Urology research & practice最新文献

{"title":"Comparative Study of the Efficacy and Tolerability of Palmex® (Roystonea regia Lipid Extract), Saw Palmetto, Finasteride and Tamsulosin in Patients with Benign Prostatic Hyperplasia.","authors":"Raúl Guzmán Mederos, Mónica Reyes Bello, Julio César Fernández Travieso, Manuel Pedroso Gastón, Sigfredo Calzadilla Feijoo, Miriam Hernández Rech, Maria de Los Angeles Viamontes Lu, Yenney Reyes Nuñez, Jilma Mena Figueroa, Zunilda Rodríguez Suárez, Lai López Rodríguez, Niurka Basulto Turran, Yolanda Cruz Gómez, Meilis Mesa Angarica, Sarahí Mendoza Castaño, Maytee Robaina García, Gladys Jiménez Rivero","doi":"10.5152/tud.2025.24067","DOIUrl":"https://doi.org/10.5152/tud.2025.24067","url":null,"abstract":"<p><strong>Objective: </strong>Evaluate and compare the efficacy and tolerability of the treatment with Palmex®, saw palmetto, finasteride, or tamsulosin administered for 6 months to patients with benign prostatic hyperplasia (BPH).</p><p><strong>Methods: </strong>This multicenter, open, prospective, comparative study was conducted in men !40 years with mild and moderate BPH according to the International Prostate Symptoms Score (IPSS) (!1, <19). The study included 200 patients (50 per group) who were randomly allocated to receive Palmex® (320 mg/d), saw palmetto (320 mg/d), finasteride (5 mg/d), or tamsulosin (0.4 mg/d). The primary study outcome was the improvement of the maximum urinary flow (Qmax), while significant decreases in IPSS values, prostate size, and residual post-voiding volume were secondary efficacy variables. Statistical analysis was performed according to Intention to treat.</p><p><strong>Results: </strong>The demographic baseline characteristics of all the groups were similar. All groups exhibited a significant mean increase in Qmax from baseline to week 24, being 3.8 mL/s (27.7%), 3.6 mL/s (23.1%), 4.2 mL/s (28.6%), and 4.1 mL/s (26.3%) on Palmex®, saw palmetto, finasteride, and tamsulosin, respectively. Likewise, all the treatments significantly reduced the IPSS scores by 74.2% (Palmex®), 74.6% (saw palmetto), 60.3% (finasteride), and 74.2% (tamsulosin), also decreasing the prostate size and the residual post-voiding volume. No significant differences among the groups were found regarding any efficacy variable. The treatments were well tolerated.</p><p><strong>Conclusion: </strong>Palmex® for 6 months demonstrated to have a comparable efficacy to saw palmetto, finasteride, and tamsulosin in patients with mild and moderate BPH, being safe and well tolerated.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"302-309"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Penile Girth and Length in the Erect State in Reassuring Patients with Small Penis Anxiety.","authors":"Sameh Fayek GamalEl Din, Nashaat Ismail Nabil, Mohamed A Khalil, Amgad Elseginy, Mohamed Ahmed AbdElSalam","doi":"10.5152/tud.2025.24133","DOIUrl":"https://doi.org/10.5152/tud.2025.24133","url":null,"abstract":"<p><strong>Objective: </strong>The present study examined the impact of measuring penile girth and length in the erect state on reassuring individuals with small penis anxiety (SPA) in the flaccid state.</p><p><strong>Methods: </strong>This study included 200 potent men aged 25-40 years old. All candidates were assessed by the validated Arabic version of the International Index of Erectile Function (ArIIEF-5), Hospital Anxiety and Depression Scale (HADS), Beliefs about Penile Size, and Cosmetic Procedure Screening questionnaires. Participants were divided into 100 healthy participants and 100 participants with SPA. We measured penile length and girth in the flaccid state in participants with SPA. After 2 weeks, we measured penile length and girth in the erect state by injecting 0.25 cc diluted prostaglandin E1 (PGE-1) in the corporeal bodies. Also, participants with SPA were reassessed by the ArIIEF-5 and the HADS in the erect state.</p><p><strong>Results: </strong>Penile length in the flaccid state was in the normal range 9.33 ± 0.81 cm that increased to 10.37 ± 0.89 cm in the erect state. The penile girth in the flaccid state was also in the normal range 8.08 ± 0.85 cm that increased to 9.33 ± 0.85 cm in the erect state. Significant decreases in the scores of HADS after PGE-1 injection were noted, denoting improvement in the patient's quality of life. The ArIIEF-5 score insignificantly increased after re-counseling in the erect state. Despite a significant reduction in anxiety and depression levels after re-counseling in the erect state, yet, they did not show any correlation with the penile dimensions in the flaccid and the erect states.</p><p><strong>Conclusion: </strong>Although the current study failed to demonstrate significant correlations between penile dimensions in the erect state and the ArIIEF-5 and the HADS scores. Yet, there was significant decrease in HADS score and insignificant increase in ArIIEF-5 score denoting that men with SPA should be counseled in the erect state.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"316-321"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Penis Length and Circumference According to WHO Regions: Who has the Biggest One?","authors":"Hadi Mostafaei, Keiichiro Mori, Satoshi Katayama, Fahad Quhal, Benjamin Pradere, Takafumi Yanagisawa, Ekaterina Laukhtina, Frederik König, Reza Sari Motlagh, Pawel Rajwa, Hanieh Salehi-Pourmehr, Sakineh Hajebrahimi, Shahrokh F Shariat","doi":"10.5152/tud.2025.24038","DOIUrl":"https://doi.org/10.5152/tud.2025.24038","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to perform a systematic review and meta-analysis of stretched, erect, and flaccid penis length as well as circumference according to geographic WHO regions.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, and Cochrane Library were searched for articles published until February 2024. Studies in which a healthcare professional evaluated the penis size were considered eligible. After assessing the risk of bias, a systematic review and meta-analyses were performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement, and the outcomes were grouped based on the WHO regions.</p><p><strong>Results: </strong>A total of 33 studies comprising 36 883 patients were included. The risk of bias in the included studies was moderate/low. A comprehensive systematic review was done and meta-analyses performed for flaccid length [n = 28 201, mean (SE) 9.22 (0.24) cm], stretched length [n = 20 814, mean (SE) 12.84 (0.32) cm], erect length [n = 5669, mean (SE) 13.84 (0.94) cm], flaccid circumference [n = 30 117, mean (SE) 9.10 (0.12) cm], and erect circumference [n = 5168, mean (SE) 11.91 (0.18) cm]. The mean length of the stretched penis was largest in Americans [14.47 (0.90) cm]. The mean length of the flaccid penis was the largest in the Americas [10.98 (0.064) cm]. The mean flaccid penile circumference was largest in Americans [n = 29 714, mean (SE) 10.00 (0.04) cm].</p><p><strong>Conclusions: </strong>Penis sizes vary across WHO regions, suggesting the need to adjust standards according to geography to better understand councilmen and their partners. These data provide a framework for discussing body image expectations and therapeutic strategies in this sensitive and emotional subject matter.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"291-301"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison on Surgical Outcomes of Mini-Versus Standard-Percutaneous Nephrolithotomy in Staghorn Calculi: A Systematic Review and Meta-Analysis.","authors":"Noka Yogahutama, Muhammad Isa Fuad Affan, Alan Primi Ladese, Nicholas Abraham","doi":"10.5152/tud.2025.24125","DOIUrl":"https://doi.org/10.5152/tud.2025.24125","url":null,"abstract":"<p><p>Percutaneous Nephrolithotomy (PCNL) has become the standard for managing staghorn calculi. Smaller access sheath Mini-PCNL (M-PCNL) has been known for its advantages in surgical outcomes compared with Standard-PCNL (S-PCNL) in various settings. We conducted this systematic review to compare surgical outcomes and postoperative complications of M-PCNL vs. S-PCNL in staghorn calculi treatment. A systematic search of the literature was performed on PubMed, Cochrane Library, ProQuest, Scopus, ClinicalTrials.gov, and Google Scholar according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA Statement). Five randomized controlled trial (RCT) and 5 cohort studies were included. Risk of bias assessment was evaluated using Cochrane risk of bias (RoB) 2 and Cochrane RoB in Nonrandomized Studies - of Interventions (ROBINS-I). Ten studies involving 1733 staghorn calculi patients met the inclusion criteria. The stone-free rate (SFR) was comparable (odds ratio (OR) 1.13, 95% CI: 0.90-1.43, P = .28) compared to S-PCNL. Pooled analysis showed that M-PCNL resulted in a significantly lower shorter operative time (mean differences (MD) 14.06, 95% CI: 6.09-22.03, P < .001), lower blood transfusion (OR 0.46, 95% CI: 0.29-0.72, P < .001), and lower hemoglobin drop (MD !0.37, 95% CI: !0.72 to !0.03, P = .03) compared to S-PCNL. This meta-analysis suggests that while M-PCNL has comparable SFR to S-PCNL, it offers benefits in terms of shorter operative time, reduced blood transfusion needs, and less hemoglobin drop.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"281-290"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Bladder Microbiota in Female Patients with Overactive Bladder Syndrome.","authors":"Esra Kaya, Tayfun Sahınkanat, Murat Aral","doi":"10.5152/tud.2025.24040","DOIUrl":"https://doi.org/10.5152/tud.2025.24040","url":null,"abstract":"<p><strong>Objective: </strong>With the demonstration that the bladder is not sterile, the relationship between bladder microbiota and urinary system diseases has begun to be investigated. The aim of our study is to investigate the relationship between overactive bladder (OAB) syndrome and bladder microbiota.</p><p><strong>Methods: </strong>A total of 20 OAB syndrome patients and 20 controls were included in the study. Urine samples were taken with a transurethral catheter. We developed a modified expanded quantitative urine culture method and inoculated them into anaerobic blood culture bottles and thioglycolate medium at the bedside. The MALDI-TOF MS system was used for bacterial identification.</p><p><strong>Results: </strong>Thirty-five bacteria were identified in the patient group and 30 in the control group. As a result of culture, 16 different genera and 29 different types of bacteria were identified. Staphylococcus (25.7%) was the most common bacterial genus in the patient group, followed by Streptococcus (17.1%) and Lactobacillus (14.3%). Lactobacillus (26.7%) was the most frequently detected bacterial genus in the control group, followed by Streptococcus (13.3%) and Enterococcus (13.3%). The rate of Staphylococcus epidermidis in the patient group (22.9%) was found to be significantly higher than in the control group (0%) (P = .006). In the patient group, Lactobacillus gasseri's incidence (2.9%) was found to be significantly lower than in the control group (20.0%) (P = .042).</p><p><strong>Conclusion: </strong>Our study shows that patients with OAB have a significantly different microbiota compared to the control group.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"310-315"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freehand Transperineal Prostate Biopsy Improves the Detection Rate of Clinically Significant Prostate Cancer.","authors":"Juan Manuel Bujaldon, Gonzalo Juan Vitagliano, Leandro Blas, Martin Maqueda Vocos, Hernando Rios Pita","doi":"10.5152/tud.2025.24026","DOIUrl":"https://doi.org/10.5152/tud.2025.24026","url":null,"abstract":"<p><strong>Objective: </strong>Freehand transperineal prostate biopsy (fTP-Bx) has been established as an alternative within the transperineal approach for prostate cancer (CaP) diagnosis. The primary objective was to compare the rate of overall CaP detection and clinically significant (greater than or equal to International Society of Urological Pathology 2) in patients with biopsy-naive between freehand transperineal prostate biopsy (fTP-Bx) and transperineal grid biopsy (TP-Bx) techniques. The secondary objective was to show the characteristics of the procedure and measure the associated complications.</p><p><strong>Methods: </strong>A retrospective review of all patients who underwent fTP-Bx (n: 326) and TP-Bx (n: 118) in our department was conducted between October 2020 and May 2023 due to suspected CaP based on elevated prostate-specific antigen (PSA), suspicious digital rectal examination, or those under active surveillance protocol. The chisquare test and Fisher's exact test were used to compare categorical variables.</p><p><strong>Results: </strong>A retrospective review of all patients who underwent fTP-Bx (n: 326) and TP-Bx (n: 118) in our department was conducted between October 2020 and May 2023 due to suspected CaP based on elevated prostate-specific antigen (PSA), suspicious digital rectal examination, or those under active surveillance protocol. The chisquare test and Fisher's exact test were used to compare categorical variables.</p><p><strong>Conclusion: </strong>Freehand transperineal prostate biopsy achieved a higher rate of clinically significant CaP detection than TP-Bx in biopsy-naive patients, accompanied by a lower number of postoperative complications.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"269-274"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Skull Metastases of Prostate Cancer at Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computed Tomography Era: PSMA Uptake Characteristics and Oncological Outcomes.","authors":"Baris Esen, Okan Falay, Kayhan Tarim, Hulya Seymen, Mert Kilic, Sevil Bavbek, Yakup Kordan, Mehmet Onur Demirkol, Derya Tilki, Tarik Esen","doi":"10.5152/tud.2025.24164","DOIUrl":"https://doi.org/10.5152/tud.2025.24164","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate prostate-specific membrane antigen (PSMA) uptake characteristics and the oncological outcomes in patients with skull metastases.</p><p><strong>Methods: </strong>The records of 345 serial PSMA positron emission tomography (PET)/computed tomography (CT) scans of 96 patients with metastatic prostate cancer (PCa) were evaluated retrospectively. Skull bone metastasis was detected in 18 patients (18/96, 18.7%), with a mean age of 72.4 ± 9.1 years, and in 40 PSMA PET/CT scans (40/345, 11.6%). Involved skull bones, PSMA uptake characteristics, and CT counterparts of metastatic lesions were centrally reviewed. Prostate specific antigen (PSA) levels at the time of skull metastasis detection and PSMA-detected other metastatic lesions were recorded.</p><p><strong>Results: </strong>All patients with a skull metastasis showed multiple other metastatic bone lesions, and 6 (33.3%) had visceral metastasis. Seven (38.9%) patients had solitary skull lesions, whereas 11 (61.1%) had multiple skull metastases. Twenty-two out of 37 (59.5%) metastatic lesions had no CT counterpart. The median SUVmax was significantly higher in metastatic lesions with a CT counterpart (median 9.09 vs. 4.63, P = .018). At a median follow-up of 23.4 mo (interquartile range [IQR] 8.7-34.1) after detection of skull metastasis, 5 out of 11 (45.5%) hormone-sensitive and all castration-resistant patients died of PCa. The median survival of patients with castration-resistant disease was 9.92 months.</p><p><strong>Conclusion: </strong>The majority of PSMA-detected skull metastases did not show a CT counterpart, which may explain why skull metastases were rarely detected before the PSMA PET-era. In high-volume metastatic prostatic cancer cases, 68Ga-PSMA PET/CT imaging field including the vertex, may enhance the accuracy in detecting tumor extent and metabolic tumor volume.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 5","pages":"275-280"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Levothyroxine and Testosterone Administration on Bladder Contractility in the Rat Model of Propylthiouracil-Induced Hypothyroidism.","authors":"Didem Yılmaz Oral, Berna Güven Ciloğlu, Serap Gür","doi":"10.5152/tud.2025.24099","DOIUrl":"10.5152/tud.2025.24099","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of testosterone (T) treatment, with or without levothyroxine, the most widely used and least effective medication for managing hypothyroidism, on the functional and histological changes in propylthiouracil (PTU)- induced hypothyroid rat bladders.</p><p><strong>Methods: </strong>Male rats (n=35) were split into control, hypothyroid, hypothyroid rats treated with levothyroxine (20 µg/kg/day, oral, 2-weeks), hypothyroid rats treated with Sustanon (10 mg/kg,iIM, once/week, 2-weeks), and hypothyroid rats treated with combined treatment groups. Hypothyroidism was induced by PTU (0.05% in drinking water, 6 weeks). The serum concentration of triiodothyronine (T3), thyroxine (T4), total T, and the detrusor muscle's contractile responses were determined. A morphological study was conducted using Masson trichrome staining.</p><p><strong>Results: </strong>Triiodothyronine, T4, and T levels were considerably reduced in rats with hypothyroidism; however, these hormones were restored by levothyroxine and Sustanon. Compared to controls, the combination therapy improved the ratio of smooth muscle to collagen and the contractile responses to carbachol, electrical field stimulation, and adenosine triphosphate in the hypothyroid bladder.</p><p><strong>Conclusion: </strong>The authors' research suggests that hypothyroidism may affect the contractility and morphology of the bladder. In males with hypothyroidism and urogenital system dysfunction, combination therapy with thyroid hormones and T has a major impact on repairing detrusor smooth muscle contractility and bladder histomorphology.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Temperature Changes Between Holmium-YAG Laser and Thulium Fiber Laser in an In Vitro Setting.","authors":"Vaibhavkumar Patel, Kshitij Raghuvanshi, Krushnadevsinh Jadeja, Rajeev Chaudhari","doi":"10.5152/tud.2025.24100","DOIUrl":"10.5152/tud.2025.24100","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate and compare the rise in the temperature for the safety of the ureter and kidney parenchyma when firing the holmium laser and the thulium fiber laser (TFL).</p><p><strong>Methods: </strong>We performed a laboratory experiment to measure the rise in temperature upon firing holmium laser and a TFL in a 10 cm3 transparent test tube in an outdoor environment and then in a container with normal saline.</p><p><strong>Results: </strong>In a 10 cc test tube with static water at 25°C, the rise in temperature with holmium and TFL depends on the firing time, keeping power constant. On continuous firing for 10, 20, and 30 seconds, the temperature rose to 35.1, 42.7, and 53.2°C with holmium. The temperature went up to 38.3, 46.8, and 55.4°C when TFL was used. The power was kept at 10 W for both types of lasers. The temperature rise was relatively low when the test tube was immersed in a water container. It was even lower with irrigation.</p><p><strong>Conclusion: </strong>The rise in the temperature reaches to hazardous level in static water with a firing time of 30 seconds, which is almost equivalent to holmium and TFL. Thus, while using lasers in RIRS and ureteroscopy, the firing time should not exceed 20 seconds and adequate irrigation is required to prevent damage to the tissues. Also, the rise in temperature was almost equivalent to holmium and TFL; hence, TFL can be safely used in laser lithotripsy in any part of the genitourinary (GU) system.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"219-224"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of St. John's Wort Oil on Urethral Stricture: An Experimental Study in Rat Model.","authors":"Kazım Yelsel, Ergün Alma, Ömer Yüceer, Zeynel Abidin Taş, Berna Totan Ateş, Murat Kobaner, Halil Esimek, Adem Altunkol, Umut Ünal, Ali Ayyıldız","doi":"10.5152/tud.2025.24068","DOIUrl":"10.5152/tud.2025.24068","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to evaluate the effect of yellow and red centaury St. John's Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model.</p><p><strong>Methods: </strong>A total of 24 male rats were divided into 5 groups. No urethral damage was induced in the sham group. The urethras of all rats in the other groups was traumatized at 6 o'clock with a specially designed urethrotome blade. Group 1 was administered 0.5 cc of St. JW oil once daily for 15 days. Group 2 was administered 0.5 cc of red centaury oil intraurethrally once daily for 15 days. The traumatized rats in Group 3 were not treated (St. JW and red centaury oil were not administered). St. JW oil was administered to 3 rats in the Sham 1 group (Group 4), and red centaury oil was administered to 3 rats in the Sham 2 group (Group 5). A 20-G/32-mm intravenous cannula sheath was used for intraurethral administration. On the 15th day, rats were sacrificed and penectomy was performed for histologic evaluation.</p><p><strong>Results: </strong>Spongiofibrosis, mucosal inflammation, and congestion were significantly decreased in the yellow St. JW oil group when compared with the red centaury oil group and the untreated group (group to which neither St. JW nor red centaury oil was administered).</p><p><strong>Conclusion: </strong>In this study, intraurethral administration of yellow St. JW oil was found to significantly reduce mucosal inflammation, spongiofibrosis, and obstruction after urethral trauma. According to the results of this study, we think that St. JW oil may be a promising option in the treatment of urethral stricture.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"261-266"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}