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Assessment of hepatitis B knowledge among Moroccans 摩洛哥人乙型肝炎知识评估
Vacunas (English Edition) Pub Date : 2024-10-01 DOI: 10.1016/j.vacune.2024.10.007
Salma Madihi , Samia Boukaira , Hind Bouafi , Abdelouaheb Benani
{"title":"Assessment of hepatitis B knowledge among Moroccans","authors":"Salma Madihi ,&nbsp;Samia Boukaira ,&nbsp;Hind Bouafi ,&nbsp;Abdelouaheb Benani","doi":"10.1016/j.vacune.2024.10.007","DOIUrl":"10.1016/j.vacune.2024.10.007","url":null,"abstract":"<div><h3>Objective</h3><div>Little is known about the knowledge of hepatitis B infection in Morocco. This article describes the general population and students' knowledge of hepatitis B infection.</div></div><div><h3>Material and methods</h3><div>A questionnaire was designed between November and December 2022 to capture demographic data (gender, age, occupation, and city) and 12 HBV-related questions. The study population comprised 402 Moroccan individuals, of whom 100 were students. Students' knowledge was compared between public and private middle and high schools.</div></div><div><h3>Results</h3><div>Overall, 64.43% indicated prior awareness of hepatitis B, 33.58% were aware of the nature and the global prevalence of the disease, and 13.68% were knowledgeable about chronicity rate in Morocco. The contagious potential of hepatitis B virus (HBV) was appreciated by 35.1% of respondents while 51.5% were aware of its various transmission routes. The risk of vertical transmission and the availability of a hepatitis B vaccine were recognized by 57.7% and 56.1%, respectively. Vaccination status against hepatitis B was confirmed by 23% of respondents and 16.3% were aware of their HBV serostatus. While only 28% knew someone affected by hepatitis B, 69.4% acknowledged awareness of other types of hepatitis. Age and education type were factors associated with a good knowledge of the different aspects of HBV infection. The only gender-related difference reported concerned the existence of a hepatitis B vaccine knowledge.</div></div><div><h3>Conclusion</h3><div>We highlight contrasting levels of HBV knowledge in the Moroccan general population and students. Results demonstrate the need to implement prevention programs in order to overcome the gap between public and private school outcomes.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 4","pages":"Pages 462-469"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population COVID-19患者的C4和CH50水平与咳嗽和鼻出血的关系:伊朗人群的回顾性分析
Vacunas (English Edition) Pub Date : 2024-10-01 DOI: 10.1016/j.vacune.2024.10.006
Seyed Ali Hashemi , Forouzan Rostami , Babak Shaghaghi , Mahla Niknam , Elham Abani , Abdol Sattar Pagheh , Arezou Khosrojerdi , Fatemeh Rezaei
{"title":"Association of C4 and CH50 levels with cough and rhinorrhea in COVID-19 patients: A retrospective analysis in the Iranian population","authors":"Seyed Ali Hashemi ,&nbsp;Forouzan Rostami ,&nbsp;Babak Shaghaghi ,&nbsp;Mahla Niknam ,&nbsp;Elham Abani ,&nbsp;Abdol Sattar Pagheh ,&nbsp;Arezou Khosrojerdi ,&nbsp;Fatemeh Rezaei","doi":"10.1016/j.vacune.2024.10.006","DOIUrl":"10.1016/j.vacune.2024.10.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The wide spectrum of COVID-19 symptoms, ranging from mild manifestations to severe pulmonary damage and mortality, prompted this study to investigate the relationship between clinical symptoms and complement system (CS) activation in COVID-19 patients.</div></div><div><h3>Materials and method</h3><div>This retrospective study focused on 100 PCR-positive COVID-19 individuals admitted to Imam Khomeini and Bu Ali hospitals in Sari City from April to June 2021. The levels of C3 and C4 proteins in their blood were measured using nephelometry, and CH50 tests were done with single radial immunodiffusion to determine the activity of CS.</div></div><div><h3>Results</h3><div>The study found that high blood pressure, smoking, and diabetes were the most common underlying conditions among the patients, with prevalence rates of 29%, 24%, and 23%, respectively. Positive correlations were found between C4 and CH50 levels and the presence of cough and rhinorrhea in the subjects. Stratifying patients into 2 groups based on cough or rhinorrhea revealed a significant difference in CH50.</div></div><div><h3>Conclusion</h3><div>The findings suggest that COVID-19 patients with hypertension or diabetes mellitus may benefit from targeting CS for disease management.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 4","pages":"Pages 448-453"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of optimizing routine immunization schedules in pediatric heart transplantation 优化小儿心脏移植常规免疫计划的重要性
Vacunas (English Edition) Pub Date : 2024-10-01 DOI: 10.1016/j.vacune.2024.10.003
Sofía Bassy Navarro , Nuria Gil Villanueva , Manuela Camino-López , Roberto Alonso Fernández , Beatriz Lázaro-Martín , Alicia Hernanz-Lobo , Marisa Navarro Gómez
{"title":"Importance of optimizing routine immunization schedules in pediatric heart transplantation","authors":"Sofía Bassy Navarro ,&nbsp;Nuria Gil Villanueva ,&nbsp;Manuela Camino-López ,&nbsp;Roberto Alonso Fernández ,&nbsp;Beatriz Lázaro-Martín ,&nbsp;Alicia Hernanz-Lobo ,&nbsp;Marisa Navarro Gómez","doi":"10.1016/j.vacune.2024.10.003","DOIUrl":"10.1016/j.vacune.2024.10.003","url":null,"abstract":"<div><h3>Objective</h3><div>Vaccination is the most effective preventive measure to reduce the risk of infection in patients receiving immunosuppressive treatment, such as heart transplant (HT) patients. The objectives of this study are to describe and evaluate the vaccination status of a group of pediatric HT recipients.</div></div><div><h3>Material and methods</h3><div>Retrospective descriptive study of 75 pediatric patients who underwent HT at a tertiary hospital between January 2000 and September 2020. Demographic, clinical (immunization before and after HT, and attendance to vaccination counselling consultation), and analytical (hepatitis A and B serology before and after HT) variables were collected.</div></div><div><h3>Results</h3><div>Patients &gt;<!--> <!-->12 months reached the HT with better vaccination coverage than those &lt;<!--> <!-->12 months: 78.9 % versus 60.7 % had a complete vaccination schedule (<em>P</em> <!-->=<!--> <!-->.15). Post-HT vaccination update rate is low; only 13.3 % of patients had a complete schedule according to their age. The post-HT vaccination update of the human papillomavirus vaccine is higher in women (<em>P</em> <!-->=<!--> <!-->.02). We did not find statistical differences between other vaccines according to sex. A total of 13.3 % of patients attended post-HT vaccination counselling consultation, being better immunised than those who did not (<em>P</em> <!-->=<!--> <!-->.01).</div></div><div><h3>Conclusions</h3><div>The evaluation and optimization of vaccination schedules of patients with HT remains suboptimal. A follow-up of these patients and their relatives in vaccination specialised consultations can improve the immunization status of pediatric HT recipients.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 4","pages":"Pages 454-461"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 vaccine rumour and resistance in Indonesia: Analysing vaccine hesitancy and cultural myths circulated on online platforms 印度尼西亚的 COVID-19 疫苗谣言与抵制:分析网络平台上流传的疫苗犹豫和文化神话
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.08.003
Rachmah Ida , Sri Endah Kinasih , Syafrida Nurrachmi Febriyanti , Ratih Puspa , Muhammad Saud , Mohd Syuhaidi Abu Bakar
{"title":"COVID-19 vaccine rumour and resistance in Indonesia: Analysing vaccine hesitancy and cultural myths circulated on online platforms","authors":"Rachmah Ida ,&nbsp;Sri Endah Kinasih ,&nbsp;Syafrida Nurrachmi Febriyanti ,&nbsp;Ratih Puspa ,&nbsp;Muhammad Saud ,&nbsp;Mohd Syuhaidi Abu Bakar","doi":"10.1016/j.vacune.2024.08.003","DOIUrl":"10.1016/j.vacune.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Rumours and misinformation about the COVID-19 vaccine have been massively circulated on social media platforms, ranging from misleading information, hoaxes, and conspiracy theories to exaggerating stories mixed with the circulation of cultural myths regarding the vaccine.</p></div><div><h3>Methods</h3><p>This study examines the contents of social media platforms such as Twitter, YouTube, TikTok, and WhatsApp posts, also sourced from other Indonesian online portal news and mainstream media websites.</p></div><div><h3>Results</h3><p>This research identifies quantitatively several rumours, misleading information, conspiracy theories, and other misinformation, resistance, and rejection toward issues related to the COVID-19 vaccine from March to April 2021. We then combine it with an analysis of the narratives of vaccine resistance and cultural myths that have made people hesitate or apathetic in participating in national vaccine programs by the Indonesian government.</p></div><div><h3>Conclusion</h3><p>Sourced from the content analysis of this study, we categorised some themes such as vaccine development, availability, access, morbidity, mortality, harmful excesses, safety, and efficacy, both contained and presented in short narratives, visual graphics, memes, and cartoons. This study suggests that these rumours, misleading stories, and myths, may result in the Indonesian public's vaccine resistance and hesitancy, especially since May the Indonesian government stopped distributing the Astra Zeneca vaccines and the controversial issue regarding the availability of ‘Vaccine Nusantara’ (term as ‘Archipelago Vaccine’). This situation may influence the public's attitude to distrust the government and be distracted by misinformation about the vaccination program. Moreover, we see that cultural beliefs and religious stances have made complicated the hesitancy and resistance of the public against the COVID-19 vaccine.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 313-322"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social media as a supporting mechanism during COVID-19 in Indonesia: A quantitative study on isolation among elders 社交媒体作为印度尼西亚 COVID-19 期间的支持机制:关于老年人孤独感的定量研究
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.08.005
Mustain Mashud , Muhammad Saud , Rachmah Ida , Asia Ashfaq
{"title":"Social media as a supporting mechanism during COVID-19 in Indonesia: A quantitative study on isolation among elders","authors":"Mustain Mashud ,&nbsp;Muhammad Saud ,&nbsp;Rachmah Ida ,&nbsp;Asia Ashfaq","doi":"10.1016/j.vacune.2024.08.005","DOIUrl":"10.1016/j.vacune.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><p>COVID-19 pandemic has posed mental health challenges for people from all walks of life, including the elders in Indonesia. Due to the wide-ranging effects of this pandemic due to various phases of smart, partial, or full lockdown, people worldwide have faced serious problems particularly with their mental health.</p></div><div><h3>Methods</h3><p>This quantitative study analyses the experiences of the general public particularly focused on elders, those who are in isolation due to the COVID-19 protocols and limited social or physical interaction within the society. For investigating the social support mechanism among respondents, we have gathered a sample of respondents who are elders and using social media. The data reflect the opinion of respondents on elders during this pandemic. A survey was designed to gather data from elders facing mental health issues and using social media platforms to seek information in Indonesia. An online social support scale, self-awareness and insight scale were deployed to measure responses to the issue at hand.</p></div><div><h3>Results</h3><p>The data show that the elders had varied conceptualisations about COVID-19 relating to the pandemic, i.e., eating habits, fear of death, strengthening religiosity in eating practices, fear of interacting with people, and interaction patterns. Elders were restricted to their places and had limited physical social interactions, thus social media platforms have played a significant role in developing online interaction among elders, to speak and discuss their matters for coping with the issues of isolation and mental health.</p></div><div><h3>Conclusion</h3><p>The online media platform is considered a great support for elders to stay connected with families, friends, as well as with other communities. The study concludes that despite declaring the non-emergency status of COVID-19, elders have still suffered with long-term repercussions of this pandemic affecting their mental health.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 347-354"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An immune system fighting against pneumococcus 对抗肺炎球菌的免疫系统
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.07.005
C. Ruiz-Ruiz , E. Redondo Margüello
{"title":"An immune system fighting against pneumococcus","authors":"C. Ruiz-Ruiz ,&nbsp;E. Redondo Margüello","doi":"10.1016/j.vacune.2024.07.005","DOIUrl":"10.1016/j.vacune.2024.07.005","url":null,"abstract":"<div><p>Pneumococcus is a common coloniser of the human nasopharynx. However, it can also cause human diseases such as otitis or pneumonia, which may progress into invasive forms such as bacteremic pneumonia, meningitis, or sepsis. This bacterium reaches and establishes itself in the nasopharynx through different mechanisms, which include evasion of the host immune system. Moreover, certain factors such as the coinfection with viruses favour colonisation, as well as the ability of pneumococcus to cause diseases. Our immune system responds to pneumococcal colonisation and infection through the innate and adaptive responses, which can be stimulated by pneumococcal vaccines. In the following article, we will briefly review the mechanisms of pneumococcal infection and how our immune system responds to it; as well as the immune response generated after vaccination and its impact on the prevention of pneumococcal disease.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 415-419"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2445146024000542/pdfft?md5=2c5eb376acd418d9982a7f4140dc3907&pid=1-s2.0-S2445146024000542-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immunization questionnaire for understanding unwellness (TIQUU): Fun learning about vaccination using an innovative storytelling approach 了解不健康的免疫接种问卷 (TIQUU):用创新的讲故事方式趣味学习疫苗接种知识
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.08.002
Waqaas A. Butt , Faizan G. Mustafa , Zeeshan Ahsan , Shaharyar Salim , Hasan Nawaz Tahir , Asad I. Mian
{"title":"The immunization questionnaire for understanding unwellness (TIQUU): Fun learning about vaccination using an innovative storytelling approach","authors":"Waqaas A. Butt ,&nbsp;Faizan G. Mustafa ,&nbsp;Zeeshan Ahsan ,&nbsp;Shaharyar Salim ,&nbsp;Hasan Nawaz Tahir ,&nbsp;Asad I. Mian","doi":"10.1016/j.vacune.2024.08.002","DOIUrl":"10.1016/j.vacune.2024.08.002","url":null,"abstract":"<div><h3>Background</h3><p>Vaccination is a pivotal tool in public health. In LMICs like Pakistan, challenges hinder high immunization rates. This study addresses gaps in vaccination knowledge among school children through innovative educational interventions. The study aims to enhance vaccination awareness and contribute to health education discourse.</p></div><div><h3>Methodology</h3><p>This quasi-experimental study was conducted in 4 private schools in Karachi, Pakistan, from February to May 2021. Children aged 8–12 years in grades 2–5 were enrolled. An interactive discussion on vaccine safety and immunization was conducted using a bilingual pictorial storybook. Group-I experienced traditional Urdu book reading, while Group-II engaged with a digital animated video in English. A pre-test was conducted to assess baseline knowledge about immunization followed by an interactive discussion and immediately a post-test. Test scores were analyzed using paired sample <em>t</em>-test using Stata 17.0 version.</p></div><div><h3>Results</h3><p>The study enrolled 400 students in Karachi, Pakistan. Both groups exhibited significant knowledge shifts regarding vaccine-related topics. Group-I (Analog Urdu) showed changes in understanding sickness reasons, vaccine timing, newborn protection, sports injury response, and memory impact. Group-II (Digital English) displayed shifts in illness understanding, recommended actions, injection and vaccine knowledge, safety perceptions, measles prevention, and management during sports injury. A statistically significant improvement in mean scores was observed.</p></div><div><h3>Conclusion</h3><p>As a proactive and early strategy to alleviate the societal burden of under-immunization, cost-effective educational interventions can be integrated into school curricula. Our approach through bilingual pictorial storybooks and animated videos has been proven effective and helps one grasp immunization's importance.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 304-312"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of new tools to increase the rate of influenza vaccination in patients considered at risk during the campaigns of 2019, 2020 and 2021 在 2019 年、2020 年和 2021 年活动期间,利用新工具提高高危患者的流感疫苗接种率
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.07.002
Beatriz Santos López , Mónica López Campos , Carmen Viñas Viamonte , Paula Aragón Puig , Elena Buades Pérez , Inés Loreto Gallán Farina
{"title":"Influence of new tools to increase the rate of influenza vaccination in patients considered at risk during the campaigns of 2019, 2020 and 2021","authors":"Beatriz Santos López ,&nbsp;Mónica López Campos ,&nbsp;Carmen Viñas Viamonte ,&nbsp;Paula Aragón Puig ,&nbsp;Elena Buades Pérez ,&nbsp;Inés Loreto Gallán Farina","doi":"10.1016/j.vacune.2024.07.002","DOIUrl":"10.1016/j.vacune.2024.07.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Influenza infection is a significant public health issue that causes substantial morbidity and mortality in the population every year. Vaccination is the most effective measure for its prevention. The aim of this study is to analyse the influence of automated letters as a patient recruitment method after their discontinuation in a population where they were previously used, comparing it with the population of another healthcare centre with similar characteristics that has never employed this method.</p></div><div><h3>Materials and methods</h3><p>An observational and retrospective study was conducted, analysing the influenza vaccination coverage among the at-risk population in 2 healthcare centres with very similar population characteristics during 3 vaccination campaigns (2019, 2020, and 2021). Both descriptive and analytical studies were carried out.</p></div><div><h3>Results</h3><p>Vaccination rates in the centre that actively recruited patients while the letter sending was still in effect were 46.4% in 2019 and 61% in 2020, decreasing to 25.8% in 2021 after its withdrawal (<em>p</em> <!-->&lt;<!--> <!-->.001). Influenza vaccination was significantly higher during the 3 campaigns at the health centre that used the letter. The groups in which vaccination rates decreased most significantly were those aged 65 and older and those with heart disease.</p></div><div><h3>Conclusions</h3><p>The implementation of automated letters has proven to be particularly effective among patients considered at risk.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 340-346"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoinformatics strategy for designing a multi-epitope chimeric vaccine to combat Neisseria gonorrhoeae 设计抗淋病奈瑟菌多表位嵌合疫苗的免疫信息学策略
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.08.009
P. Priyamvada , Rayapadi G. Swetha , Rupsha Dasgupta , Anand Anbarasu , Sudha Ramaiah
{"title":"Immunoinformatics strategy for designing a multi-epitope chimeric vaccine to combat Neisseria gonorrhoeae","authors":"P. Priyamvada ,&nbsp;Rayapadi G. Swetha ,&nbsp;Rupsha Dasgupta ,&nbsp;Anand Anbarasu ,&nbsp;Sudha Ramaiah","doi":"10.1016/j.vacune.2024.08.009","DOIUrl":"10.1016/j.vacune.2024.08.009","url":null,"abstract":"<div><h3>Introduction</h3><p>The increasing prevalence of <em>Neisseria gonorrhoeae</em> has become a significant global concern. Consequently, it is of utmost importance to explore prophylactic approaches to combat the anti-microbial resistance in <em>N. gonorrhoeae</em>.</p></div><div><h3>Objective</h3><p>The present study aims to design a multi-epitopic vaccine construct using immunoinformatics and pan-genomic methodology.</p></div><div><h3>Methods</h3><p>The initial phase involves retrieving and re-annotating the 133 complete genome sets of <em>N. gonorrhoeae</em>. Subsequently, a pan-genome analysis was conducted to identify the core genes, followed by gene mapping. Non-homologous outer-membrane proteins were filtered out and analyzed using various epitope prediction algorithms targeting major histocompatibility complex (MHC-I, MHC-II), and B cells. The optimal epitopes were selected based on immunogenicity, antigenicity, toxicity, and solubility. Then, the vaccine constructs were designed using different combinations of linkers, Histidine (His) tags, adjuvants, and the finalized epitopes.</p></div><div><h3>Results</h3><p>The vaccine construct, V13 was screened as the most suitable candidate based on its physiochemical and antigenicity properties. Computational techniques assessed the efficacy of V13 against different immune receptors supported by immune simulation, indicating its safety for inducing immune responses against <em>N. gonorrhoeae.</em></p></div><div><h3>Conclusion</h3><p>The chimeric multi-epitopic vaccine V13 construct can potentially trigger a diverse array of protective immune responses and serve as a promising starting point for future experimental investigations.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 385-402"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post COVID-19 era: Re-emergence of known and future (X) viral pathogens 后 COVID-19 时代:已知和未来(X)病毒病原体的再次出现
Vacunas (English Edition) Pub Date : 2024-07-01 DOI: 10.1016/j.vacune.2024.08.010
Pryanka Thakur , Vikram Thakur , Monika Sapra , Sonakshi Srivastava , Sanjay Kumar Singh Patel
{"title":"Post COVID-19 era: Re-emergence of known and future (X) viral pathogens","authors":"Pryanka Thakur ,&nbsp;Vikram Thakur ,&nbsp;Monika Sapra ,&nbsp;Sonakshi Srivastava ,&nbsp;Sanjay Kumar Singh Patel","doi":"10.1016/j.vacune.2024.08.010","DOIUrl":"10.1016/j.vacune.2024.08.010","url":null,"abstract":"<div><p>The world has successfully overcome the menace of Coronavirus disease-19 (COVID-19) pandemic waves, nature has unleashed a new curveball in the years 2022 and 2023 with other highly infectious viral diseases. Understanding the origin and different transmission routes, evolution, the mechanism of their emergence, immune evasion, and vaccine research while dealing with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has advanced our scientific knowledge and public health infrastructure to address unknown future viral pathogens already underway. The current review briefly discussed the worldwide pandemics of Monkeypox (Mpox) and polio viral infection along with the origin theories of other global viral outbreaks post-COVID-19 era in 2022 and 2023 like Ebola, unexplained hepatitis in pediatric children, avian influenza, and Langya virus. The role of climate, biodiversity, zoonotic transmission, and trajectory of these viral infections. It also highlights the containment, preventive, and treatment strategies that are being developed.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"25 3","pages":"Pages 403-414"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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