamics and histological changes of human CTEPH features. Transcriptome analysis in Sham and CTEPH pigs revealed molecular RV remodeling close to human patients with pulmonary arterial hypertension with decompensated RV function and notably identified changes in genes involved in Ca²⁺ signaling. At the cellular level, CTEPH myocytes presented reduced L-type Ca²⁺ current in association with reduced mRNA of <i>CACNA1C</i>. Furthermore, CTEPH myocytes showed lower [Ca²⁺]_i transients, decreased sarcoplasmic reticulum Ca²⁺ content, and decreased cell shortening, related to reduced SERCA2a (Sarco/endoplasmic reticulum Ca²⁺-ATPase isoform 2a) protein expression. Moreover, CTEPH cardiomyocytes exhibited reduced Ca²⁺ spark occurrence, which relied on smaller RyR2 (ryanodine receptor 2) clusters and T-tubule disorganization. Finally, these alterations in Ca²⁺ homeostasis were also associated with an increased store-operated Ca²⁺ entry and the de novo expression of the Ca²⁺ sensor protein STIM1L (stromal interaction molecule 1 long isoform) in CTEPH myocytes as well as in RV from human patients with pulmonary arterial hypertension.</p><p><strong>Conclusions: </strong>Our data reveal cellular Ca²⁺ cycling remodeling that participates in the pathogenesis of RV dysfunction and may constitute therapeutic targets to limit the development of RV dysfunction.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012293"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antecedent Flu-Like Illness and Onset of Idiopathic Dilated Cardiomyopathy: The DCM Precision Medicine Study.","authors":"Hanyu Ni, Jinwen Cao, Daniel D Kinnamon, Elizabeth Jordan, Garrie J Haas, Mark Hofmeyer, Evan P Kransdorf, Jamie Diamond, Anjali Owens, Brian Lowes, Douglas Stoller, W H Wilson Tang, Mark H Drazner, Palak Shah, Jane E Wilcox, Stuart D Katz, Javier Jimenez, Supriya Shore, Daniel P Judge, Jonathan O Mead, Jason Cowan, Patricia K Parker, Gordon S Huggins, Ray E Hershberger","doi":"10.1161/CIRCHEARTFAILURE.124.012602","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012602","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have speculated that a viral infection may act as a trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe the frequency of patients with DCM who reported experiencing symptoms of flu-like illness before their DCM diagnosis and to examine if this experience modified the association between genetics and DCM.</p><p><strong>Methods: </strong>We analyzed data from the family-based cross-sectional DCM Study conducted between 2016 and 2021. Self-reported symptoms of flu-like illness proximal to DCM diagnosis were obtained from patient interviews. Exome sequencing identified rare variants (pathogenic, likely pathogenic, or variant of uncertain significance) in DCM genes. In a case-only design, logistic mixed models were used to examine if flu-like illness modified the effect of these rare variants on DCM risk. Firth logistic regression was used to examine if flu-like illness modified the effect of each of 13 400 141 common autosomal variants (minor allele frequency ≥1%) on DCM risk.</p><p><strong>Results: </strong>Of 1164 patients with DCM, 30.2% reported symptoms of flu-like illness proximal to DCM diagnosis. The percentage of patients with antecedent flu-like illness by variant classification was 30.0% for pathogenic/likely pathogenic, 29.6% for variant of uncertain significance only, and 30.0% for no pathogenic/likely pathogenic/variant of uncertain significance. Antecedent flu-like illness was not found to modify the effect of carrying any pathogenic, likely pathogenic, or variant of uncertain significance variants on DCM risk (interaction relative risk, 0.9 [95% CI, 0.7-1.3]). However, significant modification of the effect of rs2102158 (3q24) by antecedent flu-like illness (<i>P</i>=2.74×10^-8) was identified by case-only genome-wide association study.</p><p><strong>Conclusions: </strong>Approximately one-third of patients with DCM experienced flu-like illness symptoms before DCM diagnosis. We did not find evidence that a flu-like illness modified the effect of rare variants on DCM risk; however, our genome-wide association study analysis suggested that flu-like illness may modify the effect of a common variant on DCM risk.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT03037632.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":"18 5","pages":"e012602"},"PeriodicalIF":7.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}