Urology research & practice最新文献

{"title":"Time-Dependent Endocrine Signaling as a Modifiable Therapeutic Variable in Advanced Prostate Cancer.","authors":"Ivan Bivolarski","doi":"10.5152/tud.2026.25129","DOIUrl":"https://doi.org/10.5152/tud.2026.25129","url":null,"abstract":"","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-2"},"PeriodicalIF":1.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transurethral Bipolar Enucleation vs. Transurethral Monopolar Enucleation of the Prostate for the Treatment of Bladder Outlet Obstruction Due to Benign Prostatic Hyperplasia.","authors":"Ahmed G Mohamed, Osama Sayed, Ramy Nageib Masoud, Amr Medhat Massoud, Sherif Abdel Rahman Abdul Hay, Ahmed Abdelbary, Mohamed F Elebiary, Hany Fathy","doi":"10.5152/tud.2026.25075","DOIUrl":"https://doi.org/10.5152/tud.2026.25075","url":null,"abstract":"<p><p>  Objective: To compare the feasibility of bipolar transurethral enucleation (B-TUEP) and monopolar transurethral enucleation (M-TUEP) for the management of benign prostatic obstruction.</p><p><strong>Methods: </strong>This prospective randomized study involved 160 patients: 80 patients who were subjected to B-TUEP; and 80 patients who were subjected to M-TUEP. Patients were evaluated preoperatively and for 1 year postoperatively.</p><p><strong>Results: </strong>At the 12-month follow-up, no statistically significant intergroup differences were observed in operative time, resected tissue weight, International Prostate Symptom Score, or maximum urinary flow rate. Postoperative rates of re-catheterization for acute urinary retention, urinary incontinence, and urinary tract infections were also comparable between groups. However, the B-TUEP group exhibited significantly less intraoperative bleeding (P < .001). The M-TUEP group experienced significantly longer postoperative catheterization, and hospital stays (P < .001). Furthermore, the M-TUEP group demonstrated significantly lower mean intraoperative serum sodium levels (P < .001), with 1 patient experiencing TUR (Transurethral resection) syndrome.</p><p><strong>Conclusion: </strong>The findings indicate comparable efficacy between M-TUEP and B-TUEP for benign prostatic hyperplasia treatment, although B-TUEP demonstrates superior safety. Monopolar transurethral enucleation of the prostate remains a safe and effective alternative in the absence of bipolar technology. Cite this article as: Mohamed AG, Sayed O, Masoud RN, et al. Transurethral bipolar enucleation vs. transurethral monopolar enucleation of the prostate for the treatment of bladder outlet obstruction due to benign prostatic hyperplasia. Urol Res Pract. 2026, 52, 0075 doi: 10.5152/ tud.2026.25075.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Human Epidermal Growth Factor Receptor 2 in Bladder Cancer: Evaluating Its Role as a More Robust Clinicopathological Biomarker Compared to Programmed Death Ligand 1 Expression.","authors":"Ankur Mittal, Kunal Malhotra, Vikas Panwar, Sanjeev Kishore, Mohammed Taher, Avin Singhal","doi":"10.5152/tud.2026.25061","DOIUrl":"https://doi.org/10.5152/tud.2026.25061","url":null,"abstract":"<p><p>  Objective: This retrospective cross-sectional analytical study evaluated the clinicopathological associations of programmed death ligand 1 (PD-L1) and human epidermal growth factor receptor 2 (HER2/neu) expression in 250 patients with urothelial carcinoma of the urinary bladder, with particular emphasis on their relationship to tumor stage and lymph node involvement.</p><p><strong>Methods: </strong>A retrospective observational study was conducted on 250 patients with urothelial carcinoma who underwent immunohistochemical evaluation of PD-L1, using a tumor proportion score (TPS) of ≥1%, and HER2/neu with 3+ considered positive. Formalin-fixed paraffin-embedded tissue from transurethral resection of bladder tumor and cystectomy specimens was analyzed by immunohistochemistry. The HER2/ neu was scored using a standard 0-3+ system, and PD-L1 expression was assessed by TPS. Associations were tested using chi-square or Fisher's exact tests. Multivariable logistic regression evaluated whether HER2/neu independently predicted nodal involvement after adjustment for age, sex, tumor stage, and morphology. Statistical significance was set at P < .05.</p><p><strong>Results: </strong>The HER2/neu 3+ positivity was present in 100/250 patients (40%) and was significantly associated with nodal involvement (P = .019). On multivariable logistic regression, HER2/neu is independently associated with nodal involvement, reflecting aggressive tumor biology (adjusted OR 2.41; 95% CI 1.33-4.36; P = .004). Among node-negative patients (N0, n = 200), 35.5% were HER2/neu positive, rising stepwise to 50.0% in N1, 54.5% in N2, and 71.4% in N3 disease, supporting a relationship between HER2/ neu overexpression and nodal progression. In contrast, PD-L1 positivity (TPS ≥1%) was observed in 129/250 patients (51.6%) and was not significantly associated with age, sex, tumor stage, nodal status, grade, multiplicity, or morphology (all P > .05).</p><p><strong>Conclusion: </strong>The HER2/neu was an independent clinicopathological biomarker associated with nodal involvement and aggressive tumor biology in urothelial carcinoma. PD-L1 showed limited clinicopathological utility in this cohort, though it retains predictive value for immune checkpoint inhibitor therapy.   Cite this article as: Mittal A, Malhotra K, Panwar V, Kishore S, Taher M, Singhal A. Targeting human epidermal growth factor receptor 2 in bladder cancer: evaluating its role as a more robust clinicopathological biomarker compared to programmed death ligand 1 expression. Urol Res Pract. 2026, 52, 0061, doi: 10.5152/tud.2026.25061.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of microRNAs and Centromere Protein Genes in Prostate Cancer and Metastatic Progression.","authors":"Makbule Nihan Somuncu, İlknur Karalezli, Yunus Emre Göger, Ayşe Gül Zamani, Mahmut Selman Yıldırım, Asuman Deveci, Mustafa Cihat Avunduk, Giray Karalezli","doi":"10.5152/tud.2026.26143","DOIUrl":"10.5152/tud.2026.26143","url":null,"abstract":"<p><strong>Objective: </strong>Accurate prediction of disease progression and metastatic potential remains a major challenge in prostate cancer management. This study aimed to evaluate the expression profiles of selected microRNAs (miRNAs) and cell cycle-related genes as centromere protein genes (CENPs) in prostate cancer and to explore their potential clinical relevance in distinguishing metastatic disease.</p><p><strong>Methods: </strong>Formalin-fixed paraffin-embedded prostate tissue samples from patients with benign prostatic hyperplasia, localized prostate cancer, and metastatic prostate cancer were analyzed. Quantitative real-time polymerase chain reaction (PCR) (qRTPCR) was used to assess the expression of miRNAs targeted CENPs as well as CENPA, CENPC, HJURP, and AURKB. Expression patterns were further validated in the metastatic prostate cancer cell line PC3. Relative expression levels were calculated using the 2-ΔΔCt (cycle threshold) method.</p><p><strong>Results: </strong>Expression analysis of selected miRNAs revealed a significant upregulation of hsa-miR-4755-5p in the metastatic PCa (P = .027), despite no significant differences in fold change. Additionally, hsa-miR-5680 showed a significantly higher fold change in the metastatic group compared to controls (P = .034). Although not statistically significant (P > .05), hsa-miR-5688, hsa-miR-20a-5p, and hsa-miR-4500 demonstrated a consistent trend toward downregulation, as indicated by lower ΔΔCt values in both PCa and metastatic groups relative to controls. In PCa cell line CENPA, CENPC,and HJURP expression levels increased over time, whereas AURKB was downregulated.</p><p><strong>Conclusion: </strong>The findings indicate that combined dysregulation of specific microRNAs and centromere-associated genes characterizes metastatic prostate cancer. This molecular signature may provide clinically relevant information for risk stratification and warrants further investigation as a potential adjunct to conventional prognostic markers in prostate cancer. Cite this article as: Somuncu MN, Karalezli I, Göger YE, et al. Dysregulation of microRNAs and centromere protein genes in prostate cancer and metastatic progression. Urol Res Pract., 52, 0143, doi:10.5152/tud.2026.26143.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holmium Laser Enucleation of the Prostate Vs. Bipolar Transurethral Resection of the Prostate for Small-Volume Prostates: A Comparative Analysis of Clinical Outcomes.","authors":"Abdullah Gölbaşı, Burak Elmaağaç, Hüseyin Biçer, Ali Yasin Özercan, Sefa Günal, Murat Keske","doi":"10.5152/tud.2026.25132","DOIUrl":"10.5152/tud.2026.25132","url":null,"abstract":"<p><strong>Objective: </strong>Benign prostatic hyperplasia is a common cause of lower urinary tract symptoms (LUTS) in aging men. While transurethral resection of the prostate (TURP) is the traditional surgical standard, holmium laser enucleation of the prostate (HoLEP) has emerged as a safe and effective alternative. Evidence comparing both techniques in small prostates (<50 mL) remains limited.</p><p><strong>Methods: </strong>This retrospective study included male patients aged 40-80 years who underwent bipolar TURP (B-TURP) or HoLEP between 2023 and 2025 for LUTS refractory to medical therapy, with prostate volume <50 mL. Pre- and postoperative parameters, including operative time, resected tissue weight, irrigation volume, hospital stay, catheterization time, and functional scores (International Prostate Symptom Score (IPSS), International Index of Erectile Function-5 (IIEF-5), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), peak urinary flow rate (Qmax), postvoid residual urine (PVR)) were compared.</p><p><strong>Results: </strong>No significant differences were found between groups regarding age, body mass index, comorbidities, prostate-specific antigen, prostate volume, ICIQ-SF scores, IIEF-5, complication rates, or postoperative hemoglobin decrease (all P > .05). Holmium laser enucleation of the prostate showed longer operative time, greater irrigation use, and higher resected tissue weight/percentage (P = .03, .02, <.001, <.001), while hospital stay and catheterization were shorter (both P < .001). Both procedures improved Qmax and IPSS and reduced PVR (all P < .001); the increase in Qmax was greater in HoLEP (P = .025).</p><p><strong>Conclusion: </strong>Both B-TURP and HoLEP are safe and effective for small prostates; however, HoLEP offers advantages in resected tissue weight, Qmax improvement, and shorter hospital stay/catheterization.   Cite this article as: G.lbaşı A, Elmaağa. B, Bi.er H, .zercan AY, Günal S, Keske M. Holmium laser enucleation of the prostate vs. bipolar transurethral resection of the prostate for small-volume prostates: A comparative analysis of clinical outcomes. Urol Res Pract. 2025;51(6):225-229.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 6","pages":"225-229"},"PeriodicalIF":1.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Standard TRUS-Guided Prostate Biopsy the End of the Game?","authors":"Erdal Benli, Nurullah Kadim, Ahmet Yüce, Abdullah Çırakoğlu, Mevlüt Keleş, Ayhan Arslan","doi":"10.5152/tud.2026.25103","DOIUrl":"10.5152/tud.2026.25103","url":null,"abstract":"<p><strong>Objective: </strong>Prostate cancer (PCa) remains a major cause of morbidity and mortality among men worldwide, and histopathologic tissue sampling plays a pivotal role in diagnosis. Although transrectal ultrasound-guided prostate needle biopsy (TRUS biopsy) has been the standard diagnostic technique for decades, its effectiveness has increasingly been questioned with the widespread adoption of cognitive and magnetic resonance imaging (MRI)-targeted biopsy techniques. The aim of this study wa to present the clinical outcomes and costs of TRUS-guided prostate biopsy performed in the clinic and to compare its costs with those of MRI-targeted biopsy.</p><p><strong>Materials and methods: </strong>Data from 221 patients who underwent prostate biopsy were retrospectively analyzed. Patient comorbidities, prostate-specific antigen levels, digital rectal examination findings, histopathologic results, and biopsy-related costs were recorded. Cost data for MRI-targeted biopsy were obtained from 9 private hospitals located in different regions of the country.</p><p><strong>Results: </strong>Prostate cancer was detected in 40.3% (n = 89) of the 221 patients. Clinically significant PCa was identified in 29.9% (n = 66), whereas malignancy could not be excluded in 1.4% (n = 3). The mean cost of TRUS-guided prostate biopsy performed in the clinic was calculated as US $26.8. In contrast, based on data obtained from 9 hospitals, the reported mean cost of MRI-targeted biopsy was US $1449.</p><p><strong>Conclusion: </strong>Transrectal ultrasound-guided prostate needle biopsy remains an effectivemand highly cost-efficient diagnostic method in patients with suspected PCa. This technique may be particularly valuable in clinical settings where access to MRI-targeted biopsy is limited.   Cite this article as: Benli E, Kadim N, Yüce A, Çırakoğlu A, Keleş M, Arslan A. Is standard TRUS-guided prostate biopsy the end of the game? Urol Res Pract. 2025;51(6): 237-241.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 6","pages":"237-241"},"PeriodicalIF":1.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrograde Intrarenal Renal Surgery versus Supine Mini Percutaneous Nephrolithotripsy in Treatment of Renal Pelvic Stones Less than 2 cm, Randomized Clinical Study.","authors":"Ahmed Hakim Abdelgawad, Mamdouh Abdelhamid Elhawy, Al Ayman Hussein Fathy Hussein, Tarek Kh Fathelbab, Amr Kamal Rabea Tolba, Ahmed Mohamed Fawzy","doi":"10.5152/tud.2026.25121","DOIUrl":"10.5152/tud.2026.25121","url":null,"abstract":"<p><strong>Objective: </strong>Retrograde intrarenal surgery (RIRS) is the first-line treatment for kidney stones between 1 and 2 cm and can serve as an alternative to percutaneous nephrolithotomy for larger stones in high-risk patients, including those with bleeding disorders, obesity, renal congenital abnormalities, or solitary kidneys. We aimed to compare the safety and efficacy of supine mini-percutaneous nephrolithotomy (PCNL) versus RIRS for the treatment of renal pelvic stones less than 2 cm.</p><p><strong>Methods: </strong>This prospective, randomized, double-blinded study included 50 patients aged >18 years, of both sexes, with renal stones <2 cm. Patients were randomized into 2 equal groups: Group A underwent supine mini-PCNL, while Group B underwent RIRS. Stone and patient characteristics, SFR, and perioperative events were compared between groups.</p><p><strong>Results: </strong>A total of 50 patients equally distributed into the 2 groups. Operative time was significantly lower in Group A than in Group B (P < .05), while fluoroscopic time was significantly higher in Group A than in Group B (P < .05). Also, hospital stay was significantly longer in Group A compared to Group B (P < .001). SFR and retreatments were comparable between both groups. Complications were also similar, with no significant differences observed.</p><p><strong>Conclusions: </strong>Supine mini-PCNL remains an effective option for achieving high stone clearance with a shorter operative time while avoiding ureteral access manipulation, while RIRS provides advantages such as reduced radiation exposure, shorter hospitalization but with a higher need for stenting and secondary procedures. Supine mini- PCNL is not inferior to RIRS in the treatment of less than 2 cm renal stones.   Cite this article as: Abdelgawad AH, Elhawy MA, Hussein AAHF, Fathelbab TK, Tolba AKR, Fawzy AM. Retrograde intrarenal renal surgery versus supine mini percutaneous nephrolithotripsy in treatment of renal pelvic stones less than 2 cm, randomized clinical study. Urol Res Pract. 2025;51(6): 230-236.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 6","pages":"230-236"},"PeriodicalIF":1.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of D-Mannose Monotherapy vs. Other Agents in Preventing Recurrent Urinary Tract Infections in Women: A Systematic Review and Meta-Analysis.","authors":"Ahmed Al-Hajjaj, Alaa Al-Maatoq, Asaad Al-Asadi","doi":"10.5152/tud.2026.25070","DOIUrl":"10.5152/tud.2026.25070","url":null,"abstract":"<p><p>Recurrent urinary tract infections (rUTIs) are common and often difficult to manage among women and are frequently treated with antibiotic prophylaxis. However, growing awareness of antibiotic resistance has encouraged interest in non-antibiotic alternatives such as D-mannose, a naturally occurring sugar believed to prevent rUTIs by inhibiting bacterial adhesion to the urothelial surface. This review aims to evaluate the efficacy and safety of D-mannose monotherapy in preventing rUTIs in adult women compared with antibiotics, placebo, or no treatment. A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature searches were performed using PubMed and EMBASE. Eligible studies were randomized controlled trials or cohort studies evaluating D-mannose monotherapy for rUTIs prevention in adult women. The primary outcome was UTI recurrence, and the secondary outcome was adverse effects. Five studies met the inclusion criteria (3 RCTs, 1 prospective cohort, and 1 retrospective cohort), including 1038 women. A meta-analysis of 3 eligible studies comparing D-mannose to placebo/control (n = 831) demonstrated a non-significant reduction in rUTIs in the D-mannose group (risk ratio = 0.37, 95% CI 0.11-1.30, P = .10) with high heterogeneity (I2 = 94%). The largest and highestquality study showed no significant difference between D-mannose and placebo. Across all included studies, D-mannose appears to be well tolerated, with only mild and infrequent side effects. Although D-mannose appears safe and well-tolerated, the current evidence does not support its routine use in the prevention of recurrent urinary tract infections. Further high-quality trials are necessary to clarify its effectiveness in clinical practice.   Cite this article as: Hajjaj AA, Maatoq AA, Asadi AA. Efficacy of D-mannose monotherapy vs. other agents in preventing recurrent urinary tract infections in women: A systematic review and meta-analysis. Urol Res Pract. 2025;51(6):208-216.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 6","pages":"208-216"},"PeriodicalIF":1.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible and Navigable Suction Ureteral Access Sheath for Ureteral Stones: A Novel \"Çapa\" Surgical Technique.","authors":"Rıfat Burak Ergül, M Fırat Özervarlı, Vineet Gauhar, Steffi Kar-Kei Yuen, Olivier Traxer, Tzevat Tefik","doi":"10.5152/tud.2026.25073","DOIUrl":"10.5152/tud.2026.25073","url":null,"abstract":"<p><strong>Objective: </strong>The flexible and navigable suction (FANS) ureteral access sheath (UAS) is an optimal innovation for retrograde intrarenal surgery (RIRS), proven to increase stonefree rates while reducing complications and the need for reintervention.1 This novel study aims to be the first to demonstrate the efficacy and reliability of FANS UAS in the treatment of ureteral stones.</p><p><strong>Material and methods: </strong>A 61-year-old male patient presented with left flank pain. A non-contrast computed tomography (CT) scan revealed 4 stones of 9, 8, 6, and 6 mm in the distal ureter. A JJ stent was placed as part of initial management. One month later, the patient underwent ureteroscopy with FANS UAS to manage the ureteral stones.</p><p><strong>Results: </strong>The operation was successfully completed within 90 minutes. Ureteroscopy was performed using a 9.8 Fr single-use Redpine flexible ureteroscope, which was advanced through an 11/13 Fr, 40 cm FANS UAS. During laser lithotripsy, stone fragments were efficiently aspirated into the FANS UAS, thereby minimizing mucosal trauma. The Post-ureteroscopy lesion scale (PULS) score was recorded as 0.2 Following complete stone removal, a 6 Fr JJ stent was placed, and the procedure was completed without complications. A non-contrast CT scan obtained 24 hours postoperatively confirmed a stone-free status. The JJ stent was removed one week later.</p><p><strong>Conclusion: </strong>The use of FANS UAS in ureteral stone management proved to be safe an effective, facilitating efficient stone clearance without mucosal injury. This novel technique offers a promising adjunct to standard ureteroscopy, particularly in cases requiring precise fragmentation control and low complication risk.   Cite this article as: Ergül RB, Ozervarli M, Gauhar V, et al. Flexible and navigable suction (FANS) ureteral access sheath for ureteral stones: A novel \".apa\" surgical technique. Urol Res Pract. 2025;51(6): 248-249.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 6","pages":"248-249"},"PeriodicalIF":1.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Study of the Incidence and Characteristics of Post-Obstructive Diuresis Following Pyeloplasty for Unilateral Pelvi-Ureteric Junction Obstruction.","authors":"Ashitosh D Pokharkar, Rohit Bhashkar Meshram, Charu Yadav, Amit Gupta, Partap S Yadav, Subhasis Roy Choudhury, Rajiv Chadha","doi":"10.5152/tud.2026.25023","DOIUrl":"10.5152/tud.2026.25023","url":null,"abstract":"<p><strong>Objectives: </strong>To study the characteristics of urine production and post-obstructive diuresis (POD) following pyeloplasty for unilateral pelvi-ureteric junction obstruction (PUJO) in children and identify risk factors for the development of significant POD.</p><p><strong>Methods: </strong>A prospective observational study was conducted on pediatric patients undergoing pyeloplasty for unilateral PUJO. Post-operative urine output was measured from the affected kidney via nephrostomy catheter placed during surgery and from the opposite normal kidney via per-urethral catheter. Biochemical analysis of the urine sample was performed. Patients were divided into 2 groups: Group-1 with POD (total urine output (UO) >4 mL/kg/hour) (n = 19; 63.33%), and Group-2 (without POD) (n = 11; 36.66%). Preoperative imaging findings were analyzed in the 2 groups which may indicate risk for POD. Hydration was maintained in all patients with POD and remained stable with appropriate oral replacement.</p><p><strong>Results: </strong>Post-obstructive diuresis occurred in Group-1 patients within 48 hours after surgery and resolved by postoperative day 5. They had statistically significant lower median renal parenchymal thickness and higher median renal pelvis antero-posterior diameter (APD), differential ratio of kidney size and proportion of grade-4 hydronephrosis (HN) than Group-2 patients. Urine from the affected kidney had significantly higher mean UO, pH, fractional excretion of sodium (FeNa+), potassium (FeK+), magnesium (FeMg+) and lower specific gravity, creatinine clearance, (phosphorus) FePO4 than urine from the normal kidney.</p><p><strong>Conclusion: </strong>Post-obstructive diuresis occurring in children with pyeloplasty for unilateral PUJO is usually well tolerated by maintaining hydration. Patients with larger kidneys, more severe HN, higher pelvis APD, and parenchymal thinning are at a significantly higher risk.   Cite this article as: Pokharkar AD, Meshram RB, Yadav C, et al. A prospective study of the incidence and characteristics of post-obstructive diuresis following pyeloplasty for unilateral pelvi-ureteric junction obstruction. Urol Res Pract. 2025;51(6): 242-247.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"51 6","pages":"242-247"},"PeriodicalIF":1.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}