The Turkish journal of pediatrics最新文献

{"title":"A case of neonatal galactosemia presenting with rare hematologic problems: factor V deficiency and hemophagocytic lymphohistiocytosis.","authors":"Şule Toprak, Ümran Koral, Serdar Alan, Hacer Fulya Gülerman, Meryem Albayrak","doi":"10.24953/turkjpediatr.2026.6374","DOIUrl":"10.24953/turkjpediatr.2026.6374","url":null,"abstract":"<p><strong>Background: </strong>In the neonatal period, classical galactosemia usually presents with nonspecific clinical signs such as feeding intolerance, jaundice, lethargy, hypotonia, vomiting, and failure to thrive. Hemophagocytic lymphohistiocytosis (HLH) is very rare, with only a few case reports. The mechanism of HLH in metabolic disorders is unclear. It is thought to be related to tissue damage and impaired lymphocyte and histiocyte function, or some form of macrophage activation through metabolite accumulation. Various exogenous agents can inhibit factor V (FV) secretion or reduce its activity by inhibiting sulphatization, glycosylation, or phosphorylation.</p><p><strong>Case presentation: </strong>Here we report the case of a newborn who presented with elevated prothrombin time and activated partial thromboplastin time in the setting of liver failure and transient low FV levels and was subsequently diagnosed with HLH secondary to galactosemia.</p><p><strong>Conclusion: </strong>Neonatal galactosemia can lead to secondary HLH and transient FV deficiency. Our experience suggests that FV deficiency in neonates with galactosemia may develop secondary to liver damage and/or impaired glycosylation, and resolves with adequate treatment of the underlying disease.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"695-699"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional gastrointestinal disorders in Turkish infants: impact of feeding practices, sleep quality, and maternal depression.","authors":"Betül Yıldırım, Egemen Tural, Nevzat Aykut Bayrak, Özlem Erdede","doi":"10.24953/turkjpediatr.2026.6619","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.6619","url":null,"abstract":"<p><strong>Background: </strong>Functional gastrointestinal disorders (FGIDs) significantly impact infant well- being and healthcare utilization, yet comprehensive data using updated Rome IV criteria in Turkish populations remains limited. Our objective was to determine the prevalence and characteristics of FGIDs in Turkish infants and examine associations with feeding patterns, sleep quality, and maternal depression.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in a tertiary hospital between February and August 2020. A total of 459 infants aged 1-12 months were enrolled. FGIDs were diagnosed according to Rome IV criteria. Feeding characteristics, sleep quality assessed by the Brief Infant Sleep Questionnaire, and maternal depression measured using the Edinburgh Postnatal Depression Scale were recorded through face-to-face interviews. Comparisons were primarily performed between infants with and without FGIDs. Multivariable logistic regression adjusted for infant age was used to evaluate the association between feeding type and FGIDs.</p><p><strong>Results: </strong>At least one FGID was identified in 53.2% of infants (n=244). Co-occurrence of multiple FGIDs was observed in 92 infants. Infants with FGIDs were significantly younger than those without FGIDs with a median age of 3 months (interquartile range [IQR]: 2-5) vs 6 months (IQR: 3-9) (p<0.001). Poor sleep was markedly more prevalent among infants with FGIDs compared to those without (45.1% vs 22.3%, p<0.001). Mothers of infants with FGIDs had higher depression scores than mothers of infants without FGIDs (median: 7.0 [IQR: 4-11] vs 5.0 [3-10], p=0.030). In multivariable logistic regression analysis adjusted for infant age, the overall feeding model was not statistically significant (p=0.240); however, mixed breast milk and formula feeding was associated with increased FGID risk compared to exclusive breastfeeding (adjusted odds ratio: 2.16, 95% confidence interval: 1.17-3.98, p=0.014).</p><p><strong>Conclusions: </strong>FGIDs affect over half of Turkish infants and are associated with sleep disturbances and maternal depressive symptoms. Mixed breast-formula feeding independently increased FGID risk after age adjustment. Integrated care approaches addressing feeding practices, sleep quality, and maternal mental health are warranted.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"369-380"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal knowledge, attitudes, and practices regarding childhood fever: a cross-sectional study.","authors":"Nihan Uygur Külcü, Kutlay Gür, Özlem Erdede, Erdal Sarı","doi":"10.24953/turkjpediatr.2026.6662","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.6662","url":null,"abstract":"<p><strong>Background: </strong>Fever remains one of the most common reasons for pediatric visits and is a key issue in family health literacy. Misconceptions and fears often lead to inappropriate interventions or delayed medical care. Understanding mothers' perceptions of childhood fever is essential for effective health education. This study explored maternal attitudes and practices regarding fever to inform future health education strategies and guideline development.</p><p><strong>Methods: </strong>A cross-sectional, descriptive study was conducted via face-to-face interviews with mothers of children attending a tertiary pediatric outpatient clinic for non-febrile complaints. Primary outcomes included knowledge of fever definition, medication use, and home remedies. Secondary outcomes assessed the impact of sociodemographic factors and reasons for seeking care. Incorrect antipyretic administration (inappropriate dose or dosing interval) was analyzed using multivariable logistic regression.</p><p><strong>Results: </strong>Of 1000 participating mothers (aged 18-51, mostly high school graduates), 73.8% administered the correct antipyretic dose, while 15.7% used insufficient and 4.3% excessive doses. The main concern (93%) was preventing febrile convulsions. Traditional advice (45.4%) and online sources (32.4%) were frequently consulted. In infants under one year, mothers more often contacted a physician instead of using antipyretics at 38 °C. Tepid sponging with vinegar was less used in children under 1 and those aged 2-3 years at 40 °C. Multivariable analysis showed that lower maternal education, absence of a home thermometer, prematurity history, and absence of a family history of febrile seizures were independently associated with incorrect antipyretic administration; the strongest association was observed for absence of a home thermometer (adjusted odds ratio: 2.74, 95% confidence interval: 1.89-3.98). Mothers of adolescents (12-18 years) were less likely to use home-based interventions and showed a greater tendency toward seeking medical care at 38 °C. Families with one child were less likely to undress the child during a fever compared to those with multiple children.</p><p><strong>Conclusions: </strong>Targeted education addressing misconceptions and inappropriate fever management practices could enhance outcomes and reduce unnecessary healthcare utilization.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"381-392"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic spectrum in patients with 16p11.2 deletion: a single tertiary centre experience in Türkiye.","authors":"Ahmet Kablan, Abdüllatif Bakır, Elifcan Taşdelen, Firdevs Dinçsoy Bir, Abdulkerim Kolkıran, Melike Ataseven Kulalı, Ergin Atasoy, Deniz Menderes, Ayşegül Efe, Mustafa Kılıç, İzzet Erdal","doi":"10.24953/turkjpediatr.2026.7003","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.7003","url":null,"abstract":"<p><strong>Background: </strong>The 16p11.2 deletion is one of the most frequent recurrent copy number variations associated with a broad neurodevelopmental and phenotypic spectrum. Despite its relatively well-characterized genomic region, clinical expressivity remains highly variable, posing challenges for diagnosis and management.</p><p><strong>Methods: </strong>We conducted a retrospective single-centre study of 25 individuals with molecularly confirmed 16p11.2 deletions, including 13 males (52%), 12 females (48%), and 7 familial (28%). Both de novo and inherited cases were included. The main testing method was chromosomal microarray, although karyotyping and additional tests such as sequencing and trinucleotide repeat testing were also utilized. Comprehensive clinical data were collected from medical records, including neurodevelopmental, neuropsychiatric, metabolic, skeletal, and systemic features.</p><p><strong>Results: </strong>The majority of the cases had the typical ~600 kilobase deletion while two had distal ~220kb deletion. One patient was found to have a double genetic diagnosis. Developmental delay was almost universal in the probands, with expressive language significantly more impaired than receptive language abilities. Intellectual disability / learning difficulties and language problems were observed in 18/25 (72%) cases. Around half of the probands showed obesity and related hyperphagia. Autism spectrum disorder, attention deficit hyperactivity disorder, stereotypic movements, and aggressive behaviour were frequently reported. Epilepsy was present in thirteen patients (52%), with electroencephalographic abnormalities supporting generalized or focal epileptiform activity. Dysmorphic facial features and skeletal anomalies such as pes equinovarus, syndactyly, and scoliosis were variably present. Brain magnetic resonance imaging revealed abnormalities in several patients, including hypoplasia of the corpus callosum and intracranial hypertension. Additional systemic findings included hepatic steatosis, constipation, and ophthalmologic anomalies. Parental testing revealed asymptomatic or mildly affected carriers in multiple cases.</p><p><strong>Conclusion: </strong>Our findings emphasize the broad and heterogeneous clinical spectrum of 16p11.2 deletions in a Turkish cohort. Early recognition, multidisciplinary evaluation, and family-based genetic counselling are essential for timely diagnosis and optimal care of affected individuals.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"416-427"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procalcitonin and proadrenomedullin in pediatric acute leukemia: biomarkers for infection and beyond.","authors":"Jagdish Prasad Meena, Harshita Makkar, Sujata Bhattacharya, Ruksana Sidhique P R, Aditya Kumar Gupta, Ashutosh Halder, Rachna Seth","doi":"10.24953/turkjpediatr.2026.6705","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.6705","url":null,"abstract":"<p><strong>Background: </strong>The clinical utility of procalcitonin (PCT) and proadrenomedullin (ProADM) in children with malignancies remains inadequately characterized. This study was designed to assess baseline PCT and ProADM levels at the time of leukemia diagnosis and to compare their profiles during subsequent episodes of febrile neutropenia (FN).</p><p><strong>Methods: </strong>Children aged 18 years or younger with newly diagnosed acute leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), were prospectively recruited for this study. Serum levels of PCT and ProADM were measured at baseline, prior to the initiation of chemotherapy at the time of diagnosis, and were reassessed during subsequent episodes of FN.</p><p><strong>Results: </strong>A total of 80 children with acute leukemia were prospectively enrolled, with a median age of 5 years (interquartile range [IQR]: 3-7 years). The study population comprised of ALL in 67.5% of cases and AML in 32.5%. At the time of diagnosis, prior to chemotherapy initiation (n=80), the median serum PCT level was 0.19 ng/mL (IQR: 0.07-0.54), while the median ProADM level was 0.04 nmol/L (IQR: 0.01-0.07). Among the 80 patients, 32 children subsequently developed FN and had paired serum samples available for comparative analysis. During FN episodes, both biomarkers showed a significant increase relative to baseline values. Median PCT increased from 0.16 ng/mL (0.08-0.52) at diagnosis to 0.32 ng/mL (0.08-0.50) during FN (P = 0.03), while median ProADM increased from 0.03 nmol/L (0.006-0.05) to 0.41 nmol/L (0.20-0.81) (P < 0.001). At the time of leukemia diagnosis, splenomegaly was the only clinical factor significantly associated with elevated baseline PCT levels (P = 0.010). Subgroup analysis revealed distinct biomarker patterns: in children with ALL, PCT levels remained largely unchanged between diagnosis and FN, possibly reflecting an underlying baseline inflammatory state, whereas ProADM showed a significant rise during FN, suggesting greater specificity for infectious events. In contrast, in AML, both PCT and ProADM increased significantly during FN, indicating their potential utility as infection-related biomarkers in this subgroup.</p><p><strong>Conclusion: </strong>Both PCT and ProADM were significantly elevated in FN when patients with acute leukemia were analyzed as a whole. However, subgroup analysis revealed differing patterns: in ALL, only ProADM remained significantly associated with FN, whereas PCT showed no significant association. In contrast, in AML, both biomarkers were significantly elevated. These findings suggest that ProADM may have greater clinical utility in guiding the management of febrile episodes, particularly in ALL.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"461-470"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensatory kidney enlargement and blood pressure patterns in children with a solitary functioning kidney.","authors":"Adem Yasin Köksoy, Derya Bako","doi":"10.24953/turkjpediatr.2026.7319","DOIUrl":"10.24953/turkjpediatr.2026.7319","url":null,"abstract":"<p><strong>Background: </strong>Children with a solitary functioning kidney (SFK) are at risk for hypertension and kidney injury despite compensatory renal growth. However, the relationship between compensatory enlargement and blood pressure abnormalities remains controversial. This study is an exploratory observational study aimed at assessing ambulatory blood pressure monitoring (ABPM) parameters in children with an SFK and to evaluate the relationship between compensatory kidney enlargement and blood pressure indices.</p><p><strong>Methods: </strong>Thirty-three children aged 6-18 years with an SFK (22 renal agenesis, 11 atrophic kidneys) were evaluated. Compensatory enlargement was defined as kidney length >97.5th percentile for height. All participants underwent anthropometric assessment, serum creatinine measurement, estimated glomerular filtration rate (GFR) calculation, and 24-hour ABPM. ABPM values were expressed as standard deviation scores (SDS) adjusted for age and sex.</p><p><strong>Results: </strong>Compensatory enlargement was present in 17 (51.5%) patients. Those with compensatory enlargement showed significantly higher 24-hour systolic BP SDS (0.64±1.07 vs. -0.22±1.03, p=0.024), nighttime systolic BP SDS (1.36±1.04 vs. 0.38±0.93, p=0.008), nighttime diastolic BP SDS (1.42±1.17 vs. 0.48±0.70, p=0.009), and nighttime MAP SDS (1.43±0.99 vs. 0.48±0.84, p=0.006). Kidney length SDS correlated positively with 24-h systolic BP SDS (r=0.44, p=0.01) and nighttime MAP SDS (r=0.45, p=0.009). Logistic regression analysis revealed that compensatory enlargement independently predicted elevated blood pressure (OR 10.06, 95% CI 1.03-97.77, p=0.047) after adjustment for age, height SDS, and weight SDS.</p><p><strong>Conclusions: </strong>Compensatory hypertrophy in SFK may not be entirely benign and could reflect an adaptive process associated with altered blood pressure regulation. Higher nocturnal blood pressure in patients with compensatory enlargement may suggest subclinical hemodynamic stress. These findings suggest that children with compensatory kidney enlargement may exhibit subtle alterations in ambulatory blood pressure patterns, warranting further investigation in larger longitudinal studies.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"428-438"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Clarifying the statistical reporting in the multivariate analysis of retinopathy of prematurity biomarkers\".","authors":"Chenglv Liu, Lijie Dong, Qiaoling Yang, Lang Bai","doi":"10.24953/turkjpediatr.2026.8711","DOIUrl":"10.24953/turkjpediatr.2026.8711","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"549-550"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-transplant autoimmunity in a child: a lupus-like syndrome emerging in the context of chronic graft-versus-host disease.","authors":"Bengisu Menentoğlu, Selen Duygu Arık, Salih Güler, Deniz Tuğcu, Zeynep Karakas, Nuray Aktay Ayaz","doi":"10.24953/turkjpediatr.2026.6820","DOIUrl":"10.24953/turkjpediatr.2026.6820","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune manifestations are increasingly recognized as late complications following hematopoietic stem cell transplantation (HSCT), particularly in association with chronic graft-versus-host disease (cGvHD). However, the occurrence of systemic lupus erythematosus (SLE)-like features remains extremely rare, especially in pediatric patients. Understanding the mechanisms underlying such manifestations, including the role of mixed chimerism, is important for early recognition and management.</p><p><strong>Case presentation: </strong>We report the case of a girl with thalassemia major who underwent HSCT from a fully matched unrelated donor at the age of six years. Her early post-transplant course was complicated by gastrointestinal cGvHD, followed by autoimmune hemolytic anemia and arthritis, which responded to corticosteroids and methotrexate. Four years post-HSCT, she developed a lupus-like syndrome characterized by malar rash, serositis, cytopenias, arthritis, high-titer antinuclear antibodies (ANA), elevated anti-double-stranded DNA (anti-dsDNA) antibodies, and low complement levels, fulfilling the American College of Rheumatology classification criteria for SLE. At the time of symptom onset, mixed chimerism was documented, with a notable proportion of recipient-derived lymphocytes. Treatment with mycophenolate mofetil and hydroxychloroquine led to rapid clinical and laboratory improvement.</p><p><strong>Conclusion: </strong>This case illustrates the evolving nature of post-transplant immune dysregulation and suggests that declining donor chimerism may contribute to the reactivation of autoreactive lymphocytes, leading to atypical autoimmune manifestations. In pediatric patients presenting with unusual post-transplant symptoms, careful clinical assessment and immune monitoring may aid in timely diagnosis. Individualized immunosuppressive therapy can facilitate symptom control and support favorable long-term outcomes.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"539-546"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features associated with <i>Pseudomonas aeruginosa</i> colonization in children under 2 years of age: a retrospective study of Cystic Fibrosis Registry.","authors":"Ece Ocak, Güzin Cinel, Gökçen Dilşa Tuğcu, Sanem Eryılmaz Polat, Dilber Ademhan Tural, Beste Özsezen, Ebru Yalçın, Nural Kiper, Velat Şen, Hadice Selimoğlu Şen, Derya Ufuk Altıntaş, Ayşe Ayzıt Kılınç, Haluk Çokuğraş, Hakan Yazan, Gokçen Ünal, Aslı İmran Yılmaz, Ilim Irmak, Ebru Damadoğlu, Gökçen Kartal Öztürk, Esen Demir, Erdem Başaran, Ayşen Bingöl, Nihat Sapan, Yakup Canıtez, Pelin Asfuroğlu, Ayşe Tana Aslan, Koray Harmancı, Melih Hangül, Mehmet Köse, Ali Özdemir, Gizem Özcan, Nazan Çobanoğlu, Zeynep Gökçe Gayretli Aydın, Özlem Keskin, Hasan Yüksel, Şebnem Özdoğan, Erdem Topal, Gönül Çaltepe, Demet Can, Pervin Korkmaz, Mehmet Kılıç, Tuğba Şişmanlar Eyüboğlu, Sevgi Pekcan, Erkan Çakır, Nagehan Emiralioğlu, Uğur Özçelik, Deniz Doğru","doi":"10.24953/turkjpediatr.2026.7593","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.7593","url":null,"abstract":"<p><strong>Background: </strong>Respiratory colonization with Pseudomonas aeruginosa is associated with increased morbidity and mortality in cystic fibrosis (CF) patients. This study aims to assess the clinical characteristics and associated factors of CF infants under two years of age with P. aeruginosa colonization in Türkiye.</p><p><strong>Method: </strong>Of the 1637 patients registered in the Cystic Fibrosis Registry of Türkiye in 2019, 284 patients under two years of age were included in this retrospective cross-sectional study. Patients were classified into two groups: those with P. aeruginosa colonization (Group 1) and those without (Group 2). Cystic fibrosis transmembrane conductance regulator (CFTR) gene functions were categorized according to CFTR mutation functional class.</p><p><strong>Results: </strong>Twenty-three patients (8.1%) were categorized as Group 1 and 262 participants (91.9%) were classified as Group 2. Infants with P. aeruginosa colonization (Group 1) were more likely to have minimal CFTR function compared with those without colonization (87% vs. 39.8%, p = 0.017). In addition, both Staphylococcus aureus colonization (47.8% vs. 7.3%, p < 0.001) and methicillin-resistant S. aureus positivity (17.4% vs. 6.1%, p = 0.042) were observed more commonly in Group 1. There were no statistical differences between the groups in terms of age at diagnosis, gender, mean z-scores of weight and height, newborn screening test positivity, sweat chloride test results, and pancreatic insufficiency (p > 0.05). Univariate logistic regression analysis did not identify significant associated factors for P. aeruginosa colonization.</p><p><strong>Conclusions: </strong>Our findings suggest that minimal CFTR function and S. aureus colonization are associated with P. aeruginosa colonization in CF patients under two years of age. Further studies are needed to investigate associated factors for early P. aeruginosa colonization, eradication treatment effectiveness, and longitudinal outcomes of in CF patients under two years of age.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"439-449"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullying victimization in pediatric patients with celiac disease.","authors":"Ulaş Emre Akbulut, Atike Atalay, İshak Abdurrahman Işık, Nazlı Sivil, Memduha Sarı, Arzu Aras, Coşkun Fırat Özkeçeci, Koray Kara, Kayı Eliaçık, Hasan Ali İnal","doi":"10.24953/turkjpediatr.2026.7149","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.7149","url":null,"abstract":"<p><strong>Background: </strong>In this study, we aimed to investigate peer bullying and its psychosocial consequences in children with celiac disease. We examined the relationship between adherence to diet and anxiety and depressive symptoms.</p><p><strong>Methods: </strong>The sample in this cross-sectional study consisted of 124 pediatric celiac patients on a gluten-free diet for one year or more. One hundred thirty-nine healthy children comparable in age and sex were enrolled as the control group. The Revised Olweus Bully Victim Questionnaire (OBVQ) was used to evaluate the peer victimization. The Revised Child Anxiety and Depression Scale and Strengths and Difficulties Questionnaire were used to assess children's anxiety and depressive symptoms, and emotional and behavioral symptoms, respectively. Hierarchical logistic regression analysis was performed to identify independent predictors of dietary non-adherence.</p><p><strong>Results: </strong>The proportion of children classified as bullying victims based on the OBVQ was significantly higher in the celiac disease group than in the healthy controls. Children who did not comply with diet therapy experienced significantly higher rates of peer bullying than those who adhered to the diet (p=0.004). However, multivariate analysis indicated that depressive symptoms appeared to account for this relationship - while bullying initially predicted dietary non-adherence (odds ratio [OR]: 3.274, p=0.004), this effect became non-significant when depression was controlled (OR: 2.177, p=0.098), whereas depression remained a significant independent predictor (OR: 1.093, p=0.044). Significant positive correlations were observed between peer bullying and anxiety and depression symptom scores. Peer bullying also exhibited positive correlations with emotional and behavioral symptoms.</p><p><strong>Conclusions: </strong>The study findings show that children with celiac disease experience higher rates of peer bullying than their healthy peers. More importantly, our results suggest that the association between bullying and dietary adherence may be largely explained by co-occurring depressive symptoms. We therefore recommend that depressive symptom screening and treatment should be integrated into the management of celiac disease in children, particularly for those experiencing peer victimization.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 3","pages":"471-484"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}