Supramolecular Materials最新文献

{"title":"Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy","authors":"Haonan Ma ,&nbsp;Yifan Jin ,&nbsp;Jintao Li ,&nbsp;Xuedong Xiao ,&nbsp;Chengfei Liu ,&nbsp;Wei Tian","doi":"10.1016/j.supmat.2025.100113","DOIUrl":"10.1016/j.supmat.2025.100113","url":null,"abstract":"<div><div>Combination chemotherapy has been considered a crucial approach in cancer treatment to address the limitations of traditional single-drug therapy. However, the common strategies that encapsulate therapeutic agents with different mechanisms into a single “package” often lead to unsatisfactory anticancer activity because of the relatively low loading capacities, inconsistent reproducibility, and unpredictable release kinetics. In this study, we reported the construction of ruthenium (II)-coordinated supramolecular drug self-delivery systems. These systems are proposed to provide a stable and efficient transport platform for delivering drugs, thereby enhancing the effectiveness of combination chemotherapy. Ruthenium (II)-coordinated supramolecular polymer (RuSP) was first formed through host-guest interaction between <em>β</em>-cyclodextrin (<em>β</em>-CD) units grafted onto a hyaluronic acid chain (HA-CD) and (Benzene)Ru(curcuminato)Cl (Ru-Cur). The obtained RuSP then further self-assembled into ruthenium (II)-coordinated supramolecular drug self-assemblies (RuSDSAs). Upon internalization into cancer cells, RuSDSAs could be effectively degraded in acidic tumor microenvironment as for the smart dissociation of host-guest interaction, allowing for the controlled release of Ru-Cur and enhancing the efficacy of combination chemotherapy. Biological evaluation demonstrated that RuSDSAs achieved good anticancer effects and are biologically safe.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive to adaptive supramolecular hydrogels for diabetic wound treatment","authors":"Shalini Balakrishnan ,&nbsp;Revathy Remesh ,&nbsp;Krishnan Kartha Kalathil ,&nbsp;Anie Y","doi":"10.1016/j.supmat.2024.100081","DOIUrl":"10.1016/j.supmat.2024.100081","url":null,"abstract":"<div><div>Wound healing is a dynamic process involving four phases such as hemostasis, inflammation, proliferation, and remodeling of tissue at the wound site. Diabetes patients are more susceptible to the development of chronic wounds as high blood glucose levels in them cause increased chances of infection and disrupted tissue regeneration. Therefore, effective treatments are essential for the successful management of diabetic wounds. Among various methods, hydrogel-based treatments have gained popularity as it is biocompatible and economically viable. In addition, hydrogels enhance wound repair by providing a moist environment and by acting like the extracellular matrix. The development of stimuli-responsive supramolecular hydrogels that can encapsulate and release drugs, antioxidants, enzymes, or cells under specific conditions has expanded remarkably the treatment options for healing difficult wounds. Recent advancement in this area of research has added many features to stimuli-responsive supramolecular hydrogel in ensuring their sustained release in a controlled manner under the influence of specific pathophysiological conditions. This helps in correcting the wound environment by quenching reactive oxygen species (ROS), balancing pH, or acting as a scaffold for the formation of a matrix. Therefore, such stimuli-responsive supramolecular hydrogels have been termed as ‘smart’ materials in many places. In this review, we look into the recent developments in the fabrication of <em>smart supramolecular hydrogels</em> that detect the physiological changes in diabetic wound and adapt to the environment by undergoing structural or functional changes that are important in tackling many issues related to diabetic wound treatment.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable ultrahigh-affinity molecular recognition","authors":"Fang-Yuan Chen ,&nbsp;Han-Fang Zhang ,&nbsp;Kang Cai ,&nbsp;Dong-Sheng Guo","doi":"10.1016/j.supmat.2025.100101","DOIUrl":"10.1016/j.supmat.2025.100101","url":null,"abstract":"<div><div>High-affinity molecular recognition plays a crucial role in both biological and artificial host-guest systems, ensuring robustness in complex environments or at extremely low concentrations. Achieving exceptionally high binding affinity in artificial receptors remains a fundamental challenge for supramolecular chemistry. However, while ultrahigh binding affinity is desirable for stability, it may limit the dynamic behavior of host-guest systems, thereby restricting potential applications. Hence, controllable ultrahigh-affinity molecular recognition (<strong>CUAMR</strong>) systems allow guest release in response to precise stimuli (such as photo, pH and redox), which hold significant promise across diverse fields. This paper focuses on the introduction of <strong>CUAMR</strong> and functional applications of such controllable systems, highlighting current challenges and future prospects.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lego-like Visible Assembly of Responsive Components via Flexible Supramolecular Connectivity to Realize High-capacity Information Encoding","authors":"Guiqiang Zhu ,&nbsp;Qian Zhang ,&nbsp;Benwei Peng ,&nbsp;Siyuan Liu ,&nbsp;Cuiling Lin ,&nbsp;Alexander J.C. Kuehne ,&nbsp;Mengjiao Cheng ,&nbsp;Feng Shi","doi":"10.1016/j.supmat.2025.100099","DOIUrl":"10.1016/j.supmat.2025.100099","url":null,"abstract":"<div><div>Self-assembly in life that creates complex creatures with colorful biological activities, relies heavily on all-scale diverse components and high-capacity assembly information, which directs assembly patterns by specifying the connectivity of components. Despite of nanoscale colloids or connectivity via DNA hybridization providing rich possibility to store information, the execution of encoding at the level of macroscopic bulk materials remains improving, especially on the connectivity diversity. Here, we demonstrate visible self-assembly of millimeter-scaled hydrogels with flexible Lego-like connectivity for high-capacity encoding by storing the assembly information of both orthogonally stimulus-responsive components and interfacial supramolecular binding. Three categories of hydrogels with response to temperature, redox conditions, and UV light, are used as the intelligent building components. Meanwhile, reversible electrostatic interactions are applied as the interfacial supramolecular connectivity, which undergoes on-demand assembly/disassembly to create diverse structures similar to Lego playing. Mechanistic study is obtained by quantify the connectivity via in-situ measurements of interfacial binding forces between components. The flexible supramolecular connectivity of responsive components has provided abundant assembly possibility with good control, leading to a high encoding capacity of over 800 billion codes for a simple 5 × 5 assembly. This strategy induces myriad self-assembly pathways to broaden the design of information storage, and improves the execution of encoding at a bulk material level.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the inverse relationship between Am/Eu separation capability and softness of N-heterocyclic carboxylate ligands","authors":"Pin-Wen Huang ,&nbsp;Cong-Zhi Wang ,&nbsp;Zhe Su ,&nbsp;De-Xiang Jiang ,&nbsp;Jun-Li Wang ,&nbsp;Qun-Yan Wu ,&nbsp;Jian-Hui Lan ,&nbsp;Wei-Qun Shi","doi":"10.1016/j.supmat.2025.100092","DOIUrl":"10.1016/j.supmat.2025.100092","url":null,"abstract":"<div><div>In the advanced spent fuel wet reprocessing process, mutual separation of trivalent actinide ions (An³⁺) and lanthanide ions (Ln³⁺) is extremely challenging. The development of back-extraction separation ligands is considered to be a viable alternative to realized efficient An/Ln separation. Using density functional theory (DFT) calculations, we have studied the back-extraction behaviours and Am/Eu separation capabilities of three ethylenediamine N-heterocyclic carboxylate ligands including N, N, N’-tris (2-pyridylmethyl)-N’-(ethylacetate) ethylenediamine (HL^3py), N, N, N’-tris (2-pyrazinylmethyl)-N’-(ethylacetate) ethylenediamine (HL^3pz), and N, N, N’-tris (2-triazinylmethy)-N’-(ethylacetate) ethylenediamine (HL^3tz). Although HL^3pz is softer than HL^3py, HL^3py shows slightly better Am³⁺ selectivity over Eu³⁺compared to HL^3pz. This inverse relationship between ligands’ softness and their Am/Eu separation capabilities was explored through bonding nature analyses and back-extraction reactions. Though small in magnitude, Am-N_ring and Eu-N_ring bonds in the studied extraction complexes possess different extend of covalent component, and this difference may be the key mechanism of these back extractants for Am/Eu separation. Due to the hydrogen bonding and intermolecular interactions, the Am, Eu ions and extractants usually assemble in organic diluent forming supramolecular complexes. In this work, the thermodynamic properties of back-extraction from Am/Eu-DMDOHEMA and Am/Eu-HDEHP supramolecular species have been explored for the first time through quantum chemical calculations, which well reproduced the relative differences in selectivity Am³⁺ back extraction with HL^3py and HL^3pz, offering an explanation for the inverse relationship between ligand's softness and its Am³⁺ preference.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Printed metal organic frameworks-based supramolecular hydrogel as biological materials","authors":"Moses Kumi ,&nbsp;Bridget Kpomah ,&nbsp;Onome Ejeromedoghene ,&nbsp;Aboagye Gifty Takyiwaa ,&nbsp;Onomen Agnes Ehizojie","doi":"10.1016/j.supmat.2025.100100","DOIUrl":"10.1016/j.supmat.2025.100100","url":null,"abstract":"<div><div>In the dynamic landscape of biomaterials, the fusion of 3D-printed Metal-Organic Frameworks (MOFs) with supramolecular hydrogel technologies marks a pivotal shift toward generating next-generation biological materials. This comprehensive review sheds light on the fabrication of MOF-based supramolecular hydrogels using state-of-the-art 3D-printing methodologies. Herein, the distinct structural and functional attributes of these hybrid materials, setting the stage for their groundbreaking applications as biomaterials for wound care, bone regeneration, wearable electronics, and biosensing devices were addressed. These applications demonstrate the ability of 3D-printed MOF-based supramolecular hydrogels to redefine the norms in biomedical engineering and wearable technology landscapes. A deep dive into the functional properties of 3D-printed MOF-based biomaterials reveals their remarkable biofunctional attributes and the harmonious interplay between 3D-printed MOF structures and hydrogel networks. The review navigates through the existing challenges and unfolds the prospects within this fast-evolving domain, offering valuable insights into emergent growth trajectories and the scalability prospects of these hybrid materials. In conclusion, we spotlight the bright prospects of 3D-printed MOF-based supramolecular hydrogels, advocating their pivotal role in spearheading the development of biofunctional materials. Serving as an essential guide, this review targets researchers and industry experts, steering the course for future explorations and utilizations in this flourishing area of research.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in active filler-contained polymer solid-state electrolytes for lithium-metal batteries: A concise review","authors":"Hang Ding ,&nbsp;Mingli Wang ,&nbsp;Xinyuan Shan ,&nbsp;Guang Yang ,&nbsp;Ming Tian","doi":"10.1016/j.supmat.2025.100097","DOIUrl":"10.1016/j.supmat.2025.100097","url":null,"abstract":"<div><div>Lithium-metal batteries (LMBs) usually are regarded as the pinnacle of next-generation energy storage due to the high specific capacity and low redox potential of the Li-metal anode. However, their development is hindered by safety hazards related to flammable electrolytes and uncontrolled side reactions within the battery. Both polymer and solid-state inorganic electrolytes, despite their potential, exhibit shortcomings that limit their practical applications. Active filler-containing polymer electrolytes (AFPEs) offer a promising solution by combining the benefits of both types. Enhanced by supramolecular interactions between the polymer matrix and active fillers, AFPEs demonstrate superior electrochemical performance over traditional polymer electrolytes. This review discusses the progress in active fillers and various polymer matrices, examining the factors that enhance performance, particularly ionic conductivity. It also outlines the future research directions of AFPEs, aiming to broaden the application of solid electrolytes in high-performance LMBs.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications","authors":"Yu Yin ,&nbsp;Wu Wei ,&nbsp;Kai Zhang","doi":"10.1016/j.supmat.2025.100095","DOIUrl":"10.1016/j.supmat.2025.100095","url":null,"abstract":"<div><div>Chiral mesoporous silica nanoparticles (CMSNs) are a distinct subset of mesoporous silica nanoparticles, combining the favorable physicochemical properties of MSNs with unique chiral architectures at both molecular and macroscopic scales. These helical structures endow CMSNs with specialized functionalities, enabling their applications in chiral catalysis, enantioselective recognition, chiral separation, drug delivery, and optical devices, making them a focal point in materials and biomedical research. Significant progress has been achieved in the synthesis of CMSNs, particularly in understanding the mechanisms of chirality formation and the critical role of surfactant templates in guiding chiral structures. This review summarizes these advancements, emphasizing experimental and theoretical insights. Key applications of CMSNs, especially in drug delivery systems, are explored in detail, highlighting their potential to enhance bioavailability and therapeutic efficacy. Looking ahead, CMSN research presents exciting opportunities, including precise control over chiral structures, the development of novel templating strategies, and the exploration of broader applications. These advancements are expected to drive progress in nanoporous silica technologies and open new frontiers in materials science and nanomedicine.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the sensing mechanism of bis-urea macrocycle-based anion receptor: a theoretical study","authors":"G.S. Gopika Krishnan,&nbsp;K. Muraleedharan","doi":"10.1016/j.supmat.2025.100111","DOIUrl":"10.1016/j.supmat.2025.100111","url":null,"abstract":"<div><div>Understanding how the bis-urea macrocycle molecules can sense different invited anionic substances is becoming increasingly crucial. In this context, we have theoretically studied a new host-guest such as the interaction of 7,13-dibromo-1,4,8,11-tetraazacyclotetradecane-5,12‑dione (BUM) with the anions like SO₄²⁻, SO₃²⁻, CH₃COO⁻, NO₂⁻, and NO₃⁻. DFT and TD-DFT are used to calculate thermodynamics, electronic structure, electric-field induced properties, and photo-physical characteristics in order to investigate the mechanism of selective sensing of these anions. The free energy change (ΔG_ads) and adsorption energies (E_ads) suggest that these anionic interactions are thermodynamically feasible with strong to moderate adsorption energy with the receptor. The conductivity and sensitivity between the anions can be improved by the external electric field regulated investigation. Because of the intramolecular charge transfer transitions, internal conversions, and related configurational modifications, BUM-SO₃²⁻ exhibits good fluorescence in the BUM-anion complexes, indicating its significance for practical utility.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable power sources for transient bioelectronics","authors":"Li Dong ,&nbsp;Liangjie Shan ,&nbsp;Yafei Wang,&nbsp;Ji Liu","doi":"10.1016/j.supmat.2024.100082","DOIUrl":"10.1016/j.supmat.2024.100082","url":null,"abstract":"<div><div>The development of biodegradable power sources has opened new avenues for transient bioelectronics, offering temporary energy solutions for implantable medical devices. This review presents a systematic overview on the design, materials, and functionalities of biodegradable devices for energy storage, harvesting, and transfer. Biodegradable batteries and supercapacitors provide reliable, short-term energy for implantable devices, while triboelectric and piezoelectric nanogenerators enable continuous energy harvesting from biomechanical sources. Additionally, wireless energy transfer systems enable safe power delivery without direct contact with biological tissues, broadening the scope of implantable bioelectronics. Future research should prioritize enhancing biocompatibility, increasing energy density, and refining degradation control to extend the practical applications of biodegradable power sources in bioelectronics.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}