Orso Pusterla, Corin Willers, Robin Sandkühler, Simon Andermatt, Sylvia Nyilas, Philippe C Cattin, Philipp Latzin, Oliver Bieri, Grzegorz Bauman
{"title":"An automated pipeline for computation and analysis of functional ventilation and perfusion lung MRI with matrix pencil decomposition: TrueLung.","authors":"Orso Pusterla, Corin Willers, Robin Sandkühler, Simon Andermatt, Sylvia Nyilas, Philippe C Cattin, Philipp Latzin, Oliver Bieri, Grzegorz Bauman","doi":"10.1016/j.zemedi.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.08.001","url":null,"abstract":"<p><strong>Purpose: </strong>To introduce and evaluate TrueLung, an automated pipeline for computation and analysis of free-breathing and contrast-agent free pulmonary functional magnetic resonance imaging.</p><p><strong>Materials and methods: </strong>Two-dimensional time-resolved ultra-fast balanced steady-state free precession acquisitions were transferred to TrueLung, which included image quality checks, image registration, and computation of perfusion and ventilation maps with matrix pencil decomposition. Neural network whole-lung and lobar segmentations allowed quantification of impaired relative perfusion (R<sub>Q</sub>) and fractional ventilation (R<sub>FV</sub>). TrueLung delivered functional maps and quantitative outcomes, reported for clinicians in concise documents. We evaluated the pipeline using 1.5T data from 75 children with cystic fibrosis by assessing the feasibility of functional MR imaging, average scan time, and the robustness of the functional outcomes. Whole-lung and lobar segmentations were manually refined when necessary, and the impact on R<sub>Q</sub> and R<sub>FV</sub> was quantified.</p><p><strong>Results: </strong>Functional imaging was feasible in all included CF children without any dropouts. On average, 7.9 ± 1.8 (mean±SD) coronal slice positions per patient were acquired, resulting in a mean scan time of 6min 20s per patient. The whole pipeline required 20min processing time per subject. TrueLung delivered the functional maps of all the subjects for radiological assessment. Quality controlling maps and segmentations lasted 1min 12s per patient. The automated segmentations and quantification of whole-lung defects were satisfying in 88% of patients (97% of slices) and the lobar quantification in 73% (93% of slices). The segmentations refinements required 16s per patient for the whole-lung, and 2min 10s for the lobe masks. The relative differences in R<sub>FV</sub> and R<sub>Q</sub> between fully-automated and manually refined data were 0.7% (1.2%) and 2.0% (2.9%) for whole-lung quantification (median, [third quartile]), and excluding two outliers, 1.7% (3.9%) and 1.2% (3.8%) for the lobes, indicating the refinements could be potentially omitted in several patients.</p><p><strong>Conclusions: </strong>TrueLung quickly delivers functional maps and quantitative outcomes in an objective and standardized way, suitable for radiological and pneumological assessment with minimal manual input. TrueLung can be used for clinical research in cystic fibrosis and might be applied across various lung diseases.</p>","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Fröhlich, Torsten Rahne, Alexander Müller, Oliver Dziemba
{"title":"Influence of skin flap thickness on the transmission characteristics of middle ear implant audio processors.","authors":"Laura Fröhlich, Torsten Rahne, Alexander Müller, Oliver Dziemba","doi":"10.1016/j.zemedi.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.08.002","url":null,"abstract":"<p><strong>Objective: </strong>To measure signal transmission characteristics for audio processors of an active middle ear implant as a function of skin flap thickness, i.e., distance between audio processor and the implant's receiver coil.</p><p><strong>Methods: </strong>Output sound pressure levels for 90 dB input sound pressure level (OSPL90), reference test gains as function of frequency for an input sound pressure level of 60 dB (RTG60), and reference test gains (RTG - high frequency averages) were recorded in a hearing aid test box for Samba 2 Hi, Samba 2 Lo, and AP404 audio processors (MED-EL, Innsbruck, Austria) positioned on an implant-in-the-box and distances of 0-10 mm between audio processors and the receiver coil.</p><p><strong>Results: </strong>For all audio processors, the OSPL90 and RTG decreased linearly with increasing distance. The effect was dependent on audio processor type and the strongest reduction was observed for Samba 2 Lo. Between distances of 0 mm and 10 mm, the relative change of RTG was - 9,9 dB for Samba 2 Hi, -10,3 dB for AP404, and -27,7 dB for Samba 2 Lo.</p><p><strong>Conclusions: </strong>Skin thickness is a clinically significant factor which has to be considered in VSB treatment. In combination with insufficient transducer coupling or in patients with hearing thresholds close to the indication criteria limit, a thick skin flap could lead to loss of transmitted energy resulting in insufficient audiological outcome with the active middle ear implant.</p>","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michaela A U Hoesl, Lothar R Schad, Stanislas Rapacchi
{"title":"Erratum to \"Volumetric <sup>23</sup>Na single and triple-quantum imaging at 7T: 3D-CRISTINA\" [Z Med Phys 32 (2022) 199-208].","authors":"Michaela A U Hoesl, Lothar R Schad, Stanislas Rapacchi","doi":"10.1016/j.zemedi.2024.07.008","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.07.008","url":null,"abstract":"","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah, Sebastian Meyer, Vladimir Bashkirov, Reinhard Schulte, Robert P Johnson, Katia Parodi, Guillaume Landry
{"title":"Erratum to \"The role of Monte Carlo simulation in understanding the performance of proton computed tomography\" [Z Med Phys 32 (2022) 23-38].","authors":"George Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah, Sebastian Meyer, Vladimir Bashkirov, Reinhard Schulte, Robert P Johnson, Katia Parodi, Guillaume Landry","doi":"10.1016/j.zemedi.2024.07.012","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.07.012","url":null,"abstract":"","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Fattori, Jan Hrbacek, Harald Regele, Christian Bula, Alexandre Mayor, Stefan Danuser, David C Oxley, Urs Rechsteiner, Martin Grossmann, Riccardo Via, Till T Böhlen, Alessandra Bolsi, Marc Walser, Michele Togno, Emma Colvill, Daniel Lempen, Damien C Weber, Antony J Lomax, Sairos Safai
{"title":"Erratum to \"Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers\" [Z Med Phys 32 (2022) 52-62].","authors":"Giovanni Fattori, Jan Hrbacek, Harald Regele, Christian Bula, Alexandre Mayor, Stefan Danuser, David C Oxley, Urs Rechsteiner, Martin Grossmann, Riccardo Via, Till T Böhlen, Alessandra Bolsi, Marc Walser, Michele Togno, Emma Colvill, Daniel Lempen, Damien C Weber, Antony J Lomax, Sairos Safai","doi":"10.1016/j.zemedi.2024.07.011","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.07.011","url":null,"abstract":"","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gerd Heilemann, Mark Matthewman, Peter Kuess, Gregor Goldner, Joachim Widder, Dietmar Georg, Lukas Zimmermann
{"title":"Erratum to \"Can Generative Adversarial Networks help to overcome the limited data problem in segmentation?\" [Z Med Phys 32 (2022) 361-368].","authors":"Gerd Heilemann, Mark Matthewman, Peter Kuess, Gregor Goldner, Joachim Widder, Dietmar Georg, Lukas Zimmermann","doi":"10.1016/j.zemedi.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.07.006","url":null,"abstract":"","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukas Nierer, Florian Kamp, Michael Reiner, Stefanie Corradini, Moritz Rabe, Olaf Dietrich, Katia Parodi, Claus Belka, Christopher Kurz, Guillaume Landry
{"title":"Erratum to \"Evaluation of an anthropomorphic ion chamber and 3D gel dosimetry head phantom at a 0.35 T MR-linac using separate 1.5 T MR-scanners for gel readout\" [Z Med. Phys. 32 (2022) 312-325].","authors":"Lukas Nierer, Florian Kamp, Michael Reiner, Stefanie Corradini, Moritz Rabe, Olaf Dietrich, Katia Parodi, Claus Belka, Christopher Kurz, Guillaume Landry","doi":"10.1016/j.zemedi.2024.07.002","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.07.002","url":null,"abstract":"","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas M Brisson, Martin Krämer, Leonie A N Krahl, Alexander Schill, Georg N Duda, Jürgen R Reichenbach
{"title":"Erratum to \"A novel multipurpose device for guided knee motion and loading during dynamic magnetic resonance imaging\" [Z Med Phys 32 (2022) 500-513].","authors":"Nicholas M Brisson, Martin Krämer, Leonie A N Krahl, Alexander Schill, Georg N Duda, Jürgen R Reichenbach","doi":"10.1016/j.zemedi.2024.07.005","DOIUrl":"https://doi.org/10.1016/j.zemedi.2024.07.005","url":null,"abstract":"","PeriodicalId":101315,"journal":{"name":"Zeitschrift fur medizinische Physik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}