Chirurgia最新文献

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Is the Dressing Optional? A Retrospective Comparison of Clinical Outcomes and Environmental Impact of Skin Glue Alone Versus Glue with Dressing After Open Inguinal Hernia Repair. 穿衣是可选的吗?腹股沟疝开放性修补术后单独使用皮肤胶与敷料联合使用皮肤胶的临床效果及环境影响的回顾性比较。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3290
Nida Khan, Havil Stephen Alexander, Mukhil Rajendran, Dominika Krasicka, Premjithlal Bhaskaran, Rafique Umer Harvitkar, Christie Swaminathan, Victoria Pegna
{"title":"Is the Dressing Optional? A Retrospective Comparison of Clinical Outcomes and Environmental Impact of Skin Glue Alone Versus Glue with Dressing After Open Inguinal Hernia Repair.","authors":"Nida Khan, Havil Stephen Alexander, Mukhil Rajendran, Dominika Krasicka, Premjithlal Bhaskaran, Rafique Umer Harvitkar, Christie Swaminathan, Victoria Pegna","doi":"10.21614/chirurgia.3290","DOIUrl":"https://doi.org/10.21614/chirurgia.3290","url":null,"abstract":"<p><p><b>Introduction:</b> Open inguinal hernia repair is a frequently performed day-case operation. Cyanoacrylate skin adhesive provides a waterproof, occlusive seal and, in principle, does not require any additional postoperative dressing. Despite this, practice varies considerably, with many surgeons continuing to apply dressings out of habit rather than clinical necessity. As healthcare systems increasingly recognise the environmental impact of surgical consumables, understanding whether these dressings offer measurable benefits is essential. This study compared glue-only closure with glue plus dressing, evaluating clinical outcomes and the potential reduction in avoidable carbon emissions. Material and Method: A retrospective comparative analysis was undertaken of elective open inguinal hernia mesh repairs performed at our trust. Eighty patients were included: 40 managed with glue alone and 40 with glue plus dressing. Data collected included postoperative wound complications and dressing use. There was one wound infection in the glue plus dressing group and no wound infections in the glue only group. There was no statistically significant difference in infection rates between groups (1/40 vs 0/40; Fisher's exact test, p = 1.0). Overall wound complication rates were low in both groups. <b>Results:</b> Patients receiving dressings generated additional waste, with variable provision of take-home dressings resulting in an estimated 150 450 g CO2e per patient. Glue-only closure produced negligible dressing-related emissions. Additionally, patients in the glue-only group reported greater satisfaction with wound self care. Conclusion: The addition of postoperative dressings conferred no clinical advantage yet introduced avoidable environmental harm. Omitting routine dressings when glue is used is a safe, simple, and immediately adoptable measure to improve the sustainability of open inguinal hernia repair.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 Ahead of print","pages":"1-6"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technical Approaches to Digestive Tract Reconstruction in Laparoscopic Pancreaticoduodenectomy - A Technical Note. 腹腔镜胰十二指肠切除术消化道重建的技术途径-技术说明。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3282
Călina Aranghelovici, Adrian Mihai Eftimie, Elena Mihaela Vrabie, Ion Barbu, Iulian Mosteanu, Alexandra Trotea, Gheorghe Potlog, Cezar Stroescu, Irina Balescu, Vladislav Brasoveanu, Nicolae Bacalbasa
{"title":"Technical Approaches to Digestive Tract Reconstruction in Laparoscopic Pancreaticoduodenectomy - A Technical Note.","authors":"Călina Aranghelovici, Adrian Mihai Eftimie, Elena Mihaela Vrabie, Ion Barbu, Iulian Mosteanu, Alexandra Trotea, Gheorghe Potlog, Cezar Stroescu, Irina Balescu, Vladislav Brasoveanu, Nicolae Bacalbasa","doi":"10.21614/chirurgia.3282","DOIUrl":"https://doi.org/10.21614/chirurgia.3282","url":null,"abstract":"<p><p>Pancreaticoduodenectomy is one of the most technically demanding procedures in digestive surgery. Historically, laparoscopy in pancreatic surgery was limited to staging and palliative interventions. Since the first laparoscopic pancreaticoduodenectomy was completed in 1994, significant advances have improved perioperative safety, operative time, and lowered postoperative morbidity. Nevertheless, the complexity of pancreatic surgery paired with the technical challenges of pancreatic minimally invasive approach have restricted laparoscopic pancreatoduodenectomy to high-volume centers until recent times. The aim of this technical note presentation is to describe novel laparoscopic techniques of performing the three anastomoses - pancreaticojejunostomy and pancreaticogastrectomy, hepaticojejunostomy, and gastrojejunostomy- in an intracorporeal fashion, highlighting methods of facilitating the reconstructive process. This technical note s purpose is to also present new training models for surgeons, meant to reduce post-operative complications, such as pancreatic fistula or biliary leakage, to shorten operating times, and, ultimately, to increase the availability of laparoscopic pancreaticoduodenectomy as a safe and efficient treatment option.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"219-227"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Relevance of Biomarkers in Prostate Cancer: The Role of NKX3.1, AMACR, and Ki-67 in Risk Stratification - A Comprehensive Clinicopathological Analysis. 前列腺癌生物标志物的临床相关性:NKX3.1、AMACR和Ki-67在风险分层中的作用——一项全面的临床病理分析
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3287
Mihai-Cătălin Roşu, Manuela Enciu, Mariana Aşchie, Cristina Anita Ionescu, Mihaela Pundiche, Nicolae Dobrin, Constanţa Ștefanov, Antonela-Anca Nicolau, Leopa Nicoleta, Bogdan Caraban, Sorin Deacu, Gabriela-Izabela Bălţătescu, Ionuţ Bulbuc, Ion Alexandru Popovici, Lucian Cristian Petcu
{"title":"Clinical Relevance of Biomarkers in Prostate Cancer: The Role of NKX3.1, AMACR, and Ki-67 in Risk Stratification - A Comprehensive Clinicopathological Analysis.","authors":"Mihai-Cătălin Roşu, Manuela Enciu, Mariana Aşchie, Cristina Anita Ionescu, Mihaela Pundiche, Nicolae Dobrin, Constanţa Ștefanov, Antonela-Anca Nicolau, Leopa Nicoleta, Bogdan Caraban, Sorin Deacu, Gabriela-Izabela Bălţătescu, Ionuţ Bulbuc, Ion Alexandru Popovici, Lucian Cristian Petcu","doi":"10.21614/chirurgia.3287","DOIUrl":"https://doi.org/10.21614/chirurgia.3287","url":null,"abstract":"<p><p><b>Introduction:</b> Accurate risk stratification, essential for the therapeutic approach (especially surgical) of prostate cancer, is based on standard histopathological criteria. The biological heterogeneity of this neoplasm requires the identification of complementary markers that reflect the molecular mechanisms of tumor progression. The aim of this study was to evaluate the correlation between immunohistochemical markers of metabolism (AMACR, NKX3.1) and proliferation (Ki-67) and histopathological aggressiveness in ADK (prostate adenocarcinoma). <b>Methods:</b> This retrospective, single-center clinicopathological study included 385 patients with prostatic lesions from Sf. Apostol Andrei Emergency Clinical Hospital in Constanta (2023 2024). Of these, 198 cases of ADK were selected for the main immunohistochemical analysis. The cases were classified according to the Gleason system and Grade Groups. The expression of AMACR, NKX3.1 and Ki-67 markers was assessed by immunohistochemistry and correlated with Grade Groups, as well as with the presence of chronic inflammation and peritumoral glandular atrophy. <b>Results:</b> Increased AMACR expression (93.9% of cases) and increased Ki-67 index ( 20% in 29.3% cases) were significantly correlated with high Grade Groups (p 0.001). Loss of NKX3.1 expression increased from Grade Group 1 to Grade Group 4, followed by a lower frequency in Grade Group 5, indicating a non-linear association with histopathological grade (p for trend 0.001). The concomitant presence of chronic inflammation and glandular atrophy was associated with high Grade Groups and with a significantly higher Ki-67 index (p=0.001 and p 0.001). Triple staining (AMACR/p63/HMWCK) showed no discordant cases in distinguishing ADK from benign lesions that mimic prostate cancer. <b>Conclusions:</b> The extended immunohistochemical profile (AMACR, NKX3.1, Ki-67) provides valuable biological information correlated with tumor aggressiveness. Integrating these markers into the preoperative evaluation, along with standard histopathological evaluation and the peritumoral microenvironment, may contribute to a more accurate risk stratification. However, these findings are correlative, and their clinical applicability requires validation through further prospective studies.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"162-171"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Pancreatitis as an Extrapulmonary Manifestation and Pulmonary Embolism as a Complication of COVID-19: A Case Report. 急性胰腺炎作为肺外表现和肺栓塞作为COVID-19并发症:1例报告
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3278
Ljiljana Milić, Dragana Arbutina, Dragica Mitrović, Marko Šurlan, Aleksandar Karamarković
{"title":"Acute Pancreatitis as an Extrapulmonary Manifestation and Pulmonary Embolism as a Complication of COVID-19: A Case Report.","authors":"Ljiljana Milić, Dragana Arbutina, Dragica Mitrović, Marko Šurlan, Aleksandar Karamarković","doi":"10.21614/chirurgia.3278","DOIUrl":"https://doi.org/10.21614/chirurgia.3278","url":null,"abstract":"<p><p><b>Introduction:</b> Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, first emerged in Wuhan, China, in late 2019. Besides respiratory involvement, COVID-19 may cause coagulation abnormalities, leading to thromboembolic events. Mild forms of acute pancreatitis have also been reported in patients with COVID-19 pneumonia. The aim of this case report is to highlight rare extrapulmonary manifestations of SARS-CoV-2 infection, with emphasis on pancreatic involvement. Case Report: A male patient was admitted with sore throat, dry cough, and fever up to 38.0°C. He had received the first dose of the Sinopharm COVID-19 vaccine three weeks prior and was obese (BMI 44.7 kg/m²). On admission, he developed pulmonary thromboembolism. Color Doppler ultrasonography of the lower extremities showed no signs of superficial or deep vein thrombosis. On the eleventh day of treatment, laboratory tests revealed elevated serum amylase, lipase, and leukocyte count. Abdominal ultrasonography demonstrated a hyperechoic, non-enlarged pancreas, consistent with mild acute pancreatitis. Given the widespread presence of endothelial cells, SARS-CoV-2 infection may affect multiple extrapulmonary organs, including the CNS, cardiovascular system, kidneys, pancreas, liver, and gastrointestinal tract. Conclusion: SARS-CoV-2 infection may lead not only to pneumonia but also to thromboembolic complications and mild acute pancreatitis. Awareness of such rare extrapulmonary manifestations is important for timely diagnosis and management.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"228-233"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Training, Protocol Adherence and Safety Culture in Anaesthesia and Intensive Care Units in Romania: A Cross-Sectional Study. 罗马尼亚麻醉和重症监护病房的持续培训、协议遵守和安全文化:一项横断面研究。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3271
Gabriel Petre Gorecki, Ovidiu Horea Bedreag, Dorel Săndesc, Horaţiu Moldovan, Dan Gabriel Costea, Anamaria Hărăbor, Dan Nicolae Păduraru, Alexandru Cosmin Palcău, Magdalena Miulescu, Ioana Roşca, Dragoş Predescu, Silviu Constantinoiu
{"title":"Continuous Training, Protocol Adherence and Safety Culture in Anaesthesia and Intensive Care Units in Romania: A Cross-Sectional Study.","authors":"Gabriel Petre Gorecki, Ovidiu Horea Bedreag, Dorel Săndesc, Horaţiu Moldovan, Dan Gabriel Costea, Anamaria Hărăbor, Dan Nicolae Păduraru, Alexandru Cosmin Palcău, Magdalena Miulescu, Ioana Roşca, Dragoş Predescu, Silviu Constantinoiu","doi":"10.21614/chirurgia.3271","DOIUrl":"https://doi.org/10.21614/chirurgia.3271","url":null,"abstract":"<p><p><b>Background:</b> High-quality and safe care in Anaesthesia and Intensive Care Units (AICUs) relies on continuous professional development, strict adherence to safety protocols, and a supportive organisational culture. Understanding how these factors interact is essential for improving both patient safety and staff well-being. <b>Methods:</b> A cross-sectional online survey was conducted in November 2024 among 109 healthcare professionals working in Romanian AICUs. The questionnaire assessed access to professional training, compliance with safety procedures, communication quality, managerial support, and job satisfaction, using five-point Likert scales. Data were analysed using descriptive statistics, Chi-square tests, Mann Whitney U tests, and Spearman s correlation coefficients. <b>Results:</b> Training satisfaction was significantly associated with perceived preparedness for emergency situations (ÃÂ=0.44, p 0.01). Adherence to safety protocols correlated positively with perceptions of a strong safety culture (ÃÂ=0.39, p 0.01). Managerial support showed a moderate positive correlation with job satisfaction (0.48, p 0.01) and willingness to report incidents ( 0.42, p 0.01). Respondents from private hospitals reported slightly higher openness to feedback and more frequent training opportunities compared to those from public institutions. <b>Conclusions:</b> The findings underscore the importance of interdisciplinary training, empathetic leadership, and constructive feedback mechanisms in fostering a positive safety culture and enhancing professional motivation in AICU settings.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"172-181"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological Characteristics of Breast Tumors with Neuroendocrine Features: A Retrospective Case Series. 具有神经内分泌特征的乳腺肿瘤的临床病理特征:回顾性病例系列。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3286
Mihaela-Mădălina Gavrilescu, Alexandra Nicoleta Dumitraşcu, Răzvan Vieriu, Maria-Gabriela Aniţei, Iulian Radu, Viorel Scripcariu
{"title":"Clinicopathological Characteristics of Breast Tumors with Neuroendocrine Features: A Retrospective Case Series.","authors":"Mihaela-Mădălina Gavrilescu, Alexandra Nicoleta Dumitraşcu, Răzvan Vieriu, Maria-Gabriela Aniţei, Iulian Radu, Viorel Scripcariu","doi":"10.21614/chirurgia.3286","DOIUrl":"https://doi.org/10.21614/chirurgia.3286","url":null,"abstract":"<p><p><b>Introduction:</b> Breast neoplasms with neuroendocrine characteristics form a rare and heterogeneous group that includes both invasive carcinomas showing neuroendocrine differentiation and primary neuroendocrine tumors arising in the breast. Because these lesions are uncommon, their clinicopathological features and biological behavior are still not fully elucidated. <b>Methods:</b> We conducted a retrospective analysis of 22 patients diagnosed with breast tumors showing neuro-endocrine features and treated in 1st Surgical Unit of Regional Institute of Oncology, Iasi. Clinicopathological characteristics, immunohistochemical profile and treatment patterns were analyzed. <b>Results:</b> The median age at diagnosis was 66.1 years (range: 35 83). Most tumors corresponded to invasive carcinoma of no special type with neuroendocrine differentiation, while a smaller subset fulfilled the criteria for primary neuroendocrine neoplasms of the breast. Immunohistochemical analysis revealed a predominantly luminal immunophenotype, characterized by strong estrogen receptor expression and absence of HER2 overexpression. T0he median Ki-67 proliferation index was 40.3%. Lymph node involvement was observed in 45.5% of cases. All patients were treated according to standard breast cancer protocols, including surgery, chemotherapy, endocrine therapy and radiotherapy when indicated. The median follow-up was 26 months. Survival analysis included 20 patients with available follow-up data, while 2 patients were lost to follow-up. During the follow-up period, 9 deaths were recorded, corresponding to an overall mortality rate of approximately 45%. <b>Conclusions:</b> In our study, breast tumors with neuroendocrine features exhibited a luminal immunophenotype and did not demonstrate a clearly distinct clinical behavior compared with conventional hormone receptor positive breast cancer. Neuroendocrine differentiation may therefore represent a morphological feature within the luminal spectrum rather than a distinct biological entity.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"130-138"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Biomarkers and CT-Derived Muscle Indices in Sarcopenia Associated with Pancreatic Neoplasm: A Comparative Clinical Study. 血清生物标志物和ct来源的肌肉指数与胰腺肿瘤相关的肌肉减少:一项比较临床研究。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3291
Costel-George Gherghescu, Radu Andrei Baz, Constantin Dina, Eugen Dumitru, Georgeta Camelia Cozaru, Mihaela Manea, Ioana Popescu, Ana-Maria Grigorescu, Stere Popescu, Andrei Dumitru
{"title":"Serum Biomarkers and CT-Derived Muscle Indices in Sarcopenia Associated with Pancreatic Neoplasm: A Comparative Clinical Study.","authors":"Costel-George Gherghescu, Radu Andrei Baz, Constantin Dina, Eugen Dumitru, Georgeta Camelia Cozaru, Mihaela Manea, Ioana Popescu, Ana-Maria Grigorescu, Stere Popescu, Andrei Dumitru","doi":"10.21614/chirurgia.3291","DOIUrl":"https://doi.org/10.21614/chirurgia.3291","url":null,"abstract":"<p><p><b>Background:</b> Sarcopenia is a frequent and clinically relevant condition in patients with pancreatic neoplasm, contributing to poor prognosis, reduced therapeutic tolerance, and increased mortality. The identification of reliable circulating biomarkers, alongside imaging-based muscle assessment, may improve early detection and risk stratification. <b>Methods:</b> This randomized prospective study included 61 patients, of whom 36 had pancreatic neoplasm associated with sarcopenia and 25 served as controls. Serum levels of osteonectin (SPARC), C-terminal agrin fragment (CAF), procollagen type III N-terminal peptide (P3NP), myostatin (MSTN), and insulin-like growth factor-1 (IGF-1) were measured using ELISA. Skeletal muscle index (SMI) and psoas muscle index (PMI) were assessed using CT at the L3 level. <b>Results:</b> Patients with pancreatic neoplasm and sarcopenia showed significantly altered biomarker profiles compared to controls. Osteonectin (median 936.4 vs. 539.9, p 0.001), CAF (2135.9 vs. 1165.5, p 0.001), P3NP (8.01 vs. 5.34, p 0.001), myostatin (47.71 vs. 7.85, p 0.001), and IGF-1 (142 vs. 106.7, p 0.001) were all elevated. The highest biomarker levels were consistently observed in the pancreatic neoplasm group compared to other disease groups. Additionally, 100% of patients with pancreatic neoplasm exhibited reduced SMI, confirming the high prevalence of sarcopenia. Biomarker levels were not significantly influenced by tumor location. <b>Conclusions:</b> The combined use of circulating biomarkers and CT-derived muscle indices provides a clinically relevant approach for identifying sarcopenia in pancreatic cancer.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"151-161"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Axillary Dissection to Sentinel Node Biopsy: Three Decades Redefining Axillary Surgery in Early Breast Cancer - A Narrative Review. 从腋窝解剖到前哨淋巴结活检:三十年来对早期乳腺癌腋窝手术的重新定义-一篇叙述性综述。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3289
Draga-Maria Mandi, Florin Grama, Daniel Cristian, Adrian Bordea, Răzvan Valentin Scăunaşu, Iulia-Alecsandra Sălcianu, Traian Pătraşcu
{"title":"From Axillary Dissection to Sentinel Node Biopsy: Three Decades Redefining Axillary Surgery in Early Breast Cancer - A Narrative Review.","authors":"Draga-Maria Mandi, Florin Grama, Daniel Cristian, Adrian Bordea, Răzvan Valentin Scăunaşu, Iulia-Alecsandra Sălcianu, Traian Pătraşcu","doi":"10.21614/chirurgia.3289","DOIUrl":"https://doi.org/10.21614/chirurgia.3289","url":null,"abstract":"<p><p><b>Introduction:</b> Axillary lymph node dissection (ALND) has been the gold standard for axillary staging in breast cancer for over a century. The introduction of sentinel lymph node biopsy (SLNB) in the 1990s offered a minimally invasive alternative with comparable staging accuracy and significantly reduced morbidity. Multiple landmark randomized controlled trials have since demonstrated that completion ALND can be safely omitted in selected patients with positive sentinel lymph nodes without compromising oncologic outcomes. This narrative review aims to examine the evolution from ALND to SLNB, critically evaluate the landmark trials that shaped current practice, and discuss ongoing controversies and future directions in axillary management in early breast cancer. <b>Materials and Methods:</b> A comprehensive literature search was performed using PubMed/MEDLINE, Scopus, and Web of Science databases. Search terms included \"sentinel lymph node biopsy\", \"axillary lymph node dissection\", \"breast cancer\", and \"axillary management.\" Landmark randomized controlled trials, systematic reviews, meta-analyses, and current clinical practice guidelines were identified and reviewed. <b>Results:</b> The NSABP B-32 trial validated SLNB as an accurate staging tool equivalent to ALND. The ACOSOG Z0011 trial demonstrated no survival benefit from completion ALND in patients with 1-2 positive sentinel lymph nodes undergoing breast-conserving surgery. The AMAROS trial demonstrated that irradiation of the axilla provides equivalent locoregional disease control compared to surgical dissection, while carrying a substantially more favorable morbidity profile.The IBCSG 23-01 trial confirmed that ALND can be omitted for sentinel node micrometastases. Most recently, the SENOMAC trial extended these findings to patients with 1-2 macrometastases in a broader population. <b>Conclusions:</b> SLNB has become the established standard for axillary staging in early breast cancer with a clinically negative axilla, superseding ALND entirely. Progressive de-escalation of axillary surgery has been consistently supported by high-level evidence without compromising survival. Future research will determine the feasibility of further de-escalation, particularly after neoadjuvant chemotherapy.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"200-210"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic Challenges of Hysterectomy in Benign Gynecological Pathology - Perspectives from a Systematic Review. 良性妇科病理子宫切除术的策略挑战-从系统回顾的角度。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3172
Nicoleta Alina Mareş, Alexandru Iordache, Niculae Iordache
{"title":"Strategic Challenges of Hysterectomy in Benign Gynecological Pathology - Perspectives from a Systematic Review.","authors":"Nicoleta Alina Mareş, Alexandru Iordache, Niculae Iordache","doi":"10.21614/chirurgia.3172","DOIUrl":"https://doi.org/10.21614/chirurgia.3172","url":null,"abstract":"<p><p>Hysterectomy is the most common non-obstetric surgical procedure performed in women of all ages, representing a point of intersection between surgery and gynecology, with multiple possible approaches. The lack of a clear consensus on standardized selection criteria for benign pathology results in variability and decisions that may not accurately reflect the specific characteristics of each case. This is a narrative systematic review aimed at identifying and organizing the criteria reported in the literature regarding the selection of surgical techniques for hysterectomy, providing an informative foundation for an individualized and practical approach that supports evidence-based, personalized surgical decision-making. We performed a systematic search in the PubMed, Cochrane Library, and Embase databases between January 1, 2015, and June 1, 2025, considering only English-language randomized controlled trials. The search strategy included both controlled and free terms, combined using Boolean operators. We selected the eight most relevant studies, with a high level of confidence following the quality assessment and consistent findings with the specialized literature. The choice of the optimal surgical technique should be individualized, based on a thorough evaluation of each patient and the expertise of the medical team, to achieve the best possible functional outcomes and quality of life after the intervention.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"121 2","pages":"188-199"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The AIMS Academy Medical Writing Training for Clinicians and Medical Students: A 3-year Prospective Educational Intervention Study and Survey. 针对临床医生和医学生的AIMS医学写作培训:一项为期3年的前瞻性教育干预研究和调查。
IF 0.8
Chirurgia Pub Date : 2026-04-01 DOI: 10.21614/chirurgia.3283
Giulio Mari, Richard Sassun, Jacopo Crippa, Pietro Achilli, Antonino Spinelli, Isacco Montroni, Abe Fingerhut
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