{"title":"Artificial intelligence in endoscopic diagnosis of esophageal squamous cell carcinoma and precancerous lesions.","authors":"Nuoya Zhou, Xianglei Yuan, Wei Liu, Qi Luo, Ruide Liu, Bing Hu","doi":"10.1097/CM9.0000000000003490","DOIUrl":"10.1097/CM9.0000000000003490","url":null,"abstract":"<p><strong>Abstract: </strong>Esophageal squamous cell carcinoma (ESCC) poses a significant global health challenge, necessitating early detection, timely diagnosis, and prompt treatment to improve patient outcomes. Endoscopic examination plays a pivotal role in this regard. However, despite the availability of various endoscopic techniques, certain limitations can result in missed or misdiagnosed ESCCs. Currently, artificial intelligence (AI)-assisted endoscopic diagnosis has made significant strides in addressing these limitations and improving the diagnosis of ESCC and precancerous lesions. In this review, we provide an overview of the current state of AI applications for endoscopic diagnosis of ESCC and precancerous lesions in aspects including lesion characterization, margin delineation, invasion depth estimation, and microvascular subtype classification. Furthermore, we offer insights into the future direction of this field, highlighting potential advancements that can lead to more accurate diagnoses and ultimately better prognoses for patients.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meng Li, Xinxin Zhang, Chunlei Zhou, Lei Lin, Lei Miao, Haiyan Wu, Jing He
{"title":"Neuroblastoma risk decreased by NSUN3 rs7653521 C>T polymorphism in Chinese children.","authors":"Meng Li, Xinxin Zhang, Chunlei Zhou, Lei Lin, Lei Miao, Haiyan Wu, Jing He","doi":"10.1097/CM9.0000000000003512","DOIUrl":"10.1097/CM9.0000000000003512","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Medical JournalPub Date : 2025-02-20Epub Date: 2025-01-17DOI: 10.1097/CM9.0000000000003465
Feiyan Wang, Yuhua Qu, Hua Jiang
{"title":"Allogeneic hematopoietic stem cell transplantation for thalassemia major using matched unrelated donors and haploidentical related donors.","authors":"Feiyan Wang, Yuhua Qu, Hua Jiang","doi":"10.1097/CM9.0000000000003465","DOIUrl":"10.1097/CM9.0000000000003465","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"490-492"},"PeriodicalIF":7.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanism of mitochondrial oxidative phosphorylation disorder in male infertility.","authors":"Kai Meng, Qian Liu, Yiding Qin, Wenjie Qin, Ziming Zhu, Longlong Sun, Mingchao Jiang, Joseph Adu-Amankwaah, Fei Gao, Rubin Tan, Jinxiang Yuan","doi":"10.1097/CM9.0000000000003126","DOIUrl":"10.1097/CM9.0000000000003126","url":null,"abstract":"<p><strong>Abstract: </strong>Male infertility has become a global concern, accounting for 20-70% of infertility. Dysfunctional spermatogenesis is the most common cause of male infertility; thus, treating abnormal spermatogenesis may improve male infertility and has attracted the attention of the medical community. Mitochondria are essential organelles that maintain cell homeostasis and normal physiological functions in various ways, such as mitochondrial oxidative phosphorylation (OXPHOS). Mitochondrial OXPHOS transmits electrons through the respiratory chain, synthesizes adenosine triphosphate (ATP), and produces reactive oxygen species (ROS). These mechanisms are vital for spermatogenesis, especially to maintain the normal function of testicular Sertoli cells and germ cells. The disruption of mitochondrial OXPHOS caused by external factors can result in inadequate cellular energy supply, oxidative stress, apoptosis, or ferroptosis, all inhibiting spermatogenesis and damaging the male reproductive system, leading to male infertility. This article summarizes the latest pathological mechanism of mitochondrial OXPHOS disorder in testicular Sertoli cells and germ cells, which disrupts spermatogenesis and results in male infertility. In addition, we also briefly outline the current treatment of spermatogenic malfunction caused by mitochondrial OXPHOS disorders. However, relevant treatments have not been fully elucidated. Therefore, targeting mitochondrial OXPHOS disorders in Sertoli cells and germ cells is a research direction worthy of attention. We believe this review will provide new and more accurate ideas for treating male infertility.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"379-388"},"PeriodicalIF":7.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mediating role of immune cells in causal relationships between lipids and intracranial aneurysm.","authors":"Haodong Jiang, Baowen Zhang, Junjun Li, Xiaobing Jiang","doi":"10.1097/CM9.0000000000003497","DOIUrl":"10.1097/CM9.0000000000003497","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"484-486"},"PeriodicalIF":7.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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