RSC Mechanochemistry最新文献_第2页

Moving mechanochemistry forward: mechanocatalysis 推动机械化学向前发展：机械催化

RSC Mechanochemistry Pub Date : 2026-03-02 DOI: 10.1039/D6MR90005D

Ferdi Schüth and Claudia Weidenthaler

引用次数: 0

Mechanochemical synthesis of aspirin nanocrystals for pharmaceutical applications 制药用阿司匹林纳米晶体的机械化学合成

RSC Mechanochemistry Pub Date : 2026-02-16 DOI: 10.1039/D5MR00118H

G. D. S. Kanchana Garumanna, Ranjit Thakuria and Nadeesh M. Adassooriya

{"title":"Mechanochemical synthesis of aspirin nanocrystals for pharmaceutical applications","authors":"G. D. S. Kanchana Garumanna, Ranjit Thakuria and Nadeesh M. Adassooriya","doi":"10.1039/D5MR00118H","DOIUrl":"https://doi.org/10.1039/D5MR00118H","url":null,"abstract":"Aspirin's oral bioavailability is about 50%, but this can be significantly improved through nanocrystal formulation and polymorphic transformation. However, achieving homogeneous nanocrystals with optimal stability and morphology remains challenging. In this study, pure aspirin was synthesized chemically, and nanocrystals were generated using both neat grinding (NG) and liquid-assisted grinding (LAG). Key parameters such as nature of liquid, liquid-to-solid ratio (η), milling frequency, milling time, and temperature were systematically optimized. Both solution crystallisation and mechanochemical milling successfully produced Form IV, which remains stable for over 60 days under ambient conditions (22–27 °C and 45–75% RH). Using water as the added liquid consistently converts aspirin Form IV to stable Form I under η = 0.07–0.15, 30 Hz and 10–120 minutes of milling. With cyclohexane, Form IV transforms to Form I within 30 minutes at η = 0.1, but reverts to Form IV after 60 minutes, and increasing η maintains it in Form IV for a period of over 60 days. Optimal nanocrystals were obtained by milling at 30 Hz for 30 minutes around 28 °C, with η between 0.1 and 0.2. Water proves to be most effective, as its hydrogen bonding disrupts the aspirin crystal lattice, and high surface tension improves shear stress transfer. This yields nanocrystals of ∼150 nm, reduces the melting point by 25.1 °C, and achieves ∼90% drug release within 6.5 minutes at pH 1.2, highlighting the potential of aspirin nanocrystals for enhanced bioavailability and therapeutic performance.","PeriodicalId":101140,"journal":{"name":"RSC Mechanochemistry","volume":" 3","pages":" 393-401"},"PeriodicalIF":0.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/mr/d5mr00118h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanochemical approach to gallate bioMOFs: efficient synthesis and Cr(vi) removal from aqueous and soil systems 没食子酸酯生物燃料的机械化学方法：有效合成和从水和土壤系统中去除Cr（vi）

RSC Mechanochemistry Pub Date : 2026-02-10 DOI: 10.1039/D5MR00123D

Alisson Luiz Rocha Balbino, Giovanna Pereira Correia, Gustavo Henrique Correia dos Santos, Priscilla Jussiane Zambiazi, João Paulo da Silva Souza, Bryan Alberto Laura Larico, Denise de Lima Dias Delarica, Kathleen Fernandes, Mara Regina Moitinho, Luciana Pires Rodrigues Betioli, José Marques, Dagoberto de Oliveira da Silva, Paulo Filho Marques de Oliveira and Liane Marcia Rossi

{"title":"Mechanochemical approach to gallate bioMOFs: efficient synthesis and Cr(vi) removal from aqueous and soil systems","authors":"Alisson Luiz Rocha Balbino, Giovanna Pereira Correia, Gustavo Henrique Correia dos Santos, Priscilla Jussiane Zambiazi, João Paulo da Silva Souza, Bryan Alberto Laura Larico, Denise de Lima Dias Delarica, Kathleen Fernandes, Mara Regina Moitinho, Luciana Pires Rodrigues Betioli, José Marques, Dagoberto de Oliveira da Silva, Paulo Filho Marques de Oliveira and Liane Marcia Rossi","doi":"10.1039/D5MR00123D","DOIUrl":"https://doi.org/10.1039/D5MR00123D","url":null,"abstract":"Heavy metal atoms, such as chromium, lead, cadmium, and others, are harmful to health and the environment and can cause irreversible impacts at certain concentrations. Given the hazards and increasing levels of chromium in aquatic and soils systems due to anthropogenic activities, it is important to implement heavy metal adsorption technologies for sustainable and green development. Here, two bioMOFs were synthetized via mechanochemistry, a solvent-free and environmentally friendly method that enables faster reactions compared to conventional solvothermal synthesis. Both MOFs use gallate as the organic linker, and the reactions were performed using a vibratory ball mill. The Fe-gallate MOF was obtained after 15 minutes of milling and the Mg-gallate MOF, after 60 minutes of milling, both significantly faster than what was reported before. The maximum Cr(VI) removal efficiency (29%) was obtained with the mechanochemically synthesized Fe-gallate. The material was further applied to Cr-rich soil samples, confirming its efficiency in chromium removal from complex matrices. These findings reinforce the potential of mechanochemistry as a sustainable route for the synthesis of advanced materials, particularly bioMOFs, providing greener alternatives from material selection to synthesis and application.","PeriodicalId":101140,"journal":{"name":"RSC Mechanochemistry","volume":" 3","pages":" 378-392"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/mr/d5mr00123d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lithium-mediated mechanochemical annulative dimerization of diarylacetylenes for synthesis of 1,4-dihydrodinaphthopentalenes 锂离子介导的二芳基乙炔机械化学环结二聚反应合成1,4-二氢二萘戊二烯

RSC Mechanochemistry Pub Date : 2026-02-05 DOI: 10.1039/D5MR00145E

Koya M. Hori, Yoshifumi Toyama, Takato Mori, Takumu Nakamura, Yohei Ono and Hideto Ito

{"title":"Lithium-mediated mechanochemical annulative dimerization of diarylacetylenes for synthesis of 1,4-dihydrodinaphthopentalenes","authors":"Koya M. Hori, Yoshifumi Toyama, Takato Mori, Takumu Nakamura, Yohei Ono and Hideto Ito","doi":"10.1039/D5MR00145E","DOIUrl":"https://doi.org/10.1039/D5MR00145E","url":null,"abstract":"1,4-Dihydrodiarenopentalenes, the reduced derivatives of diarenopentalene, have attracted attention owing to their rigid planar π-conjugated ladder framework, photophysical properties, C2-chiral structure, and potential applications in physical organic chemistry and materials science. Unlike the established methods for parent diarenopentalenes, the synthetic method for 1,4-dihydrodiarenopentalenes is less established, and the constructed structures are highly limited to dihydrodibenzopentalenes with trialkylsilyl substituents. Herein, we report a novel method for synthesizing 1,4-dihydrodinaphthopentalene derivatives by mechanochemical annulative dimerization of 2-(arylethynyl)naphthalenes with a lithium(0) wire. This reaction is easy to handle—even in an ambient atmosphere at room temperature—and requires a minimum amount of tetrahydrofuran for efficient grinding, resulting in the formation of various 1,4-diaryl-1,4-dihydrodinaphthopentalenes within 15 min. Furthermore, structural and theoretical analyses, as well as photophysical and chiro-optical measurements, reveal untapped properties of chiral 1,4-dihydrodinaphthopentalene.","PeriodicalId":101140,"journal":{"name":"RSC Mechanochemistry","volume":" 3","pages":" 330-337"},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/mr/d5mr00145e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water greatly impacts on the nanomechanical degradation of functionalized surfaces 水对功能化表面的纳米机械降解有很大影响

RSC Mechanochemistry Pub Date : 2026-02-02 DOI: 10.1039/D5MR00030K

Martin E. Zoloff Michoff, Przemysław Dopieralski and Dominik Marx

引用次数: 0

Amorphous-to-crystalline transformation: a mechanochemical pathway to imine-linked covalent organic frameworks 无定形到结晶的转变：一个机械化学途径到亚胺连接的共价有机框架。

RSC Mechanochemistry Pub Date : 2026-01-29 DOI: 10.1039/D5MR00161G

Normanda Brown, Yogendra Nailwal, Tyra Blair, Ziad Alsudairy, Qingsong Zhang, Krystal Kennedy, Yi Liu and Xinle Li

{"title":"Amorphous-to-crystalline transformation: a mechanochemical pathway to imine-linked covalent organic frameworks","authors":"Normanda Brown, Yogendra Nailwal, Tyra Blair, Ziad Alsudairy, Qingsong Zhang, Krystal Kennedy, Yi Liu and Xinle Li","doi":"10.1039/D5MR00161G","DOIUrl":"10.1039/D5MR00161G","url":null,"abstract":"Amorphous-to-crystalline transformation is of profound importance in the crystallization of covalent organic frameworks (COFs), yet its potential through solid-state mechanochemistry remains largely unexplored. Here, we introduce a mechanochemical amorphous-to-crystalline pathway to synthesize imine-linked COFs under ambient conditions. By ball milling their amorphous progenitors, nine imine-linked COFs with distinct core structures, topologies (hcb, sql, kgm, and dia), and dimensions are constructed in as little as one hour. Notably, the unique advantage of this method is highlighted by the successful synthesis of a highly crystalline, porous pyrene-based COF inaccessible by de novo mechanosynthesis. A mechanochemical “scrambling” reaction of imine-based model compounds confirms the high reversibility of the imine bonds in the solid state, which is crucial for facilitating error correction during COF reconstruction. This study underscores mechanochemistry as an effective means for amorphous-to-crystalline transformation, establishing a facile, generic, and green pathway to imine-linked COFs, including those unattainable via conventional de novo mechanosynthesis.","PeriodicalId":101140,"journal":{"name":"RSC Mechanochemistry","volume":" 3","pages":" 371-377"},"PeriodicalIF":0.0,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ball mass, surface, and contact dynamics in mechanochemical reactions 球质量、表面和接触动力学在机械化学反应中的作用。

RSC Mechanochemistry Pub Date : 2026-01-28 DOI: 10.1039/D5MR00146C

Marisol F. Rappen, Justus Mäder, Tino Schwemin, Sven Grätz and Lars Borchardt

引用次数: 0

When chirality breaks: mechanochemical degradation of biaryl atropisomers 手性断裂时：联芳基反二聚体的机械化学降解

RSC Mechanochemistry Pub Date : 2026-01-27 DOI: 10.1039/D5MR00132C

Leon Poljanić, Tom Leyssens, Laurent Collard and Daniel M. Baier

引用次数: 0

Selective mechanochemical conversion of post-consumer polyethylene terephthalate waste into hcp and fcu UiO-66 metal–organic frameworks† 消费后聚对苯二甲酸乙二醇酯废物选择性机械化学转化成hcp和fcu UiO-66金属有机骨架

RSC Mechanochemistry Pub Date : 2026-01-08 DOI: 10.1039/D4MR00126E

Tomislav Stolar, Dilara Bayram, Anastasia May, Remie Sundermann, Carsten Prinz, Klas Meyer, Anett Myxa, Jana Falkenhagen and Franziska Emmerling