Urology research & practice最新文献

Altered Endothelin Receptor Expression in Idiopathic Male Infertility: A Potential Therapeutic Target. 特发性男性不育症内皮素受体表达改变：一个潜在的治疗靶点。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24104

Richard Weiten, Melanie V Brandenstein, Manuel Huerta, Tim Nestler, Axel Heidenreich, Enno Storz, Jan Herden

{"title":"Altered Endothelin Receptor Expression in Idiopathic Male Infertility: A Potential Therapeutic Target.","authors":"Richard Weiten, Melanie V Brandenstein, Manuel Huerta, Tim Nestler, Axel Heidenreich, Enno Storz, Jan Herden","doi":"10.5152/tud.2025.24104","DOIUrl":"https://doi.org/10.5152/tud.2025.24104","url":null,"abstract":"Objective: Idiopathic male infertility is frequently associated with impaired semen quality, particularly in men diagnosed with oligo-astheno-teratozoospermia (OAT) syn- drome. Recent studies suggest a potential role of the endothelin (ET) system, particu- larly ET receptors A (ETAR) and B (ETBR), in male reproductive physiology. Moreover, antiestrogens such as tamoxifen and clomiphene, which are commonly used empiri- cally in this context, may influence ET signaling pathways. However, the relationship between ET receptor expression and specific subtypes of male infertility remains poorly understood. Methods: Semen samples were collected from 56 men: 15 fertile controls with normo- zoospermia and 41 infertile men with abnormal semen parameters, including 22 with OAT syndrome and 19 with isolated teratozoospermia. Men with identifiable female- factor infertility were excluded. Seminal ETAR and ETBR expression were analyzed using immunofluorescence microscopy, Western blotting, enzyme-linked immunosor- bent assay (ELISA), and flow cytometry. Results: The ETAR expression was significantly reduced in infertile men compared to fertile controls (P < .05). The ETBR was undetectable in all samples from patients with OAT syndrome. Notably, 2 distinct ETAR expression profiles were observed within the OAT group: one subgroup with ETAR levels comparable to controls and another with markedly diminished expression, indicating potential phenotypic heterogeneity within OAT syndrome. Conclusion: Altered ETAR expression and the absence of ETBR in men with idiopathic infertility, particularly those with OAT syndrome, highlight a potential role for ET sig- naling in male reproductive dysfunction. Stratification based on ETAR expression may support individualized therapeutic strategies, including ET-targeted or antiestrogen- based therapies, to improve fertility outcomes in this population.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Prostate Cancer Cells by an Isopeptidase Inhibitor NSC632839. 异肽酶抑制剂NSC632839靶向前列腺癌细胞

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24115

Ummuhan Demir, Rabia Erdogdu

{"title":"Targeting Prostate Cancer Cells by an Isopeptidase Inhibitor NSC632839.","authors":"Ummuhan Demir, Rabia Erdogdu","doi":"10.5152/tud.2025.24115","DOIUrl":"https://doi.org/10.5152/tud.2025.24115","url":null,"abstract":"Objective: Posttranslational protein modifications are crucial for fine-tuning protein function. NSC632839 is a dual deubiquitination and desumoylation inhibitor. The desumoylation enzyme SENP2 is one of the targets of NSC632839. This study aimed to evaluate NSC632839 as an antiproliferative agent in prostate cancer (PCa). Methods: The IC50 values for NSC632839 were determined in PCa cell lines PC3 and LNCaP and normal fibroblast cells CCD-1072Sk by crystal violet staining. The colony- formation ability of PC3 and LNCaP cells upon NSC632839 treatment was evaluated by a 2D colony-formation assay. The expression level of SENP2 and its correlation with androgen receptor (AR) were investigated in PCa tissue samples using publicly avail- able datasets. Results: The IC50 values of NSC632839 were 3.1, 1.9, and 17.7 for LNCaP, PC3, and CCD- 1072Sk, respectively. In this IC50 concentration, NSC632839 completely abolished the colony-formation ability of PC3 cells. The expression level of SENP2 was elevated in metastatic PCa tissue samples and was correlated with the AR. Conclusion: NSC632839 was an antiproliferative agent in PCa cells at low doses. Therefore, NSC632839 is a strong drug candidate requiring further studies.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Platelet-Derived Growth Factor Alpha and Beta Receptors in Primary Tumor Cells of Patients with Renal Cell Carcinoma. 肾细胞癌患者原发肿瘤细胞中血小板衍生生长因子α和β受体的表达

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24154

Maria Volkova, Dmitry Khochenkov, Anna Olshanskaya, Yulia Khochenkova, Elyso Solomko, Saida Ashuba, Ilya Tsimafeyeu

{"title":"Expression of Platelet-Derived Growth Factor Alpha and Beta Receptors in Primary Tumor Cells of Patients with Renal Cell Carcinoma.","authors":"Maria Volkova, Dmitry Khochenkov, Anna Olshanskaya, Yulia Khochenkova, Elyso Solomko, Saida Ashuba, Ilya Tsimafeyeu","doi":"10.5152/tud.2025.24154","DOIUrl":"https://doi.org/10.5152/tud.2025.24154","url":null,"abstract":"Objective: This study aimed to assess the expression of platelet-derived growth factor receptors alpha and beta (PDGFR!/\") in primary tumor cells of patients with renal cell carcinoma (RCC). Methods: Platelet-derived growth factor receptors alpha and beta expression was analyzed in RCC specimens from 65 RCC patients (pT1a-T4NanyMany) using immunohis- tochemistry. Expression levels were quantified using the semi-quantitative H-score (HS) method, and correlations between PDGFR!/\" expression and tumor characteris- tics were evaluated. The impact of PDGFR!/\" expression on patient survival was also examined. Results: Platelet-derived growth factor receptor alpha was expressed in the cytoplasm and membrane of 58.5% of primary RCC cells, with an HS of 62.9 ± 8.4, significantly higher than PDGFR\" expression (44.6%; 26.6 ± 5.3; P > .05). Platelet-derived growth factor receptor alpha expression correlated with tumor grade (r = 0.471; P < .0001) and the pN+ category (r = 0.280; P = .024). Platelet-derived growth factor receptor beta expression correlated with tumor grade (r = 0.286; P = .021), venous tumor thrombosis (r = 0.263; P = .034), M+ category (r = 0.305; P = .014), and adrenal metastases (r = 0.306; P = .041). Neither PDGFR! nor PDGFR\" expression levels influenced patient survival. Conclusion: Platelet-derived growth factor receptor alpha was more highly expressed in RCC cells compared to PDGFR\". Overexpression of PDGFR!/\" was associated with higher tumor grade and advanced RCC stages, though it did not affect patient survival.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering New Horizons: Update to Quadruple-D Score to Predict Stone-Free Rate with Advanced Non-invasive Lithotripsy Technology. 揭示新视野：更新4d评分预测先进的无创碎石技术的结石清除率。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24152

Aaron Tigor Sihombing, Zola Wijayanti, Steven Steven, Dicky Stefanus

{"title":"Uncovering New Horizons: Update to Quadruple-D Score to Predict Stone-Free Rate with Advanced Non-invasive Lithotripsy Technology.","authors":"Aaron Tigor Sihombing, Zola Wijayanti, Steven Steven, Dicky Stefanus","doi":"10.5152/tud.2025.24152","DOIUrl":"https://doi.org/10.5152/tud.2025.24152","url":null,"abstract":"Objective: To evaluate the efficacy of the Quadruple-D scoring system in predicting stone-free rate (SFR) using the newer Generation Piezoelectric lithotripter. Methods: A prospective observational study was conducted from January to December 2023, involving patients who underwent extracorporeal shock wave litho- tripsy (ESWL) for renal stones sized 5-20 mm. Evaluation parameters included stone density, skin-to-stone distance (SSD), stone size (ellipsoid stone volume), and location, with Quadruple-D scores calculated based on predetermined cutoffs. Extracorporeal shock wave lithotripsy sessions utilized the \"Piezolith 3000 Plus\" lithotripter, and SFR was assessed 4 weeks post-procedure. Statistical analysis included Student's t-test and receiver operating characteristic curve analysis. Results: Of the 40 eligible patients, 75% achieved stone-free status post-ESWL. Stone density and SSD emerged as leading predictors of SFR, with new cut-off values identi- fied. Comparative analysis demonstrated improved predictive power of the Piezolith Q-D score over the previous Quadruple-D score (AUC: 84% and 80% respectively). Although stone location and size also influenced outcomes, their significance varied in this study. Conclusion: The Piezolith Q-D score system exhibits promise in predicting SFR post- ESWL with piezoelectric lithotripters. External validation and larger-scale studies are warranted to establish the scoring system's reliability and applicability across diverse populations.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Microvessel Density and Growth Factor Levels Between Inner and Outer Prepuce in Distal Hypospadias. 尿道下裂远端内、外包皮微血管密度及生长因子水平的比较。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.24132

Gaurav Prasad, Himanshu H, Anjan Kumar Dhua, Seema Kaushal, Aswini Prabakaran, Shahnaz Ahmad Lone, Prabudh Goel, Sandeep Agarwala, Devendra Kumar Yadav, Hem Chandra Sati

{"title":"Comparison of Microvessel Density and Growth Factor Levels Between Inner and Outer Prepuce in Distal Hypospadias.","authors":"Gaurav Prasad, Himanshu H, Anjan Kumar Dhua, Seema Kaushal, Aswini Prabakaran, Shahnaz Ahmad Lone, Prabudh Goel, Sandeep Agarwala, Devendra Kumar Yadav, Hem Chandra Sati","doi":"10.5152/tud.2025.24132","DOIUrl":"https://doi.org/10.5152/tud.2025.24132","url":null,"abstract":"Objective: Preputial flaps are frequently used in hypospadias repair, but the healing potential of preputial tissue remains a concern. This study aimed to evaluate the microvessel density (MVD) and growth factor receptor levels (VEGFR and TGF-!R) in the prepuce of patients with hypospadias compared to controls and to compare these parameters between the inner and outer preputial layers to determine their relative suitability for hypospadias repair. Methods: The study included children under 14 years of age undergoing primary distal hypospadias surgery as cases and individuals undergoing elective circumcision as controls. Specimens from the inner and outer prepuce were collected, and immunohistochemical staining was performed using CD31 antibodies to assess MVD and VEGFR and TGF-!R antibodies to evaluate growth factor levels. The staining intensity was semi- quantitatively analyzed using a histological scoring system. Results: Microvessel density was significantly higher in the inner prepuce than the outer prepuce in both cases and controls (P < .05), suggesting a potential advantage of inner prepuce tissue in hypospadias repair. Conversely, VEGFR levels were significantly higher in the outer prepuce in cases (P < .05), indicating different healing potentials between these layers. Transforming growth factor ! receptor levels were significantly lower in both the inner and outer prepuce of controls compared to cases (P < .05). Other findings did not reach statistical significance. Conclusion: The higher MVD in the inner prepuce suggests it may be preferable for hypospadias repair. However, the differential VEGFR levels between the inner and outer prepuce highlight complex healing dynamics, emphasizing the need for further research to draw definitive conclusions.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting the Impact of Pelvicalyceal System (PCS) Anatomy on Clinical Outcomes in Retrograde Intrarenal Surgery (RIRS) Studies: Can We Do Better? - Methodological Review from the Section of EAU Endourology. 报道盆腔系统（PCS）解剖对逆行肾内手术（RIRS）研究临床结果的影响：我们能做得更好吗？-泌尿外科泌尿科的方法回顾。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.25032

Ali Talyshinskii, Yerkebulan Mukhambetov, Ulanbek Zhanbyrbekuly, Lazaros Tzelves, Patrick Juliebø-Jones, Theodoros Tokas, Giorgio Bozzini, Wissam Kamal, Bhaskar Kumar Somani

{"title":"Reporting the Impact of Pelvicalyceal System (PCS) Anatomy on Clinical Outcomes in Retrograde Intrarenal Surgery (RIRS) Studies: Can We Do Better? - Methodological Review from the Section of EAU Endourology.","authors":"Ali Talyshinskii, Yerkebulan Mukhambetov, Ulanbek Zhanbyrbekuly, Lazaros Tzelves, Patrick Juliebø-Jones, Theodoros Tokas, Giorgio Bozzini, Wissam Kamal, Bhaskar Kumar Somani","doi":"10.5152/tud.2025.25032","DOIUrl":"https://doi.org/10.5152/tud.2025.25032","url":null,"abstract":"To analyze available randomized clinical trials (RCTs) comparing retrograde intrarenal surgery (RIRS) with other modalities for urinary stone treatment to determine the extent of comparing the pelvicalyceal system (PCS) anatomy between patients. In December 2024, a search was conducted in databases and was limited to publications that describe comparisons of experimental and control groups in the context of RIRS for stones only in the kidney (PCS). Only RCTs comparing RIRS with other modalities without publication date restriction were included due to their highest level of evidence in the hierarchy of primary research. The parameters used in the selected studies were analyzed to compare the differences between the groups, focusing on PCS anatomy. The final analysis included 27 publications from 2421 articles. The presence and/or degree of hydronephrosis were analyzed in 8 studies. Direct morphometric measurements were compared in 4 studies and were focused on the lower pole only, namely the infundibulopelvic angle, infundibular length, and infundibular width. Features such as the position of the renal pelvis in relation to the kidney parenchyma (intrarenal, extrarenal), number and orientation of calyces, as well as the existing PCS classifications were not compared or used. This review shows gaps in the literature while assessing and reporting on PCS anatomy in studies with RIRS. Unless studies mention these anatomical factors without excluding certain groups of patients, it is difficult to compare outcomes between modalities and in between studies.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"12-21"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparison of Postoperative Urological Infection Rates Between Supine and Prone Positions During Percutaneous Nephrolithotomy. 经皮肾镜取石术中仰卧位与俯卧位术后泌尿系统感染率的比较。

Urology research & practice Pub Date : 2025-05-21 DOI: 10.5152/tud.2025.25024

Nattanachoti Batratanakij, Chatchawet Liwrotsap, Teerayut Tangpaitoon

{"title":"A Comparison of Postoperative Urological Infection Rates Between Supine and Prone Positions During Percutaneous Nephrolithotomy.","authors":"Nattanachoti Batratanakij, Chatchawet Liwrotsap, Teerayut Tangpaitoon","doi":"10.5152/tud.2025.25024","DOIUrl":"https://doi.org/10.5152/tud.2025.25024","url":null,"abstract":"Objective: Urological infection is a significant complication following percutaneous nephrolithotomy (PCNL), which can be performed in supine or prone positions, but its impact on infection rates remains debated. This study compares postoperative uro- logical infection rates between supine and prone PCNL and identifies associated risk factors. Methods: A retrospective study was conducted on 290 patients who underwent PCNL between January 2014 and August 2023 in the Thammasat University Hospital. Patients were allocated into 2 groups in a 1 : 2 ratio, with 87 patients in the supine group and 203 patients in the prone group. Statistical analysis included t-tests, Mann-Whitney U tests, Fisher's exact test, and logistic regression models. Results: Postoperative infection rates were significantly lower in the supine group, including fever (33.3% vs. 62.1%, P < .001), UTI (11.5% vs. 32.5%, P < .001), and sepsis (6.9% vs. 17.2%, P = .021). Multivariable analysis identified positive preoperative urine culture (RR 4.41, P < .001) and prone positioning (RR 4.38, P = 0.004) as independent risk factors. The operative time was significantly shorter in the supine group (103.9 ± 42.6 vs. 116.3 ± 38.9 min, P = .016). Stone-free rates and blood loss were comparable, whereas pleural complications were higher in the prone group (6.4% vs. 0%, P = .016). Conclusion: Supine PCNL is associated with significantly lower postoperative infec- tion rates, shorter operative times, and reduced pleural complications compared to the prone position. These findings support supine PCNL as a safer and equally effective alternative management for renal calculi.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 1","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of STONE, Guy's Stone, and Seoul National University Renal Stone Complexity (S-ReSC) Scoring Systems for PCNL Monotherapy in Staghorn Stones. STONE、Guy’s STONE和首尔国立大学肾结石复杂性（S-ReSC）评分系统在PCNL单药治疗鹿角结石中的比较

Urology research & practice Pub Date : 2025-04-04 DOI: 10.5152/tud.2025.24128

Santhosh Srinivasan, Sharanya Padma, Abdul Azeez Ambalath, Poulose Chally, Pankaj Bhirud

{"title":"Comparison of STONE, Guy's Stone, and Seoul National University Renal Stone Complexity (S-ReSC) Scoring Systems for PCNL Monotherapy in Staghorn Stones.","authors":"Santhosh Srinivasan, Sharanya Padma, Abdul Azeez Ambalath, Poulose Chally, Pankaj Bhirud","doi":"10.5152/tud.2025.24128","DOIUrl":"https://doi.org/10.5152/tud.2025.24128","url":null,"abstract":"Objective: Accurate evaluation of staghorn stones is crucial for predicting the likeli hood of achieving stone-free status through percutaneous nephrolithotomy. Scoring systems such as the Stone size, Tract length, Obstruction, Number of calyces, Essence of stone density (STONE) score, Guy's Stone score, and Seoul National University Renal Stone Complexity (S-ReSC) score have been developed to quantify stone complexity and guide clinical decision-making.Methods: This was a prospective comparative study conducted with 52 staghorn calculi patients. Grading of the stone was done by using 3 scoring systems. An imaging study using ultrasound kidneys, ureters, and bladder was performed for early detection of remnant fragments to determine stone-free rate on postoperative day 4. Postoperative complications were categorized by using Clavien-Dindo classification system. Receiver operating characteristic curves were constructed to evaluate the predictive value of 3 stone criteria on the stone-free rate.Results: According to the Guy's Stone score and S-ReSC score systems, all patients with grade IV and high complexity stones had residual stones by the end of POD 4. In contrast, the STONE criteria reported that 11.1% of high complexity stones were stone free. All 3 stone scoring systems indicated a significant increase in the occurrence of complications with increasing stone complexity. The S-ReSC scoring system exhibited the highest AUC of 0.831, indicating it has superior predictive performance compared to Guy's Stone criteria (AUC: 0.790) and the STONE criteria (AUC: 0.765).Conclusions: Among the STONE, Guy's Stone, and S-ReSC scoring systems, the S-ReSC scoring system has proven to be the most effective for assessing both SFR and complications.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 6","pages":"359-365"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wellness and Prevalence of Hypogonadism Among Male Resident Physicians. 男性住院医师性腺功能减退的健康和患病率。

Urology research & practice Pub Date : 2025-04-04 DOI: 10.5152/tud.2025.24121

Basil F Mirza, Gene Austin Krishingner, Kevin J Campbell

{"title":"Wellness and Prevalence of Hypogonadism Among Male Resident Physicians.","authors":"Basil F Mirza, Gene Austin Krishingner, Kevin J Campbell","doi":"10.5152/tud.2025.24121","DOIUrl":"https://doi.org/10.5152/tud.2025.24121","url":null,"abstract":"Objective: Hypogonadism is estimated to affect up to 30% of men aged 40-70, with a range of symptoms and health implications. Despite its prevalence, its impact on resident physicians, a group known to experience high levels of stress, irregular sleep patterns, and long working hours, remains largely unexplored. This study aimed to evaluate the prevalence and impact of hypogonadism among male resident physicians.Methods: A prospective study was conducted involving male physicians training at a tertiary referral institution. Participation was offered through distribution to Accreditation Council for Graduate Medical Education (ACGME) program coordinators and program directors. Participants were given the Androgen Deficiency in the Aging Male (ADAM) and 36-Item Short Form Health Survey questionnaires, and underwent labs including testosterone, follicle-stimulating hormone (FSH), luteinizing hormone, and estradiol levels.Results: Of the 651 male trainees, 27 residents were interested in participating for a response rate of 4.1%. Sixty-seven percent (18/27) completed the surveys and 22% (6/27) completed lab work. Two-thirds of the participants who completed the lab work had total testosterone levels below 400 ng/dL, and half of the participants scored positively on the ADAM questionnaire. A total of 44.4% of participants reported that their health was worse compared to a year prior.Conclusion: Male resident physicians are an at-risk population for symptoms and signs of hypogonadism. This population may benefit from screening and interventions aimed at reducing the impact of hypogonadism. The findings of this study underscore the need for further research to confirm these results and explore potential interventions.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 6","pages":"351-354"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Circulating Tumor Cells in T1 Stage Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis. 循环肿瘤细胞在T1期非肌肉浸润性膀胱癌中的应用：系统回顾和荟萃分析。

Urology research & practice Pub Date : 2025-04-04 DOI: 10.5152/tud.2025.24135

Andy Zulfiqqar, Belinda Liliana, Nurul Lantika Mataho, Eko Subekti

{"title":"The Use of Circulating Tumor Cells in T1 Stage Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis.","authors":"Andy Zulfiqqar, Belinda Liliana, Nurul Lantika Mataho, Eko Subekti","doi":"10.5152/tud.2025.24135","DOIUrl":"https://doi.org/10.5152/tud.2025.24135","url":null,"abstract":"Non-muscle invasive bladder cancer (NMIBC) presents substantial variability in clinical outcomes, especially in high-grade T1 cases, which exhibit high recurrence and progression rates. Circulating tumor cells (CTCs) have emerged as a potential biomarker for cancer prognosis, with evidence linking CTC positivity to poor outcomes in various cancers. In bladder cancer (BC), studies suggest that CTC presence correlates with advanced tumor stage and treatment response, but findings are inconsistent. This study aims to clarify the association between CTC positivity and recurrence and progression to muscle invasiveness in BC. A comprehensive search was conducted using PubMed, SciVerse Scopus, Google Scholar, and the World Health Organization International Clinical Trials Registry Platform databases up to August 2024. This study focuses on assessing the predictive ability of CTCs for NMIBC recurrence and upstaging after transurethral resection of bladder tumor (TURBT). A total of 5 studies were included. Four of the 5 studies found a significant relationship between CTCs and recurrence after TURBT. The hazard ratio (HR) for recurrences was available in 5 studies, and the estimated pooled odds ratio (OR) predicted the value of recurrences for CTC- positive OR = 2.68 (95% CI: 2.11-3.25; P < .001; fixed-effect). Four studies provided data on disease progression from T1 to T2 after TURBT with an overall HR of 3.36 (95% CI: 2.68-3.25). Circulating tumor cells enhance prognostic accuracy and therapeutic strategies in NMIBC, particularly in high-risk cases. Further studies should address molecular subtype stratification and evaluate systemic chemotherapy for CTC-positive patients.","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"50 6","pages":"343-350"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0