Urology research & practice最新文献

{"title":"The Impact of Levothyroxine and Testosterone Administration on Bladder Contractility in the Rat Model of Propylthiouracil-Induced Hypothyroidism.","authors":"Didem Yılmaz Oral, Berna Güven Ciloğlu, Serap Gür","doi":"10.5152/tud.2025.24099","DOIUrl":"https://doi.org/10.5152/tud.2025.24099","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of testosterone (T) treatment, with or without levothyroxine, the most widely used and least effective medication for managing hypothyroidism, on the functional and histological changes in propylthiouracil (PTU)- induced hypothyroid rat bladders.</p><p><strong>Methods: </strong>Male rats (n=35) were split into control, hypothyroid, hypothyroid rats treated with levothyroxine (20 µg/kg/day, oral, 2-weeks), hypothyroid rats treated with Sustanon (10 mg/kg,iIM, once/week, 2-weeks), and hypothyroid rats treated with combined treatment groups. Hypothyroidism was induced by PTU (0.05% in drinking water, 6 weeks). The serum concentration of triiodothyronine (T3), thyroxine (T4), total T, and the detrusor muscle's contractile responses were determined. A morphological study was conducted using Masson trichrome staining.</p><p><strong>Results: </strong>Triiodothyronine, T4, and T levels were considerably reduced in rats with hypothyroidism; however, these hormones were restored by levothyroxine and Sustanon. Compared to controls, the combination therapy improved the ratio of smooth muscle to collagen and the contractile responses to carbachol, electrical field stimulation, and adenosine triphosphate in the hypothyroid bladder.</p><p><strong>Conclusion: </strong>The authors' research suggests that hypothyroidism may affect the contractility and morphology of the bladder. In males with hypothyroidism and urogenital system dysfunction, combination therapy with thyroid hormones and T has a major impact on repairing detrusor smooth muscle contractility and bladder histomorphology.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Temperature Changes Between Holmium-YAG Laser and Thulium Fiber Laser in an In Vitro Setting.","authors":"Vaibhavkumar Patel, Kshitij Raghuvanshi, Krushnadevsinh Jadeja, Rajeev Chaudhari","doi":"10.5152/tud.2025.24100","DOIUrl":"https://doi.org/10.5152/tud.2025.24100","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate and compare the rise in the temperature for the safety of the ureter and kidney parenchyma when firing the holmium laser and the thulium fiber laser (TFL).</p><p><strong>Methods: </strong>We performed a laboratory experiment to measure the rise in temperature upon firing holmium laser and a TFL in a 10 cm3 transparent test tube in an outdoor environment and then in a container with normal saline.</p><p><strong>Results: </strong>In a 10 cc test tube with static water at 25°C, the rise in temperature with holmium and TFL depends on the firing time, keeping power constant. On continuous firing for 10, 20, and 30 seconds, the temperature rose to 35.1, 42.7, and 53.2°C with holmium. The temperature went up to 38.3, 46.8, and 55.4°C when TFL was used. The power was kept at 10 W for both types of lasers. The temperature rise was relatively low when the test tube was immersed in a water container. It was even lower with irrigation.</p><p><strong>Conclusion: </strong>The rise in the temperature reaches to hazardous level in static water with a firing time of 30 seconds, which is almost equivalent to holmium and TFL. Thus, while using lasers in RIRS and ureteroscopy, the firing time should not exceed 20 seconds and adequate irrigation is required to prevent damage to the tissues. Also, the rise in temperature was almost equivalent to holmium and TFL; hence, TFL can be safely used in laser lithotripsy in any part of the genitourinary (GU) system.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"219-224"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of St. John's Wort Oil on Urethral Stricture: An Experimental Study in Rat Model.","authors":"Kazım Yelsel, Ergün Alma, Ömer Yüceer, Zeynel Abidin Taş, Berna Totan Ateş, Murat Kobaner, Halil Esimek, Adem Altunkol, Umut Ünal, Ali Ayyıldız","doi":"10.5152/tud.2025.24068","DOIUrl":"https://doi.org/10.5152/tud.2025.24068","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to evaluate the effect of yellow and red centaury St. John's Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model.</p><p><strong>Methods: </strong>A total of 24 male rats were divided into 5 groups. No urethral damage was induced in the sham group. The urethras of all rats in the other groups was traumatized at 6 o'clock with a specially designed urethrotome blade. Group 1 was administered 0.5 cc of St. JW oil once daily for 15 days. Group 2 was administered 0.5 cc of red centaury oil intraurethrally once daily for 15 days. The traumatized rats in Group 3 were not treated (St. JW and red centaury oil were not administered). St. JW oil was administered to 3 rats in the Sham 1 group (Group 4), and red centaury oil was administered to 3 rats in the Sham 2 group (Group 5). A 20-G/32-mm intravenous cannula sheath was used for intraurethral administration. On the 15th day, rats were sacrificed and penectomy was performed for histologic evaluation.</p><p><strong>Results: </strong>Spongiofibrosis, mucosal inflammation, and congestion were significantly decreased in the yellow St. JW oil group when compared with the red centaury oil group and the untreated group (group to which neither St. JW nor red centaury oil was administered).</p><p><strong>Conclusion: </strong>In this study, intraurethral administration of yellow St. JW oil was found to significantly reduce mucosal inflammation, spongiofibrosis, and obstruction after urethral trauma. According to the results of this study, we think that St. JW oil may be a promising option in the treatment of urethral stricture.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"261-266"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Renorrhaphy During Renal Mass Excision in Laparoscopic Nephron-Sparing Surgery: A Novel Surgical Technique.","authors":"Nurullah Hamidi, Tuncel Uzel","doi":"10.5152/tud.2025.24062","DOIUrl":"https://doi.org/10.5152/tud.2025.24062","url":null,"abstract":"<p><strong>Objective: </strong>Laparoscopic nephron sparing surgery (NSS) can be performed by mainly 2 methods, offclamp or on-clamp. Continuous bleeding during the off-clamp method may impair the clear visualization of the border between the tumor and parenchyma, even though it is done safely in experienced hands. Therefore, some surgical modifications may be needed during mass excision and renorraphy. In this video brief, we aimed to present a new off-clamp NSS technique and our case series. The difference of this technique from others is that renorrhaphy was performed during mass excision concurrently to reduce the amount of bleeding.</p><p><strong>Materials and methods: </strong>Laparoscopic transperitoneal NSS was performed on a 40-year-old male patient with a lowcomplexity lower pole mass (2.5 × 2 cm) in the right kidney, characterized by a RENAL nephrometry score of 4p. On left lateral decubitus position, after port placement, the ascending colon was medialized and the right ueter was found. The renal pedicle was dissected, and the main renal artery was secured with the vessel loop. After opening Gerota's fascia, the mass was found on the lateral side of lower pole. The excision margin was determined by cautery. A 3-0 V-Loc suture was fixed to the anterior abdominal wall just before mass excision. Along the margin, the renal parenchyma was incised by scissors at a depth of 3-4 mm. Excision continued until there was enough place to pass the suture. Then renorrhaphy was started with the V-Loc suture to reduce bleeding. Suturing continued until reaching to excision limit. Excision continued until serious bleeding occurred. If serious bleeding occurred, suturing was performed again. If there was no bleeding, excision was completed after controlling the tumor base with suturing. Intraperitoneal air pressure was reduced to detect hidden bleeding. Anti-bleeding powder was applied to the excision area. Written informed consent was obtained from the patients who agreed to take part in the study.</p><p><strong>Results: </strong>The total operative and renorraphy time was 85 and 10 minutes, respectively. The bleeding amount was 150 mL. The pathologic report confirmed a 2.5 × 2 × 2 cm clear cell renal cell carcinoma. No major complications were observed during surgery. After 46 months, there is no local recurrence or metastasis.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"267-268"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Kinetics and Protein Profiles of Co-Cultured Adult and Fetus Rabbit Bladder Smooth Muscle Cells.","authors":"Hayrunisa Kahraman Esen, Burcu Biltekin, Mevlit Korkmaz, B Haluk Güvenç","doi":"10.5152/tud.2025.24120","DOIUrl":"https://doi.org/10.5152/tud.2025.24120","url":null,"abstract":"<p><strong>Objective: </strong>Bladder tissue models have been developed using smooth muscle cells (SMCs) on various scaffolds to mimic bladder morphology and physiology. This study investigates the effects of co-culturing fetal and adult SMCs on growth properties and protein profiles to understand cellular interactions and population kinetics.</p><p><strong>Methods: </strong>Bladder tissue samples from 10 adult and 10 fetal New Zealand rabbits were divided into 5 groups: adult SMCs (A), fetal SMCs (F), 50%A+50%F (A+F), 75%A+25%F (3A+F), and 25%A+75%F (A+3F). Population doubling time (PDT) of 3 × 106 cells from each group was measured after 48 and 72 hours. Protein concentrations were estimated by spectrophotometric analysis and analyzed via SDS-PAGE gel electrophoresis. Cells exhibited typical SMC morphology, confirmed by positive staining for α-SMA and MYH11.</p><p><strong>Results: </strong>Median cell counts of single cultures were significantly higher than co-cultures (P < .05), but cell viability was comparable (P > .05). Population doubling time at 72 hours for A, F, A+F, 3A+F, and A+3F were 89.4, 92.0, 89.4, 127.9, and 145.0 hours, respectively. Protein concentrations were similar between fetal and adult co-cultures (P > .05). Electrophoresis at 48 hours revealed a unique 80kDa band in adult cells and a 32kDa band in co-cultured cells.</p><p><strong>Conclusion: </strong>Co-culturing resulted in increased PDT, altered protein concentrations, and changes in protein profiles, while each cell population maintained its phenotype. Fetal bladder SMCs maintained their morphology and viability when co-cultured with adult SMCs, resulting in a significant limitation in the cumulative proliferation rate. This may be dependent on alterations of protein profiles of adult and fetal SMCs promoted by rearrangements in co-cultures.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"240-246"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vesicoureteral Reflux in Children with Accidental Diagnosis of Unilateral Small Size Kidney.","authors":"Mohsen Mohammadi, Khadijeh Ebrahimi, Soraya Khafri, Maryam Nikpour, Hadi Sorkhi","doi":"10.5152/tud.2025.24060","DOIUrl":"https://doi.org/10.5152/tud.2025.24060","url":null,"abstract":"<p><strong>Objective: </strong>A majority of small size kidney in children were diagnosed after a urinary tract infection (UTI) and with high-grade vesicoureteral reflux (VUR). This study was conducted in children who were diagnosed accidentally and investigated for VUR and UTI.</p><p><strong>Methods: </strong>This longitudinal retrospective study was conducted in children with a diagnosis of a small kidney accidentally discovered by ultrasonography and referred to Children's Hospital in Babol, Iran, between 2012-2022. They were investigated by DMSA (dimercapto succinic acid) renoscintigraphy scans. Vesicoureteral reflux was diagnosed by voiding Ccystourethrography (VCUG) or radionuclide cystography (RNC). All children were followed for at least for 1 year with urine culture and urinalysis every 1-2 months for detection of UTI. Significance was set at P less than .05.</p><p><strong>Results: </strong>The mean age of the children with small-size kidneys was 5.52 ± 3.70 years, and 58.1% were boys. Out of the 86 children, 28 (32.6%) were found to have VUR, with approximately 71.4% of them being boys. Breaking down by gender, 40% of boys and 28.6% of girls with small-sized kidneys had VUR. Among the children with and without VUR, 42.9% and 10.3% experienced UTIs, respectively (P=.74). The predominant causative microorganism for UTIs was Escherichia coli (55.6%), with Klebsiella (22.4%) and Enterobacter (22.4%) accounting for the remaining cases.</p><p><strong>Conclusion: </strong>Accidental diagnoses of small-size kidneys in children revealed a notable presence of VUR, with a higher prevalence in boys. This suggests that VUR may constitute a significant etiological factor in the development of small-size kidneys. We recommend that these children must be evaluated for VUR.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"230-233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interim Results of Rigicon Penile Prosthesis Implantation in a Single Center: The Largest Series in Türkiye.","authors":"Muhammet İhsan Karaman, Rasim Güzel, Duygu Kirkik, Orhan Koca","doi":"10.5152/tud.2025.24122","DOIUrl":"https://doi.org/10.5152/tud.2025.24122","url":null,"abstract":"<p><strong>Objective: </strong>To analyze data from patient information forms (PIFs) submitted to the manufacturer of a new 3-piece inflatable penile prosthesis (IPP), the Rigicon Infla10® , to summarize interim outcomes of 250 implantations in a single center, which is the largest series in Türkiye.</p><p><strong>Methods: </strong>A retrospective review of PIFs from 250 patients implanted with the IPP between January 2021 and December 2023 was performed to assess patient characteristics, surgical data, device durability, patient satisfaction, and rates of reoperation for any reason.</p><p><strong>Results: </strong>The mean ± SD (range) follow-up was 21.2 ± 8.7 (6-36) months and the mean ± SD patient age was 56.2 ± 9.1 years. The average surgical time was 47 minutes. Of the total, 2.4% of devices required removal or revision. Mechanical failure of the device was reported in 3 patients (1.2%). One patient (0.4%) required revision for noise during pumping. Two patients (0.8%) requested device removal because of dissatisfaction. No infections were observed in this series. A total of 97.6% of the Rigicon Infla10® devices were free from explant or revision. The satisfaction rate based on a single question asked to the patient by the surgeon 6 months after surgery was 98.4%.</p><p><strong>Conclusion: </strong>All Rigicon Infla10® IPPs implanted in the center prior to January 2024 were included in the retrospective analysis of volunteered PIFs. Initial durability from reoperation was demonstrated to be superior compared to other contemporary devices. Additionally, high satisfaction with treatment outcomes was reported by 92.4% of patients.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"234-239"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Chatbot Responses to the Most Popular Questions Regarding Erectile Dysfunction.","authors":"İrfan Şafak Barlas, Lütfi Tunç","doi":"10.5152/tud.2025.24098","DOIUrl":"https://doi.org/10.5152/tud.2025.24098","url":null,"abstract":"<p><strong>Objective: </strong>Erectile dysfunction (ED) is a common cause of male sexual dysfunction. We aimed to evaluate the quality of ChatGPT and Gemini's responses to the most frequently asked questions about ED.</p><p><strong>Methods: </strong>This study was conducted as a cross-sectional, observational study. Google Trends was used to determine the most frequently asked questions on the internet. ChatGPT-3.5 and Gemini were compared for these chatbots' answers to the questions about ED. Two urologists with board certificates assessed the quality of responses using the Global Quality Score (GQS).</p><p><strong>Results: </strong>Fifteen questions about ED were included according to the Google Trends. ChatGPT was able to answer all the questions systematically, whereas Gemini could not answer two questions. Upon assessing the quality of the responses provided by both researchers with the GQS, it was observed that the frequency of low-quality responses from Gemini exceeded that of ChatGPT. The agreement between researchers was 92% for ChatGPT and 95% for Gemini.</p><p><strong>Conclusion: </strong>Despite the expeditious and comprehensive answers provided by chatbots, we identified inadequacies in their responses related to ED. In their current state, they cannot replace the patient-centered approach of healthcare professionals and require further development.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"253-260"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting the Presence of Renal Cortical Cysts in Kidney Donors.","authors":"Sevim Nuran Kuşlu Çiçek, Amil Huseynov","doi":"10.5152/tud.2025.24116","DOIUrl":"https://doi.org/10.5152/tud.2025.24116","url":null,"abstract":"<p><strong>Objective: </strong>Simple renal cysts (SRCs) represent the most frequently occurring type of renal cysts, frequently observed in the elderly population. While generally considered benign, SRCs may sometimes be connected to comorbid conditions such as hypertension, aortic diseases, and renal dysfunction. This research aims to investigate the factors influencing the development of SRCs in kidney donors and the associated risks.</p><p><strong>Methods: </strong>This retrospective cohort study included 1012 living kidney donors, aged 18-87 years, who underwent renal transplant donor nephrectomy between 2008 and 2023. Data on demographic information, cyst characteristics, comorbidities, and associated risk factors were collected and analyzed using statistical methods, including Binary Logistic Regression Analysis. Renal cysts were identified and classified using computed tomography (CT) and magnetic resonance imaging (MRI) methods.</p><p><strong>Results: </strong>Renal cortical cysts were more frequently observed in males (52.76%) compared to females (47.24%), with a significant difference (P=.031). Donors with renal cortical cysts were significantly older (mean age 54.43 ± 12.17 years) compared to those without cysts (46.26 ± 12.35 years, P < .001). Substantial differences were likewise noted in fasting blood glucose, uric acid, creatinine, HbA1c, and glomerular filtration rate (GFR). The prevalence of aortic atherosclerosis was notably elevated in donors with cysts (47.74%) compared to those without (23.57%, P < .001). Binary logistic regression analysis indicated that older age and being male were significant factors influencing the presence of cortical cysts.</p><p><strong>Conclusion: </strong>The study confirms that SRCs are the most common renal cyst type and are more frequently observed in the elderly population. While generally benign, SRCs may be associated with increased uric acid levels and other comorbidities, suggesting potential impacts on kidney health. Additional studies are required to investigate these associations. The presence of SRCs in kidney donors is significantly associated with male gender, age, uric acid levels, and creatinine levels. These findings should be considered during the evaluation of potential kidney donors, particularly regarding the associated risks and management of SRCs.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"225-229"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta Analysis of Efficacy and Safety of Prostate Biopsy: A Comparison Between Transperineal and Transrectal Approach.","authors":"Syah Mirsya Warli, Stivano Rizky Valentino Torry, Dhirajaya Dharma Kadar, Ginanda Putra Siregar, Fauriski Febrian Prapiska","doi":"10.5152/tud.2025.24094","DOIUrl":"https://doi.org/10.5152/tud.2025.24094","url":null,"abstract":"<p><p>Improved prostate biopsy procedures have been developed to overcome traditional limitations, aiming to enhance cancer diagnosis accuracy. To assess the existing knowledge of the effectiveness and risks linked to transperineal (TP) vs. transrectal (TR) prostate biopsy. Approaches: a comprehensive search was carried out in PubMed, Embase, Web of Science, and Cochrane Library to locate all pertinent papers published till June 8, 2023. Data on cancer detection rate and complications after prostate biopsy were gathered and analyzed via Review Manager software. A subgroup analysis was conducted to evaluate the influence of the study type. A total of 19 publications, involving 80133 patients with suspicion of prostate cancer who underwent prostate biopsy, were enrolled in the analysis. The pooled estimate demonstrated no significant differences in the cancer detection rate between TR and TP (risk difference (RD)=0.03; 95% CI: -0.01 to 0.08; P = .12). In terms of complications, the TP approach significantly decreased the risk of rectal bleeding (odds ratio (OR)=0.24; 95% CI: 0.12-0.51; P < .001), fever and urinary tract infection (OR=0.28; 95% CI: 0.15-0.52; P < .001), and sepsis (OR=0.50; 95% CI: 0.28-0.90; P=.02) compared to the TR approach. In conclusion, there was no significant disparity in the cancer detection rate between TP and TR approaches. However, the TP strategy exhibited an advantage over TR due to a reduced risk of infection and rectal bleeding. Further research is needed to validate these results and develop a more efficient diagnostic approach for prostate cancer.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 4","pages":"208-218"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}