Multivisceral Resection for Locally Advanced Colon Cancer: Clinical and Treatment Characteristics Based on Final Pathological Evaluation. A Retrospective Study.

IF 0.8 Q4 SURGERY
Chirurgia Pub Date : 2025-08-01 DOI:10.21614/chirurgia.3182
Bogdan Filip, Ana Grigoras, Madalina Gavrilescu, Ionut Hutanu, Iulian Radu, Viorel Scripcariu, Dragos-Viorel Scripcariu
{"title":"Multivisceral Resection for Locally Advanced Colon Cancer: Clinical and Treatment Characteristics Based on Final Pathological Evaluation. A Retrospective Study.","authors":"Bogdan Filip, Ana Grigoras, Madalina Gavrilescu, Ionut Hutanu, Iulian Radu, Viorel Scripcariu, Dragos-Viorel Scripcariu","doi":"10.21614/chirurgia.3182","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Radical resection remains the most important factor that influences long term survival for patients with colon cancer. In order to achieve R0 resections in cases of locally advanced colon cancer a multivisceral resection is required. The aim of this study is to give insights regarding tumour characteristics, surgical treatment, early results and final evaluation of surgical specimen. <b>Methods:</b> This retrospective study includes all consecutive patients positively diagnosed with colon cancer between January 2018 and January 2025 in whom multivisceral resection was performed. We evaluated the clinical characteristics of the patients, the type of surgery, postoperative complications and the final pathological staging. We grouped the patients based on pathological evaluation and TNM staging system in pT3, pT4a and pT4b. <b>Results:</b> During this period there were 968 patients diagnosed with colon cancer in whom surgery was performed, of those multivisceral resection was performed in 82 cases (8.47%). Based on final pathological evaluation 21 patients (25.6%) presented pT3 tumours and the rest, 74.4% were pT4 tumours, the vast majority were patients with pT4b tumours (43 cases, 52.4%). Most common organs resected were small bowel 26 patients (31.7%), bladder 29 cases (34.1%), genital organs in 24 cases (28.2%) and abdominal wall in 22 cases (25.9%). Based on pathological evaluation pT4b tumours were more frequent moderate (55.8%) and poorly (7%) differentiated with lymphatic (67.4%), vascular (39.5%) and perineural invasion (27.9%) by comparison with pT3 or pT4a tumours. Severe complication occurred in 7.31%. <b>Conclusions:</b> Multivisceral resection represents a relatively safe procedure in the radical treatment of patients with advanced colonic cancer. Our study demonstrates that if this procedure is done in a tertiary centre by a surgical team with high expertise and experience in treatment of advanced abdominal malignancies it can provide a safe solution for these patients.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 4","pages":"396-402"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chirurgia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21614/chirurgia.3182","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Radical resection remains the most important factor that influences long term survival for patients with colon cancer. In order to achieve R0 resections in cases of locally advanced colon cancer a multivisceral resection is required. The aim of this study is to give insights regarding tumour characteristics, surgical treatment, early results and final evaluation of surgical specimen. Methods: This retrospective study includes all consecutive patients positively diagnosed with colon cancer between January 2018 and January 2025 in whom multivisceral resection was performed. We evaluated the clinical characteristics of the patients, the type of surgery, postoperative complications and the final pathological staging. We grouped the patients based on pathological evaluation and TNM staging system in pT3, pT4a and pT4b. Results: During this period there were 968 patients diagnosed with colon cancer in whom surgery was performed, of those multivisceral resection was performed in 82 cases (8.47%). Based on final pathological evaluation 21 patients (25.6%) presented pT3 tumours and the rest, 74.4% were pT4 tumours, the vast majority were patients with pT4b tumours (43 cases, 52.4%). Most common organs resected were small bowel 26 patients (31.7%), bladder 29 cases (34.1%), genital organs in 24 cases (28.2%) and abdominal wall in 22 cases (25.9%). Based on pathological evaluation pT4b tumours were more frequent moderate (55.8%) and poorly (7%) differentiated with lymphatic (67.4%), vascular (39.5%) and perineural invasion (27.9%) by comparison with pT3 or pT4a tumours. Severe complication occurred in 7.31%. Conclusions: Multivisceral resection represents a relatively safe procedure in the radical treatment of patients with advanced colonic cancer. Our study demonstrates that if this procedure is done in a tertiary centre by a surgical team with high expertise and experience in treatment of advanced abdominal malignancies it can provide a safe solution for these patients.

多脏器切除治疗局部晚期结肠癌:基于最终病理评估的临床和治疗特点。回顾性研究。
背景:根治性切除仍然是影响结肠癌患者长期生存的最重要因素。为了在局部晚期结肠癌病例中实现R0切除,需要多脏器切除。本研究的目的是提供有关肿瘤特征,手术治疗,手术标本的早期结果和最终评估的见解。方法:本回顾性研究包括2018年1月至2025年1月期间所有连续确诊为结肠癌并行多脏器切除术的患者。我们评估了患者的临床特征、手术类型、术后并发症和最终病理分期。我们根据病理评估和TNM分期系统将患者分为pT3、pT4a和pT4b。结果:本组968例确诊结肠癌患者行手术治疗,其中82例行多脏器切除,占8.47%。最终病理评价为pT3肿瘤21例(25.6%),pT4肿瘤74.4%,绝大多数为pT4b肿瘤(43例,52.4%)。最常见的脏器是小肠26例(31.7%),膀胱29例(34.1%),生殖器官24例(28.2%),腹壁22例(25.9%)。病理评价pT4b肿瘤与pT3或pT4a肿瘤相比,多为中度(55.8%)和低分化(7%),伴淋巴(67.4%)、血管(39.5%)和神经周围浸润(27.9%)。严重并发症发生率为7.31%。结论:在晚期结肠癌患者的根治性治疗中,多脏器切除是一种相对安全的方法。我们的研究表明,如果在三级中心由一个在治疗晚期腹部恶性肿瘤方面具有高专业知识和经验的外科团队进行该手术,可以为这些患者提供安全的解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Chirurgia
Chirurgia Medicine-Surgery
CiteScore
1.00
自引率
0.00%
发文量
75
审稿时长
4-8 weeks
期刊介绍: Chirurgia is a bimonthly journal. In Chirurgia, original papers in the area of general surgery which neither appeared, nor were sent for publication in other periodicals, can be published. You can send original articles, new surgical techniques, or comprehensive general reports on surgical topics, clinical case presentations and, depending on publication space, - reviews of some articles of general interest to surgeons from other publications. Chirurgia is also a place for sharing information about the activity of various branches of the Romanian Society of Surgery, information on Congresses and Symposiums organized by the Romanian Society of Surgery and participation notes in other scientific meetings. Letters to the editor: Letters commenting on papers published in Chirurgia are welcomed. They should contain substantive ideas and commentaries supported by appropriate data, and should not exceed 2 pages. Please submit these letters to the editor through our online system.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信