Supramolecular Materials最新文献

{"title":"Recent advances in chirality sensing/recognition using supramolecular macrocycles","authors":"Chunhong Liu ,&nbsp;Leyong Wang ,&nbsp;Zhouyu Wang ,&nbsp;Wanhua Wu ,&nbsp;Cheng Yang","doi":"10.1016/j.supmat.2025.100107","DOIUrl":"10.1016/j.supmat.2025.100107","url":null,"abstract":"<div><div>Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based chiral sensors offer unique advantages over traditional small-molecule chiral sensors. This review highlights recent advancements in chiral sensing using supramolecular macrocycles, categorizing them into two primary groups: achiral and chiral macrocycles, based on their configurational features. Furthermore, it systematically outlines the synthetic strategies for these macrocycles, emphasizing their applications in chiral recognition and sensing.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing supramolecular materials design with artificial intelligence","authors":"Haoqi Zhu ,&nbsp;Zhongyi Wang ,&nbsp;Luofei Li ,&nbsp;Liang Dong ,&nbsp;Ying Li ,&nbsp;Bin Xue ,&nbsp;Yi Cao","doi":"10.1016/j.supmat.2024.100090","DOIUrl":"10.1016/j.supmat.2024.100090","url":null,"abstract":"<div><div>The design and development of supramolecular materials are hindered by complex non-covalent interactions and a lack of comprehensive rational design theories. Traditional \"trial-and-error\" methods are inefficient and labor-intensive, slowing progress in creating materials with precise tunability, robust stability, multifunctionality, and dynamic behavior. This perspective highlights major difficulties in supramolecular materials research and the transformative potential of artificial intelligence (AI) and machine learning (ML) in revolutionizing the field. Key challenges in applying AI include limited data availability, data quality issues, and the path-dependent nature of assembly processes. To overcome data scarcity, we discuss strategies such as transfer learning, data augmentation, and federated learning to enhance model performance with small datasets. We propose developing Intelligent Data Manufacturing Platforms—advanced laboratory automation systems designed to generate large volumes of high-quality data. By integrating AI algorithms with robotics in a closed-loop experimental system, these platforms enable high-throughput experimentation, autonomous decision-making, and iterative refinement of AI models through continuous data acquisition. This accelerates the design-build-test-learn cycle, fostering innovation and facilitating the development of next-generation supramolecular materials. By establishing standardized data repositories and encouraging global collaboration, this framework propels the field toward a data-intensive paradigm.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed chitosan-based flexible electrode with antimicrobial properties for electrical stimulation therapy in wound healing","authors":"Moses Kumi ,&nbsp;Zishuo Hou ,&nbsp;Yibo Zhang ,&nbsp;Yutian Yang ,&nbsp;Chang Han ,&nbsp;Tengjiao Wang ,&nbsp;Peng Li","doi":"10.1016/j.supmat.2025.100110","DOIUrl":"10.1016/j.supmat.2025.100110","url":null,"abstract":"<div><div>Enhanced bioelectrical stimulation near wound sites plays a crucial role in promoting the wound healing cascade, such as, supporting regular collagen deposition, proper extracellular matrix (ECM) remodeling. This study presents an antimicrobial porous flexible hydrogel electrode (APFE) for personalized electrical stimulation (ES) therapy, targeting infected diabetic wound healing. The APFE addresses these limitations by combining the antimicrobial properties of quaternary ammonium-modified chitin with the conductive polymer PEDOT: PSS, creating a flexible, wound-conforming electrode. Fabricated using 3D printing technology, the APFE can be tailored to conform to the unique anatomical contours of a patient’s wound, thereby enhancing its ability to support cell migration and proliferation– critical processes that ultimately accelerate wound healing. Characterization studies show that the APFE exhibits a tensile strength around ≈2.43± 0.57 MPa, and a stretchability of approximately ≈48.91 ± 2.84 %, closely matching skin flexibility (54 ± 17 %). The electrode’s porous and hydrophilic structure enhances moisture retention, making it suitable for diverse wound environments. <em>In vitro</em> results demonstrated good cell viability and around 85.71 % and 93.65 % bacterial inhibition for pathogens like Methicillin-resistant <em>Staphylococcus aureus (</em>MRSA<em>)</em> and <em>Escherichia coli (E. coli)</em> respectively in APFE 3<em>. In vivo</em> studies using infected diabetic mouse wounds demonstrated accelerated wound closure approaching 98.99 % in APFE 3 by Day 14, compared to 79.53 % in controls. Histological analysis confirmed increased re-epithelialization and collagen deposition, key histopathological markers of tissue regeneration, drive improved repair mechanisms and ultimately promote wound healing. These results reinforce the potential of the APFE as a customizable, scalable solution for diabetic wound care.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent patterning via visible light-triggered dynamic diselenide exchange","authors":"Jianbing Liu ,&nbsp;Peng Zhao ,&nbsp;Yizheng Tan ,&nbsp;Huaping Xu","doi":"10.1016/j.supmat.2025.100115","DOIUrl":"10.1016/j.supmat.2025.100115","url":null,"abstract":"<div><div>Fluorescent polymeric materials have recently gained significant attention in diverse fields, including biological imaging, luminescent sensing, encryption, and anti-counterfeiting. However, the patterning of many materials mentioned above has primarily been achieved through soft lithography technology using ultraviolet light, which can cause unnecessary damage to the materials and is limited by a shallow penetration depth. Herein, we introduce oligo(p-phenylene vinylene) derivatives (cyano-OPVs) as fluorescent molecules into diselenide-containing polyurethane (PUSeSe). Upon swelling, OPV molecules transition from aggregates to monomers, resulting in a blue shift in fluorescence spectra. By leveraging diselenide metathesis within the material, we successfully stabilized the monomeric state of OPV, enabling the inscription of green fluorescent images in illuminated regions, distinct from the original orange emission of the aggregated state. These materials can be effectively patterned within ten minutes under gentle and harmless visible light illumination. This visible light-induced fluorescence patterning method offers a convenient approach for designing advanced anti-counterfeiting materials with broader applications.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid","authors":"Beibei Lu ,&nbsp;Zhenyuan Wang ,&nbsp;Ying Xu ,&nbsp;Yue Liu ,&nbsp;Bo Ruan ,&nbsp;Jichuan Zhang ,&nbsp;Jianglin Zhang ,&nbsp;Jiaheng Zhang ,&nbsp;Tao Zhang","doi":"10.1016/j.supmat.2025.100093","DOIUrl":"10.1016/j.supmat.2025.100093","url":null,"abstract":"<div><div>Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field of skin anti-aging. This study used matrine and lauric acid to prepare an ionic liquid to enhance transdermal permeability and solve irritation. The results of the monomer of bakuchiol showed that the ionic liquid-loaded bakuchiol significantly improved the skin permeability of bakuchiol and completely solved the problem of low irritation of bakuchiol. As a single component, its penetration rate is 4.17 times that of retinol and 3.48 times that of bakuchiol, therefore it has a stronger inflammation inhibition rate and collagen expression ability (increasing the expression of <em>col 1a1a, col 1a1b</em>, and <em>col 1a2</em>). As a substitute for retinol, bakuchiol has great potential in anti-aging applications.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric-triboelectric hybrid nanogenerator based on tough, stretchable BaTiO3 doped antibacterial hydrogel for self-powered sensors","authors":"Runi Hou,&nbsp;Lijian Xu,&nbsp;Maolin Yu,&nbsp;Zengmin Tang,&nbsp;Bin Zhou,&nbsp;Qiao Zhang,&nbsp;Na Li,&nbsp;Jianxiong Xu","doi":"10.1016/j.supmat.2025.100096","DOIUrl":"10.1016/j.supmat.2025.100096","url":null,"abstract":"<div><div>The pursuit of nanogenerators with superior electrical output performance is crucial for advancing high-performance self-powered sensors, yet enhancing their performance through effective strategies remains a formidable challenge. Herein, a kind of piezoelectric-triboelectric hybrid nanogenerator (PTENG) utilizing a tough, stretchable BaTiO₃ doped hydrogel was developed. To this end, a functional hydrogel of oxidized sodium alginate (OSA) crosslinked poly(acrylic acid-<em>co</em>-acrylamide) (P(AA-<em>co</em>-AM)) in the presence of BaTiO₃ (BTO) nanoparticles was initially prepared and then immersed in FeCl₃ solution to form OSA/P(AA-<em>co</em>-AM)/Fe³⁺-BTO (O/P/Fe-BTO) hydrogels. Due to the multiple interaction (such as dynamic Schiff base cross-linking bond, metal coordination and hydrogen bonding), along with the synergistic contributions of each component, the as-prepared O/P/Fe-BTO hydrogels displayed outstanding mechanical property (tensile stress of 2.14 MPa, tensile strain of 876 %, toughness of 9.96 MJ/m³), good conductivity (0.14 S/m) and excellent antibacterial activity. Subsequently, a kind of PTENG was constructed by employing the O/P/Fe-BTO hydrogels as electrode materials. Leveraging both triboelectric and piezoelectric effects, the PTENG demonstrated excellent electrical output performance (open-circuit voltage of 222 V and short-circuit current of 5.35 μA). As a practical demonstration, the application of PTENG in self-powered strain and tactile sensors was demonstrated, manifesting their promising potential in self-powered sensing system. Overall, this work represents a noteworthy advancement in the domain of self-powered flexible electronics, with the potential for application in a wide range of complex scenarios.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular organization and optical properties of nanoscale and microscale films of an anisometric europium(III) complex","authors":"A.A. Knyazev ,&nbsp;R.M. Ziyatdinova ,&nbsp;A.S. Krupin ,&nbsp;A.T. Gubaidullin ,&nbsp;Yu.G. Galyametdinov","doi":"10.1016/j.supmat.2025.100106","DOIUrl":"10.1016/j.supmat.2025.100106","url":null,"abstract":"<div><div>An anisometric Eu(III) complex was used to produce nanoscale and microscale films by three different methods. These films demonstrated considerable differences in their supramolecular organization and optical properties. The impact of the fabrication method and supramolecular organization on optical properties of the films was studied. The nanoscale films deposited from solutions were found to have excitation spectra identical to those of diluted solutions with the maximum at 330 nm. The microscale films fabricated by vitrification from their melts or solvent evaporation from solutions were found to contain J-aggregates. Their spectra were comparable to those of concentrated solutions with the maximums at about 400 nm. For the first time, we report growing a monocrystal of a lanthanide’s mesogenic complex and its characterization by X-ray crystallography. The type of intermolecular interactions was identified and the size and shape of the aggregates were characterized. Formation of J-aggregates in microscale vitrified films was shown to be the key factor that provided these materials with the properties of excitation not only by UV light but also by inexpensive visible light sources with wavelengths corresponding to the absorption range of 390–425 nm.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy","authors":"Yongsheng Li ,&nbsp;Kan Yang ,&nbsp;Luyang Zhao","doi":"10.1016/j.supmat.2025.100109","DOIUrl":"10.1016/j.supmat.2025.100109","url":null,"abstract":"<div><div>Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising strategy for adjuvant melanoma therapy. However, most current review articles on tyrosinase inhibitors are primarily focused on discussing molecular inhibitor design and their depigmentation effects, while comprehensive reviews addressing their melanoma-sensitizing potential remain scarce. In this review, we systematically summarized recent development of tyrosinase inhibitor-mediated melanoma therapeutic treatment. Firstly we introduced the inhibiting mechanism of tyrosinase inhibitors and their development with various chemical structures and supramolecular assembly strategy. Then the tyrosinase inhibitor sensitization to irradiation/photodynamic therapy, chemotherapy, and immunotherapy was reviewed in detail, respectively, where the unique role of tyrosinase inhibitor in these therapeutic schemes are highlighted. Finally, we discuss potential optimization strategies for employing tyrosinase inhibitors in melanoma sensitization. This review timely addresses the critical gap in literature regarding tyrosinase inhibitor-mediated melanoma sensitization. It not only provides perspectives for clinical melanoma treatment but also facilitates the expansion of tyrosinase inhibitors' biomedical applications, thereby advancing the development of next-generation tyrosinase-targeted therapeutics.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances of supramolecular systems in precise cancer theranostics","authors":"Le Liu,&nbsp;Fan Huang,&nbsp;Jianfeng Liu,&nbsp;Meng Xiao","doi":"10.1016/j.supmat.2025.100116","DOIUrl":"10.1016/j.supmat.2025.100116","url":null,"abstract":"<div><div>Cancer remains a leading cause of death globally, with traditional treatments like surgery, chemotherapy, and radiotherapy often causing severe side effects and facing challenges due to tumor heterogeneity and complex microenvironments. Precision medicine, which tailors treatments to individual patients based on molecular and cellular understanding of diseases, offers a promising approach to improve cancer treatment outcomes. Supramolecular chemistry, focusing on molecular aggregates formed by non-covalent interactions, has emerged as a powerful tool in this context. This review explores the applications of supramolecular chemistry in precise cancer theranostics. Supramolecular chemistry, based on non-covalent interactions, can construct unique molecular aggregates with advantages like low immunotoxicity, dynamic reversibility, and modular structure, suitable for precision medicine. The review details these characteristics, and categorizes various supramolecular interactions including hydrogen bonds, electrostatic interactions, π-π stacking, metal-ion coordination bonds, hydrophobic interactions, and corresponding self-assembly systems, and their applications in drug delivery, tumor microenvironment modulation, and radiosensitization, etc. This article provides new directions for the development of supramolecular materials and precise cancer treatment.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular coordination modulating organic room temperature phosphorescence for multi-level information encryption","authors":"Depeng Liu ,&nbsp;Jiaying Zhou ,&nbsp;Longqiang Li ,&nbsp;Min Qi ,&nbsp;Wuzhen Luo ,&nbsp;Guangqiang Yin ,&nbsp;Tao Chen","doi":"10.1016/j.supmat.2025.100105","DOIUrl":"10.1016/j.supmat.2025.100105","url":null,"abstract":"<div><div>Organic room temperature phosphorescent (RTP) materials have emerged as a prominent research area due to their unique luminescent properties and wide applications. However, it remains a great challenge to realize a distinct RTP modulation by one stimulus, although it is highly desirable for developing high-level information encryption. Herein, we fabricate two distinct RTP films by incorporating terpyridine (Tpy) derivatives with a carboxylic or amine group into polyvinyl alcohol (PVA), exhibiting entirely different optical responses upon the introduction of dynamic lanthanide (Ln) coordination. The RTP film fabricated by carboxylic group-functionalized Tpy derivative shows significant changes in fluorescence and RTP emissions upon the addition of Ln³⁺ due to efficient triplet-to-singlet Förster resonance energy transfer (TS-FRET). On the contrary, the RTP film prepared by amine group-functionalized Tpy derivative demonstrates almost unchanged optical properties after introducing Ln³⁺. Encouraged by such a distinct Ln³⁺ modulation, multi-level information encryption is well demonstrated with a largely improved security level. This study not only contributes to the development of modulable RTP materials but also promotes the advancement of high-level information encryption.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}