Urology research & practice最新文献

Optimized Surgical Outcomes in Living Donor Nephrectomy: A Single-Center Experience with 250 Cases Using a Novel Technique. 活体供肾切除术的最佳手术效果：250例使用新技术的单中心经验。

Urology research & practice Pub Date : 2025-06-04 DOI: 10.5152/tud.2025.25030

Amil Huseynov

{"title":"Optimized Surgical Outcomes in Living Donor Nephrectomy: A Single-Center Experience with 250 Cases Using a Novel Technique.","authors":"Amil Huseynov","doi":"10.5152/tud.2025.25030","DOIUrl":"https://doi.org/10.5152/tud.2025.25030","url":null,"abstract":"Objective: Laparoscopic donor nephrectomy has become a standard of care for living kidney donors, providing reduced morbidity, quicker recovery, and enhanced patient satisfaction compared with open techniques. This study evaluates a modified laparoscopic donor nephrectomy technique designed to minimize colon mobilization while optimizing visualization, thereby improving donor outcomes. Methods: A cross-sectional study of 250 consecutive living donor nephrectomies performed by a single surgeon between March 2022 and March 2024 was conducted. All donors underwent preoperative imaging (3D computed tomography and computed tomographic angiography). The modified approach avoided splenic flexure dissection and introduced early ligation of the adrenal vein. We analyzed intraoperative parameters (operative time, estimated blood loss, complications) and postoperative measures (hospital stay, pain scores, complication rates, satisfaction) were analyzed. Results: The mean operative time was 72.8 ± 16.2 minutes, with an estimated blood loss of 100 ± 40 mL. No conversions to open surgery or intraoperative transfusions were required. The mean length of hospital stay was 2.0 ± 1.0 days. Postoperative pain (mean Visual Analog Scale [VAS] 2.5 ± 1.8) was low, and major vascular injury occurred in 0.8% of cases. Wound infection and incisional hernia rates were each 0.8%. Patient satisfaction was high (Patient Satisfaction Questionnaire [PSQ] 3.3 ± 1.4), indicating favorable perceptions of comfort and outcomes. Conclusion: This modified laparoscopic donor nephrectomy technique is safe, effective, and associated with enhanced patient comfort and reduced complications. The findings underscore its potential to improve donor experiences, potentially expanding the living donor pool. Further investigations should confirm these outcomes over a longer follow-up period.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 2","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Pressure Balloon Dilatation in Infants with Primary Obstructive Megaureter: A Single-Center Case Series. 高压球囊扩张在原发性阻塞性血压计婴儿中的应用：单中心病例系列。

Urology research & practice Pub Date : 2025-06-04 DOI: 10.5152/tud.2025.24045

Anna Suihko, Liisi Ripatti, Niklas Pakkasjärvi

{"title":"High-Pressure Balloon Dilatation in Infants with Primary Obstructive Megaureter: A Single-Center Case Series.","authors":"Anna Suihko, Liisi Ripatti, Niklas Pakkasjärvi","doi":"10.5152/tud.2025.24045","DOIUrl":"https://doi.org/10.5152/tud.2025.24045","url":null,"abstract":"Objective: The aim was to evaluate the efficacy of high-pressure balloon dilatation (HPBD) for primary obstructive megaureter (POM) treatment in infants. Methods: The authors retrospectively reviewed medical records of 5 infants diagnosed with symptomatic or progressive POM and treated with HPBD between 2015 and 2022 in one hospital, analyzing changes in ureteral and anteroposterior pelvic diameters, Society for Fetal Urology grading, parenchymal thickness, differential renal function, complications, and subsequent surgical needs. Results: High-pressure balloon dilatation was performed on 5 patients, median age 5 months. No statistically significant changes were detected in ureteral diameter (median 11.0-7.0 mm, P = .125), anteroposterior diameters (median 21.5-18 mm, P= .255), parenchymal thickness (median 5.0-5.0 mm, P = .317), or differential renal function post-procedure. Follow-up was median 34 months. Three patients showed improvement in obstructive renogram findings. Complications were primarily related to guidewire insertion and double-J stent placement. Two patients, both younger than 6 months, required open ureteral reimplantation. Conclusion: High-pressure balloon dilatation serves as a minimally invasive approach for POM but is not universally effective, with a high complication rate and 40% of infants needing open surgery post HPBD.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 2","pages":"70-76"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Efficacy of Thulium Fiber Laser Versus Pneumatic Lithotripsy in Ureteric Stones During Semirigid Ureteroscopy. 半硬质输尿管镜下输尿管结石铥纤维激光与气压碎石治疗的安全性和有效性。

Urology research & practice Pub Date : 2025-06-04 DOI: 10.5152/tud.2025.25011

Abhay Dinkar Mahajan, Saiswaroop Yamajala, Sumeet Abhay Mahajan

{"title":"Safety and Efficacy of Thulium Fiber Laser Versus Pneumatic Lithotripsy in Ureteric Stones During Semirigid Ureteroscopy.","authors":"Abhay Dinkar Mahajan, Saiswaroop Yamajala, Sumeet Abhay Mahajan","doi":"10.5152/tud.2025.25011","DOIUrl":"https://doi.org/10.5152/tud.2025.25011","url":null,"abstract":"Objective: During the treatment of ureteric stones by semirigid ureteroscopy, pneumatic, and laser lithotripsy are commonly used for stone lithotripsy. This is the first prospective study to compare pneumatic with thulium fiber laser (TFL) lithotripsy for ureteric stones during semirigid ureteroscopy. Methods: A prospective evaluation was conducted on 100 patients, divided into group A (50 patients) who underwent TFL lithotripsy and group B (50 patients) who underwent pneumatic lithotripsy for ureteric stones treated by ureteroscopy. Urine culture and plain computed tomography (CT) scan were done in all the patients. Intraoperative stone clearance was assessed by endoscopic inspection and fluoroscopic evaluation. Postoperative stone clearance was evaluated at 7 days and 3 months by sonography and plain x-ray. Those patients with persistent or increased hydroureteronephrosis were further evaluated by CT scan to detect residual fragments and/or ureteric strictures. Results: The stone size, volume, and HU were comparable in both the groups. The lithotripsy time with TFL was significantly longer compared to pneumatic (12.41 vs. 5.16 minutes). Intraoperatively, the vision was better with TFL as compared to the pneumatic group (2 vs. 10 patients). Retropulsion was significantly less with TFL com- pared to pneumatic lithotripsy (2 vs. 10 patients). The complications and the stone-free rates were comparable in both the groups. Conclusion: Thulium fiber laser has distinct advantage of better vision and less retropulsion compared to pneumatic lithotripsy. It is also a safer modality as compared to the conventional pneumatic lithotripsy during the treatment of ureteric stones with ureteroscopy.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 2","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Low-Cost Gelatin-Based Model for Ultrasound-Guided Percutaneous Renal Access. 超声引导下经皮肾通路的低成本明胶模型。

Urology research & practice Pub Date : 2025-06-04 DOI: 10.5152/tud.2025.24018

Enrique Pulido-Contreras, Hedler Olaf Gonzalez-Villegas, Jorge Alejandro Lopez-Hernandez, Javier Medrano-Sanchez, Miguel Angel Garcia-Padilla

{"title":"A Low-Cost Gelatin-Based Model for Ultrasound-Guided Percutaneous Renal Access.","authors":"Enrique Pulido-Contreras, Hedler Olaf Gonzalez-Villegas, Jorge Alejandro Lopez-Hernandez, Javier Medrano-Sanchez, Miguel Angel Garcia-Padilla","doi":"10.5152/tud.2025.24018","DOIUrl":"https://doi.org/10.5152/tud.2025.24018","url":null,"abstract":"Objective: The aim of this study was to develop and validate a low-cost and reproducible training model using gelatin that can be useful for acquiring the necessary skills for successful ultrasound-guided access in percutaneous nephrolithotomy without exposing patients to clinical risks. Methods: A prospective and analytical study involving 12 urology residents was conducted to validate the model using content and construct validation systems. The study consisted of 2 parts: content validation through expert opinion surveys and construct validation through resident skill assessments before and after training on the model. This model imitates the calyx to puncture and was developed using pitted olives in dense gelatin. The model was constructed for a total cost of $29.7 per unit with an easy and reproducible construction. Each model can be used to perform approximately 40 punctures before the image quality deteriorates. Results: Globally, this training model increased skills. Puncture time decreased from 106 to 40.5 seconds after training (P = .002). The study found that the model was accepted by 71.4% of urologists as a safe training alternative and provided a risk-free environment for practicing the 2 skills required for a successful puncture: adjusting the ultrasound machine for an adequate image of the target and surrounding tissues and needle-probe alignment. Conclusion: This model is easy to build, reproducible, and cost-effective. It enhances the residents' skills to increase success and safety when performing ultrasound-guided percutaneous access.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 2","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy in Using Urodynamic Parameters of Intravesical Electrical Stimulation for Detrusor Underactivity. 膀胱内电刺激尿动力学参数治疗逼尿肌活动不足的疗效观察。

Urology research & practice Pub Date : 2025-06-04 DOI: 10.5152/tud.2025.24181

Anil Kmar, Aviral Sivastava, Rachana Tripathy, Lalit Kumar, Yashasvi Singh, Ujwal Kumar, Sameer Trivedi, S N Sankhwar

引用次数: 0

Drug-Coated Balloon (Optilume®) for the Management of Bulbar Urethral Stricture, Our Experience. 药物包被球囊（Optilume®）治疗尿道球囊狭窄，我们的经验。

Urology research & practice Pub Date : 2025-06-04 DOI: 10.5152/tud.2025.25020

Ibrahim Alnadhari, Muammer Alshrani, Asim Alhattami, Walid Shanaa, Omar Ali, Osama Abdeljaleel, Hana J Abukhadijah, Ahmad Shamsodini

{"title":"Drug-Coated Balloon (Optilume®) for the Management of Bulbar Urethral Stricture, Our Experience.","authors":"Ibrahim Alnadhari, Muammer Alshrani, Asim Alhattami, Walid Shanaa, Omar Ali, Osama Abdeljaleel, Hana J Abukhadijah, Ahmad Shamsodini","doi":"10.5152/tud.2025.25020","DOIUrl":"https://doi.org/10.5152/tud.2025.25020","url":null,"abstract":"Objective: The drug (paclitaxel)-coated balloon (DCB) Optilume® is designed to dilate the urethral lumen via balloon dilation while also promoting long-term urethral patency through the targeted and circumferential delivery of paclitaxel. As an antimitotic agent, paclitaxel functions by inhibiting cellular proliferation and migration. The objective of this study is to assess the safety and efficacy of this DCB in managing bulbar urethral strictures. Methods: This study is a retrospective study, involving 19 patients who underwent treatment with DCB for bulbar strictures. Patients' characteristics, preoperative and postoperative maximum flow rates (Qmax), and the duration until recurrence were recorded. Postoperative complications were also noted. Results: Success was achieved in 15 out of 19 patients (78.9%) with a median follow up period of 352 days. The mean maximum urine flow rate preoperatively was 5 mL/s (with a range of 4.00-6.50 mL/s). Subsequent mean flow rates at 3 months, 6 months, 12 months, and 24 months post-treatment were 32 mL/s, 32 mL/s, 24 mL/s, and 20 mL/s, respectively. Notably, there was no recurrence among the 7 patients without previous surgical interventions (47%, P-value .01). The mean duration of stricture-free survival following surgery was 648 days (approximately 21.6 months) (95% CI 500.4-700.2). Importantly, no complications were reported throughout the study. Conclusion: The use of DCB for managing bulbar urethral stricture demonstrated a success rate of 78.9%. Patients without a history of urethral surgery exhibited significantly improved treatment outcomes. Furthermore, the study reported no significant complications associated with the use of DCB.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 2","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Endothelin Receptor Expression in Idiopathic Male Infertility: A Potential Therapeutic Target. 特发性男性不育症内皮素受体表达改变：一个潜在的治疗靶点。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24104

Richard Weiten, Melanie V Brandenstein, Manuel Huerta, Tim Nestler, Axel Heidenreich, Enno Storz, Jan Herden

{"title":"Altered Endothelin Receptor Expression in Idiopathic Male Infertility: A Potential Therapeutic Target.","authors":"Richard Weiten, Melanie V Brandenstein, Manuel Huerta, Tim Nestler, Axel Heidenreich, Enno Storz, Jan Herden","doi":"10.5152/tud.2025.24104","DOIUrl":"10.5152/tud.2025.24104","url":null,"abstract":"Objective: Idiopathic male infertility is frequently associated with impaired semen quality, particularly in men diagnosed with oligo-astheno-teratozoospermia (OAT) syn- drome. Recent studies suggest a potential role of the endothelin (ET) system, particu- larly ET receptors A (ETAR) and B (ETBR), in male reproductive physiology. Moreover, antiestrogens such as tamoxifen and clomiphene, which are commonly used empiri- cally in this context, may influence ET signaling pathways. However, the relationship between ET receptor expression and specific subtypes of male infertility remains poorly understood. Methods: Semen samples were collected from 56 men: 15 fertile controls with normo- zoospermia and 41 infertile men with abnormal semen parameters, including 22 with OAT syndrome and 19 with isolated teratozoospermia. Men with identifiable female- factor infertility were excluded. Seminal ETAR and ETBR expression were analyzed using immunofluorescence microscopy, Western blotting, enzyme-linked immunosor- bent assay (ELISA), and flow cytometry. Results: The ETAR expression was significantly reduced in infertile men compared to fertile controls (P < .05). The ETBR was undetectable in all samples from patients with OAT syndrome. Notably, 2 distinct ETAR expression profiles were observed within the OAT group: one subgroup with ETAR levels comparable to controls and another with markedly diminished expression, indicating potential phenotypic heterogeneity within OAT syndrome. Conclusion: Altered ETAR expression and the absence of ETBR in men with idiopathic infertility, particularly those with OAT syndrome, highlight a potential role for ET sig- naling in male reproductive dysfunction. Stratification based on ETAR expression may support individualized therapeutic strategies, including ET-targeted or antiestrogen- based therapies, to improve fertility outcomes in this population.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Prostate Cancer Cells by an Isopeptidase Inhibitor NSC632839. 异肽酶抑制剂NSC632839靶向前列腺癌细胞

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24115

Ummuhan Demir, Rabia Erdogdu

{"title":"Targeting Prostate Cancer Cells by an Isopeptidase Inhibitor NSC632839.","authors":"Ummuhan Demir, Rabia Erdogdu","doi":"10.5152/tud.2025.24115","DOIUrl":"10.5152/tud.2025.24115","url":null,"abstract":"Objective: Posttranslational protein modifications are crucial for fine-tuning protein function. NSC632839 is a dual deubiquitination and desumoylation inhibitor. The desumoylation enzyme SENP2 is one of the targets of NSC632839. This study aimed to evaluate NSC632839 as an antiproliferative agent in prostate cancer (PCa). Methods: The IC50 values for NSC632839 were determined in PCa cell lines PC3 and LNCaP and normal fibroblast cells CCD-1072Sk by crystal violet staining. The colony- formation ability of PC3 and LNCaP cells upon NSC632839 treatment was evaluated by a 2D colony-formation assay. The expression level of SENP2 and its correlation with androgen receptor (AR) were investigated in PCa tissue samples using publicly avail- able datasets. Results: The IC50 values of NSC632839 were 3.1, 1.9, and 17.7 for LNCaP, PC3, and CCD- 1072Sk, respectively. In this IC50 concentration, NSC632839 completely abolished the colony-formation ability of PC3 cells. The expression level of SENP2 was elevated in metastatic PCa tissue samples and was correlated with the AR. Conclusion: NSC632839 was an antiproliferative agent in PCa cells at low doses. Therefore, NSC632839 is a strong drug candidate requiring further studies.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Platelet-Derived Growth Factor Alpha and Beta Receptors in Primary Tumor Cells of Patients with Renal Cell Carcinoma. 肾细胞癌患者原发肿瘤细胞中血小板衍生生长因子α和β受体的表达

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24154

Maria Volkova, Dmitry Khochenkov, Anna Olshanskaya, Yulia Khochenkova, Elyso Solomko, Saida Ashuba, Ilya Tsimafeyeu

{"title":"Expression of Platelet-Derived Growth Factor Alpha and Beta Receptors in Primary Tumor Cells of Patients with Renal Cell Carcinoma.","authors":"Maria Volkova, Dmitry Khochenkov, Anna Olshanskaya, Yulia Khochenkova, Elyso Solomko, Saida Ashuba, Ilya Tsimafeyeu","doi":"10.5152/tud.2025.24154","DOIUrl":"10.5152/tud.2025.24154","url":null,"abstract":"Objective: This study aimed to assess the expression of platelet-derived growth factor receptors alpha and beta (PDGFR!/\") in primary tumor cells of patients with renal cell carcinoma (RCC). Methods: Platelet-derived growth factor receptors alpha and beta expression was analyzed in RCC specimens from 65 RCC patients (pT1a-T4NanyMany) using immunohis- tochemistry. Expression levels were quantified using the semi-quantitative H-score (HS) method, and correlations between PDGFR!/\" expression and tumor characteris- tics were evaluated. The impact of PDGFR!/\" expression on patient survival was also examined. Results: Platelet-derived growth factor receptor alpha was expressed in the cytoplasm and membrane of 58.5% of primary RCC cells, with an HS of 62.9 ± 8.4, significantly higher than PDGFR\" expression (44.6%; 26.6 ± 5.3; P > .05). Platelet-derived growth factor receptor alpha expression correlated with tumor grade (r = 0.471; P < .0001) and the pN+ category (r = 0.280; P = .024). Platelet-derived growth factor receptor beta expression correlated with tumor grade (r = 0.286; P = .021), venous tumor thrombosis (r = 0.263; P = .034), M+ category (r = 0.305; P = .014), and adrenal metastases (r = 0.306; P = .041). Neither PDGFR! nor PDGFR\" expression levels influenced patient survival. Conclusion: Platelet-derived growth factor receptor alpha was more highly expressed in RCC cells compared to PDGFR\". Overexpression of PDGFR!/\" was associated with higher tumor grade and advanced RCC stages, though it did not affect patient survival.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering New Horizons: Update to Quadruple-D Score to Predict Stone-Free Rate with Advanced Non-invasive Lithotripsy Technology. 揭示新视野：更新4d评分预测先进的无创碎石技术的结石清除率。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24152

Aaron Tigor Sihombing, Zola Wijayanti, Steven Steven, Dicky Stefanus

{"title":"Uncovering New Horizons: Update to Quadruple-D Score to Predict Stone-Free Rate with Advanced Non-invasive Lithotripsy Technology.","authors":"Aaron Tigor Sihombing, Zola Wijayanti, Steven Steven, Dicky Stefanus","doi":"10.5152/tud.2025.24152","DOIUrl":"10.5152/tud.2025.24152","url":null,"abstract":"Objective: To evaluate the efficacy of the Quadruple-D scoring system in predicting stone-free rate (SFR) using the newer Generation Piezoelectric lithotripter. Methods: A prospective observational study was conducted from January to December 2023, involving patients who underwent extracorporeal shock wave litho- tripsy (ESWL) for renal stones sized 5-20 mm. Evaluation parameters included stone density, skin-to-stone distance (SSD), stone size (ellipsoid stone volume), and location, with Quadruple-D scores calculated based on predetermined cutoffs. Extracorporeal shock wave lithotripsy sessions utilized the \"Piezolith 3000 Plus\" lithotripter, and SFR was assessed 4 weeks post-procedure. Statistical analysis included Student's t-test and receiver operating characteristic curve analysis. Results: Of the 40 eligible patients, 75% achieved stone-free status post-ESWL. Stone density and SSD emerged as leading predictors of SFR, with new cut-off values identi- fied. Comparative analysis demonstrated improved predictive power of the Piezolith Q-D score over the previous Quadruple-D score (AUC: 84% and 80% respectively). Although stone location and size also influenced outcomes, their significance varied in this study. Conclusion: The Piezolith Q-D score system exhibits promise in predicting SFR post- ESWL with piezoelectric lithotripters. External validation and larger-scale studies are warranted to establish the scoring system's reliability and applicability across diverse populations.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0