Circulation: Heart Failure最新文献

{"title":"Real-Time Pressure-Volume Loop Assessment of Left Ventricular Performance to Evaluate Suitability for Repair in Congenitally Corrected Transposition of the Great Arteries.","authors":"Kyong-Jin Lee, Kaitlin Flannery, Michael Ma, Deborah Ho","doi":"10.1161/CIRCHEARTFAILURE.124.012609","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012609","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012609"},"PeriodicalIF":7.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurohormonal and Renal Effects of 14-Day Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction.","authors":"Kristoffer Berg-Hansen, Nigopan Gopalasingam, Kristian Hylleberg Christensen, Mads Svart, Nikolaj Rittig, Roni Nielsen, Kent Lodberg, Niels Møller, Henrik Wiggers","doi":"10.1161/CIRCHEARTFAILURE.124.012167","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012167","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012167"},"PeriodicalIF":7.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways to Precision Medicine in Hypertrophic Cardiomyopathy: Opportunities and Challenges in Plasma Proteomics.","authors":"Usman A Tahir","doi":"10.1161/CIRCHEARTFAILURE.124.012593","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012593","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012593"},"PeriodicalIF":7.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Donor-Derived Cell-Free DNA Levels Are Associated With Reduced Myocardial Blood Flow but Not Angiographic Cardiac Allograft Vasculopathy: The EVIDENT Study.","authors":"Cathrine M Moeller, Daniel Oren, Andrea Fernandez Valledor, Gal Rubinstein, Ersilia M DeFilippis, Salwa Rahman, Yonatan Mehlman, Elena M Donald, Dor Lotan, Edward Lin, Kyung T Oh, Sun H Lee, Jayant K Raikhelkar, Justin A Fried, David Majure, Farhana Latif, Gabriel T Sayer, Nir Uriel, Kevin J Clerkin","doi":"10.1161/CIRCHEARTFAILURE.124.011756","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011756","url":null,"abstract":"<p><strong>Background: </strong>Cardiac allograft vasculopathy (CAV) leads to impaired myocardial blood flow (MBF), increasing the risk of cardiovascular death or retransplant among heart transplantation (HT) recipients. Data on elevation in donor-derived cell-free DNA (dd-cfDNA) and CAV in the absence of rejection are mixed. We sought to test the hypothesis that CAV with reduced MBF (RMBF) is associated with elevated dd-cfDNA.</p><p><strong>Methods: </strong>A retrospective review was conducted on HT recipients at a high-volume center who underwent dd-cfDNA testing between September 2019 and November 2022. Inclusion criteria included undergoing CAV screening with cardiac positron emission tomography scans and coronary angiograms. Patients were grouped by the presence of angiographic CAV diagnosis and MBF reserve evaluated through cardiac positron emission tomography. The latter was subdivided into normal MBF or RMBF, with RMBF defined as an MBF reserve ≤2. Elevated dd-cfDNA was defined as ≥0.12%.</p><p><strong>Results: </strong>Two hundred fifty-six HT recipients were included (median age, 55 years; 27.6% female; median, 8 years [interquartile range (IQR), 5-14] post-HT). Ischemic etiology of heart failure was more prevalent in the RMBF group (36%) compared with the normal MBF group (20%; <i>P</i>=0.02). The prevalence and magnitude of a positive dd-cfDNA test with angiographic CAV (29%; median, 0.26% [IQR, 0.15%-0.62%]) were not significantly different from those without CAV (30%; <i>P</i>=0.94; median, 0.31% [IQR, 0.17%-0.71%]; <i>P</i>=0.38). However, RMBF patients exhibited significantly higher dd-cfDNA prevalence and levels (51%; median, 0.81% [IQR, 0.48%-1.11%]) compared with normal MBF patients (27%; <i>P</i><0.001; median, 0.25% [IQR, 0.15%-0.52%]; <i>P</i><0.001).</p><p><strong>Conclusions: </strong>HT recipients with angiographic CAV had similar dd-cfDNA levels and rates as those without. Notably, dd-cfDNA levels and rates were significantly elevated in patients with RMBF assessed by positron emission tomography compared with those with normal MBF.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011756"},"PeriodicalIF":7.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes.","authors":"Alexander C Egbe, Ahmed E Ali, William R Miranda, Heidi M Connolly, Barry A Borlaug","doi":"10.1161/CIRCHEARTFAILURE.124.011981","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011981","url":null,"abstract":"<p><strong>Background: </strong>Patients with Fontan palliation have reduced aerobic capacity because of impaired cardiac, pulmonary, and skeletal muscle function. However, the assessment of aerobic capacity in this population still relies on comparisons with people without cardiovascular disease rather than comparison with the expected aerobic capacity of other Fontan patients. The purpose of this study was to determine the expected aerobic capacity of adults with Fontan palliation.</p><p><strong>Methods: </strong>Adults with Fontan palliation who underwent a cardiopulmonary exercise test at Mayo Clinic (2003-2023) were stratified into quartiles based on the predicted peak oxygen consumption (VO₂). We assessed the correlates of predicted peak VO₂ and the relationship between predicted peak VO₂ quartiles and cardiovascular outcomes (death/transplant).</p><p><strong>Results: </strong>Of 323 patients (age, 29±9 years; 177 [55%] men), the median peak VO₂ was 19.1 (15.2-23.9) mL/kg per minute, and this corresponds to a predicted peak VO₂ of 51% (range, 19-88; interquartile range, 41-62). After multivariable adjustments, the correlates of predicted peak VO₂ were body mass index (β±SE, -2.61±0.95; 2.61% decrease in predicted peak VO₂ per 5 kg/m² increase in body mass index; <i>P</i>=0.009), systemic saturation (β±SE, 3.65±0.85; 3.65% increase in predicted peak VO₂ per 5% increase in oxygen saturation; <i>P</i><0.001), and Fontan pressure (β±SE, -1.24±0.22; 1.24% decrease in predicted peak VO₂ per 1 mm Hg increase in Fontan pressures; <i>P</i><0.001). There was a 47% increase in the risk for death/transplant from a higher predicted peak VO₂ quartile to the next lower quartile (adjusted hazard ratio, 1.47 [95% CI, 1.09-2.05]; <i>P</i>=0.01).</p><p><strong>Conclusions: </strong>The results of the current study would help calibrate the interpretation of exercise test data in adults with Fontan palliation and improve risk stratification in this population. It also underscores the need to maintain normal Fontan hemodynamics and body weight, which are important determinants of aerobic capacity.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011981"},"PeriodicalIF":7.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights From a 20-Year Follow-Up of the First Heart Transplant Recipient to Complete an Ironman Triathlon.","authors":"Stephen J Foulkes, Rachel J Skow, Andre La Gerche, Wayne J Tymchak, Mark J Haykowsky","doi":"10.1161/CIRCHEARTFAILURE.124.012027","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012027","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012027"},"PeriodicalIF":7.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and Procedural Competencies in the Cardiac Intensive Care Unit.","authors":"Willard N Applefeld, Jacob C Jentzer, Saraschandra Vallabhajosyula","doi":"10.1161/CIRCHEARTFAILURE.124.011641","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011641","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011641"},"PeriodicalIF":7.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Management and Transplant Considerations in Pediatric Pulmonary Hypertension Due to Left Heart Disease: A Scientific Statement From the American Heart Association.","authors":"Rachel K Hopper, Georg Hansmann, Seth A Hollander, Anne I Dipchand, Oscar van der Have, Colleen Iler, Cynthia Herrington, Erika B Rosenzweig, Juan C Alejos, Karin Tran-Lundmark","doi":"10.1161/HHF.0000000000000086","DOIUrl":"https://doi.org/10.1161/HHF.0000000000000086","url":null,"abstract":"<p><p>Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased afterload and is an important consideration for heart transplant eligibility. However, the epidemiology, pathophysiology, optimal diagnostic and treatment approaches, and thresholds for pulmonary vascular resistance in pulmonary hypertension associated with left heart disease remain unclear because of lack of evidence, particularly in pediatrics. The result is heterogeneity with respect to hemodynamic assessment, use of pulmonary vasodilator therapies, and heart transplant listing. This scientific statement aims to synthesize the available data and highlight areas of general consensus as well as important knowledge gaps.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e000086"},"PeriodicalIF":7.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic Response to 1-Leg Cycling Exercise Predicts Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction.","authors":"Mark B Badrov, Tomoyuki Tobushi, Catherine F Notarius, Evan Keys, Massimo Nardone, David Z Cherney, Susanna Mak, John S Floras","doi":"10.1161/CIRCHEARTFAILURE.124.011962","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011962","url":null,"abstract":"<p><strong>Background: </strong>In heart failure, sympathetic excess and exercise intolerance impair quality of life. In heart failure with reduced ejection fraction, exercise stimulates a reflex increase in muscle sympathetic nerve activity (MSNA) that relates inversely to peak oxygen uptake (V̇O_2peak). Whether similar sympathoexcitatory responses are present in heart failure with preserved EF (HFpEF) and relate to V̇O_2peak are unknown.</p><p><strong>Methods: </strong>In 13 patients with HFpEF (70±6 years), 17 comorbidity-matched controls (CMC; 67±8 years), and 18 healthy controls (65±8 years), we measured heart rate, blood pressure, and MSNA (microneurography) during (1) 7-minute baseline; (2) 2-minute isometric handgrip (40% maximal voluntary contraction) or rhythmic handgrip (50% and 30% maximal voluntary contraction) exercise, followed by 2-minute postexercise circulatory occlusion; and (3) 4-minute 1-leg cycling (2 minutes each at mild and moderate intensity). V̇O_2peak was obtained by open-circuit spirometry.</p><p><strong>Results: </strong>Resting MSNA was higher and V̇O_2peak was lower in HFpEF versus CMCs and healthy controls (all <i>P</i><0.05). During handgrip, MSNA increased in all groups (all <i>P</i><0.05); in HFpEF, MSNA was greater than CMCs and healthy controls during HG and postexercise circulatory occlusion at 40% isometric handgrip (all <i>P</i><0.05) and HG only at 50% and 30% rhythmic handgrip (all <i>P</i><0.05). During cycling, MSNA (bursts·min^-1) decreased during mild (-4±4; <i>P</i>=0.01) and moderate (-8±6; <i>P</i><0.001) cycling in healthy controls, was unchanged during mild (+1±7; <i>P</i>=0.42) and moderate (+2±8; <i>P</i>=0.28) cycling in CMCs, yet increased in HFpEF during mild (+8±8; <i>P</i><0.001) and moderate (+9±10; <i>P</i><0.001) cycling. In HFpEF, the change in MSNA during moderate cycling related inversely to relative (<i>r</i>=-0.72; <i>R</i> ²=0.51; <i>P</i><0.01) and percent-predicted (<i>r</i>=-0.63; <i>R</i> ²=0.39; <i>P</i>=0.03) V̇O_2peak. No statistically significant relationships were detected in controls (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>In contrast to CMCs, patients with HFpEF exhibit augmented MSNA at rest and during exercise. The magnitude of such paradoxical sympathoexcitation during dynamic cycling relates inversely to V̇O_2peak, consistent with a neurogenic, vasoconstrictor limit on exercise capacity in HFpEF.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011962"},"PeriodicalIF":7.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Disparities Are Associated With Delayed Access to Tafamidis in Transthyretin Cardiac Amyloidosis.","authors":"Peter Miller, Pierre Elias, Andrew J Einstein, Mathew S Maurer, Gasmelseed Y Ahmed, Timothy J Poterucha","doi":"10.1161/CIRCHEARTFAILURE.124.012075","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012075","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012075"},"PeriodicalIF":7.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}