Circulation: Heart Failure最新文献

{"title":"Prolonged Extreme Asymptomatic Hypertroponinemia as a Milestone in Diagnosis of Familial Arrhythmogenic Right Ventricular Cardiomyopathy.","authors":"Sergej Prijic, Ivana Cerovic, Vladislav Vukomanovic, Sasa Popovic, Maja Popovic, Sanja Ninic, Stasa Krasic, Marija Zdravkovic","doi":"10.1161/CIRCHEARTFAILURE.124.012713","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012713","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012713"},"PeriodicalIF":7.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forgotten After Discharge? ECMO Patients Deserve Better.","authors":"Shan P Modi, Manreet K Kanwar","doi":"10.1161/CIRCHEARTFAILURE.125.013176","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.125.013176","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013176"},"PeriodicalIF":7.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Heart Abnormalities in Patients With Lung Disease, OSA, and Chronic Thromboemboli at Risk for or With Known Pulmonary Hypertension.","authors":"Yogesh N V Reddy, Robert P Frantz, Paul M Hassoun, Anna Hemnes, Evelyn Horn, Jane A Leopold, Franz Rischard, Erika B Rosenzweig, Nicholas S Hill, Serpil C Erzurum, Gerald J Beck, J Emanuel Finet, Christine L Jellis, Stephen C Mathai, Reena Mehra, W H Wilson Tang, Barry A Borlaug","doi":"10.1161/CIRCHEARTFAILURE.125.012912","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.125.012912","url":null,"abstract":"<p><strong>Background: </strong>Patients with lung disease, sleep apnea, and chronic thromboemboli can develop pulmonary hypertension, currently classified as group 3 or 4. Many of these patients also have risk factors for heart failure with preserved ejection fraction (HFpEF), but the optimal approach to identify the disease overlap remains unclear.</p><p><strong>Methods: </strong>Pretest probability for HFpEF was determined using the HFpEF-ABA algorithm among adjudicated group 3 or 4 patients at risk for pulmonary hypertension in the PVDOMICS study (Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics). Patients were stratified by current resting right heart catheterization criteria, and in a separate analysis, stratified only by HFpEF-ABA probability into low (<25%), intermediate, and high (≥75%) HFpEF probability groups.</p><p><strong>Results: </strong>Among 598 patients with group 3 disease, 27% (n=161) had elevated pulmonary capillary wedge pressure (PCWP) with postcapillary pulmonary hypertension even at rest, which was associated with the highest exercise PCWP. However, regardless of this resting PCWP-based classification, a larger subset had intermediate-to-high HFpEF-ABA probabilities (32% [n=197] high and 57% [n=358] intermediate HFpEF probability). High HFpEF probability in group 3 disease was associated with higher resting and dynamic PCWP response to NO, fluid, and exercise (<i>P</i><0.0001 for all). These changes were comparable with more traditionally defined HFpEF without pulmonary vascular disease (n=61) but less severe than those with combined precapillary and postcapillary pulmonary hypertension HFpEF (n=31; interaction <i>P</i>=0.006). Increasing HFpEF probability in group 3 disease was associated with worse left heart remodeling, quality of life, 6-minute walk distance, and peak VO₂ (<i>P</i><0.0001 for all). Findings were replicated in group 4 disease (n=102).</p><p><strong>Conclusions: </strong>Quantifying pretest probability for HFpEF in patients with sleep apnea, lung disease, or chronic thromboemboli identifies a progressive gradient for dynamic PCWP abnormalities with worse functional status and quality of life. These subclinical left heart abnormalities are not universally detectable by resting right heart catheterization alone and call for further study of whether strategies to prevent or treat HFpEF might improve functional status in these patients with high risk of occult HFpEF.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012912"},"PeriodicalIF":7.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic Right Heart Catheterization Before Transcatheter Mitral and Tricuspid Therapies.","authors":"Cosmo Godino, Antonio Sisinni, Luca Raone, Francesco Maria Sparasci, Andrea Munafò, Alberto Margonato, Luca Testa, Maurizio Taramasso, Fabien Praz, Sami Alnasser, Neil Fam, Rodrigo Estevez-Loureiro, Francesco Saia, Francesco Bedogni, Azeem Latib, Claudia Baratto, Francesca Coppi, Marianna Adamo, Altin Palloshi, Gabriele Crimi, Scott Lim, Francesco Maisano, Ryan J Tedford, Sergio Caravita","doi":"10.1161/CIRCHEARTFAILURE.124.012489","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012489","url":null,"abstract":"<p><p>Recent findings emphasize the potential role of invasive hemodynamic assessment in guiding transcatheter mitral and tricuspid valve percutaneous interventions. Right heart catheterization-derived parameters offer insights into hemodynamic changes associated with valvular heart diseases, pulmonary hypertension phenotyping, and right ventricular to pulmonary artery coupling. This might improve prognostic stratification for candidates to transcatheter therapies. This review provides a clinical overview of available data regarding the utility of preoperative right heart catheterization-derived parameters in patients undergoing mitral and tricuspid percutaneous repair or replacement.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012489"},"PeriodicalIF":7.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between the Sheets: A Rare Case of HeartMate 3 Pump Failure Due to Electrostatic Interference.","authors":"Boaz Elad, Ersilia M DeFilippis, Edward Lin, Jennifer Haythe, Vivian Feldman, Ilan Richter, Melana Yuzefpolskaya, Paolo C Colombo, Koji Takeda, Yuji Kaku, Gabriel Sayer, Nir Uriel, Dor Lotan","doi":"10.1161/CIRCHEARTFAILURE.124.012750","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012750","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012750"},"PeriodicalIF":7.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy.","authors":"Julien Ochala, Miao Feng, Qian Wang, Chahida Chaami, Edgar Nollet, Christopher T A Lewis, Anthony L Hessel, Michelle Michels, Kenneth C Bedi, Kenneth B Margulies, Jose R Pinto, Kenneth S Campbell, Diederik W D Kuster, Jolanda van der Velden","doi":"10.1161/CIRCHEARTFAILURE.124.012614","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012614","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy is often linked to likely pathogenic and pathogenic variants in genes encoding myofilament proteins. The exact molecular mechanisms by which these lead to cardiac dysfunction and metabolic remodeling remain incompletely understood. Hence, here, we sought to determine whether likely pathogenic and pathogenic variants in thick (<i>MYL2</i>) and thin (<i>TNNI3</i> or <i>TNNT2</i>) filament genes modulate the myosin super-relaxed state, a critical molecular regulator of heart energetics.</p><p><strong>Methods: </strong>We isolated cardiac strips from the septum of 13 patients with hypertrophic cardiomyopathy with <i>MYL2</i>, <i>TNNI3</i>, or <i>TNNT2</i> gene variants and 10 nonfailing donors. We performed 2'-(or-3')-<i>O</i>-(<i>N</i>-methylanthraniloyl) ATP chase experiments and X-ray diffraction as well as all-atomistic molecular dynamics simulations.</p><p><strong>Results: </strong>We observed that, despite preserved myofilament lattice, likely pathogenic and pathogenic variants in thick and thin filament proteins have opposite effects on cardiac myosin autoinhibition and the subsequent proportion of myosin molecules in the ATP-preserving super-relaxed state. As expected, <i>MYL2</i>-associated thick filament variants depressed myosin super-relaxation. However, with <i>TNNI3</i>- or <i>TNNT2</i>-related thin filament variants, myosin heads adopt an energy-saving biochemical hibernating state. Ultimately, these thin filament defects blunted the in vitro response to the hypertrophic cardiomyopathy-targeted inhibitor, mavacamten.</p><p><strong>Conclusions: </strong>Our findings indicate that, in hypertrophic cardiomyopathy, cardiac myosin super-relaxed state, associated ATP consumption, and in vitro mavacamten responsiveness depend on the type of myofilament variants. Our data warrant careful analyses of variant-specific responses to myosin inhibitors in the clinic.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012614"},"PeriodicalIF":7.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Related Prognosis of VA-ECMO-Treated Cardiogenic Shock: A Post-Hoc Analysis of the HYPO-ECMO Trial.","authors":"Guillaume Baudry, Nicolas Girerd, Kevin Duarte, Luca Monzo, Clément Delmas, Harriette G C Van Spall, Antoine Kimmoun, Bruno Levy","doi":"10.1161/CIRCHEARTFAILURE.124.012702","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012702","url":null,"abstract":"<p><p><b>Background:</b> The sex-related prognosis of patients with cardiogenic shock (CS) undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear. Our analyses aim to assess sex-specific outcomes in patients with CS receiving VA-ECMO and explored whether the effect of moderate hypothermia (MH) on clinical outcomes was modified by sex. <b>Methods:</b> In this post-hoc analysis of the HYPO-ECMO trial, clinical outcomes were compared by sex. The primary outcome was 30-day all-cause mortality (ACM). Key secondary outcomes included ACM and a composite outcome of ACM, heart transplant, escalation to left ventricular assist device implantation, or stroke at 30, 60 and 180 days. <b>Results:</b> Among the 334 patients enrolled in the trial, 81 (24%) were female. At 30 days, 45.7% of female and 46.6% of male patients experienced the primary outcome, with no sex differences (adjusted OR, 1.01 [0.57 - 1.78], p=0.98 and log-rank test, p=0.93). No significant sex differences were observed in all-cause mortality at 60 and 180 days (adjusted OR, 0.87 [0.49 - 1.52], p=0.61 and 0.83 [0.47 - 1.46], p=0.51, respectively) or in the composite outcome up to 180 days (p>0.2 for all). The effect of MH on the primary outcome (aOR, 0.73 [0.43 - 1.25], p=0.25 and 0.67 [0.26 - 1.76], p=0.41, in male and female respectively, interaction p-value = 0.88) and secondary outcomes (interaction p-value >0.3 for all) was not modified by sex. <b>Conclusions:</b> In this post-hoc analysis of the HYPO-ECMO trial, male and female experienced similar outcomes in CS treated with VA-ECMO. Sex did not significantly modify the effect of moderate hypothermia on outcomes. <b>Registration:</b> URL: https://clinicaltrials.gov Unique Identifier: NCT02754193.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrioventricular Dyssynchrony and Dyspnea in Heart Failure With Preserved Ejection Fraction.","authors":"Teodora Donisan, Sara Inglis, Samuel J Asirvatham, Barry A Borlaug","doi":"10.1161/CIRCHEARTFAILURE.125.013183","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.125.013183","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013183"},"PeriodicalIF":7.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-Life Echocardiographic Effects of the Amyloidogenic p.V142I Transthyretin Variant.","authors":"Vishal N Rao, Brian L Claggett, Michel G Khouri, Amil M Shah, Scott D Solomon, Senthil Selvaraj","doi":"10.1161/CIRCHEARTFAILURE.125.013212","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.125.013212","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where Adults With Heart Failure Die: Insights From the CDC-WONDER Database.","authors":"Farman Ali, Shaaf Ahmad, Aman Ullah, Ali Salman, Adarsh Raja, Faizan Ahmed, Prinka Perswani, Ahsan Alam, Jishanth Mattumpuram, Muhammad Talha Maniya, Hamza Janjua, Tyler J Bonkowski, Aravinda Nanjundappa","doi":"10.1161/CIRCHEARTFAILURE.124.012447","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012447","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is associated with high mortality rates and substantial health care costs. While there is growing emphasis on integrating palliative care for patients with HF, limited data exist on the locations where adults with HF spend their final days. The study aimed to analyze the location and circumstances of death among adults with HF in the United States using Centers for Disease Control and Prevention's Wide-ranging Online Data for epidemiological Research data.</p><p><strong>Methods: </strong>Mortality data from individuals aged ≥20 years, with HF listed as the cause of death between 1999 and 2023, were analyzed. The places of death were categorized as the emergency room, hospice/nursing home, inpatient medical facility, or home. Multinomial logistic regression was performed to examine the associations between demographic factors and death location.</p><p><strong>Results: </strong>HF-related mortality rates declined from 1999 (3.60% and 143.6 age-adjusted mortality rate) to 2010 (3.47% and 123.1 age-adjusted mortality rate). However, rates gradually increased thereafter, reaching 5.18% and 168.1 age-adjusted mortality rate in 2023. Deaths at home nearly doubled, rising from 18.41% (50 648 of 275 132) in 1999 to 33.47% (132 470 of 395 826) in 2023. Hospice/nursing home deaths increased from 30.95% (85 144 of 275 132) in 1999 to 34.71% (116 634 of 336 014) in 2017, but declined to 29.54% (116 931 of 395 826) by 2023. Young adults (20-34 years) had the highest proportion of inpatient deaths. Sex, ethnicity, and urbanization were significant predictors of death location, with men, White individuals, and those in large metropolitan areas more likely to die in medical facilities.</p><p><strong>Conclusions: </strong>This study underscores the shifting trends in the locations of death among patients with HF, with a ≈2-fold increase in HF-related deaths occurring at home over the past 2 decades. The recent decline in hospice/nursing home deaths, following a period of steady growth, calls for an in-depth examination of contributing barriers. Further research is essential to understand the sociodemographic factors driving disparities in HF-related death locations.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012447"},"PeriodicalIF":7.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}