Vacunas (English Edition)最新文献_第3页

Impact and evolution of influenza A virus: a comprehensive review on zoonosis, animal health, and control strategies 甲型流感病毒的影响和演变：关于人畜共患病、动物卫生和控制策略的综合综述

Vacunas (English Edition) Pub Date : 2026-04-01 Epub Date: 2026-05-06 DOI: 10.1016/j.vacune.2026.500650

D. Chowdhury , A. Das , M. Mishra , T. Khutere , Jayashree , R. Manna , S.H. Bodakhe

{"title":"Impact and evolution of influenza A virus: a comprehensive review on zoonosis, animal health, and control strategies","authors":"D. Chowdhury , A. Das , M. Mishra , T. Khutere , Jayashree , R. Manna , S.H. Bodakhe","doi":"10.1016/j.vacune.2026.500650","DOIUrl":"10.1016/j.vacune.2026.500650","url":null,"abstract":"<div><div>Influenza Because of its genetic and antigenic variability, an IAV can spread across species and cause seasonal epidemics and sporadic pandemics, posing a serious threat to global health. Control efforts are complicated by its evolution and interspecies dynamics, which call for coordinated surveillance and response tactics. In order to improve pandemic preparedness and inform health policy, this review attempts to compile the most recent information on the evolution, epidemiology, and interspecies transmission of IAV using a One Health perspective. Peer-reviewed research, worldwide surveillance data, and molecular analyses (such as RT-qPCR and antigenic mapping) were the main topics of a thorough literature review. Key areas included IAV's antigenic drift and shift, host range (humans, swine, poultry, wild avians), and reassortment events, with emphasis on One Health frameworks integrating genomics and evolutionary studies. IAV's antigenic variability, driven by hemagglutinin and neuraminidase protein changes, facilitates immune evasion, requiring frequent vaccine updates. Swine and avian species serve as reservoirs and mixing vessels, contributing to novel strains like the 2009 H1N1 pandemic virus. Molecular tools and worldwide surveillance are essential for tracking strain diversity and guiding vaccine development. Drug resistance, intricate interspecies transmission, and deficiencies in real-time zoonotic risk assessment are among the difficulties. Transdisciplinary One Health approaches are necessary for effective IAV management, combining evolutionary research, genomic surveillance, and animal reservoir management to reduce zoonotic threats. To stop future pandemics and address the serious health and economic effects of IAV, enhanced worldwide surveillance and rapid-response vaccination platforms are crucial.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 2","pages":"Article 500650"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147827292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the impact of vaccination on cholera dynamics with water treatment, hygiene, and awareness as control strategies 模拟以水处理、卫生和意识为控制策略的疫苗接种对霍乱动态的影响

Vacunas (English Edition) Pub Date : 2026-04-01 Epub Date: 2026-05-06 DOI: 10.1016/j.vacune.2026.500487

M.K. Kolawole, A.A. Adeniji

{"title":"Modeling the impact of vaccination on cholera dynamics with water treatment, hygiene, and awareness as control strategies","authors":"M.K. Kolawole, A.A. Adeniji","doi":"10.1016/j.vacune.2026.500487","DOIUrl":"10.1016/j.vacune.2026.500487","url":null,"abstract":"<div><div>Cholera remains a significant public health threat, driven by inadequate sanitation, limited access to clean water, and poor health education. Despite the availability of vaccines, outbreaks persist, underscoring the need to integrate pharmaceutical and non-pharmaceutical interventions. This study investigates cholera transmission dynamics by examining the roles of vaccination, water treatment, hygiene practices, and public awareness.</div><div>An epidemiological model was developed to capture cholera transmission, incorporating both pharmaceutical (vaccination) and non-pharmaceutical (hygiene, water treatment, awareness) control measures. The system of nonlinear differential equations was analyzed using the Homotopy Perturbation Method (HPM), a semi-analytical technique that facilitates both analytical approximation and efficient numerical simulations.</div><div>Analytical and numerical results reveal that vaccination alone significantly reduces transmission rates. However, when combined with non-pharmaceutical measures—particularly public awareness—the reduction is more substantial and sustained. Public awareness plays a catalytic role by promoting behavioral changes and enhancing compliance with hygiene and water safety measures. Numerical simulations show that integrated interventions yield the most pronounced and lasting decline in cholera prevalence.</div><div>The study demonstrates that while vaccination is effective, its impact is maximized when combined with non-pharmaceutical strategies, especially public education. These findings support the adoption of integrated public health approaches and resource allocation strategies in cholera-endemic regions. The results provide a framework for designing targeted and sustainable intervention programs.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 2","pages":"Article 500487"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147827293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of vaccination on bacterial resistance 疫苗接种对细菌耐药性的影响

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-05 DOI: 10.1016/j.vacune.2026.500630

Josep de la Flor i Brú

引用次数: 0

The critical need for broad spectrum vaccines against emerging coronaviruses 迫切需要针对新出现的冠状病毒的广谱疫苗

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-11 DOI: 10.1016/j.vacune.2026.500631

Balamurugan Shanmugaraj , Ashwini Malla , Balasubramanian Murugesan

引用次数: 0

Transmission dynamics and evolution of Monkeypox virus (MPXV) during the 2024 global outbreak: implications for surveillance, treatment and vaccination 猴痘病毒（MPXV）在2024年全球暴发期间的传播动态和进化：对监测、治疗和疫苗接种的影响

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-11 DOI: 10.1016/j.vacune.2026.500628

H. Fatima , M.M. Arif , M.S. Chatha , Q. Ali , K. Batool

{"title":"Transmission dynamics and evolution of Monkeypox virus (MPXV) during the 2024 global outbreak: implications for surveillance, treatment and vaccination","authors":"H. Fatima , M.M. Arif , M.S. Chatha , Q. Ali , K. Batool","doi":"10.1016/j.vacune.2026.500628","DOIUrl":"10.1016/j.vacune.2026.500628","url":null,"abstract":"<div><div>Monkeypox virus (MPXV), a zoonotic Orthopoxvirus, has emerged as a global public health concern following its widespread outbreaks in 2024. The virus rapidly spread to 117 countries, marking a significant shift from its traditionally endemic regions. This unexpected emergence in non-endemic areas has highlighted the need to update current knowledge regarding its transmission, epidemiology, and public health implications. This review evaluates the 2024 outbreak, emphasizing the virus's mutational evolution, transmission modes, and current monitoring and treatment strategies. Data were compiled from WHO reports, epidemiological databases, and recent genomic studies. Key variables such as the basic reproductive number (R₀), secondary attack rates, and case trends were analyzed. Phylogenetic analysis and mutation profiling revealed over 300 mutations, including a new sublineage within Clade I, linked to increased transmissibility and immune escape. Human-to-human transmission occurred primarily through direct skin contact, with sexual transmission also playing a significant role. Environmental changes such as deforestation and pollution were identified as contributing factors in cross-species transmission. Surveillance tools, including RT-PCR, wastewater monitoring, and contact tracing, proved effective in outbreak control. Although MPXV is currently considered a moderate global health threat, urgent measures are required to prevent further spread. Strengthening diagnostic tools, advancing targeted therapies through biomarker-based approaches, and expanding vaccination efforts will be critical for future preparedness and control.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 1","pages":"Article 500628"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent information about Mpox disease 关于Mpox疾病的最新信息

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-11 DOI: 10.1016/j.vacune.2026.500486

R. Dowran , Z. Karimizadeh , A. Mohebbi , S.M. Jazayeri , F.S. Taghavi , M.J. Rasaee

{"title":"Recent information about Mpox disease","authors":"R. Dowran , Z. Karimizadeh , A. Mohebbi , S.M. Jazayeri , F.S. Taghavi , M.J. Rasaee","doi":"10.1016/j.vacune.2026.500486","DOIUrl":"10.1016/j.vacune.2026.500486","url":null,"abstract":"<div><div>Monkeypox virus (MPXV) was first discovered in monkeys in a laboratory in Denmark in 1958, and the first human case was reported in Congo in 1970. It causes a disease called Mpox disease which is mainly characterized by rashes. Viral transmission occurs through body fluids, respiratory droplets, saliva, the content of vesicles, and lesions in addition to skin contact. Initially, Mpox was restricted to Africa, and sporadic cases outside Africa had a history of travel or links to Africa. The first outbreak outside Africa was in the US with the etiology of animal importation. The first outbreak of Mpox without any proven link to African sources was observed in 2022. The etiology of the recent increase in Mpox cases is an increase in animal reservoir population and animals’ adaptation to urban environments. MPXV is capable of crossing species and has a wide range of hosts; however, not all of them are specified currently. All mammals should be considered susceptible to MPXV, and investigating its new and unknown host should be seriously pursued. The recent discovery of Mpox outside Africa has shed light that health research is vital for preventing, controlling, and/or eradicating infectious diseases at their origins. The ability to monitor and respond to Mpox requires enhanced global preparedness. This is a comprehensive review of the discovery, history of the disease and transmission, immune system response and immune evasion, vaccination, and the possibility of turning into an outbreak with the countries at higher risk of infection.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 1","pages":"Article 500486"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and burden of malaria in Pakistan and its provinces (1990–2023): Insights from the global burden of disease study 巴基斯坦及其各省的疟疾趋势和负担（1990-2023）：来自全球疾病负担研究的见解

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-11 DOI: 10.1016/j.vacune.2026.500627

Z. Ahsan , M. Ahsan , A.K. Durvesh

{"title":"Trends and burden of malaria in Pakistan and its provinces (1990–2023): Insights from the global burden of disease study","authors":"Z. Ahsan , M. Ahsan , A.K. Durvesh","doi":"10.1016/j.vacune.2026.500627","DOIUrl":"10.1016/j.vacune.2026.500627","url":null,"abstract":"<div><h3>Background</h3><div>Malaria remains a major public health concern in Pakistan. This study assessed national and subnational trends in malaria burden from 1990 to 2023 using Global Burden of Disease (GBD 2023) estimates.</div></div><div><h3>Methods</h3><div>An ecological time-trend analysis was conducted using GBD 2023 data to examine malaria-related disability-adjusted life years (DALYs), mortality, prevalence, and incidence across Pakistan and its provinces/regions. Data were disaggregated by age, gender, and geography. 33 years annual percentage change (APC), and incidence rate ratios (IRRs) were calculated using Poisson regression to quantify temporal trends.</div></div><div><h3>Results</h3><div>Between 1990 and 2023, Pakistan demonstrated a substantial decline across all indicators: DALYs decreased by 31.6%, mortality by 27.1%, prevalence by 39.5%, and incidence by 58.8%. The highest burden persisted in Balochistan (DALY rate: 747.0 per 100,000) and Sindh (657.5 per 100,000), while the lowest was recorded in Punjab (7.9 per 100,000) and Azad Jammu & Kashmir (8.2 per 100,000). Temporal analysis revealed three major resurgence peaks 2003–2005, 2013–2015, and 2021–2023 the latter corresponding to the post-flood outbreak following Pakistan’s 2022 monsoon floods. Poisson regression showed downward national trends for DALYs (IRR = 0.997; 95% CI: 0.994–0.999), prevalence (IRR = 0.997; 95% CI: 0.996–0.998), and incidence (IRR = 0.990; 95% CI: 0.989–0.991).</div></div><div><h3>Conclusion</h3><div>Despite national progress, regional disparities persist, particularly in Sindh and Balochistan. The 2022–2023 resurgence highlights the influence of climate shocks on transmission. Strengthening surveillance, adopting climate-resilient vector control, and ensuring equitable resource allocation are vital to sustain progress and achieve malaria elimination by 2035.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 1","pages":"Article 500627"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake and determinants of the human papillomavirus vaccine and its determinants among undergraduates of a Nigerian university 尼日利亚一所大学本科生对人乳头瘤病毒疫苗的摄取和决定因素及其决定因素

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-11 DOI: 10.1016/j.vacune.2026.500625

Adetunmise Oluseyi Olajide, Roqeebat Titilope Bolarinwa, Olufemi Yiyinola Makinde, Florence Oluyemisi Adeyemo

{"title":"Uptake and determinants of the human papillomavirus vaccine and its determinants among undergraduates of a Nigerian university","authors":"Adetunmise Oluseyi Olajide, Roqeebat Titilope Bolarinwa, Olufemi Yiyinola Makinde, Florence Oluyemisi Adeyemo","doi":"10.1016/j.vacune.2026.500625","DOIUrl":"10.1016/j.vacune.2026.500625","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the uptake and determinants of the Human Papillomavirus (HPV) vaccine among undergraduates of a Nigerian university.</div></div><div><h3>Materials and methods</h3><div>A descriptive cross-sectional design was employed. A stratified random sample of 318 students was drawn from a population of 1042. Data were collected using a validated self-administered questionnaire (reliability index = 0.70) and analyzed with SPSS version 21. Descriptive statistics and Pearson correlation were used; the level of significance was set at 0.05.</div></div><div><h3>Results</h3><div>The majority (55.7%) of respondents were aged 19–22 years. Over half (52.4%) had below-average knowledge of the HPV vaccine. Vaccine uptake was low.</div><div>65 of 318 respondents (20.4%) had received at least one dose. The main barrier was vaccine unavailability (66.7%). High cost (<em>r</em> = −0.163, <em>p</em> = .004) and peer reviews (<em>r</em> = 0.173, <em>p</em> = .002) were significantly associated with uptake. Other factors (cultural beliefs, fear of side effects, family history, and trust in the healthcare system) were not statistically significant (<em>p</em> > .05).</div></div><div><h3>Conclusions</h3><div>These findings suggest that improving vaccine availability and affordability, leveraging healthcare provider recommendations and positive peer influence are necessary to increase uptake of the HPV vaccine, reinforce policies and reduce the burden of HPV-related cancers in this population.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 1","pages":"Article 500625"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of a solution-focused approach on reducing of vaccine refusal 以解决方案为重点的做法对减少拒绝接种疫苗的影响

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-11 DOI: 10.1016/j.vacune.2026.500489

M. Kaplan , B. Erci

{"title":"The effect of a solution-focused approach on reducing of vaccine refusal","authors":"M. Kaplan , B. Erci","doi":"10.1016/j.vacune.2026.500489","DOIUrl":"10.1016/j.vacune.2026.500489","url":null,"abstract":"<div><h3>Background</h3><div>Vaccine refusal remains a persistent and complex global health issue, influenced by sociocultural beliefs, misinformation, lack of trust, and personal experiences. Despite extensive immunization campaigns, vaccination rates often remain below optimal levels. Understanding the factors driving vaccine hesitancy is essential for developing effective interventions. This study aimed to identify the factors influencing parents' vaccination attitudes and to evaluate the effectiveness of solution-focused brief therapy (SFBT) among parents who refused to vaccinate their infants aged 0–24 months.</div></div><div><h3>Methods</h3><div>The study population consisted of parents residing in the Bingöl province who did not want to vaccinate their newborns, infants, and children between the ages of 0 and 24 months. Using a pretest-posttest experimental control model, both groups completed a socio-demographic form and the Parent Attitudes About Childhood Vaccines (PACV) scale pre-intervention. The experimental group received four weekly SFBT sessions, followed by a posttest for both groups.</div></div><div><h3>Results</h3><div>A statistically significant improvement (p < 0.05) was observed in the PACV scores of parents in the SFBT group, whereas no significant change was noted in the control group (p > 0.05). The regression analysis revealed that gender, education level, previous vaccination experiences, and problematic vaccination experiences significantly influenced parental attitudes, accounting for 32% of the total variance.</div></div><div><h3>Conclusions</h3><div>It was determined that administering SFBT to parents who refused to vaccinate their 0–24-month-old children may be an effective method to reduce the number of vaccine refusal cases. These findings also highlight the importance of sociodemographic and experiential factors in shaping vaccine-related attitudes.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"27 1","pages":"Article 500489"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonorrhea: Another immunopreventable sexually transmitted infection 淋病：另一种免疫可预防的性传播感染

Vacunas (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-02 DOI: 10.1016/j.vacune.2026.500509

Fernando Moraga-Llop

引用次数: 0