Vacunas (English Edition)最新文献

{"title":"Fifteen years of vaccination against the human papilloma virus in Spain. An update","authors":"F. Moraga-Llop","doi":"10.1016/j.vacune.2023.10.001","DOIUrl":"10.1016/j.vacune.2023.10.001","url":null,"abstract":"<div><p><span>Prophylactic vaccination against human papillomavirus (HPV) is the cornerstone of the World Health Organisation global strategy to accelerate the elimination of cervical cancer as a </span>public health<span><span> problem. At the end of 2007, the first two HPV vaccines were marketed in Spain. Therefore, 15 years have passed since the start of vaccination, included in the schedule of systematic immunizations for girls. Coinciding with this anniversary, this recommendation has been extended to boys. A vaccination that therefore achieves immunisation equity, regardless of sex. The purpose of this work is to offer an update on vaccination against HPV in Spain after 5 years of the initial work previously published on the historical origins of the </span>virus and the beginnings of this immunisation, the second (after hepatitis B) for the prevention of cancer, and of the achievements and advances obtained.</span></p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 4","pages":"Pages 394-399"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135509835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immuno-informatics design of a multimeric epitope peptide-based vaccine against dengue virus serotype-2","authors":"Mohamed Sheik Tharik Abdul Azeeze ,&nbsp;Rajaguru Arivuselvam","doi":"10.1016/j.vacune.2023.10.012","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.10.012","url":null,"abstract":"<div><h3>Introduction</h3><p>Dengue viral infection affects approximately 130 countries worldwide. According to WHO reports, 40% of the global population lives in rural areas with a high risk of contracting dengue. Researchers have identified four distant strains of the dengue virus, and a single vaccine has not permanently controlled the emergence of all four distant strains. Therefore, a vaccine is required for each of the four strains to address the current situation.</p></div><div><h3>Objectives</h3><p>The objective of this study was to design a multi-epitope-based vaccine for the dengue virus-2 strain that elicits a robust immune response while being safe and non-allergenic.</p></div><div><h3>Results</h3><p><span>Firstly, we analyzed the envelope protein<span><span> for its physicochemical and antigenic properties. Next, we predicted MHC I, MHC II, and B-cell epitopes with high accuracy and evaluated their properties. Then, we constructed a vaccine using a suitable adjuvant and linkers, and predicted the secondary and tertiary structure of the vaccine, and the tertiary structure was validated. After conducting </span>molecular docking with toll-like receptors, we utilized the best-docked result for molecular stimulation. Finally, we analyzed the </span></span>immune stimulation against the vaccine, and the results showed positive immune responses from macrophages, DC cells, T-cells, and B-cells. Additionally, we found that the vaccine was excreted from the human body.</p></div><div><h3>Conclusions</h3><p>Our study demonstrates the potential of using immunoinformatic tools and immunological knowledge to design a multi-epitope-based vaccine for the dengue virus-2 strain. This approach could be applied to designing vaccines for other diseases, and further studies are required to validate its effectiveness in vivo<em>.</em></p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 4","pages":"Pages 380-393"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138448094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vaccination on the entire population and dose-response relation of COVID-19","authors":"Abdul Malek,&nbsp;Ashabul Hoque","doi":"10.1016/j.vacune.2023.10.005","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.10.005","url":null,"abstract":"<div><h3>Objective</h3><p>The objective of this study is to develop a mathematical model for the COVID-19 pandemic including vaccination, the transmissibility of the virus-pathogen dose-response relationship, vaccine efficiency, and vaccination rate.</p></div><div><h3>Methods</h3><p>The Runge-Kutta (RK-45) method was applied to solve the proposed model with MATLAB code and the calculated results show the dynamics of the individuals in each compartment. The data of total death due to the COVID-19 pandemic in the case of the USA were collected from GitHub and the re-use of this data needs no ethical clearance. The control reproduction number was used to assess the dose-response relationship and critical vaccination coverage.</p></div><div><h3>Results</h3><p>We have calculated the probability of infection and the infection risk against the different exposure doses and the virus copies, respectively. The results show that the probability of infection increases with the increasing exposure dose for certain virus copies and the risk of infection decreases with the increasing of virus copies for a certain exposure dose. The results also show that the critical vaccination coverage demands increase with an increase in transmission rate and decrease with increasing vaccine efficacy.</p></div><div><h3>Conclusions</h3><p>It was seen that the critical vaccination coverage corresponding to an increased transmission rate rise sharply in the beginning and then reached a threshold. Moreover, the real data of the total death cases in the USA were compared with the fitted curved of the model which validated the proposed model. Vaccination against COVID-19 is essential to control the pandemic, and achieving high vaccine uptake in the population can reduce the pandemic as fast as possible.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 4","pages":"Pages 278-290"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138448169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An immunoinformatics approach to study the epitopes of SARS-CoV-2 helicase, Nsp13","authors":"Sushant Kumar,&nbsp;Khushboo Kumari,&nbsp;Gajendra Kumar Azad","doi":"10.1016/j.vacune.2023.07.003","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.07.003","url":null,"abstract":"<div><h3>Introduction and objective</h3><p><span>Vaccines are administered worldwide to control on-going coronavirus disease-19 (COVID-19) pandemic caused by SARS-CoV-2. Vaccine efficacy is largely contributed by the epitopes present on the </span>viral proteins<span> and their alteration might help emerging variants to escape host immune surveillance. Therefore, this study was designed to study SARS-CoV-2 Nsp13 protein, its epitopes and evolution.</span></p></div><div><h3>Methods</h3><p>Clustal Omega was used to identify mutations in Nsp13 protein. Secondary structure<span><span> and disorder score was predicted by CFSSP and PONDR-VSL2 webservers. Protein stability was predicted by DynaMut webserver. B cell epitopes were predicted by IEDB DiscoTope 2.0 tools and their 3D structures were represented by discovery studio. Antigenicity and </span>allergenicity of epitopes were predicted by Vaxijen2.0 and AllergenFPv.1.0. Physiochemical properties of epitopes were predicted by Toxinpred, HLP webserver tool.</span></p></div><div><h3>Results</h3><p>Our data revealed 182 mutations in Nsp13 among Indian SARS-CoV-2 isolates, which were characterised by secondary structure and per-residue disorderness, stability and dynamicity predictions. To correlate the functional impact of these mutations, we characterised the most prominent B cell and T cell<span> epitopes contributed by Nsp13. Our data revealed twenty-one epitopes, which exhibited antigenicity, stability and interactions with MHC class-I and class-II molecules. Subsequently, the physiochemical properties of these epitopes were analysed. Furthermore, eighteen mutations reside in these Nsp13 epitopes.</span></p></div><div><h3>Conclusions</h3><p>We report appearance of eighteen mutations in the predicted twenty-one epitopes of Nsp13. Among these, at least seven epitopes closely matches with the functionally validated epitopes. Altogether, our study shows the pattern of evolution of Nsp13 epitopes and their probable implications.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 190-202"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49729337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination coverage among laboratory personnel - health safety imperative for all","authors":"Sabina Šegalo ,&nbsp;Arzija Pašalić ,&nbsp;Daniel Maestro ,&nbsp;Zhaohui Su ,&nbsp;Nafija Serdarević ,&nbsp;Anes Jogunčić ,&nbsp;Aida Ramić-Čatak ,&nbsp;Almedina Hajrović ,&nbsp;Snežana Unčanin ,&nbsp;Lejla Čano Dedić ,&nbsp;Berina Hasanefendić","doi":"10.1016/j.vacune.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.07.001","url":null,"abstract":"<div><h3>Aim</h3><p><span>The objective of the study was to evaluate disparities in </span>vaccination coverage<span> among laboratory personnel in health care facilities and to identify risk factors for nonvaccination.</span></p></div><div><h3>Materials and methods</h3><p>A multicenter, quantitative, cross-sectional study was conducted between November 2020 and February 2021. The validated bilingual questionnaire was distributed online through professional association networks. Descriptive and inferential statistics were included in the analysis.</p></div><div><h3>Results</h3><p><span><span>Of the 640 respondents, approximately one-third (30.9%) had received an annual influenza vaccination. Significantly higher vaccination coverage rates were reported for </span>measles, tuberculosis, and hepatitis B (82.8%, 78.3%, and 72.5%, respectively). Influenza vaccination coverage was higher among LPs with higher education (</span><em>p</em> &lt; 0.001), in microbiology laboratories (<em>p</em> = 0.009), in the private sector (<em>p</em> = 0.012), and twice as high in EU countries (<em>p</em> &lt; 0.001). Measles vaccination coverage was lower among LPs older than 45 years (<em>p</em> &lt; 0.001), had a college degree (<em>p</em> = 0.015), and were EU citizens (<em>p</em> = 0.002). Better tuberculosis vaccination coverage was found among LPs older than 45 years (<em>p</em> &lt; 0.001), with higher educational degrees (<em>p</em> = 0.003), employed in microbiology laboratories (<em>p</em> = 0.004), and working in the private sector (<em>p</em> = 0.025). Hepatitis B vaccination coverage was higher among LPs under 45 years (<em>p</em> = 0.020), with higher levels of education (<em>p</em> = 0.003), and with respect to territorial affiliation (<em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>The present study showed that the vaccination coverage rate was satisfactory for most LPs against hepatitis B, tuberculosis, and measles, while the coverage rate against influenza was low.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 166-173"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49729367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The end of COVID-19 public health emergency of international concern (PHEIC): And now what?","authors":"Núria Torner","doi":"10.1016/j.vacune.2023.05.001","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.05.001","url":null,"abstract":"","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 164-165"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49703251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between human microbiota and vaccines; Current perspectives","authors":"Masoud Keikha ,&nbsp;Mehdi Zandhaghighi ,&nbsp;Shahram Shahraki Zahedani","doi":"10.1016/j.vacune.2023.07.007","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.07.007","url":null,"abstract":"","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 255-257"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49707096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of adverse effects after the first COVID-19 booster dose: evidence from Greece","authors":"Petros Galanis ,&nbsp;Aglaia Katsiroumpa ,&nbsp;Irene Vraka ,&nbsp;Vanessa Chrysagi ,&nbsp;Olga Siskou ,&nbsp;Olympia Konstantakopoulou ,&nbsp;Theodoros Katsoulas ,&nbsp;Parisis Gallos ,&nbsp;Daphne Kaitelidou","doi":"10.1016/j.vacune.2023.07.004","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.07.004","url":null,"abstract":"<div><h3>Background</h3><p>In general, COVID-19 vaccines are safe and effective, but minor adverse effects are common. However, adverse effects have not been measured in several countries including Greece.</p></div><div><h3>Objective</h3><p>To estimate the prevalence of adverse effects after the first COVID-19 booster dose, and to identify possible risk factors.</p></div><div><h3>Material and methods</h3><p>We conducted a cross-sectional study with a convenience sample in Greece during November 2022. We measured several adverse effects after the booster dose, such as fatigue, headaches, fever, chills, nausea, etc. We considered gender, age, chronic disease, self-assessment of health status, COVID-19 diagnóstico, and self-assessment of COVID-19 course as possible predictors of adverse effects.</p></div><div><h3>Results</h3><p>In our sample, 96% developed at least one adverse effect. Half of the participants (50.2%) developed one to five adverse effects, 35.9% developed six to ten adverse effects, and 9.5% developed 11 to 16 adverse effects. Mean number of adverse effects was 5.5. The most frequent adverse effects were pain at the injection site<span> (84.3%), fatigue (70.8%), muscle pain (61%), swelling at the injection site (55.2%), headache (49.8%), fever (42.9%), and chills (41%). Females developed more adverse effects than males (p &lt; 0.001). The prevalence of adverse effects of COVID-19 vaccines was statistically significant and positively associated with the severity of COVID-19 among COVID-recovered individuals (p &lt; 0.05). Moreover, younger age was associated with increased adverse effects (p &lt; 0.001).</span></p></div><div><h3>Conclusions</h3><p>Almost all participants in our study developed minor adverse effects after the booster dose. Female gender, COVID-19 patients with worse clinical course, and younger individuals experienced more often adverse effects.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 210-217"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49707093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of sudden sensorineural hearing loss associated with BNT162b2 COVID-19 vaccine: Pooled results from register-based nationwide studies","authors":"Paulo Ricardo Martins-Filho","doi":"10.1016/j.vacune.2023.07.008","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.07.008","url":null,"abstract":"","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 258-259"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49703195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated factors in the intention of vaccination against COVID-19, in Popayán, Cauca Colombia","authors":"Omar Andrés Ramos Valencia ,&nbsp;Yuliana Buitrón Gonzalez ,&nbsp;Jorge Sotelo Daza ,&nbsp;Andrés Felipe Villaquiran","doi":"10.1016/j.vacune.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.vacune.2023.06.001","url":null,"abstract":"<div><p>Vaccination against the COVID-19 pandemic, decreed by the WHO in 2020, has shown in the initial trials an admissible efficacy for the scientific community, but with many doubts and concerns for the communities, developing the phenomenon known as vaccine hesitancy.</p></div><div><h3>Objective</h3><p>To understand the factors associated with the intention or rejection of vaccination against COVID-19 in the city of Popayán in the year 2022.</p></div><div><h3>Methodology</h3><p>Cross-sectional descriptive-analytical study, carried out between August 2021 and March 2022; with a non-probabilistic sampling, for convenience, with a sample size of 993 people; A questionnaire-type survey was applied in person and virtually to know the intention of vaccination, knowledge and perceptions.</p></div><div><h3>Results</h3><p>The surveyed population was characterized as 56.19% female, 49.24% between 18 and 28 years old; 23.16% state that they do not intend to be vaccinated against COVID-19, the main reasons being: not being well informed 56.29%, ineffective vaccine 54.8% and that the vaccine weakens the immune system 27,5%; as well as the low confidence with the Vaccination Plan and with the pharmaceutical companies that produce the vaccine.</p></div><div><h3>Conclusion</h3><p>The intention to vaccinate against COVID-19 is determined not only by the technical-administrative dynamics of the immunization program and the health system, variables of the context and the perception of risk, add up to explain the vaccination processes.</p></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"24 3","pages":"Pages 174-181"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49703243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}