Sustainable Horizons最新文献

{"title":"Power performance and dynamic characteristics of a 15 MW floating wind turbine with wave energy converter combined concept","authors":"Xun Gu ,&nbsp;Fei Lin ,&nbsp;Wei Jiang ,&nbsp;Jie Xu ,&nbsp;Jia-Ming Liu ,&nbsp;Kai Wang ,&nbsp;Tao Tao","doi":"10.1016/j.horiz.2024.100125","DOIUrl":"10.1016/j.horiz.2024.100125","url":null,"abstract":"<div><div>Recently, the large-scale development of Floating Offshore Wind Turbines (FOWTs) has raised attention to efficient energy capture and conversion. Combining a wave energy generator with a wind turbine system enhances the overall power production and reduces operating costs, effectively lowering the Levelized Cost of Electricity (LCoE). This work proposes a novel combined wind-wave energy generation concept consisting of a 15 MW class semi-submersible FOWT and four heaving-type torus-shape Wave Energy Converters (WECs) integrated with the platform columns. A fully coupled numerical model of aero-hydro-elastic-servo-mooring is developed based on the SIMO-RIFLEX framework. The power performance and dynamic response of the combined concept are statistically and analytically investigated by time-domain simulation for several sets of working load cases. The results show that introducing tori will bring additional restoring moments and damping effects to the platform, contributing to stable motion. In the rated operating condition, the pitch amplitude of the combined concept is 31.5 % less than that of the FOWT. At the same time, the torus-shaped WECs hardly affect the power performance of the wind turbine. The combined concept provides an additional contribution of wave energy, which is about 11.4 % of the annual power production in the rated operating case. Regarding dynamic characteristics, the combined concept exhibits a greater sensitivity to wave excitation.</div></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"13 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greenhouse gas emissions from urban river waters of China's major cities","authors":"Suqin Zhao ,&nbsp;Yiwen Zhang ,&nbsp;Y. Jun Xu ,&nbsp;Chen Ye ,&nbsp;Siyue Li","doi":"10.1016/j.horiz.2024.100124","DOIUrl":"10.1016/j.horiz.2024.100124","url":null,"abstract":"<div><div>Urban rivers are emerging as potent emitters of greenhouse gases (GHGs). However, the magnitude and drivers of GHG emissions from urban rivers are not well understood at a national level. Using a quantitative synthesis of 4633 data records collected from urban river waters of 23 major Chinese cities, this study delved into a systematic analysis of GHG emissions from urban rivers across China. The study showed that GHG emissions in these urban rivers varied spatially and temporally, with the highest carbon emission (CO₂ + CH₄) from the rivers draining large metropolitan areas and during the summertime. CO₂, CH₄, and N₂O concentrations in the urban river waters ranged from 22.53 to 1052.20 (188.41 ± 223.10) μmolL⁻¹, 0.02 to 21.32 (1.35 ± 1.59) μmolL⁻¹, and 0.01 to 16.81 (0.21 ± 0.72) μmolL⁻¹, respectively, with an average flux of 148.98 ± 245.30 mmolm⁻²d⁻¹ for CO₂, 9.41 ± 25.08 mmolm⁻²d⁻¹ for CH₄, and 0.19 ± 0.65 mmolm⁻²d⁻¹ for N₂O. Urban rivers also received large domestic sewage with high nutrient and carbon loadings due to huge populations, indicating the effect of wastewater treatment plant effluent and urban runoff on GHG production. These findings imply that direct GHG contributions from rivers in urban areas should be accurately quantified and consequently be included in GHG inventories of riverine GHG emissions.</div></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"13 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the patterns and mechanisms of residual currents and suspended sediment transport in the Lingdingyang of the Pearl River Delta","authors":"Lei Ren ,&nbsp;Jincai Ji ,&nbsp;Haokai Yang ,&nbsp;Hexu Wang ,&nbsp;Yaqi Wang ,&nbsp;Qin Zhu ,&nbsp;Leicheng Guo ,&nbsp;Xiaofan Lou ,&nbsp;Peng Yao ,&nbsp;Zhenchang Zhu ,&nbsp;Michael Hartnett","doi":"10.1016/j.horiz.2024.100123","DOIUrl":"10.1016/j.horiz.2024.100123","url":null,"abstract":"<div><div>Tide-averaged current, i.e., Eulerian residual current (ERC), indicates net transport of sediment and pollutants in coastal and estuarine regions. In this paper, we examine the dynamics of tidal currents and associate residual currents (RCs), suspended sediment transport and its governing mechanisms in the Lingdingyang (LDY) of the Pearl River Delta based on field data and numerical modeling. Results indicate that seaward ERCs dominate throughout the LDY. The ERCs are greater in the wet seasons than that in the dry seasons. The ERCs are smaller in the middle layer of the water column over the shoals, whereas they ware are larger in the middle layers in deep channels. The ERCs mainly discharge into the sea through the deep channel and west shoal, forming a slack water zone in the middle shoal. Vertical circulation structures of ERCs are controlled by the channel-shoal structure. A dual ERC circulation structure was observed between the channels, which is characterized with seaward and landward ERCs at the surface and bottom layers, respectively. As a result, the residual sediment transports are seaward, with large rates at the shoal than in the channel. Seaward ERCs explain residual sediment transport in the deep channel. Both ERCs and Stokes RCs (SRCs) are important over the shoal. Tidal pumping is of secondary importance and its direction varies over time and in space. These findings provide a scientific basis for understanding the channel-shoal evolution and maintenance of the navigational waterway in the LDY.</div></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"13 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000348/pdfft?md5=b50771deb1a6acc84996ae47efb39aef&pid=1-s2.0-S2772737824000348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the \"Double-Edged Sword\" effect of the digital economy on sustainable agricultural development: Evidence from China","authors":"Qingning Lin ,&nbsp;Yuqing Jian ,&nbsp;Deshuo Zhang ,&nbsp;Jingdong Li ,&nbsp;Shiping Mao","doi":"10.1016/j.horiz.2024.100122","DOIUrl":"10.1016/j.horiz.2024.100122","url":null,"abstract":"<div><div>The prolonged reliance on excessive resource utilization and unsustainable production methods has resulted in significant environmental issues in China, posing serious challenges to the sustainable development of agriculture. While the digital economy offers new opportunities for enhancing agricultural sustainability, its rapid and unregulated growth could also lead to negative effects. Therefore, exploring the relationship between the digital economy and sustainable agriculture development (SAD), along with clarifying the mechanisms involved, is of paramount importance. This study uses the EBM-GML index to calculate AGTFP as a representation of SAD and empirically tests the impact and mechanism of the digital economy on SAD. Additionally, it explores the moderating role of government behavior, specifically Agricultural fiscal support and digital policies. The main findings are as follows: (1) During the observation period, SAD showed a steady upward trend, but regional disparities widened, forming a contiguous agglomeration pattern. The decentralization of the digital economy weakened, trending towards unipolarization and homogenization, with a north-to-south diffusion. (2) The impact of the digital economy on SAD presents an inverted \"U\" shape, indicating a \"double-edged sword\" effect. This relationship remains significant after robustness and endogeneity tests. Additionally, the digital economy exhibits significant spatial effects, maintaining an inverted U-shaped relationship with SAD in neighboring areas. (3) Regional heterogeneity shows that coastal provinces are in digital economy suppression or alert areas, while inland regions are in enhancement areas. During the study period, the number of suppression and alert areas did not significantly increase, but there was a trend of shifting from coastal to inland regions. (4) When below the threshold, the digital economy promotes agricultural green technology innovation, optimizes resource allocation, and fosters synergetic agglomeration of agriculture with the secondary and tertiary industries, enhancing SAD. However, surpassing the threshold negatively impacts these mechanisms. (5) Fiscal support for agriculture smooths the inverted \"U\" curve, mitigating the negative impact of excessive digital economy growth on SAD. Conversely, digital policies steepen the inverted \"U\" curve, exacerbating these negative effects. The findings highlight the need for balanced digital economic development to support sustainable agricultural growth.</div></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"13 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000336/pdfft?md5=78c21312aba21546ee3ec63e56aea53e&pid=1-s2.0-S2772737824000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomous navigation and control for a sustainable vessel: A wind-assisted strategy","authors":"Guoqing Zhang ,&nbsp;Jiqiang Li ,&nbsp;Tengyu Chang ,&nbsp;Wenjun Zhang ,&nbsp;Lan Song","doi":"10.1016/j.horiz.2024.100117","DOIUrl":"10.1016/j.horiz.2024.100117","url":null,"abstract":"<div><p>The emission of carbon dioxide from the maritime transportation sector accounts for a significant proportion of the total emissions within the entire industry. The International Maritime Organization (IMO) has carried out a world’s inaugural preliminary strategy on the reduction of greenhouse gases from shipping transportation, and the IMO’s Marine Environment Protection Committee has pointed out that renewable energy (wind, solar, hydrogen) can provide a whole or assisted thrust for a marine surface vessel concerning the energy efficiency. One observes that the research of a sustainable vessel, which is powered by a wind-assisted thrust, is still in the early stage. This paper investigates an autonomous navigation and control strategy for a sustainable vessels for a reduction of consumption of fossil fuel, leading to a lower emission of carbon dioxide. For this purpose, two kinds of wind-assisted vessels, the wing sail-assisted vessel and rotor sail-assisted vessel are described from three aspects, the principles, installation and the mathematical model of the wind-assisted vessels. On the basis of the nonlinear mathematical model, an autonomous control scheme is proposed that uses a Backstepping technique. In addition, the adjustment strategies for the wing sail and rotor sail are discussed, which can achieve the objective of energy-saving by reducing the thrust from the propeller. From a numerical example by utilization of a rotor sail-assisted vessel, the explicitly result that a good energy-saving performance with 13% energy optimization ratio is achieved while a path following operation is carried out in the presence of the simulated wind environment. Furthermore, the feasibility of the application of wind-assisted vessel in practical engineering is discussed. Finally, the future applications and key techniques are examined to expedite the real implementation of theoretical advancements in the field of the wind-assisted vessel.</p></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"13 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000282/pdfft?md5=e1006752406d8045794068c01ca8c2ad&pid=1-s2.0-S2772737824000282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity of development goals to water scarcity of Iraq and transboundary regions","authors":"Gigi Pavur ,&nbsp;Megan C. Marcellin ,&nbsp;Davis C. Loose ,&nbsp;John J. Cardenas ,&nbsp;Benjamin D. Trump ,&nbsp;Igor Linkov ,&nbsp;Saddam Q. Waheed ,&nbsp;Mustafa Almashhadani ,&nbsp;Thomas L. Polmateer ,&nbsp;James H. Lambert ,&nbsp;Venkataraman Lakshmi","doi":"10.1016/j.horiz.2024.100121","DOIUrl":"10.1016/j.horiz.2024.100121","url":null,"abstract":"<div><p>Iraq and its transboundary regions have significant challenges from water scarcity in combination with other social and environmental factors. There are short- and long-term implications for vulnerable demographics, such as youth. With Iraq's dependence on upstream water management, there is a need to address several critical factors of transboundary watersheds such as the Haditha, Mosul, Dokan, and Euphrates-Tigris basin. This paper develops the use of particular social, hydrological, and other environmental factors in a <em>risk register of basins</em> and vulnerable populations, where societal priorities vary across scenarios of hydrology and water. Social data (i.e., gridded youth population data) and hydrological observations (i.e., precipitation, temperature, root zone soil moisture, and Normalized Difference Vegetation Index (NDVI)) are obtained from publicly available satellite-based Earth observations and global models. Risk is defined and quantified as the disruption of basin order and spatial plots are provided to improve understanding of the spatial distribution of water scarcity challenges in the region with regard to vulnerable populations. The results feature identification of the most and least disruptive scenarios including: 1) population density is lowest in basins exposed to the highest air temperatures, 2) an urban-to-rural migration pattern (such as prompted by a public health crisis) would significantly disrupt basin order, and 3) populations with greatest exposure to extreme hydrological conditions of water scarcity are found in the southern basins of Iraq in or near the Al-Muthanna governorate. The impacts of this work are to steer future investments that mitigate risk of disrupted system orders and to increase system resilience of vulnerable populations to water scarcity.</p></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"12 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000324/pdfft?md5=3786f97211cd961e47df4c8090e9cd78&pid=1-s2.0-S2772737824000324-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations into dynamic variation characteristics of near-bottom boundary flows over a long term at strait areas","authors":"Lei Ren ,&nbsp;Beinuo Zhou ,&nbsp;Yingyu Huang ,&nbsp;Shuxian Wang ,&nbsp;Qin Zhu ,&nbsp;Lilia Flores Mateos ,&nbsp;Maximo Garcia‐Jove ,&nbsp;Manman Wang ,&nbsp;Peng Yao ,&nbsp;Zhenchang Zhu","doi":"10.1016/j.horiz.2024.100120","DOIUrl":"10.1016/j.horiz.2024.100120","url":null,"abstract":"<div><p>Dynamic processes at the bottom boundary layers are crucial for various marine applications such as marine energy exploration and environmental protection. This paper explored hydrodynamic characteristics of near-bottom boundary currents based on the continuous measured velocity data at a site near the bottom boundary layer in the Strait of Georgia. Previous studies on the bottom boundary layer encompasses various aspects, including physical, chemical, and biological dimensions. However, the mechanism underlying the hierarchical structure of flow velocity remain poorly understood. Thus, the power spectrum and wavelet analysis were used to analyze the significant period of the averaged velocity and tidal characteristics, and to calculate the thickness of near-bottom boundary layer. The results indicate that the current velocities at the boundary layer tend to flow in south-eastern and north-western directions. There is a significant period of 15 days in August and September. At a depth of 301 m, the vertical velocities are stratified, indicating different velocity layers. The boundary layer thickness varies from 5.23 to 14.74 m, as indicated by the vertical structural characteristics. The structural characteristics of the seabed boundary layer are conducive to deepening our understanding of sediment's incipient motion, transport, and sedimentation process. The findings provide a theoretical foundation for future studies on sediment movement and the numerical simulation analysis of the bottom boundary layer. It is of great significance for the study of wave flow interaction and marine dynamic structure, and can provide scientific support for the development and utilization of the strait area.</p></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"12 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000312/pdfft?md5=bdab6321d3e8c4f8b475beeb54f16646&pid=1-s2.0-S2772737824000312-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of surface roughness on vibration response characteristics of flexible structures on offshore floating platforms","authors":"Zecheng Jiang ,&nbsp;Guanghua He ,&nbsp;Hassan Ghassemi ,&nbsp;Hangwei Zhang","doi":"10.1016/j.horiz.2024.100119","DOIUrl":"10.1016/j.horiz.2024.100119","url":null,"abstract":"<div><p>The expanding interest in floating offshore renewable energy technologies, including floating wind turbines and solar platforms, is attributed to their multifarious benefits. One pivotal factor influencing the power generation efficiency of these technologies is the vibration response of the flexible structures connected to the platforms, such as mooring systems, dynamic power cables, and flexible pipelines. In this research, a numerical investigation is conducted on the response characteristics of vortex-induced vibration (VIV) of cylinders with varying surface roughness in oscillatory flow. The unsteady Reynolds-averaged Navier-Stokes (URANS) equations and dynamic equation are used for fluid-structure interaction. The results reveal that for rough cylinders, multiple frequencies are involved in the vibration. For most simulated cases, the vibration frequency in the cross-flow (CF) direction is an integer multiple of the frequency of the oscillatory flow and associated with the quantity of shedding vortex pairs during a single period of the oscillatory flow. For rough cylinders, the CF vibration frequency differs by one from the number of shedding vortex pairs within one period of the oscillatory flow. With the increase of surface roughness, the maximum vibration amplitude shows an increasing trend (12%), then a decreasing trend (21%). Furthermore, the vortex shedding flow pattern presents C + S mode or S mode. This study offers valuable insights for analyzing the vibration response characteristics of authentic flexible structures.</p></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"12 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000300/pdfft?md5=5b63c514d1ea45815113372af68d0cf9&pid=1-s2.0-S2772737824000300-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Eyed Seeing: An ethical space of engagement to shape engineering and computing education for sustainable development","authors":"Riadh Habash","doi":"10.1016/j.horiz.2024.100118","DOIUrl":"https://doi.org/10.1016/j.horiz.2024.100118","url":null,"abstract":"<div><p>Universities serve as institutions for acquiring knowledge and instilling values in the learning environment, including students. These extend from the preventive moral values developed in schools to the strategic aspirational sustainability values to enhance competencies including knowledge, skills, attitudes, and ways of seeing and being worldwide. This paper is about a sustainability research experience as part of an undergraduate course on professional practice offered to engineering and computing students at the University of Ottawa, Canada. The course employs a \"learn-by-research\" approach in developing cases and projects. The experience highlights the significance of aspirational ethics in creating a distinct space of engagement steered by sustainable development as a core value for empowering and not overpowering society. This space is guided by the Two-Eyed Seeing principle which helps to engage the powers of Indigenous and Western knowledge for learning and practice. A broader Two-Eyed Seeing perspective to shape engineering and computing education was interpreted and employed. The students' anonymous survey and semi-structured interviews revealed noticeable improvements in their understanding, skills, and competencies toward sustainable development. This integrated approach to curriculum and pedagogy fosters critical and creative thinking in learners and cultivates a growth mindset that empowers them with research skills and sustainability knowledge. The outcomes of the study may act as an informing catalyst where human values and society are at the core to facilitate a transition in education for sustainable development.</p></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"12 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000294/pdfft?md5=425aa4a1eccbe326f19f5d75ac5f4e10&pid=1-s2.0-S2772737824000294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in silico insight on inhibitory potential of short-chain PFHxA and PFHxS against endogenous antioxidant enzymes","authors":"Prem Rajak ,&nbsp;Abhratanu Ganguly ,&nbsp;Sukhendu Dey","doi":"10.1016/j.horiz.2024.100116","DOIUrl":"https://doi.org/10.1016/j.horiz.2024.100116","url":null,"abstract":"<div><p>Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic chemicals that are globally used in various commercial products like cloths, carpets, cookware, firefighting foams, cosmetics, electronic products, etc. Inappropriate disposal of these consumer products could lead to environmental contamination with PFAS. Nowadays short-chain PFAS are substituting the long chain PFAS due to their short half-life. However, multiple studies have suggested that short-chain PFAS such as Perfluorohexanoic acid (PFHxA) and Perfluorohexanesulfonic acid (PFHxS) modulate antioxidant enzyme activities, induce Reactive Oxygen Species production, and contribute to oxidative stress in organisms. Notably, experimental set-ups aiming to investigate the mode of action of these compounds on antioxidants are entirely lacking. Hence in the present study, a ligand-docking approach was adopted to investigate the potential intermolecular interactions between short-chain PFAS and major antioxidants such as Glutathione peroxidase-4, Glutathione reductase, Glutathione S-Transferase, Catalase, and Superoxide dismutase-1. Three-dimensional structures of proteins were processed and docked individually with PFHxA and PFHxS using the AutoDock vina.. Results indicated significant binding affinities between various antioxidant proteins and PFAS. Interestingly, non-covalent interactions such as H-bonds, van der Waals, C<img>H bonds, halogen bonds, and alkyl/pi-alkyl were apparent at protein-ligand interface. Hence, these results suggest that both PFHxA and PFHxS may potentially interact with the endogenous antioxidants and this outcome can be detrimental to the redox homeostasis of living organisms.</p></div>","PeriodicalId":101199,"journal":{"name":"Sustainable Horizons","volume":"12 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772737824000270/pdfft?md5=b13d1a4b25418da269bfeb2ac4d69664&pid=1-s2.0-S2772737824000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}