Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology最新文献_第5页

Lektin-typisierung als leistungsfähiges epidemiologisches markersystem für Neisseria gonorrhoeae-infektionen 用口试表明这是针对

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80073-7

Hans Christian Korting , Dietrich Abeck

引用次数: 2

Kriterien zur Festsetzung von Grenzwerten für die antibakterielle Chemotherapie 现场指示值

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80150-0

Götz Linzenmeier

{"title":"Kriterien zur Festsetzung von Grenzwerten für die antibakterielle Chemotherapie","authors":"Götz Linzenmeier","doi":"10.1016/S0176-6724(88)80150-0","DOIUrl":"10.1016/S0176-6724(88)80150-0","url":null,"abstract":"<div><p>The safety of patients asks for stringent standards when fixing limit values of the minimal inhibition concentration (MIC) in mg/1. It should be possible to recognize <em>resistant</em> bacterial strains with a low error on the basis of the recommendations of the bacteriological laboratory which are eventually important for therapy. Attention is drawn to the use of recognized methods such as DIN 58940 and 58944 and the participation in interlaboratory studies. Only such bacteria should be interpreted as „susceptible“ whose MIC's are reliably below or, which is even better, much below the generally recognized average blood and tissue levels. Thus the break-points for the rating “susceptible” must be within the range of low variation. As a resalt, a few strains more would come within the “moderately susceptible” range. This would not exclude them from being selected if chemotherapy is performed with a correspondingly higher dosage (provided it is tolerated). Information on the chances of a success of therapy is improved in this way. A generous interpretation of pharmacokinetic data will in the end be more to the patient's detriment. In addition, there are numerous factors determining success or failure of therapy which cannot be established in vitro so that it is advisable to fix laboratory parameters in a stringent manner like that applied in the annexes (evaluation steps) to parts 3 and 4 of DIN 58940.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 138-144"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80150-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128991919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Viral DNA from Cells Infected with Porcine Circovirus 猪圆环病毒感染细胞的病毒DNA

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80164-0

Ilse Tischer , Hans-Jörg Buhk

引用次数: 24

Leptospiral lipopolysaccharide presence in the outer envelope: Electrophoretic evidence and immunological specificity 外包膜中存在的钩端螺旋体脂多糖:电泳证据和免疫特异性

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80171-8

Marina Cinco , Elena Banfi , Enrico Panfili

{"title":"Leptospiral lipopolysaccharide presence in the outer envelope: Electrophoretic evidence and immunological specificity","authors":"Marina Cinco , Elena Banfi , Enrico Panfili","doi":"10.1016/S0176-6724(88)80171-8","DOIUrl":"10.1016/S0176-6724(88)80171-8","url":null,"abstract":"<div><p>Purified preparations of lipopolysaccharides (LPS) extracted from two different strains of <em>Leptospira interrogans</em> have been electrophoretically analyzed in order to determine their location at the level of outer envelope (OE). Evidence has been collected for the presence of some LPS fractions in the OE, suggesting that a part of this molecule is embedded in the membrane structure. The serological specificity of the LPS has been in addition tested by means of monoclonal antiserovar antibodies (Moabs); the results indicated that the LPS structure is endowed of the immunodeterminants of the serovar. The remarkable relevance of this finding for the <em>Leptospira</em> taxonomy is discussed.</p></div><div><p>Die aus <em>Leptospira interrogans</em> Serovar <em>copenhageni</em> bzw. <em>hardjo</em> isolierten und gereinigten Lipolysaccharide (LPS) wurden elektrophoretisch untersucht, um damit ihre Lokalisation in der äußeren Hülle zu bestimmen. Der Nachweis von LPS-Fraktionen in der äußeren Hülle legt die Annahme nahe, das ein Teil des Moleküls in die Membran-Struktur eingebaut ist. Mittels monoklonaler, serovarspezifischer Antikörper wurde gezeigt, daß LPS zu der immundominanten Struktur der Serovare beiträgt.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"269 3","pages":"Pages 277-283"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80171-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13609796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Infection and Immunity to Vibrio cholerae, Salmonella typhimurium and Escherichia coli in a Rabbit Model 兔模型对霍乱弧菌、鼠伤寒沙门菌和大肠杆菌的感染和免疫

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80162-7

Piet A.M. Guinée , Wim H. Jansen, Sjoerd G.T. Rijpkema

{"title":"Infection and Immunity to Vibrio cholerae, Salmonella typhimurium and Escherichia coli in a Rabbit Model","authors":"Piet A.M. Guinée , Wim H. Jansen, Sjoerd G.T. Rijpkema","doi":"10.1016/S0176-6724(88)80162-7","DOIUrl":"10.1016/S0176-6724(88)80162-7","url":null,"abstract":"<div><p>Cholera disease can be induced in the rabbit by duodenal inoculation (DI) of <em>Vibrio cholerae</em> organisms after ligation of the cecum (C) (DIC model). When ligation of the cecum is omitted, no disease symptoms develop. In contrast, the animals are primed which becomes apparent as vibriocidal protection upon challenge with <em>V. cholerae</em> in the DIC model. This protection coincides with high anti-O antigen IgA levels in the bile. The O antigen was shown to be the protective antigen and it must be presented by live organisms. A non-enterotoxigenic mutant of <em>V. cholerae</em> induced protective immunity in the rabbit but was reported to cause mild diarrhea in human volunteers. Looking for alternatives, we applied cholera toxin, known as a mucosal adjuvant, together with killed <em>V. cholerae</em> cells to rabbits. Unfortunately, the minimum adjuvant dose was equal to the minimum toxic dose. A Salmonella typhimurium strain expressing also the <em>V. cholerae</em> O antigen induced systemic rather than local immunity which was not protective. Several Escherichia coli strains were able to elicit a local immune response, but the animal to animal differences were considerable. Therefore, <em>V. cholerae</em> itself was thought to be the most appropriate carrier organism. Some non-enterotoxigenic and auxotrophic mutants of <em>V. cholerae</em> were able to prime and did not show any undesired side-effects in the DIC model. Therefore, further attenuation of non-toxigenic <em>V. cholerae</em> strains by means of stable deletions in nutritional genes seems to be the most promising way to obtain acceptable vaccine candidates.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 260-269"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80162-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13610551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pseudomonas aeruginosa Lectins as a Model for Lectin Production, Properties, Applications and Functions 铜绿假单胞菌凝集素的产生、性质、应用和功能模型

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80135-4

Nechama Gilboa-Garber

{"title":"Pseudomonas aeruginosa Lectins as a Model for Lectin Production, Properties, Applications and Functions","authors":"Nechama Gilboa-Garber","doi":"10.1016/S0176-6724(88)80135-4","DOIUrl":"10.1016/S0176-6724(88)80135-4","url":null,"abstract":"<div><p><em>Pseudomonas aeruginosa</em> is one of the most troublesome human pathogens in the antibiotic consuming era. It produces lectins and lectinoid adhesins as secondary metabolites. The production of these compounds is genetically determined and is highly sensitive to changing environmental conditions. These dictate the type of the lectin produced [“type” variation], the lectin level [“on-off” variation], and its localization [“in-out” variation]. PA-I [galactophilic] and PA-II [fucose and mannose-binding] <em>P. aeruginosa</em> lectins are sensitive to EDTA and exhibit biophysical properties, resembling those of classical plant lectins. They exert similar in vitro biological effects and have an equal applicative potential. Lectin deficient strains and mutants of <em>P. aeruginosa</em> may be used for studies on lectin role in “conditioning” the bacterium lytic and toxic activities in its attacks on cells or macromolecules. The <em>Pseudomonas</em> lectins cofunction with lytic and toxic activities: We suggest that they serve the homing and “condition” the lytic enzyme optimal activity on cellular and macromolecular targets. Namely their role resembles that of “positioning sites” of lytic enzymes and “receptor-binding” domains of powerful microbial, plant and animal toxic or lytic systems [including immunoglobulins, which “condition” the lytic activities of complement and phagocytes], as well as certain hormones, which condition limited key lytic activities, and thereby trigger a cascade of metabolic reactions.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 3-15"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80135-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14277631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

The Effect of Shwartzman Phenomenon on the Pathogenesis of Experimental Acute Pyelonephritis in Rat Shwartzman现象对实验性急性肾盂肾炎大鼠发病机制的影响

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80149-4

Rudolf Sonak , Michael Balduf

{"title":"The Effect of Shwartzman Phenomenon on the Pathogenesis of Experimental Acute Pyelonephritis in Rat","authors":"Rudolf Sonak , Michael Balduf","doi":"10.1016/S0176-6724(88)80149-4","DOIUrl":"10.1016/S0176-6724(88)80149-4","url":null,"abstract":"<div><p>It has been shown that the mere presence of gram-negative bacteria within the kidney parenchyma does not lead to kidney damage. Various accessory manipulations modifying the resistance of the urinary tract should be used to induce kidney lesions. We present the results of our experiments with sterile bacterial filtrate applied accordingly to the technique of Shwartzman phenomenon. This way we produced experimental acute pyelonephritis in rats by an ascending route of infection. A significant pathogenic activity of sterile bacterial filtrate in comparison with saline was shown producing clinically relevant infections of the urinary tract in rats infected by concentrations of <em>E. coli</em> suspensions of 10<sup>4</sup> and 10<sup>5</sup> cfu/ml.</p></div><div><p>Die gram-negativen Bakterien allein rufen in den Nieren von Versuchstieren kaum einen entzündlichen Prozeß hervor. Verschiedene zusätzliche Manipulationen, durch welche die Resistenz des Harnwegsystems modifiziert wird, sind hierzu notwendig. In dieser Arbeil werden die Ergebnisse unserer Versuche mit sterilem bakteriellem Filtrat dargelegt. Nach der Shwartzman-Phänomen-Technik wurde das Filtrat zur Einleitung einer experimentellen Ratten-Pyelonephritis, hervorgerufen durch aszendierende bakterielle Infektion, verwendet Eine signifikante pathogenetische Wirkung des bakteriellen Filtrates gegenüber den Kontrollen mit physiologischer NaCl-Lösung konnte gezeigt werden (p < 0,01). Die auf diese Weise erzeugten klinisch-relevanten Harnwegsinfektionen wurden bei den Ratten durch die Suspensionen von <em>E. coli</em> in den Konzentrationen von 10<sup>4</sup> und 10<sup>5</sup> cfu/ml hervorgerufen.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 131-137"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80149-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14198105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Surface Antigen of Encapsulated Staphylococcus epidermidis SE-360 Protects Mice from Homologous Infection 包被表皮葡萄球菌SE-360细胞表面抗原对小鼠同源感染的保护作用

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80157-3

Yukio Ohshima

{"title":"Cell Surface Antigen of Encapsulated Staphylococcus epidermidis SE-360 Protects Mice from Homologous Infection","authors":"Yukio Ohshima","doi":"10.1016/S0176-6724(88)80157-3","DOIUrl":"10.1016/S0176-6724(88)80157-3","url":null,"abstract":"<div><p>Cell surface antigen was mechanically extracted from encapsulated strain SE-360 of <em>Staphylococcus epidermidis</em> and purified by DEAE-Sephadex A 25 (Cl<sup>−</sup> form) ion exchange chromatography. This antigen manifested type-specific activity and major sugar constituents were galactose, glucose and N-acetyl-glucosamine at the molar ratio 1.00:9.05:1.65. α-D-glucosyl- and N-acetyl-glucosaminyl-residues were closely correlated to the antigenic determinant. In mice, protection against homologous microorganisms could be achieved by active immunization with thus purified antigen. Type-specific opsonin in rabbit anti-SE-360 serum could also be absorbed.</p></div><div><p>Das Zelloberflächenantigen des bekapselten <em>Staphylococcus epidermidis</em>-Stammes SE-360 wurde mechanisch extrahiert und mittels DEAE-Sephadex A 25 (Cl<sup>−</sup>-Form)-Ionenaus-tauschchromatographie gereinigt. Dieses Antigen vermittelte eine typspezifische Aktivität. Als hauptsächliche Zuckerbestandteile konnten Galaktose, Glukose und N-Acetyl-Glukosamin in einem molaren Verhältnis von 1.00:9.05:1.65 respektive nachgewiesen werden, α-D-Glukosyl- und N-Acetyl-Glukosaminyl-Bestandteile waren mit der antigenen Determinante eng verbunden. In Mäusen konnte mit diesem Zelloberflächenantigen eine aktive Immunisierung gegen den homologen Staphylokokkenstamm durchgführt werden, auch konnten damit typspezifische Opsonine im Kaninchen-Anti-SE-360-Serum absorbiert werden.</p></div>","PeriodicalId":101291,"journal":{"name":"Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology","volume":"270 1","pages":"Pages 219-227"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0176-6724(88)80157-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14277629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Stomatococcus mucilaginosus as an Agent of CAPD Peritonitis 黏液口球菌与CAPD腹膜炎的关系

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80170-6

Helen Lanzendörfer , Karel Zaruba , Alexander Von Graevenitz

引用次数: 17

Abstracts of Papers Presented at the Session of the Virology Section of the Deutsche Gesellschaft für Hygiene und Mikrobiologie, Berlin, February 18–20, 1988 1988年2月18-20日，柏林，德国<s:1>卫生与微生物学会病毒学分会会议论文摘要

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology Pub Date : 1988-11-01 DOI: 10.1016/S0176-6724(88)80074-9

引用次数: 0