Chinese Medical Journal最新文献

{"title":"WTAP-mediated m6A modification of JUNB contributes to poor prognosis of HCC patients through the NLRP3-GSDMD pathway.","authors":"Zhijia Sun, Jiangbo Li, Zheng Zhang, Pu Liu, Ruiguan Wang, Zhuo Song, Yuzhu Tang, Chenhui Wang, Liang Guo, Yingjie Wang","doi":"10.1097/CM9.0000000000003468","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003468","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based unsupervised phenotypic clustering analysis of patients with IgA nephropathy: Distinct therapeutic responses of different groups.","authors":"Yiqin Wang, Qiong Wen, Xingji Lian, Lingling Liu, Qian Zhou, Yunfang Zhang, Chao Chen, Gengmao Wu, Cheng Wang, Qinghua Liu, Wei Chen","doi":"10.1097/CM9.0000000000003422","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003422","url":null,"abstract":"<p><strong>Background: </strong>Immunoglobulin A nephropathy (IgAN) has a heterogeneous clinical presentation. Comparison of different IgAN subgroups may facilitate the application of more targeted therapies. This study was aimed to distinct disease phenotypes in IgAN and to develop prognostic models for renal composite outcomes.</p><p><strong>Methods: </strong>Clinical and pathological data were from 2000 patients with biopsy-proven primary IgAN from four centers, including the First Affiliated Hospital of Sun Yat-sen University (SYSU), the Fifth Affiliated Hospital of Sun Yat-sen University, the Huadu District People's Hospital of Guangzhou, and Jieyang Affiliated Hospital of SYSU in China between January 2009 and December 2018 (training cohort: 1203 patients, validation cohort: 797 patients). Components from principal components analysis (PCA) were used to fit a k-means clustering algorithm and identify distinct subgroups. A subgroup-based prediction model was developed to assess prognosis and therapeutic efficacy in each subgroup.</p><p><strong>Results: </strong>The PCA-k-means clustering algorithm identified four subgroups. Subgroup 1 had significantly better long-term renal survival upon administration of a renin-angiotensin system blocker (adjusted hazard ratio [aHR]: 0.16, 95% confidence interval [CI]: 0.10-0.27, P <0.001). Subgroup 2 had a significant improvement from corticosteroid therapy (aHR: 0.19, 95% CI: 0.06-0.61, P = 0.005). Subgroups 3 and 4 had milder pathological changes and relatively stable kidney function for several years. Subgroup 3 (predominantly males) had a high incidence of metabolic risk factors, necessitating more intensive monitoring; subgroup 4 (predominantly females) had a high incidence of recurrent macroscopic hematuria. These patterns were similar in the validation cohort. A subgroup-based prognosis prediction model demonstrated an area under the curve of 0.856 in the validation dataset.</p><p><strong>Conclusion: </strong>The unsupervised clustering method provided reliable classification of IgAN patients into different subgroups according to clinical features, prognoses, and treatment responsiveness. Our subgroup-based prediction model has significant clinical utility for the assessment of risk and treatment in patients with IgAN.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination and evaluation of serum monosaccharides in patients with early-stage lung adenocarcinoma.","authors":"Wenhao Su, Cui Hao, Yifei Yang, Pengjiao Zeng, Huaiqian Dou, Meng Zhang, Yanli He, Yiran Zhang, Ming Shan, Wenxing Du, Wenjie Jiao, Lijuan Zhang","doi":"10.1097/CM9.0000000000003401","DOIUrl":"10.1097/CM9.0000000000003401","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"352-354"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of osteoarthritis treatment by exosomes.","authors":"Xiaofei Wang, Jihang Dai, Lei Xu, Zhimin Wu, Linbing Lou, Cunyi Xia, Haixiang Miao, Wenyong Fei, Jingcheng Wang","doi":"10.1097/CM9.0000000000003325","DOIUrl":"10.1097/CM9.0000000000003325","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"367-369"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese guidelines on remote programming of deep brain stimulation for patients with Parkinson's disease.","authors":"Fangang Meng, Jie Zhang, Wenbin Zhang, Ling Chen, Jianjun Wu, Shanshan Mei, Lijuan Wang, Jianguo Zhang","doi":"10.1097/CM9.0000000000003390","DOIUrl":"10.1097/CM9.0000000000003390","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"261-263"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts.","authors":"Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng","doi":"10.1097/CM9.0000000000003004","DOIUrl":"10.1097/CM9.0000000000003004","url":null,"abstract":"<p><strong>Background: </strong>P16 inactivation is frequently accompanied by telomerase reverse transcriptase ( TERT ) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT . However, direct evidence remains to be obtained to support the causal effect of epigenetic changes, such as P16 methylation, on cancer development. This study aimed to provide experimental evidence that P16 methylation directly drives cancer development.</p><p><strong>Methods: </strong>A zinc finger protein-based P16 -specific DNA methyltransferase (P16-Dnmt) vector containing a \"Tet-On\" switch was used to induce extensive methylation of P16 CpG islands in normal human fibroblast CCD-18Co cells. Battery assays were used to evaluate cell immortalization and transformation throughout their lifespan. Cell subcloning and DNA barcoding were used to track the diversity of cell evolution.</p><p><strong>Results: </strong>Leaking P16-Dnmt expression (without doxycycline-induction) could specifically inactivate P16 expression by DNA methylation. P16 methylation only promoted proliferation and prolonged lifespan but did not induce immortalization of CCD-18Co cells. Notably, cell immortalization, loss of contact inhibition, and anchorage-independent growth were always prevalent in P16-Dnmt&TERT cells, indicating cell transformation. In contrast, almost all TERT cells died in the replicative crisis. Only a few TERT cells recovered from the crisis, in which spontaneous P16 inactivation by DNA methylation occurred. Furthermore, the subclone formation capacity of P16-Dnmt&TERT cells was two-fold that of TERT cells. DNA barcoding analysis showed that the diversity of the P16-Dnmt&TERT cell population was much greater than that of the TERT cell population.</p><p><strong>Conclusion: </strong>P16 methylation drives TERT -mediated immortalization and transformation of normal human cells that may contribute to cancer development.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"332-342"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating immunological transcriptomic profile identifies DDX3Y and USP9Y on the Y chromosome as promising biomarkers for predicting response to programmed death 1/programmed death ligand 1 blockade.","authors":"Liting You, Zhaodan Xin, Feifei Na, Min Chen, Yang Wen, Jin Li, Jiajia Song, Ling Bai, Jianzhao Zhai, Xiaohan Zhou, Binwu Ying, Juan Zhou","doi":"10.1097/CM9.0000000000003403","DOIUrl":"10.1097/CM9.0000000000003403","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"364-366"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous coronary intervention vs . medical therapy in patients on dialysis with coronary artery disease in China.","authors":"Enmin Xie, Yaxin Wu, Zixiang Ye, Yong He, Hesong Zeng, Jianfang Luo, Mulei Chen, Wenyue Pang, Yanmin Xu, Chuanyu Gao, Xiaogang Guo, Lin Cai, Qingwei Ji, Yining Yang, Di Wu, Yiqiang Yuan, Jing Wan, Yuliang Ma, Jun Zhang, Zhimin Du, Qing Yang, Jinsong Cheng, Chunhua Ding, Xiang Ma, Chunlin Yin, Zeyuan Fan, Qiang Tang, Yue Li, Lihua Sun, Chengzhi Lu, Jufang Chi, Zhuhua Yao, Yanxiang Gao, Changan Yu, Jingyi Ren, Jingang Zheng","doi":"10.1097/CM9.0000000000003295","DOIUrl":"10.1097/CM9.0000000000003295","url":null,"abstract":"<p><strong>Background: </strong>The available evidence regarding the benefits of percutaneous coronary intervention (PCI) on patients receiving dialysis with coronary artery disease (CAD) is limited and inconsistent. This study aimed to evaluate the association between PCI and clinical outcomes as compared with medical therapy alone in patients undergoing dialysis with CAD in China.</p><p><strong>Methods: </strong>This multicenter, retrospective study was conducted in 30 tertiary medical centers across 12 provinces in China from January 2015 to June 2021 to include patients on dialysis with CAD. The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Secondary outcomes included all-cause death, the individual components of MACE, and Bleeding Academic Research Consortium criteria types 2, 3, or 5 bleeding. Multivariable Cox proportional hazard models were used to assess the association between PCI and outcomes. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were performed to account for potential between-group differences.</p><p><strong>Results: </strong>Of the 1146 patients on dialysis with significant CAD, 821 (71.6%) underwent PCI. After a median follow-up of 23.0 months, PCI was associated with a 43.0% significantly lower risk for MACE (33.9% [ n  = 278] vs . 43.7% [ n  = 142]; adjusted hazards ratio 0.57, 95% confidence interval 0.45-0.71), along with a slightly increased risk for bleeding outcomes that did not reach statistical significance (11.1% vs . 8.3%; adjusted hazards ratio 1.31, 95% confidence interval, 0.82-2.11). Furthermore, PCI was associated with a significant reduction in all-cause and cardiovascular mortalities. Subgroup analysis did not modify the association of PCI with patient outcomes. These primary findings were consistent across IPTW, PSM, and competing risk analyses.</p><p><strong>Conclusion: </strong>This study indicated that PCI in patients on dialysis with CAD was significantly associated with lower MACE and mortality when comparing with those with medical therapy alone, albeit with a slightly increased risk for bleeding events that did not reach statistical significance.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"301-310"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does the brain emerge from anesthesia and regain consciousness.","authors":"Xuejun Song, Jiangjian Hu","doi":"10.1097/CM9.0000000000003378","DOIUrl":"10.1097/CM9.0000000000003378","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"298-300"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secular trend and projection of overweight and obesity among Chinese children and adolescents aged 7-18 years from 1985 to 2019: Rural areas are becoming the focus of investment.","authors":"Jiajia Dang, Yunfei Liu, Shan Cai, Panliang Zhong, Di Shi, Ziyue Chen, Yihang Zhang, Yanhui Dong, Jun Ma, Yi Song","doi":"10.1097/CM9.0000000000003123","DOIUrl":"10.1097/CM9.0000000000003123","url":null,"abstract":"<p><strong>Background: </strong>The urban-rural disparities in overweight and obesity among children and adolescents are narrowing, and there is a need for long-term and updated data to explain this inequality, understand the underlying mechanisms, and identify priority groups for interventions.</p><p><strong>Methods: </strong>We analyzed data from seven rounds of the Chinese National Survey on Students Constitution and Health (CNSSCH) conducted from 1985 to 2019, focusing on school-age children and adolescents aged 7-18 years. Joinpoint regression was used to identify inflection points (indicating a change in the trend) in the prevalence of overweight and obesity during the study period, stratified by urban/rural areas and sex. Annual percent change (APC), average annual percent change (AAPC), and 95% confidence interval (CI) were used to describe changes in the prevalence of overweight and obesity. Polynomial regression models were used to predict the prevalence of overweight and obesity among children and adolescents in 2025 and 2030, considering urban/rural areas, sex, and age groups.</p><p><strong>Results: </strong>The prevalence of overweight and obesity in urban boys and girls showed an inflection point of 2000, with AAPC values of 10.09% (95% CI: 7.33-12.92%, t = 7.414, P <0.001) and 8.67% (95% CI: 6.10-11.30%, t = 6.809, P <0.001), respectively. The APC for urban boys decreased from 18.31% (95% CI: 4.72-33.67%, t = 5.926, P = 0.027) to 4.01% (95% CI: 1.33-6.75%, t = 6.486, P = 0.023), while the APC for urban girls decreased from 13.88% (95% CI: 1.82-27.38%, t = 4.994, P = 0.038) to 4.72% (95% CI: 1.43-8.12%, t = 6.215, P = 0.025). However, no inflection points were observed in the best-fit models for rural boys and girls during the period 1985-2019. The prevalence of overweight and obesity for both urban and rural boys is expected to converge at 35.76% by approximately 2027. A similar pattern is observed for urban and rural girls, with a prevalence of overweight and obesity reaching 20.86% in 2025.</p><p><strong>Conclusions: </strong>The prevalence of overweight and obesity among Chinese children and adolescents has been steadily increasing from 1985 to 2019. A complete reversal in urban-rural prevalence is expected by 2027, with a higher prevalence of overweight and obesity in rural areas. Urgent action is needed to address health inequities and increase investments, particularly policies targeting rural children and adolescents.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"311-317"},"PeriodicalIF":7.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}