Chinese Medical Journal最新文献

Efferocytosis: A new therapeutic target for stroke. Efferocytosis：中风的新治疗靶点

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-12 DOI: 10.1097/CM9.0000000000003363

Li Gao, Anatol Manaenko, Feng Zeng, Jingchen Li, Lele Liu, Ruichuan Xie, Xiaohua Zhang, John H Zhang, Qiyong Mei, Jiping Tang, Qin Hu

引用次数: 0

How does the brain emerge from anesthesia and regain consciousness. 大脑是如何从麻醉中苏醒并恢复意识的？

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-08 DOI: 10.1097/CM9.0000000000003378

Xuejun Song, Jiangjian Hu

引用次数: 0

Essential tremor plus affect disease prognosis: A longitudinal study. 震颤加影响疾病预后：纵向研究

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-08 DOI: 10.1097/CM9.0000000000003340

Runcheng He, Mingqiang Li, Xun Zhou, Lanqing Liu, Zhenhua Liu, Qian Xu, Jifeng Guo, Xinxiang Yan, Chunyu Wang, Hainan Zhang, Irene X Y Wu, Beisha Tang, Sheng Zeng, Qiying Sun

引用次数: 0

Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds. 肺腺癌肿瘤微环境中的细胞成分：有望成为小分子化合物靶点的细胞。

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-08 DOI: 10.1097/CM9.0000000000003341

Mingyu Han, Feng Wan, Bin Xiao, Junrong Du, Cheng Peng, Fu Peng

引用次数: 0

What is new about growth-friendly implants for pediatric spinal deformity? 针对小儿脊柱畸形的生长友好型植入物有哪些新特点？

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-08 DOI: 10.1097/CM9.0000000000003239

Chenkai Li, Bingtai Han, Shengru Wang, Jianguo Zhang, You Du, Yiwei Zhao, Xiaohan Ye, Dihan Sun

引用次数: 0

Landscape of respiratory syncytial virus. 呼吸道合胞病毒的分布。

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-06 DOI: 10.1097/CM9.0000000000003354

Yuping Duan, Zimeng Liu, Na Zang, Bingbing Cong, Yuqing Shi, Lili Xu, Mingyue Jiang, Peixin Wang, Jing Zou, Han Zhang, Ziheng Feng, Luzhao Feng, Lili Ren, Enmei Liu, You Li, Yan Zhang, Zhengde Xie

{"title":"Landscape of respiratory syncytial virus.","authors":"Yuping Duan, Zimeng Liu, Na Zang, Bingbing Cong, Yuqing Shi, Lili Xu, Mingyue Jiang, Peixin Wang, Jing Zou, Han Zhang, Ziheng Feng, Luzhao Feng, Lili Ren, Enmei Liu, You Li, Yan Zhang, Zhengde Xie","doi":"10.1097/CM9.0000000000003354","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003354","url":null,"abstract":"Abstract: Respiratory syncytial virus (RSV) is an enveloped, negative-sense, single-stranded RNA virus of the Orthopneumovirus genus of the Pneumoviridae family in the order Mononegavirales. RSV can cause acute upper and lower respiratory tract infections, sometimes with extrapulmonary complications. The disease burden of RSV infection is enormous, mainly affecting infants and older adults aged 75 years or above. Currently, treatment options for RSV are largely supportive. Prevention strategies remain a critical focus, with efforts centered on vaccine development and the use of prophylactic monoclonal antibodies. To date, three RSV vaccines have been approved for active immunization among individuals aged 60 and above. For children who are not eligible for these vaccines, passive immunization is recommended. A newly approved prophylactic monoclonal antibody, Nirsevimab, which offers enhanced neutralizing activity and an extended half-life, provides exceptional protection for high-risk infants and young children. This review provides a comprehensive and detailed exploration of RSV's virology, immunology, pathogenesis, epidemiology, clinical manifestations, treatment options, and prevention strategies.","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An assessment model for the efficacy of autologous CD19 chimeric antigen receptor T-cell therapy and relapse or refractory diffuse large B-cell lymphoma risk. 自体 CD19 嵌合抗原受体 T 细胞疗法疗效与复发或难治性弥漫大 B 细胞淋巴瘤风险的评估模型。

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-06 DOI: 10.1097/CM9.0000000000003343

Bin Xue, Yifan Liu, Min Zhang, Gangfeng Xiao, Xiu Luo, Lili Zhou, Shiguang Ye, Yan Lu, Wenbin Qian, Li Wang, Ping Li, Aibin Liang

引用次数: 0

Impacts of Helicobacter pylori infection and eradication on gastrointestinal microbiota: An up-to-date critical review and future perspectives. 幽门螺杆菌感染和根除对胃肠道微生物群的影响：最新评论和未来展望。

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-06 DOI: 10.1097/CM9.0000000000003348

Yu Li, Cong He, Nonghua Lu

{"title":"Impacts of Helicobacter pylori infection and eradication on gastrointestinal microbiota: An up-to-date critical review and future perspectives.","authors":"Yu Li, Cong He, Nonghua Lu","doi":"10.1097/CM9.0000000000003348","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003348","url":null,"abstract":"Abstract: Helicobacter pylori (H. pylori) infects approximately half of the population worldwide and causes chronic gastritis, peptic ulcers, and gastric cancer. Test-and-treat strategies have been recommended for the prevention of H. pylori-associated diseases. Advancements in high-throughput sequencing technologies have broadened our understanding of the complex gastrointestinal (GI) microbiota and its role in maintaining host homeostasis. Recently, an increasing number of studies have indicated that the colonization of H. pylori induces dramatic alterations in the gastric microbiota, with a predominance of H. pylori and a reduction in microbial diversity. Dysbiosis of the gut microbiome has also been observed after H. pylori infection, which may play a role in the development of colorectal cancer. However, there is concern regarding the impact of antibiotics on the gut microbiota during H. pylori eradication. In this review, we summarize the current literature concerning how H. pylori infection reshapes the GI microbiota and the underlying mechanisms, including changes in the gastric environment, immune responses, and persistent inflammation. Additionally, the impacts of H. pylori eradication on GI microbial homeostasis and the use of probiotics as adjuvant therapy are also discussed. The shifts in the GI microbiota and their crosstalk with H. pylori may provide potential targets for H. pylori-related gastric diseases and extragastric manifestations.","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic management of early esophageal cancer in patients with concomitant cirrhosis. 对合并肝硬化的早期食管癌患者进行内镜治疗。

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-06 DOI: 10.1097/CM9.0000000000003334

Zhenming Zhang, Linlin Zhu

引用次数: 0

Growing burden of inflammatory bowel disease in China: Findings from the Global Burden of Diseases 2021 and predictions to 2035. 中国炎症性肠病的负担日益加重：2021 年全球疾病负担》的研究结果及对 2035 年的预测。

IF 7.5 3区医学

Chinese Medical Journal Pub Date : 2024-11-06 DOI: 10.1097/CM9.0000000000003345

Ziqing Yu, Gechong Ruan, Xiaoyin Bai, Yinghao Sun, Hong Yang, Jiaming Qian

{"title":"Growing burden of inflammatory bowel disease in China: Findings from the Global Burden of Diseases 2021 and predictions to 2035.","authors":"Ziqing Yu, Gechong Ruan, Xiaoyin Bai, Yinghao Sun, Hong Yang, Jiaming Qian","doi":"10.1097/CM9.0000000000003345","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003345","url":null,"abstract":"Background: Inflammatory bowel disease (IBD) imposes a significant economic and social burden in China. We aim to assess the epidemiological trends of IBD in China, and to predict the burden in the near future.Methods: The incidence, mortality, prevalence, and disability-adjusted life year (DALYs) of IBD from 1990 to 2021 were obtained from Global Burden of Disease 2021. Estimated annual percentage change (EAPC), average annual percent change, total percent change, and age-period-cohort model were used to access trends. Bayesian age-period-cohort model was utilized to predict the risk of incidence and mortality.Results: In 2021, IBD affected 168,077 people in China, with 24,941 new cases and 5640 deaths. The age-standardized rate (ASR) of incidence and death was 1.4 and 0.3, respectively. The incidence and prevalence in China were lower than the global and high socio-demographic index (SDI) regions, but the ASR of incidence and prevalence (EAPC: 2.93 and 2.54, respectively) had rapidly increased from 1990 to 2021. The ASR of death and DALYs had significantly decreased (EAPC: -3.05 and -2.93, respectively). Middle-aged and elderly populations faced a severe burden of incidence and prevalence, while the elderly population faced a severe mortality burden. It is projected that by 2035, the ASR of incidence will continue to rise, whereas the death rate will continue to decline.Conclusions: The burden of IBD in China is serious and increasingly severe. Establishing a comprehensive disease management system in China will help better control the medical burden of IBD.","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0