Urology research & practice最新文献

{"title":"Circadian Syndrome and Stress Urinary Incontinence in Adult American Women: A NHANES Cross-Sectional Study.","authors":"Yuan Zheng, Tuochen Lv, Shichao Dai, Tita Tadoh Mike Pleass, Muhammad Arslan Ghaffar, Sisi Lu, Hai-Hong Jiang","doi":"10.5152/tud.2026.26028","DOIUrl":"10.5152/tud.2026.26028","url":null,"abstract":"<p><strong>Objective: </strong>The circadian syndrome (CircS) is linked with chronic diseases such as gallstones, kidney stones, and overactive bladder. However, the relationship between CircS and stress urinary incontinence (SUI) is poorly understood. The study aimed to investigate the association of CircS and SUI by analyzing data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018.</p><p><strong>Methods: </strong>The cross-sectional analysis was based on the 2007-2018 NHANES. Data on SUI were collected from the questionnaire. Three multivariate logistic regression models were used to elucidate the association between CircS and SUI prevalence. Stratified and interaction analyses were conducted to identify factors that could modify this relationship.   Results: A total of 5758 female patients were included in the study. In the fully adjusted model, patients with CircS showed a significantly higher prevalence of SUI (odds ratio [OR] = 1.250, 95% confidence interval [CI], 1.033-1.513) compared to the non-CircS group. Additionally, there was no significant correlation between the number of CircS components and the risk of SUI. The association between these factors was modified by an interaction with age (P < .001).</p><p><strong>Conclusion: </strong>There is a positive correlation between CircS and SUI prevalence. These findings provide new perspectives for future intervention strategies. However, further research is needed to explore its underlying biological mechanisms. Cite this article as: Zheng Y, Lv T, Dai S, et al. Circadian syndrome and stress urinary incontinence in adult american women: a NHANES cross-sectional study. Urol Res Pract. 2026, 52, 0028, doi: 10.5152/tud.2026.26028.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149003150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intravesical Bacillus Calmette-Guerin Treatment on Sexual Functions and Mental Health in Male and Female Patients Diagnosed with Non-Muscle Invasive Bladder Cancer.","authors":"Elife Kettas Dolek, Melih Biyikoglu, Selahittin Cayan, Samet Senel, Murat Bozlu, Erdem Akbay","doi":"10.5152/tud.2026.25045","DOIUrl":"10.5152/tud.2026.25045","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to investigate the effect of intravesical Bacillus Calmette-Guerin (BCG) treatment on sexual functions in females and males diagnosed with non-muscle invasive bladder cancer (NMIBC).</p><p><strong>Methods: </strong>The study included 87 patients, who presented to the authors' clinic, were diagnosed with NMIBC, and underwent intravesical BCG immunotherapy. All participants were interviewed thrice: before the first dose, after the third dose, and 4 weeks after the sixth dose of BCG. The Demographic Information Form, the Beck Depression Inventory (BDI), the International Index of Erectile Function (IIEF-5) (in males), and the Female Sexual Function Index (FSFI) (in females) were used in all 3 sessions.</p><p><strong>Results: </strong>Beck Depression Inventory scores of both males (4.74 ± 4.47, 10.22 ± 6.98, and 5.78 ± 4.96, respectively) and females (9.11 ± 5.33, 15.06 ± 5.3, and 9.67 ± 6.61) significantly increased after the third dose but decreased 4 weeks after the sixth dose of BCG (P < .001). In addition, it was observed that the IIEF-5 scores for males (19.7 ± 6.3, 8.24 ± 8.03, and 17.9 ± 7.11, respectively) and the FSFI scores for females (13.03 ± 8.47, 4.83 ± 6.28, and 11.66 ± 9.04 respectively) decreased after the third dose but increased 4 weeks after the sixth dose of BCG (P < .001).</p><p><strong>Conclusion: </strong>Repeated intravesical BCG treatments for patients with NMIBC may lead to sexual dysfunction (SD) and mental health. In this study, the peak SD was observed during the treatment process among male and female patients diagnosed with NMIBC who initiated a 6-week BCG treatment. In addition, both men and women were found to be mildly depressed during treatment. These findings tended to improve approximately 4 weeks after the end of the treatment. Cite this article as: Kettas Dolek E, Biyikoglu M, Cayan S, Senel S, Bozlu M, Akbay E. The effect of intravesical Bacillus Calmette- Guerin treatment on sexual functions and mental health in male and female patients diagnosed with non-muscle invasive bladder cancer. Urol Res Pract. 2026, 52, 0045, doi: 10.5152/tud.2026.25045.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Lower Urinary Tract Dysfunction Research Network Symptom Index-29 and SI-10 for Lower Urinary Tract Symptom Assessment Against with the International Prostate Symptom Score: A Cross-Cultural Validation and Agreement Study.","authors":"Vittaya Jiraanankul, Phatsinee Likitpanpisit, Thanisorn Pattanasuwon, Weerayut Wiriyabanditkul, Sarayut Kanjanatarayon, Nattapong Binsri, Satit Siriboonrid","doi":"10.5152/tud.2026.26031","DOIUrl":"10.5152/tud.2026.26031","url":null,"abstract":"<p><strong>Objective: </strong>Lower urinary tract symptoms (LUTS) impose a signi!cant burden on quality of life. Currently, no validated Thai version of the Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) or its short form (SI-10) exists. Unlike the International Prostate Symptom Score (IPSS), LURN instruments comprehensively assess incontinence, pain, urgency, voiding, and nocturia across sexes. The study aimed to translate the LURN SI-29 and SI-10 into Thai and to evaluate their psychometric properties.</p><p><strong>Methods: </strong>A prospective, cross-sectional study was conducted involving 137 patients with LUTS at a tertiary hospital in Thailand. Translation was performed in accordance with Patient-Reported Outcome Consortium guidelines. Internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coe\"cient (ICC)), concurrent validity against the Thai IPSS, discriminant validity, and clinical agreement (Bland-Altman analysis).</p><p><strong>Results: </strong>The Thai LURN SI-29 and SI-10 demonstrated excellent internal consistency (! = 0.94 and 0.85) and test-retest reliability (ICC = 0.84 and 0.82), which remained robust across all educational levels. Both instruments correlated strongly with the IPSS total score (\" = 0.85 and 0.80; P < .001). Furthermore, median LURN-SI scores increased signi!cantly stepwise across IPSS mild, moderate, and severe grades (P < .001). Exploratory domain-level analysis suggested possible sex-related symptom patterns, with men scoring higher on voiding di\"culties, while women exhibited greater incontinence and pelvic pain.</p><p><strong>Conclusion: </strong>The Thai LURN SI-29 and SI-10 are valid, reliable, and culturally appropriate. By capturing a broader symptom domain not included in the IPSS, they may support a more comprehensive LUTS evaluation. The SI-10 is ideal for rapid screening, while the SI-29 facilitates detailed assessment. Cite this article as: Jiraanankul V, Likitpanpisit P, Pattanasuwon T, et#al. Evaluating the Lower Urinary Tract Dysfunction Research Network Symptom Index-29 and SI-10 for lower urinary tract symptom assessment against the International Prostate Symptom Score: A cross-cultural validation and agreement study. Urol Res Pract. 2026, 52, 0031, 10.5152/tud.2026.26031.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Urodynamic Studies in Female Patients with Non-Neurogenic Lower Urinary Tract Dysfunction: A Retrospective Analysis.","authors":"Hanan Mohammed Shamrani","doi":"10.5152/tud.2026.26035","DOIUrl":"10.5152/tud.2026.26035","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic role of urodynamic studies (UDS) in female lower urinary tract dysfunction (LUTD) and its correlation with clinical symptoms.</p><p><strong>Methods: </strong>A retrospective study design was followed, and 89 female patients were included (2020-2025). SPSS was used for descriptive and multivariate analyses of the association between obstetric history and pelvic surgeries with UDS findings.</p><p><strong>Results: </strong>Forty-three (48.3%), 18 (20.2%), and 8 (9%) had no comorbidities, hypertension (HTN), and diabetes mellitus, respectively. Sixteen (18%) had urological problems, 54 (60.7%) were grand multiparous, and 20 (22.5%) had cesarean section (C-section). The mean volumes at first sensation, first desire to void, and strong desire to void were 111.83 ± 48.43 mL, 184.36 ± 70.73 mL, and 289.24 ± 93.60 mL, respectively. Urodynamic study findings for the mean maximum cystometric capacity were 370.46 ± 102.20 mL, maximum flow rate of 41.42 ± 47.04 mL/sec, post-void residual volume of 137.25 ± 144.0 mL, voided volume of 378.86 ± 164.87 mL, Valsalva leak point pressure of 7.43 ± 44.73 cm/H2O, and detrusor pressure at capacity was 10.86 ± 18.97 cm/H2O. Most patients had normal bladder compliance; 2 (2.2%) reported reduced compliance. Urethral assessment indicated that only 4 (4.5%) had obstructive urethra, stress incontinence, and 4 (4.5%) correlated with UDS and clinical symptoms (P < .05). A non-significant association was found between storage, voiding symptoms with UDS outcomes, except for hesitancy (P = .01) and straining (P = .04). Multinomial logistic regression analysis indicated no significant correlation of obstetric history and pelvic surgeries with UDS.</p><p><strong>Conclusion: </strong>Urodynamic studies may be helpful in providing objective functional assessment in selected or complex cases. However, in the population, UDS did not consistently confirm these cases. Cite this article as: Shamrani HM. The role of urodynamic studies in female patients with non-neurogenic lower urinary tract dysfunction: A retrospective analysis. 2026, 52, 0035, doi: 10.5152/tud.2026.26035.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected Patients with Benign Prostatic Enlargement and Detrusor Underactivity may Benefit from Prostate Surgery: An Exploratory Study.","authors":"Luís Vale, Ana Charrua, Carlos Martins-Silva, António Albino-Teixeira, Francisco Cruz, Tiago Antunes-Lopes","doi":"10.5152/tud.2026.26005","DOIUrl":"10.5152/tud.2026.26005","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate non-invasive biomarkers of detrusor underactivity (DU) in men with benign prostatic enlargement (BPE) and their ability to predict clinical and urodynamic improvement following prostate surgery. Particular attention was given to urinary adenosine triphosphate (ATP) levels, bladder contractility index (BCI), and bladder voiding efficiency (BVE).</p><p><strong>Methods: </strong>This exploratory study included 24 men with BPE undergoing prostate surgery. Based on pre-operative pressure-flow studies (P/F studies), patients were divided into DU (BCI < 100) and non-DU (BCI ≥ 100) groups. Urinary ATP levels were compared among DU patients, non-DU patients, and age-matched healthy male volunteers. Clinical and urodynamic parameters, including BCI and BVE, were assessed before and 1 year after surgery.</p><p><strong>Results: </strong>Thirteen patients were classified as DU, and 11 as non-DU. Median urinary ATP levels did not differ between groups. One year after surgery, DU patients presented a significant improvement in International Prostate Symptom Score, quality of life, Qmax, and post-void residual volume. However, median BCI did not increase after surgery. Apart from BCI, all other parameters were similar between groups after surgery. In this cohort, all DU patients with a pre-operative BVE > 40% achieved surgical success, compared to <50% of those with BVE < 40%.</p><p><strong>Conclusion: </strong>Urinary ATP does not appear to be a useful DU biomarker in men with BPE. Although prostate surgery did not significantly improve detrusor function 1 year after surgery, most DU patients experienced clinical improvement. Pre-operative BVE seems a simple non-invasive tool to identify DU patients more likely to benefit from surgery. Cite this article as: Vale L, Charrua A, Silva CM, Teixeira AA, Cruz F, Antunes-Lopes T. Selected patients with benign prostatic enlargement and detrusor underactivity may benefit from prostate surgery: an exploratory study. Urol Res Pract. 2026, 52, 0005, doi: 10.5152/tud.2026.26005.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-5"},"PeriodicalIF":1.1,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Study of a Comfort-Oriented Daytime Double-J Stent Removal Protocol: Effects on Pain, Anxiety, and Patient Satisfaction.","authors":"Xiaoyan Xu, Shuo Wu, Qingqing Yu, Rong Tang","doi":"10.5152/tud.2026.25137","DOIUrl":"10.5152/tud.2026.25137","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical impact of a modified daytime double-J (DJ) stent removal model based on comfort-oriented medical care on patient pain, anxiety, procedural efficiency, and satisfaction.</p><p><strong>Methods: </strong>Between January 2024 and June 2025, 160 patients undergoing ureteroscopy or percutaneous nephrolithotomy requiring DJ stent removal were randomly assigned to a comfort group (n = 80) or a conventional group (n = 80). The comfort group received structured preoperative education, intravenous sedation combined with urethral local anesthesia, pressurized irrigation-assisted cystoscopic removal, and postoperative follow-up. The conventional group underwent traditional outpatient cystoscopic stent removal. Outcomes included Visual Analog Scale (VAS) pain scores, Self-Rating Anxiety Scale (SAS) scores, stent removal time, patient satisfaction, and postoperative complications.</p><p><strong>Results: </strong>The comfort group reported significantly lower 24-hour VAS pain scores than the conventional group (2.6 ± 0.9 vs. 5.5 ± 1.0, P < .001). Baseline SAS scores were significantly lower in the comfort group than in the conventional group (30.2 ± 5.7 vs. 46.2 ± 7.0, P < .001), and postoperative SAS scores were 28.4 ± 4.7 vs. 42.0 ± 6.8, both P < .001. Stent removal time was shorter in the comfort group (1.90 ± 0.35 minutes vs. 2.20 ± 0.50 minutes, P = .014). Satisfaction scores and satisfaction rates were higher in the comfort group (4.6 ± 0.5 vs. 3.6 ± 0.7, 96.2% vs. 70.0%, P < .01). The 24-hour postoperative complication rate was low and not statistically significant (2.5% vs. 2.5%, P > .05).</p><p><strong>Conclusion: </strong>The comfort-oriented daytime stent removal model significantly reduces procedural pain and anxiety while improving patient satisfaction without increasing short-term complications. Cite this article as: Xu X, Wu S, Yu Q, Tang R. A randomized study of a comfort-oriented daytime double-J stent removal protocol: effects on pain, anxiety, and patient satisfaction. Urol Res Pract. 2026, 52, 0137, doi: 10.5152/tud.2026.25137.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition and Biochemical Determinants of Renal Stones: A Comprehensive Analysis of Urinary and Serum Mineral Profiles.","authors":"Pranav Prakash, Shikhar Agarwal, Rajeev Sarpal, Ashok Kumar Dogra, Archana Prakash","doi":"10.5152/tud.2026.26015","DOIUrl":"10.5152/tud.2026.26015","url":null,"abstract":"<p><strong>Objective: </strong>Renal stone formation is closely linked to disturbances in urinary and serum mineral metabolism. Analysis of stone composition along with biochemical parameters is essential for understanding the pathogenesis of different stone types.</p><p><strong>Methods: </strong>A prospective observational study was conducted among 371 patients with renal stones. Stone composition was analyzed using Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy- Energy-Dispersive X-ray Spectroscopy techniques. Serum and 24-hour urinary biochemical parameters, including calcium, oxalate, citrate, phosphate, uric acid, pH, and urine volume, were evaluated. Statistical analysis was performed to assess differences and correlations between stone types and biochemical variables.</p><p><strong>Results: </strong>The mean age was 45.3 years, with male predominance and 39.9% recurrence. Calcium oxalate monohydrate was most common. Stone types differed significantly in urinary volume, pH, and mineral excretion. Uric acid stones showed low urine pH and volume, while calcium phosphate stones had higher calcium excretion and alkaline pH, with related serum differences.</p><p><strong>Conclusion: </strong>Renal stone composition is strongly associated with specific urinary and serum biochemical abnormalities. Metabolic evaluation is crucial for identifying etiological factors and for guiding individualized preventive strategies in stone disease management. Cite this article as: Prakash P, Agarwal S, Sarpal R, Dogra AK, Prakash A. Composition and biochemical determinants of renal stones: A comprehensive analysis of urinary and serum mineral profiles. Urol Res Pract. 2026, 52, 0015, doi: 10.5152/tud.2026.26015.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Rotisserie: Dispelling the Myths of Intravesical Therapy and Pioneering a Precision Future for Bladder Cancer.","authors":"Mohammad Z Khan, Mohamed A Atta, Aly Kotb, Asmaa Ismail, Ahmed Kotb","doi":"10.5152/tud.2026.25112","DOIUrl":"10.5152/tud.2026.25112","url":null,"abstract":"<p><p>In the treatment of intermediate and high-risk non-muscle-invasive bladder cancer (NMIBC), intravesical therapy with Bacillus Calmette-Guérin or chemotherapy remains the gold standard. However, traditional methods involving patient repositioning and catheter retention lack robust evidence. A focused narrative review of international guidelines (European Association of Urology, American Urological Association, Canadian Urological Association) and PubMed-indexed literature was conducted to address the rationale, efficacy, and pharmacokinetics of intravesical delivery, with particular attention to patient rotation and catheter management. Available evidence does not demonstrate a clinically meaningful benefit of routine post-instillation patient rotation for intravesical therapy. Major international guidelines do not recommend routine patient rotation during intravesical dwell time. Dwell times beyond 1 hour show diminishing incremental benefit, and prolonged catheter retention may limit uniform urothelial contact. Modeling studies suggest increased volume may enhance mucosal penetration but must be balanced with patient tolerance. Contemporary practices increasingly support immediate catheter removal following instillation. Emerging data suggest that tumor grade and biological features may complement traditional stagebased risk stratification. It was concluded that routine patient repositioning during intravesical treatment dwell time is not supported by evidence; no scheduled turns are required, thereby improving comfort and adherence. Immediate catheter removal after instillation may optimize urothelial exposure and improve patient tolerability, while potentially reducing catheter-associated complications. Clamped Foleys should be reserved for patients unable to voluntarily retain fluid and should be removed at the earliest opportunity. Advances in tumor grading, molecular characterization, and cautiously applied artificial intelligence tools may further refine risk stratification and personalize intravesical therapy in the future. Cite this article as: Khan MZ, Atta MA, Kotb A, Ismail A, Kotb A. Beyond the rotisserie: dispelling the myths of intravesical therapy and pioneering a precision future for bladder cancer. Urol Res Pract. 2026, 52, 0112, doi: 10.5152/tud.2026.25112.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Tract Infection as a Potential Cause of Urethral Obstruction in Patients with an Indwelling Allium® Bulbar Urethral Stent.","authors":"Ufuk Yavuz, Seyfettin Çiftçi, Engin Telli, Tijen Nemut, Mustafa Melih Çulha","doi":"10.5152/tud.2026.26004","DOIUrl":"10.5152/tud.2026.26004","url":null,"abstract":"<p><strong>Objective: </strong>Urethral obstruction is a clinically relevant complication of retrievable urethral stents. This study aimed to evaluate the association between stent-related urinary tract infection (UTI) and urethral obstruction in patients treated with an Allium® bulbar urethral stent (BUS).</p><p><strong>Methods: </strong>Ninety-nine patients who underwent Allium® BUS placement for recurrent bulbar urethral stricture were retrospectively analyzed. Patients were followed monthly with uroflowmetry, postvoid residual urine measurement, and quantitative urine culture. In cases of stent removal, both urine and stent cultures were obtained and analyzed.</p><p><strong>Results: </strong>Premature stent removal due to urethral obstruction was required in 14 of 99 patients (14.1%). Urine cultures were positive in 12 of these 14 patients (85.7%), with Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis being the most frequently isolated organisms. Stent cultures were positive in 12 of these 14 patients (85.7%), demonstrating similar pathogens, including Enterococcus faecalis, Klebsiella pneumoniae, and Proteus mirabilis. In patients whose stents were removed on time or due to other complications without obstruction, positive urine and stent cultures were observed in 6.1% and 1.5% of cases, respectively. The rate of positive urine cultures was significantly higher in patients with urethral obstruction (P < .01).</p><p><strong>Conclusion: </strong>The findings suggest that urethral obstruction in patients with an indwelling Allium® BUS is more likely related to UTI rather than mechanical stent failure. Cite this article as: Yavuz U, Çiftçi S, Telli E, Nemut T, Çulha MM. Urinary tract infection as a potential cause of urethral obstruction in patients with an Indwelling Allium® bulbar urethral stent. Urol Res Pract. 2026, 52, 0004, doi: 10.5152/tud.2026.26004.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Mirabegron 25 mg Versus Oral Desmopressin 120 mcg in Treatment of Primary Nocturnal Enuresis.","authors":"Hosam Abdel-Fattah Abo-Elnasr, Mohamed Abdelrahman Alhefnawy, Mahmoud Farag, Mohamed Aboulfotouh El Gharably","doi":"10.5152/tud.2026.26009","DOIUrl":"10.5152/tud.2026.26009","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness and safety of mirabegron in the management of primary nocturnal enuresis.</p><p><strong>Methods: </strong>This prospective, randomized controlled study included 150 patients randomized into 2 equal groups: desmopressin and mirabegron. All patients underwent evaluation over a 6-month period, with assessments conducted at the end of each month. Evaluations included the frequency of wet nights per month, clinical outcomes, the percentage reduction in wet nights during treatment, and relapse following treatment. The side effects of the drugs in the studied groups were also recorded.</p><p><strong>Results: </strong>At 2, 3, 4, 5, and 6 months, the mirabegron group showed a significant increase in median percentage reduction in wet nights from baseline compared with the desmopressin group. Furthermore, there was a significant improvement in clinical outcomes for the mirabegron group compared to the desmopressin group (P < .01*). At the 1-month follow-up after treatment, 10.7% of patients in the mirabegron group had a relapse, whereas the relapse rate in the desmopressin group was 22.7%, indicating a statistically significant difference (P = .049*); the relative risk of relapse with mirabegron was 0.47 (95% CI: 0.22-1.02). The mirabegron group exhibited a significant increase in maximum bladder capacity (MBC) (270.8 ± 73.80) compared to the desmopressin group (230.933 ± 67.35; P < .001). Both groups exhibited a statistically significant increase in MBC posttreatment compared with pretreatment (P < .001*). No significant difference was observed between the 2 groups regarding any of the reported side effects.</p><p><strong>Conclusion: </strong>Mirabegron is an effective treatment for nocturnal enuresis, with better outcomes, fewer relapses, and tolerable side effects. Cite this article as: Abo-Elnasr HA, Alhefnawy MA, Farag M, El Gharably MA. Efficacy and safety of mirabegron 25 mg versus oral desmopressin 120 mcg in treatment of primary nocturnal enuresis. Urol Res Pract. 2026, 52, 0009, doi: 10.5152/ tud.2026.26009.</p>","PeriodicalId":101337,"journal":{"name":"Urology research & practice","volume":"52 ","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}