Supramolecular Materials最新文献

{"title":"Organic-inorganic nanocomposite organogel with double-network topology for enhanced mechanical and dielectric properties","authors":"Dongdong Yan ,&nbsp;Shilei Zhu ,&nbsp;Hongyao Zhao ,&nbsp;Shanhao Feng ,&nbsp;Beibei Kang ,&nbsp;Xin Yang ,&nbsp;Yanjing Zhang ,&nbsp;Zhuangzhuang Li ,&nbsp;Wenwen Yu ,&nbsp;Ya Nan Ye","doi":"10.1016/j.supmat.2025.100112","DOIUrl":"10.1016/j.supmat.2025.100112","url":null,"abstract":"<div><div>Conventional artificial nanocomposites often rely on simple blending, which can lead to agglomeration and interfacial incompatibility between the organic and inorganic phases. In contrast, natural mineralized tissues like bone and teeth exhibit outstanding mechanical performance through nanoscale, interpenetrating organic-inorganic networks. Inspired by these naturally integrated architectures, we report a double-network (DN) organic-inorganic organogel composite formed by topologically interweaving self-assembled polyoxometalate sub-nanowires (SNWs) with a poly(tert‑butyl acrylate) (PtBA) matrix. The SNWs feature sub-nanometer diameters and flexibility similar to polymer chains, enabling them to form an inorganic network that seamlessly integrates with the organic phase. This continuous, interpenetrating DN structure enhanced key mechanical properties—including tensile strength, stiffness, and toughness—while simultaneously regulating dielectric properties such as dielectric permittivity and electrical breakdown strength, yielding a versatile, multifunctional platform. Overall, this design strategy paves the way for bioinspired advanced materials that merge mechanical robustness with customizable functionalities derived from inorganic components, promising applications in flexible electronics and functional structural materials.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protonation and aggregation of the A3B-type porphyrin in floating layers and thin films","authors":"Vladislav N. Mironyuk ,&nbsp;Oday A. Hassoon ,&nbsp;Antonina I. Smirnova ,&nbsp;Tatiana Ya. Karatyshova ,&nbsp;Ammar J.K. Al-Alwani ,&nbsp;Nadezhda V. Usol’tseva ,&nbsp;Evgeny G. Glukhovskoy","doi":"10.1016/j.supmat.2025.100104","DOIUrl":"10.1016/j.supmat.2025.100104","url":null,"abstract":"<div><div>The formation features and spectral properties of Langmuir floating layers of 5-(4-hydroxyphenyl)-10,15,20-tris(4-hexadecyloxyphenyl) porphyrin on an aqueous subphase with different content of orthophosphoric acid (H₃PO₄) have been studied. The acid concentrations were 0, 10^–3, 10^–2, 10^–1, 1 M, which corresponded to subphase pH values of 5.3, 3.1, 2.3, 1.6, 1.1, respectively. At low acid concentrations (<em>C</em>_H₃_PO4 = 0 M and 10^–3 M), only one condensed phase with <em>edge-on</em> orientation of porphyrin molecules as formed. At high concentrations (<em>C</em>_H₃PO₄ = 10^–1 M and 1 M), two phases with <em>face-on</em> and <em>edge-on</em> molecular orientations were detected. The protonation of porphyrin at high acid concentrations (<em>C</em>_H₃PO₄ = 10^–1, 1 М) proceeds more efficiently, which is confirmed by high-intensity absorption peaks in the range of 683–700 nm and the presence of the shoulder of Soret band at 465 nm. The protonation leads to a stronger interaction of porphyrin macrocycle with the subphase, maintaining the <em>face-on</em> orientation not only in the gas phase, but also partially in the condensed phase. Spectral characteristics of thin films transferred onto solid substrates by the Langmuir-Schaefer method retain the features inherent to the previous floating layers. The signs of porphyrin protonation decrease at strong compression of floating layers, when they are in the condensed phase, or when LS-films undergo heat treatment at a temperature of 110 °C. Obtaining the protonated forms of porphyrins as an electron acceptor is a step towards the creation of donor-acceptor systems, effective in the development of photovoltaic devices based on organic macroheterocyclic compounds.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamental and Application of Co-assembly of Peptides and Proteins: Experiment and Computation","authors":"Newton A. Ihoeghian,&nbsp;Qing Shao","doi":"10.1016/j.supmat.2025.100103","DOIUrl":"10.1016/j.supmat.2025.100103","url":null,"abstract":"<div><div>Peptides and proteins can co-assemble into various nanostructures based on complementary non-covalent interactions such as electrostatic forces, hydrogen bonding, and hydrophobic associations. These co-assemblies create a design space of functional materials for a wide spectrum of energy, environmental, and biomedical applications. This review focuses on the fundamentals and applications of three co-assembling systems: ultra-short peptides, peptides, and proteins. We will present and discuss experimental studies demonstrating applications in drug delivery, tissue engineering, and biomaterials development. We will also discuss the contribution of computational research, including molecular dynamics simulations and machine learning, to enhance our understanding of assembly mechanisms. Integrating experimental and computational methods would provide crucial insights for understanding and designing robust functional co-assemblies with precisely controlled compositions and properties. These advances would support the development of sophisticated biomaterials for applications ranging from targeted therapeutics to regenerative medicine.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Supramolecular microgels/microgel scaffolds for tissue repair and regeneration” [Supramolecular Materials 1 (2022) 100006]","authors":"Kai Wang,&nbsp;Zhaoyi Wang,&nbsp;Haijun Hu,&nbsp;Changyou Gao","doi":"10.1016/j.supmat.2025.100102","DOIUrl":"10.1016/j.supmat.2025.100102","url":null,"abstract":"","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimuli-responsive protein hydrogels: From dynamic tuning of hydrogel mechanics to shape morphing","authors":"Hongbin Li,&nbsp;Qingyuan Bian","doi":"10.1016/j.supmat.2025.100120","DOIUrl":"10.1016/j.supmat.2025.100120","url":null,"abstract":"<div><div>Protein hydrogels represent a rapidly evolving class of biomaterials with significant potential in biomedicine, soft robotics, and tissue engineering. These hydrogels are uniquely engineered from natural or recombinant proteins, endowing them with biocompatibility, biodegradability, and precise molecular programmability. By integrating dynamic cross-linking mechanisms and responsive moieties, protein hydrogels can be engineered to respond to external stimuli such as temperature, pH, light, or ligands, and undergo reversible or irreversible changes in shape, volume, or mechanical properties. This review critically summarizes recent advances in the design and fabrication of stimuli-responsive protein hydrogels. Emphasis is placed on the molecular design strategies that are used to dynamically tune the mechanical properties and shape-morphing behaviors of protein hydrogels. Challenges and opportunities related to the rational engineering of next-generation stimuli-responsive protein hydrogels are also discussed.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring self-sorting in metallacycles: Toward advanced supramolecular systems and materials","authors":"Tongxia Jin ,&nbsp;Xin Zhang ,&nbsp;Jun-Yi Su ,&nbsp;Jun-Xiao Ding ,&nbsp;Wei-Tao Dou ,&nbsp;Lin Xu","doi":"10.1016/j.supmat.2025.100117","DOIUrl":"10.1016/j.supmat.2025.100117","url":null,"abstract":"<div><div>Supramolecular self-sorting illustrates nature’s remarkable precision, wherein molecular components selectively recognize and bind to specific partners through a delicate balance of energetic interactions and molecular dynamics. This process results in organized structures that exemplify the emergence of order from disorder. Among the non-covalent forces that drive self-sorting, metal–ligand coordination plays a crucial role in constructing complex supramolecular systems. Its inherent directionality, predictability, and strength make it especially effective for forming stable and well-defined assemblies. Inspired by natural self-assembly, researchers have devised strategies to control and synthesize a diverse array of metallacycles. Despite significant progress in this area, studies on self-sorting within metallacycles remain relatively limited. This review summarizes recent advances in both narcissistic and integrative self-sorting processes in metallacycles, emphasizing the fundamental principles behind these mechanisms and their potential applications in functional materials. A deeper understanding of these processes will support the rational design of sophisticated supramolecular systems with enhanced precision and functionality, thereby paving the way for the development of advanced materials in catalysis, sensing, and molecular electronics.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zwitterionic hydrogels from material design to wound dressing applications","authors":"Huacheng He ,&nbsp;Yijing Tang ,&nbsp;Manhui Zheng ,&nbsp;Yung Chang ,&nbsp;Hong Chen ,&nbsp;Jialun Wei ,&nbsp;Jiang Wu ,&nbsp;Jie Zheng","doi":"10.1016/j.supmat.2025.100108","DOIUrl":"10.1016/j.supmat.2025.100108","url":null,"abstract":"<div><div>Zwitterionic hydrogels, synthesized from zwitterions such as sulfobetaine, carboxybetaine, and phosphorylcholine, feature a balanced mix of positive and negative charges within the same polymer chains. They exhibit excellent antifouling properties, superior hydration, distinctive anti-polyelectrolyte behavior, tunable mechanical strength, and low immunogenicity, all of which create an environment that mimics the extracellular matrix, facilitating faster wound healing. This review examines the development and applications of zwitterionic hydrogels in wound care, highlighting their potential to enhance healing processes and reduce complications in both acute and chronic wounds. Zwitterionic hydrogels are presented with distinct functionalities such as antibacterial activity, hemostatic properties, anti-inflammatory and antioxidant effects, and adaptability to the wound environment, all contributing to improved wound healing from various perspectives. Additionally, innovative approaches enhance zwitterionic hydrogels in wound care by integrating them with various bioactive compounds, photothermal therapy, and smart materials. These enhancements enable the effective delivery of therapeutic agents directly to the wound site and facilitate responsiveness to specific wound cues, providing a comprehensive multimodal therapeutic strategy. Further, the potential challenges and future perspectives in the field are addressed, including the need for advanced material design/synthesis and the integration of machine learning to optimize hydrogel design. By exploring both current applications and forward-looking innovations, this review underscores the significance of zwitterionic hydrogels and the vast potential for their future development in revolutionizing wound care, promising not only enhanced clinical outcomes but also broad applicative potentials in medicine.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular ethanol-water clusters in alcoholic beverages: Review on 2D correlation fluorescence and NMR spectral characterizations","authors":"Hui-Shuang Li ,&nbsp;Hao-jie Bai ,&nbsp;Yi Li ,&nbsp;Yuqing Wu","doi":"10.1016/j.supmat.2025.100094","DOIUrl":"10.1016/j.supmat.2025.100094","url":null,"abstract":"<div><div>While the studies have revealed that the type and content of ingredients are crucial factors in determining the quality and taste of alcoholic beverages, the liquid-liquid condensed phase of the supramolecular network of ethanol-water clusters (E-Wc) have been demonstrated playing important influence either. The supramolecular clusters in alcoholic beverages, especially the intrinsic hydrogen-bondings (HBs) to organoleptic sensing and quality assessment, have gradually been elucidated recently. The veiling concealed on the supramolecular entities as a key proportion of the ethanol-water solution (E-Ws) starts to be disclosed with the discrete achievements in this research area. To build a full understanding of the cluster driving in versatile alcoholic beverages <em>via</em> unique techniques for characterization, this review summarizes the involved supramolecular E-Wc by fluorescence emission and NMR spectra. In particular, the two-dimensional correlation (2D-COS) analysis has been introduced as a powerful tool for characterizing the important structural profiles in clusters. With the help of carving important supramolecular E-Wc, it is hoped that the prospects and challenges in this field will be clearer and that such kinds of condensed liquid phases can possess the potential as supramolecular material additives to modulate the products with various tastes and quality in the alcoholic industry.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanically Interlocked Biomacromolecules","authors":"Yu-Xiang Wang,&nbsp;Wen-Hao Wu,&nbsp;Feng-Yi Jiang,&nbsp;Wen-Bin Zhang","doi":"10.1016/j.supmat.2023.100059","DOIUrl":"10.1016/j.supmat.2023.100059","url":null,"abstract":"<div><p>Mechanical interlocking is a prominent phenomenon both in macroscopic objects and in microscopic molecules. Not only is it aesthetically appealing, it also leads to unique properties such as extraordinary mechanical stability. This review focuses on mechanically interlocked biomacromolecules. After a brief clarification on the concept and scope, we discuss their classification and summarize the three main types of mechanically interlocked biomacromolecules (i.e., DNA, RNA, and proteins) in terms of their natural occurrence, synthetic methods, relevant applications, and functional benefits. It has been found that mechanical interlocking reshapes the conformational space of these chain molecules, which provides numerous opportunities to tailor their properties and create new functions. Since the development of \"assembly-reaction\" synergies has greatly facilitated their synthetic availability, these mechanically linked biomacromolecules will become unique and promising candidates for various applications in biomaterials and biomedicine.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240523000296/pdfft?md5=5109bb992b4a35375e12f6d3516f2eac&pid=1-s2.0-S2667240523000296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138993769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-cascade terpolymer platform for amplified chemo-chemodynamic therapy with synergistic immunogenic cell death enhancement","authors":"Wei Ma ,&nbsp;Bin Wang ,&nbsp;Dun Wang,&nbsp;Ying Liu,&nbsp;Ming-Chao Jiang,&nbsp;Jin-Yan Zhang,&nbsp;Dong-Dong Peng,&nbsp;Zhi-Cheng Li,&nbsp;Cui-Yun Yu,&nbsp;Hua Wei","doi":"10.1016/j.supmat.2024.100066","DOIUrl":"10.1016/j.supmat.2024.100066","url":null,"abstract":"<div><p>Chemodynamic therapy, which relies on the generation of cytotoxic radicals, can be amplified by a nanoplatform that produces hydroxyl radicals while also compromising natural radical scavenging mechanisms. For this purpose, a well-defined amphiphilic terpolymer, poly(oligo(ethylene glycol) monomethyl ether methacrylate)-<em>block</em>-poly(<em>N,N</em>-dimethyl aminoethyl methacrylate-<em>statistical</em>-monomer bearing ferrocene graft via azobenzene linker) (POEGMA-<em>b</em>-P(DMAEMA-<em>st</em>-(M-Azo-Fc), denoted as PAzo-Fc) is prepared by a consecutive reversible addition-fragmentation chain transfer (RAFT) polymerization technique, and is further used for doxorubicin (DOX) encapsulation to afford DOX-loaded stabilized nanomicelles, DOX@PAzo-Fc with an average hydrodynamic diameter of 86.0 nm. DOX@PAzo-Fc shows a self-cascade property for amplified CDT. That is, Azo cleavage-induced glutathione (GSH) depletion alleviates reactive oxygen species (ROS) scavenging. Together with the DOX-enhanced hydrogen peroxide generation, the Fc-mediated Fenton reaction is boosted for enhanced CDT. More importantly, the resulting amplified cascade chemo-chemodynamic therapy exerts a synergistic immunogenic cell death (ICD) enhancement effect for effective cancer immunotherapy, which further resulted in a high tumor inhibition rate of 87.8 % in murine tumor models. The uniqueness of this study is the construction of a minimalist nanoplatform based on M-Azo-Fc units for amplified CDT via simultaneously producing hydroxyl radicals and compromising natural radical scavenging mechanisms. Overall, this self-cascade terpolymer platform fabricated herein offers a facile yet robust approach for advanced combinatory cancer therapy with great potential for clinical translations.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240524000047/pdfft?md5=ddf8de3d31f9d1c7720483df2f1a5b66&pid=1-s2.0-S2667240524000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140269642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}