Problemy endokrinologii最新文献

{"title":"[Immunological status in patients with amenorrhea (literature review)].","authors":"Y S Absatarova, Y S Evseeva, E N Andreeva, Z T Zuraeva, E V Sheremetyeva, O R Grigoryan, R K Mikheev","doi":"10.14341/probl13456","DOIUrl":"10.14341/probl13456","url":null,"abstract":"<p><p>Amenorrhea is a common symptom of a whole range of nosologies among women of reproductive age, which can accompany any endocrinopathy in the stage of decompensation. In all the diversity of various links in the pathogenesis of reproductive disorders, the problem of immunopathology remains a little aside, however, the significance of these disorders is underestimated. This publication provides an overview of immune system abnormalities in a women with amenorrhea. As is known, in polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI), one of the clinical manifestations is amenorrhea. On the one hand, these nosologies differ significantly from each other in etiology, pathogenesis and approaches to therapy, and on the other hand, they have a common similarity, manifested by immunological disorders. The article provides information about the immune status of patients with PCOS and POI. Works devoted to various disorders in the immune system, pathologies of humoral and cellular immunity, which in the future may serve as the key to the development of new and non-standard methods of treating such socially significant diseases, are analyzed. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The choice of sources was prioritized for the period from 2018 to 2024.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"70 6","pages":"118-126"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The history of the institute of higher and additional professional education of the Endocrinology Reserch Centre].","authors":"S V Sumina, E A Pigarova, L K Dzeranova, A G Kuzmin","doi":"10.14341/probl13470","DOIUrl":"10.14341/probl13470","url":null,"abstract":"<p><p>The Endocrinology Reserch Centre is proud not only of its achievements in the area of personalized approach to the examination and treatment of patients in accordance with the principles of evidence-based medicine, the use of modern diagnostic and treatment technologies, but also of its rich history of training scientific and medical personnel. For many years the Center has been attracting the best and most talented graduates of higher medical institutions, becoming the \"alma mater\" for young doctors - endocrinologists, pediatric endocrinologists and nutritionists. Specialists, graduates of NMRC, make a significant contribution to the development of medicine, conducting research, creating innovative methods of treatment and helping patients not only in our country, but also abroad. However, the State Research Center of the Russian Federation FGBU «NMRC Endocrinology» is famous not only for its high-quality and comprehensive training, but also for its experienced, dedicated teaching staff, giving students unique opportunities for professional growth. The purpose of this article is to reflect the most important milestones in the development of education at NMIC Endocrinology, which began its formation more than a century ago, during the most difficult period of transition for our country.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"70 3","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[First experience using an aromatase inhibitor in combination with growth hormone to improve growth prognosis in a 14-year-old boy with growth hormone deficiency after treatment of craniopharyngioma. A case-report].","authors":"N A Mazerkina, S K Gorelyshev, A N Savateev, N A Strebkova, A L Kalinin","doi":"10.14341/probl13446","DOIUrl":"https://doi.org/10.14341/probl13446","url":null,"abstract":"<p><p>This article describes the first experience of successful use of growth hormone (GH) in combination with an aromatase inhibitor (AI), in a 14-year-old boy. At the age of 7, he presented with headaches, nausea and vomiting, and MRI revealed a craniopharyngioma (CP). An Ommaya system was implanted, and radiation therapy was performed. As a result of treatment, GH deficiency and secondary hypothyroidism developed. At age 9 years, signs of puberty appeared. Growth rate remained satisfactory until the age of 14 years. At the age of 14 growth rate slowed down, which was the reason for appointment. Upon examination, the bone age was 16 years and the projected final height without therapy was 162 cm. Given the poor growth prognosis, IA anastrozole in combination with GH was prescribed. During two years of therapy the growth gain amounted to 12.5 cm. This observation demonstrates that normal growth rates in patients with CP do not indicate preserved somatotropic function of the pituitary gland. With preserved sexual function, early or premature puberty may be observed. In such cases, IA can be prescribed in addition to GH - these are medications that inhibit the closure of growth. GH therapy in combination with IA is highly effective and safe in patients with GH deficiency after treatment of KF during puberty and allows to achieve good growth parameters.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Search for new immunohistochemical and circulating markers of insulinoma].","authors":"M Yu Yukina, E A Troshina, L S Urusova, N F Nuralieva, L V Nikankina, V A Ioutsi, O Yu Rebrova, N G Mokrysheva","doi":"10.14341/probl13466","DOIUrl":"10.14341/probl13466","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Insulinoma is a neuroendocrine tumor, the main manifestation of which is hypoglycemia. However, the symptoms of hypoglycemia can be non-specific for a long time, especially outside provocative conditions, and quite often the tumor manifests from a life-threatening condition - hypoglycemic coma. In this regard, timely laboratory diagnosis of insulinoma and determination of its aggressive course is one of the priorities in modern researches.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Search for new immunohistochemical (IHC) and circulating markers (CM) of insulinoma, including its aggressive course.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The patients examined at the Endocrinology Research Centre in the period 2017-2022 and operated on for an insulin-producing tumor were included. Before surgery and 2-12 months after it, blood sampling was performed with the determination of targeted marker proteins. Some patients underwent an extended IHC examination of the tumor, surrounding tissue and islets of Langerhans with primary antibodies to target marker proteins with an assessment of the degree of their expression. To determine the aggressive course of the tumor, the degree of malignancy (Grade), the number of tumors and signs of recurrence were characterized.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Based on the analysis of literature and pathogenetic characteristics of insulinoma, the following candidates for targeted marker proteins were selected: cocaine and amphetamine-regulated transcript (CART), chromogranin B (CrB), neuroendocrine secretory protein 55 (NESP55), glucagon-like peptide 1 (GLP1), arylalkylamine-N-acetyltransferase (AA-NAT), melatonin, and, exclusively for IHC research, protein D52 (TPD52), as well as receptors for glucagon-like peptide-1 (rGLP1) and melatonin (MTNR1b). 41 patients were included in the study, of which 10 patients underwent an extended IHC study. In patients with both aggressive and non-aggressive insulinoma after surgical treatment, CM levels did not change significantly and in individual patients they could both increase and decrease, including those patients with the expression of the corresponding marker in tumor tissue. It was shown that CART was expressed only in the tumor (in 4/10 of cases), while MTNR1b and rGLP1 were expressed in the tumor (in 6/10 and 10/10, respectively) and the islets of Langerhans (in 5/9 and 9/9, respectively). The association of marker expression with the aggressiveness of the course of insulinoma has not been revealed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The markers CART, MTNR1b and rGLP1 are of primary interest for further study in a larger sample of patients with insulinoma. Other markers (TPD52, XgB, NESP55, melatonin, AA-NAT) have not been shown to be associated with an insulin-producing tumor, therefore they are not promising for future researches. At the same time, it is necessary to continue research aimed at finding new both circulating and IHC markers in order to ","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"70 6","pages":"15-26"},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Arterial mediacalcinosis in patients with diabetes mellitus: etiopathogenetic and histopathological aspects].","authors":"O N Bondarenko, M V Yaroslavceva, G R Galstyan, N G Mokrysheva","doi":"10.14341/probl13360","DOIUrl":"https://doi.org/10.14341/probl13360","url":null,"abstract":"<p><p>In a review of the generalized results of foreign and domestic studies on the development mechanism and pathogenesis of vascular calcification. The etiopathogenetic, pathophysiological and histomorphological features of mediacalcinosis, which reveal changes in the vascular bed in patients with DM, are considered. The role of risk factors for diseases, such as increased glycemia, changes in insulin levels, impaired lipid metabolism, obesity, arterial hypertension, CKD and aging, is indicated. The role of procalcifying and anticalcifying factors in colonic vascular remodeling is discussed. Identification of informative molecular markers and factors of CS will allow in the future to develop effective strategies for drug management of the risk of their progression and individual prevention programs to improve the quality and life expectancy in patients with cardiovascular diseases.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"50-59"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Female reproductive function after radioiodine therapy for differentiated thyroid carcinoma].","authors":"M O Korchagina, E N Andreeva, M S Sheremeta, G A Melnichenko","doi":"10.14341/probl13407","DOIUrl":"https://doi.org/10.14341/probl13407","url":null,"abstract":"<p><p>Differentiated thyroid carcinoma (DTC) is the most common endocrine cancer, accounting for 90-95% of thyroid malignancy and predominant in the female population of all age groups. Surgery is the standard primary treatment for patients with DTC, followed by radioactive iodine therapy (RAIT) when indicated. After the main treatment, patients receive thyroid hormone therapy in a variety of regimens, either as a replacement therapy or as a therapy intended to suppress secretion of thyroid-stimulating hormone (TSH).The impact of RAIT on the health of individuals with DTC has been studied for years. The accumulation of 131I in organs and tissues, as well as some organs' direct involvement in the metabolism of 131I-containing substances and its excretion, can lead to secondary complications. Reproductive health in the context of RAIT has also been a popular research topic because DTC is frequently found in young individuals.We may identify a direction for future study in this field and the requirement for adjustments in patient management thanks to the data summarized in this review on the effect of RAIT for DTC on female reproductive health.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"72-82"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of 46,XX testicular disorders of sex development due to an apparent synonymous variant in the <i>WT1</i> gene: difficulties of differential diagnosis of intrauterine virililzation syndrome in a girl].","authors":"A A Buianova, I G Vorontsova, A F Samitova, Yu A Vasiliadis, E E Petryaykina, E S Demina, A N Tyulpakov","doi":"10.14341/probl13436","DOIUrl":"https://doi.org/10.14341/probl13436","url":null,"abstract":"<p><p>Disorders of sex development (DSD) represent a group of congenital conditions in which there is a discrepancy between the chromosomal and (or) gonadal sex and the structure of the genitals. Within the DSD there is a subgroup of 46,XX testicular DSD (46,XX TDSD), which may be caused by the translocation of the SRY gene, and more rarely - due to other causes (SRY-negative forms). In this report, we present an observation of a patient with SRY-negative 46,XX TDSD, in whom the condition was initially regarded as a virile form of congenital adrenal hyperplasia, then as idiopathic intrauterine virilization in a girl. Due to the development of virilization at the age of 11, the presence of testicular tissue was suspected. Molecular genetic analysis (whole exome sequencing with Sanger validation) revealed a de novo variant in exon 9 of the WT1 gene (chr11:32413528T&gt;C), which, according to predictions, did not lead to a change in the amino acid sequence (p.Thr479=, NM_024426.6), but disrupted splicing, resulting in a previously described in 46,XX TDSD a change in the C-terminal domain of WT1. After verification of the diagnosis, a gonadectomy was performed and estrogen replacement therapy was prescribed. Thus, we have described a patient with a rare form of 46,XX TDSD caused by a variant in the WT1 gene. The presented observation illustrates the difficulties of differential diagnosis of intrauterine virilization syndrome in female karyotype.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Involvement of essential trace elements in the pathogenesis of thyroid diseases: diagnostic markers and analytical methods for determination].","authors":"E A Troshina, N M Platonova, E S Senyushkina, V A Ioutsi, E S Smolin, L V Nikankina, Z T Zuraeva","doi":"10.14341/probl13402","DOIUrl":"https://doi.org/10.14341/probl13402","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To study the role of iodine, selenium and zinc in the pathogenesis of iodine deficiency and autoimmune thyroid diseases and scientifically substantiate the choice of security biomarkers and analytical methods for determination.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Serum iodine (I), selenium (Se), and zinc (Zn) concentrations were measured using inductively coupled plasma ionization tandem mass spectrometry (Agilent 8900 ICP-MS Triple Quad); by chemiluminescent immunoassay on an automatic analyzer Architect i2000 - TSH and AT-TPO in blood serum; by enzyme immunoassay - ZnT8A; biochemical method - ALP, SOD1 in 1150 people aged from 18 to 65 years (the average age of the subjects was 40±5 years). Ultrasound of the thyroid gland was performed in the supine position using a portable ultrasound machine LOGIQe with a multifrequency linear sensor 10-15 MHz; during the study, the volume of the thyroid gland, the presence of nodules and their characteristics according to the TIRADS classification, the structure of the thyroid gland and its echogenicity were assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In our study, the median serum iodine concentration was 60.68 μg/L (n=1150), with no significant difference between sexes. In 2%, the level of iodine in the blood serum was less than 30 mcg/l. Among the samples obtained (n=57), 19% were found to have a reduced iodine content in the lipophilic fraction - less than 10% of the total. In these samples, additional studies were performed on TSH, total and free T3 and T4 fractions. As a result, all indicators fell within the normal range, which indicates that there was no effect on thyroid function from a decrease in iodine content in the lipophilic fraction. In a comparative analysis of our previously obtained results of determining iodine in urine using the cerium-arsenite method and the inductively coupled plasma mass spectrometry method, it was found that both methods are generally comparable. The median selenium concentration was 83.38 µg/l, which corresponds to the reference values. The proportion of individuals with serum selenium levels less than 40 μg/L was 2.2%. A comparative analysis of groups of patients with serum selenium concentrations of less than 100 µg/l and more than 100 µg/l was carried out; in the group with low-normal selenium levels, the incidence of autoimmune thyroid pathology is 5% higher than in the comparison group. 60.3% of the adult population had zinc levels less than 1000 μg/L. The median serum zinc concentration was 632.9 μg/L. In regions with zinc deficiency, the incidence of autoimmune diseases (AI) of the thyroid gland and nodular / multinodular goiter is on average 10% higher than in regions with optimal zinc supply. There was no relationship between the content of zinc in the blood serum and antibodies to the zinc transporter (ZnT8A), alkaline phosphatase (ALP) and superoxide dismutase (SOD1), including in comparison of the data obtained in carrier","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"10-19"},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Management of primary hyperparathyroidism with rare localization of ectopic adenoma parathyroid gland].","authors":"E A Aboisheva, E S Avsievich, M O Korchagina, M V Degtyarev, E E Bibik, D G Beltsevich, E A Pigarova, M S Sheremeta","doi":"10.14341/probl13425","DOIUrl":"https://doi.org/10.14341/probl13425","url":null,"abstract":"<p><p>Topical diagnosis can be severely complicated in patients with primary hyperparathyroidism (PHPT) due to the ectopic placement of parathyroid gland (PTG) formations. We report a clinical case of PHPT in an 84-year-old patient caused by ectopic PTG adenoma located behind the right internal jugular vein at the level of the right submandibular gland. The impossibility of surgery for a long time due to the absence of a topical diagnosis has necessitated conservative treatment was required to get the hypercalcemia under control. In view of the concomitant deficiency of vitamin D, an attempt was made to use therapy with saturating doses of cholecalciferol under dynamic monitoring of the indicators of phosphorus-calcium metabolism, which allowed to achieve a significant decrease in PTH levels while maintaining normocalcemia.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Combination of Klinefelter syndrome and the classic form of congenital dysfunction of the adrenal cortex: clinical observation].","authors":"N I Volkova, I Yu Davidenko, D P Stavitskaya, E V Kudinova","doi":"10.14341/probl13298","DOIUrl":"https://doi.org/10.14341/probl13298","url":null,"abstract":"<p><p>Congenital adrenal hyperplasia (CAH) is a defect in one of the enzymes or transport proteins involved in the synthesis of cortisol in the adrenal cortex. Virile form of CAH characterized by cortisol deficiency and hyperandrogenism. Klinefelter syndrome is one of the most frequent chromosomal diseases leading to the development of primary hypogonadism. The manifestation of these two diseases could cause difficulties in diagnosis and medical treatment that lead to adverse consequences and affect the quality of life.A 43-years-old patient consulted a physician complaining about the lack of erections for 4 years, breast enlargement. At the age of 3 years based on experienced growth of pubic hair, decreased level of 17-ketosteroids in the urine and genetic analysis diagnosis of CAH, virile form was suspected. Prednisone 5 mg daily was prescribed. At the age of 5, based on phenotypic features and karyotyping Klinefelter Syndrome (XXY) was diagnosed. At the age of 13, stimulating hormonal chorionic gonadotropin drug with only one course of 10 injections was prescribed. At the age of 18, the patient independently canceled the use of prednisone. Further, he did not receive medication therapy for CAH and Klinefelter syndrome. At the age of 42, adrenal CT revealed formation of the left adrenal gland. According to the results of the hormonal activity examination, high levels of aldosterone and renin were detected. A diagnosis of left adrenal aldosteroma was made and a left-sided adrenalectomy was performed. Histological examination diagnosis of aldosteroma did not confirmed. On physical examination, BMI 30 kg/m2, genoid type of obesity, right testicle isn`t palpated, left testicle is dense, reduced in size. Small penis size. Decreased level of total testosterone, normal level of SHBG, LH and FSH was revealed. Ultrasound of the scrotum organs revealed decrease in the size of the testicles and appendages, a volumetric formation of the right testicle. Thus, diagnosis of CAH, virile form and Klinefelter syndrome, primary hypogonadism, right-sided cryptorchidism was confirmed. Hydrocortisone 30 mg daily was prescribed. Hormone replacement therapy with testosterone preparations was not prescribed until surgical treatment of neoplasm of the right testicle will be performed. On the example of this clinical case, we have demonstrate a combination of two endocrine pathologies and serious mistakes were made in the management of this patient. The management of such patients requires a multidisciplinary approach, which will avoid mistakes and improve the prognosis and quality of life of these patients.</p>","PeriodicalId":101419,"journal":{"name":"Problemy endokrinologii","volume":"71 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}